Activation of the Ras-related GTPase Rap1 by thymocyte TCR engagement and during selection

European Journal of Immunology

Volumn 30, Issue 10, 2000, Pages 2832-2841

  Amsen, Derk ^a   Kruisbeek, Ada ^a   Bos, Johannes L ^b   Reedquist, Kris ^b,c  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

^b Lab for Physiological Chemistry   (Netherlands)

^c UTRECHT UNIVERSITY   (Netherlands)

Author keywords

C3G; Cbl; Guanine nucleotide exchange factor; Small GTPase; T cell development

Indexed keywords

ADAPTOR PROTEIN; CALCIUM; CD28 ANTIGEN; GENE PRODUCT; GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; PHORBOL ESTER; RAP1 PROTEIN; RAS PROTEIN; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CALCIUM MOBILIZATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME REGULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTO ONCOGENE; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; THYMOCYTE;

ANIMAL; ANTIGENS, CD28; ANTIGENS, CD3; CALCIUM SIGNALING; CLONAL DELETION; ENZYME ACTIVATION; HUMAN; JURKAT CELLS; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PROTO-ONCOGENE PROTEINS; RAP1 GTP-BINDING PROTEINS; RAS PROTEINS; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; SPECIFIC PATHOGEN-FREE ORGANISMS; SUPPORT, NON-U.S. GOV'T; T-LYMPHOCYTES;

EID: 0033789882     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200010)30:10<2832::AID-IMMU2832>3.0.CO;2-D     Document Type: Article

References (47)

1. Development and selection of T cells: Facts and puzzles
2. Thymocyte selection: Not by TCR alone
3. GTPases in antigen receptor signalling
4. T cell receptor signal transduction pathways
5. LAT: The ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation
6. Different functions of the GTPase Rho in prothymocytes and late pre-T cells
7. Networking Rho family GTPases in lymphocytes
8. Interaction of Shc with Grb2 regulates association of Grb2 with mSOS
9. Signal transduction in T lymphocytes using a conditional allele of Sos
10. Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras
11. Multiple Ras functions can contribute to mammalian cell transformation
12. Ras-like GTPases
13. All in the family? New insights and questions regarding interconnectivity of Ras, Rap1, and Ral
14. Involvement of p21 Ras distinguishes positive and negative selection in thymocytes
15. Raf regulates positive selection
16. Selective requirement for MAP kinase activation in thymocyte differentiation
17. The MAP kinase pathway controls differentiation from double-negative to double-positive thymocyte
18. 2+-mediated activation of Rap1 in human platelets
19. Minimal Ras-binding domain of Raf1 can be used as an activation-specific probe for Ras
20. Activation of the small GTPase Ral in pratelets
21. Costimuration through CD28 suppresses T cell receptor-dependent activation of the Ras-like smart GTPase Rap1 in human T lymphocytes
22. Maintenance of human T cell anergy: Blocking of IL-2 gene transcription by activated Rap1
23. Stimulation through the T cell receptor induces Cbl association with Crk proteins and the guanine nucleotide exchange protein C3G
24. The c-cbl proto-oncogene is preferentially expressed in thymus and testis tissue and encodes a nuclear protein
25. DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the membrane
26. Role of Crk oncogene product in physiologic signaling
27. Sos, Vav, and C3G participate in B cell receptor-induced signalling pathways and differentially associate with Shc-Grb2, Crk, and Crk-L adaptors
28. Affinity and specificity requirements for the first Src homology 3 domain of th Crk proteins
29. Differential interaction of the Ras family GTP-binding proteins H-Ras, Rap1A, and R-Ras with the putative effector molecules Raf kinase and Ral-guanine nucleotide exchange factor
30. A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia
31. Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand
32. + T cells in major histocompatibility complex class II-deficient mice
33. How many thymocytes audition for selection?
34. RapV12 antagonizes Ras-dependent activation of ERK1 and ERK2 by LPA and EGF in Rat-1 fibroblasts
35. + T cells
36. + T cells
37. Activation of the Drosophila C3G leads to cell fate changes and overproliferation during development, mediated by the RAS-MAPK pathway and Rap1
38. Extracellular signal-regulated activation of Rap1 fails to interfere in Ras effector signalling
39. Microinjection of smg/rap1/Krev-1 p21 into Swiss 3T3 cells induces DNA synthesis and morphological changes
40. Mitogenic and oncogenic properties of the small G protein Rap1b
41. The influence of the MAPK pathway on T cell lineage commitment
42. A role for Ras signaling in coreceptor regulation during differentiation of a double-positive thymocyte cell line
43. The small GTPase, Rap1, mediates CD31-induced integrin adhesion
44. Rap1 is a potent activation signal for leukocyte function-associated antigen 1 distinct from protein kinase C and phosphatidylinositol-3-OH kinase
45. RAG-1-deficient mice have no mature B and T lymphocytes
46. Mutations in T cell-antigen receptor genes α and β block thymocyte development at different stages
47. + thymocytes by two distinct mechanisms differing in their requirement for CD28 costimulation: Implications for negative selection in the thymus