Population genetics of IFIH1: Ancient population structure, local selection, and implications for susceptibility to type 1 diabetes

Molecular Biology and Evolution

Volumn 27, Issue 11, 2010, Pages 2555-2566

  Fumagalli, Matteo ^a,b   Cagliani, Rachele ^a   Riva, Stefania ^a   Pozzoli, Uberto ^a   Biasin, Mara ^c   Piacentini, Luca ^c   Comi, Giacomo P ^c   Bresolin, Nereo ^a,c   Clerici, Mario ^c,d   Sironi, Manuela ^a  

^a SCIENTIFIC INSTITUTE   (Italy)

^b POLITECNICO DI MILANO   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

^d IRCCS FONDAZIONE DON CARLO GNOCCHI   (Italy)

Author keywords

antiviral response; IFIH1; local selective pressure; population structure; positive selection; type 1 diabetes

Indexed keywords

DOUBLE STRANDED RNA; HELICASE; INTERFERON;

ARTICLE; ASIA; AUTOIMMUNITY; CLADISTICS; ETHNICITY; EUROPE; GENE; GENE FREQUENCY; GENETIC POLYMORPHISM; GENETIC SELECTION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HAPLOTYPE; HUMAN; HUMAN GENETICS; IFIH1 GENE; INSULIN DEPENDENT DIABETES MELLITUS; POPULATION GENETICS; POPULATION STRUCTURE; PROTEIN DOMAIN; VIRUS INFECTION;

AMERICAS; DEAD-BOX RNA HELICASES; DIABETES MELLITUS, TYPE 1; EXONS; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GENETICS, POPULATION; HAPLOTYPES; HUMANS; INTRONS; LIKELIHOOD FUNCTIONS; NUCLEOTIDES; PHYLOGENY; POLYMORPHISM, SINGLE NUCLEOTIDE; POPULATION DYNAMICS; SELECTION, GENETIC;

EID: 77958131532     PISSN: 07374038     EISSN: 15371719     Source Type: Journal    
DOI: 10.1093/molbev/msq141     Document Type: Article

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