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Volumn 22, Issue 6, 2010, Pages 677-682

Animal models of scleroderma: Fresh insights

Author keywords

MSH; basic fibroblast growth factor; bleomycin; connective tissue growth factor; Egr 1; endothelin 1; HSC025; MCP 1; mouse model; NALP3 inflammasome; PPAR ; systemic sclerosis; vasculopathy

Indexed keywords

ALPHA INTERMEDIN; BASIC FIBROBLAST GROWTH FACTOR; CONNECTIVE TISSUE GROWTH FACTOR; CRYOPYRIN; ENDOTHELIN 1; HERBACEOUS AGENT; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA ANTIBODY; MONOCYTE CHEMOTACTIC PROTEIN 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PLANT MEDICINAL PRODUCT; PLATELET DERIVED GROWTH FACTOR; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; ROSIGLITAZONE; TRANSCRIPTION FACTOR FLI 1; TRANSCRIPTION FACTOR FRA 2; TRANSFORMING GROWTH FACTOR BETA1; TRIHYDROXY ALPHA SANSHOOL; UNCLASSIFIED DRUG;

EID: 77958061836     PISSN: 10408711     EISSN: None     Source Type: Journal    
DOI: 10.1097/BOR.0b013e32833e307b     Document Type: Review
Times cited : (16)

References (47)
  • 1
    • 0025092082 scopus 로고
    • Transcription and expression of transforming growth factor type beta in the skin of progressive systemic sclerosis: A mediator of fibrosis?
    • Gruschwitz M, Muller PU, Sepp N, et al. Transcription and expression of transforming growth factor type beta in the skin of progressive systemic sclerosis: a mediator of fibrosis? J Invest Dermatol 1990; 94:197-203.
    • (1990) J Invest Dermatol , vol.94 , pp. 197-203
    • Gruschwitz, M.1    Muller, P.U.2    Sepp, N.3
  • 2
    • 0027429490 scopus 로고
    • Immunohistochemical localization of intracellular and extracellular associated TGF-beta in the skin of patients with systemic sclerosis (scleroderma) and primary Raynaud's phenomenon
    • Gabrielli A, Di Loreto C, Taborro R, et al. Immunohistochemical localization of intracellular and extracellular associated TGF-beta in the skin of patients with systemic sclerosis (scleroderma) and primary Raynaud's phenomenon. Clin Immunol Immunopathol 1993; 68:340-349.
    • (1993) Clin Immunol Immunopathol , vol.68 , pp. 340-349
    • Gabrielli, A.1    Di Loreto, C.2    Taborro, R.3
  • 3
    • 73449115656 scopus 로고    scopus 로고
    • Transcription factor Fos-related antigen-2 induces progressive peripheral vasculopathy in mice closely resemblinghuman systemic sclerosis
    • Maurer B, Busch N,Jungel A, et al. Transcription factor Fos-related antigen-2 induces progressive peripheral vasculopathy in mice closely resemblinghuman systemic sclerosis. Circulation 2009; 120:2367-2376.
    • (2009) Circulation , vol.120 , pp. 2367-2376
    • Maurer, B.1    Busch, N.2    Jungel, A.3
  • 4
    • 77950560433 scopus 로고    scopus 로고
    • Endothelial Fli1 deficiency impairs vascular homeostasis: A role in scleroderma vasculopathy
    • Asano Y, Stawski L, Hant F, et al. Endothelial Fli1 deficiency impairs vascular homeostasis: a role in scleroderma vasculopathy. Am J Pathol 2010;176:1983-1998.
    • (2010) Am J Pathol , vol.176 , pp. 1983-1998
    • Asano, Y.1    Stawski, L.2    Hant, F.3
  • 5
    • 57049135651 scopus 로고    scopus 로고
    • Role of endogenous endothelin in endothelial dysfunction in murine model of systemic sclerosis: Tight skin mice 1
    • Richard V, Solans V, Favre J, et al. Role of endogenous endothelin in endothelial dysfunction in murine model of systemic sclerosis: tight skin mice 1. Fundam Clin Pharmacol 2008; 22:649-655.
    • (2008) Fundam Clin Pharmacol , vol.22 , pp. 649-655
    • Richard, V.1    Solans, V.2    Favre, J.3
  • 6
    • 33748747707 scopus 로고    scopus 로고
    • Fli1 and Ets1 have distinct roles in connective tissue growth factor/CCN2 gene regulation and induction of the profibrotic gene program
    • Nakerakanti SS, Kapanadze B, Yamasaki M, et al. Fli1 and Ets1 have distinct roles in connective tissue growth factor/CCN2 gene regulation and induction of the profibrotic gene program. J Biol Chem 2006; 281:25259-25269.
    • (2006) J Biol Chem , vol.281 , pp. 25259-25269
    • Nakerakanti, S.S.1    Kapanadze, B.2    Yamasaki, M.3
  • 8
    • 58249111616 scopus 로고    scopus 로고
    • Transcription factor Fli1 regulates collagen fibrillogenesis in mouse skin
    • Asano Y, Markiewicz M, Kubo M, et al. Transcription factor Fli1 regulates collagen fibrillogenesis in mouse skin. Mol Cell Biol 2009; 29:425-434.
    • (2009) Mol Cell Biol , vol.29 , pp. 425-434
    • Asano, Y.1    Markiewicz, M.2    Kubo, M.3
  • 9
    • 69949127471 scopus 로고    scopus 로고
    • Endothelin: Role in vascular disease
    • Abraham D, Dashwood M. Endothelin: role in vascular disease. Rheumatology 2008; 47 (Suppl 5):23-24.
    • (2008) Rheumatology , vol.47 , Issue.SUPPL. 5 , pp. 23-24
    • Abraham, D.1    Dashwood, M.2
  • 10
    • 34247124221 scopus 로고    scopus 로고
    • Endothelin-1-induced signaling pathways in vascular smooth muscle cells
    • Bouallegue A, Daou GB, Srivastava AK. Endothelin-1-induced signaling pathways in vascular smooth muscle cells. Curr Vasc Pharmacol 2007; 5:45-52.
    • (2007) Curr Vasc Pharmacol , vol.5 , pp. 45-52
    • Bouallegue, A.1    Daou, G.B.2    Srivastava, A.K.3
  • 11
  • 12
    • 0028029736 scopus 로고
    • Circulating endothelin-1 levels in systemic sclerosis subsets: A marker of fibrosis or vascular dysfunction?
    • Vancheeswaran R, MagoulasT, Efrat G, et al. Circulating endothelin-1 levels in systemic sclerosis subsets: a marker of fibrosis or vascular dysfunction? J Rheumatol 1994; 21:1838-1844.
    • (1994) J Rheumatol , vol.21 , pp. 1838-1844
    • Vancheeswaran, R.1    Magoulas, T.2    Efrat, G.3
  • 14
    • 0037149718 scopus 로고    scopus 로고
    • Bosentan therapy for pulmonary arterial hypertension
    • Rubin LJ, Badesch DB, Barst RJ, etal. Bosentan therapy for pulmonary arterial hypertension. N Engl J Med 2002; 346:896-903.
    • (2002) N Engl J Med , vol.346 , pp. 896-903
    • Rubin, L.J.1    Badesch, D.B.2    Barst, R.J.3
  • 15
    • 30144442121 scopus 로고    scopus 로고
    • Bosentan in pulmonary arterial hypertension secondary to scleroderma
    • Joglekar A, Tsai FS, McCloskey DA, et al. Bosentan in pulmonary arterial hypertension secondary to scleroderma. J Rheumatol 2006; 33:61-68.
    • (2006) J Rheumatol , vol.33 , pp. 61-68
    • Joglekar, A.1    Tsai, F.S.2    McCloskey, D.A.3
  • 16
    • 0036917230 scopus 로고    scopus 로고
    • Endothelial dysfunction in murine model of systemic sclerosis: Tight-skin mice 1
    • Marie I, Beny JL. Endothelial dysfunction in murine model of systemic sclerosis: tight-skin mice 1. J Invest Dermatol 2002; 119:1379-1387.
    • (2002) J Invest Dermatol , vol.119 , pp. 1379-1387
    • Marie, I.1    Beny, J.L.2
  • 17
    • 0029941445 scopus 로고    scopus 로고
    • A tandem duplication within the fibrillin 1 gene is associated with the mouse tight skin mutation
    • Siracusa LD, McGrath R, MaQ, et al. A tandem duplication within the fibrillin 1 gene is associated with the mouse tight skin mutation. Genome Res 1996; 6:300-313.
    • (1996) Genome Res , vol.6 , pp. 300-313
    • Siracusa, L.D.1    McGrath, R.2    Ma, Q.3
  • 18
    • 69449094871 scopus 로고    scopus 로고
    • Loss of peroxisome proliferator-activated receptor gamma in mouse fibroblasts results in increased susceptibility to bleomycin-induced skin fibrosis
    • Kapoor M, McCann M, Liu S, et al. Loss of peroxisome proliferator- activated receptor gamma in mouse fibroblasts results in increased susceptibility to bleomycin-induced skin fibrosis. Arthritis Rheum 2009; 60:2822-2829.
    • (2009) Arthritis Rheum , vol.60 , pp. 2822-2829
    • Kapoor, M.1    McCann, M.2    Liu, S.3
  • 19
    • 59649085854 scopus 로고    scopus 로고
    • Rosiglitazone abrogates bleomycin-induced scleroderma and blocks profibrotic responses through peroxisomeprol iferator-activated receptor-gamma
    • Wu u, Melichian DS, Chang E, et al. Rosiglitazone abrogates bleomycin-induced scleroderma and blocks profibrotic responses through peroxisomeprol iferator-activated receptor-gamma. Am J Pathol 2009; 174: 519-533.
    • (2009) Am J Pathol , vol.174 , pp. 519-533
    • Wu, U.1    Melichian, D.S.2    Chang, E.3
  • 20
    • 59649083980 scopus 로고    scopus 로고
    • Alpha-melanocyte-stimulating hormone suppresses bleomycin-induced collagen synthesis and reducestissue fibrosis in a mouse model of scleroderma: Melanocortin peptides as a novel treatment strategy for scleroderma?
    • Kokot A, Sindrilaru A, Schiller M, et al. alpha-melanocyte-stimulating hormone suppresses bleomycin-induced collagen synthesis and reducestissue fibrosis in a mouse model of scleroderma: melanocortin peptides as a novel treatment strategy for scleroderma? Arthritis Rheum 2009; 60:592-603.
    • (2009) Arthritis Rheum , vol.60 , pp. 592-603
    • Kokot, A.1    Sindrilaru, A.2    Schiller, M.3
  • 21
    • 65549108648 scopus 로고    scopus 로고
    • Role of connective tissue growth factor and its interaction with basic fibroblast growth factor andmacrophage chemoattractant protein-1 in skin fibrosis
    • Chujo S, Shirasaki F, Kondo-Miyazaki M, et al. Role of connective tissue growth factor and its interaction with basic fibroblast growth factor andmacrophage chemoattractant protein-1 in skin fibrosis. J Cell Physiol2009; 220:189-195.
    • (2009) J Cell Physiol , vol.220 , pp. 189-195
    • Chujo, S.1    Shirasaki, F.2    Kondo-Miyazaki, M.3
  • 22
    • 70349237004 scopus 로고    scopus 로고
    • Essential roles for early growth response transcription factor Egr-1 in tissue fibrosis and wound healing
    • Wu U, Melichian DS, de la Garza M, et al. Essential roles for early growth response transcription factor Egr-1 in tissue fibrosis and wound healing. Am J Pathol 2009; 175: 1041-1055.
    • (2009) Am J Pathol , vol.175 , pp. 1041-1055
    • Wu, U.1    Melichian, D.S.2    De La Garza, M.3
  • 23
    • 1842733168 scopus 로고    scopus 로고
    • Disruption of transforming growth factor beta signaling and profibrotic responses in normal skin fibroblasts by peroxisome proliferator-activated receptor gamma
    • Ghosh AK, Bhattacharyya S, Lakos G, etal. Disruption of transforming growth factor beta signaling and profibrotic responses in normal skin fibroblasts by peroxisome proliferator-activated receptor gamma. Arthritis Rheum 2004; 50:1305-1318.
    • (2004) Arthritis Rheum , vol.50 , pp. 1305-1318
    • Ghosh, A.K.1    Bhattacharyya, S.2    Lakos, G.3
  • 24
    • 49449094104 scopus 로고    scopus 로고
    • Alpha-melanocyte-stimulating hormone and related tripeptides: Biochemistry, anti-inflammatory and protective effects in vitro and in vivo, and future perspectives for the treatment of immune-mediated inflammatory diseases
    • BrzoskaT, LugerTA, MaaserC, et al. Alpha-melanocyte-stimulating hormone and related tripeptides: biochemistry, anti-inflammatory and protective effects in vitro and in vivo, and future perspectives for the treatment of immune-mediated inflammatory diseases. Endocr Rev 2008; 29:581-602.
    • (2008) Endocr Rev , vol.29 , pp. 581-602
    • Brzoska, T.1    Luger, T.A.2    Maaser, C.3
  • 25
    • 12244308531 scopus 로고    scopus 로고
    • Anti-inflammatory effects of alpha-melanocyte-stimulating hormone in celiac intestinal mucosa
    • Colombo G, Buffa R, Bardella MT, et al. Anti-inflammatory effects of alpha-melanocyte-stimulating hormone in celiac intestinal mucosa. Neuroimmuno-modulation 2002; 10:208-216.
    • (2002) Neuroimmuno-modulation , vol.10 , pp. 208-216
    • Colombo, G.1    Buffa, R.2    Bardella, M.T.3
  • 26
    • 10744232014 scopus 로고    scopus 로고
    • Collagen metabolism is a novel target of the neuropeptide alpha-melanocyte-stimulating hormone
    • Bohm M, Raghunath M, Sunderkotter C, etal. Collagen metabolism is a novel target of the neuropeptide alpha-melanocyte-stimulating hormone. J Biol Chem 2004; 279:6959-6966.
    • (2004) J Biol Chem , vol.279 , pp. 6959-6966
    • Bohm, M.1    Raghunath, M.2    Sunderkotter, C.3
  • 27
    • 70350543918 scopus 로고    scopus 로고
    • A novel inhibitor of Smad-dependent transcriptional activation suppresses tissue fibrosis in mousemodels of systemic sclerosis
    • Hasegawa M, Matsushita Y, Horikawa M, et al. A novel inhibitor of Smad-dependent transcriptional activation suppresses tissue fibrosis in mousemodels of systemic sclerosis. Arthritis Rheum 2009; 60:3465-3475.
    • (2009) Arthritis Rheum , vol.60 , pp. 3465-3475
    • Hasegawa, M.1    Matsushita, Y.2    Horikawa, M.3
  • 28
    • 33644969133 scopus 로고    scopus 로고
    • Y-box protein-1 is the crucial mediator of antifibrotic interferon-gamma effects
    • Dooley S, Said HM, Gressner AM, et al. Y-box protein-1 is the crucial mediator of antifibrotic interferon-gamma effects. J Biol Chem 2006; 281:1784-1795.
    • (2006) J Biol Chem , vol.281 , pp. 1784-1795
    • Dooley, S.1    Said, H.M.2    Gressner, A.M.3
  • 29
    • 0242384852 scopus 로고    scopus 로고
    • Interferon-gamma interferes with transforming growth factor-beta signaling through direct interaction of YB-1 with Smad3
    • Higashi K, Inagaki Y, Fujimori K, et al. Interferon-gamma interferes with transforming growth factor-beta signaling through direct interaction of YB-1 with Smad3. J Biol Chem 2003; 278:43470-43479.
    • (2003) J Biol Chem , vol.278 , pp. 43470-43479
    • Higashi, K.1    Inagaki, Y.2    Fujimori, K.3
  • 30
    • 33845497181 scopus 로고    scopus 로고
    • Inflammatory caspases and inflammasomes: Master switches of inflammation
    • Martinon F, Tschopp J. Inflammatory caspases and inflammasomes: master switches of inflammation. Cell Death Diff 2007; 14:10-22.
    • (2007) Cell Death Diff , vol.14 , pp. 10-22
    • Martinon, F.1    Tschopp, J.2
  • 31
    • 43349086139 scopus 로고    scopus 로고
    • Detection of immune danger signals by NALP3
    • Martinon F. Detection of immune danger signals by NALP3. J Leukoc Biol 2008; 83:507-511.
    • (2008) J Leukoc Biol , vol.83 , pp. 507-511
    • Martinon, F.1
  • 32
    • 45849102043 scopus 로고    scopus 로고
    • ATP is released by monocytes stimulated with pathogen-sensing receptor ligands and induces IL-1b and IL-18 in an auto-crine way
    • Piccini A, Carta S, Tassi S, et al. ATP is released by monocytes stimulated with pathogen-sensing receptor ligands and induces IL-1b and IL-18 in an auto-crine way. Proc Natl Acad Sci \USA 2008; 105:8067-8072.
    • (2008) Proc Natl Acad Sci \USA , vol.105 , pp. 8067-8072
    • Piccini, A.1    Carta, S.2    Tassi, S.3
  • 33
    • 33747191203 scopus 로고    scopus 로고
    • The inflammasome: First line of the immune response to cell stress
    • Ogura Y, Sutterwala FS, Flavell RA. The inflammasome: first line of the immune response to cell stress. Cell 2006; 126:659-662.
    • (2006) Cell , vol.126 , pp. 659-662
    • Ogura, Y.1    Sutterwala, F.S.2    Flavell, R.A.3
  • 34
    • 34247174432 scopus 로고    scopus 로고
    • A signal for the caspase-1 inflammasome free of TLR
    • Dinarello CA. A signal for the caspase-1 inflammasome free of TLR. Immunity 2008; 26:383-385.
    • (2008) Immunity , vol.26 , pp. 383-385
    • Dinarello, C.A.1
  • 35
    • 0033564334 scopus 로고    scopus 로고
    • Virus infection activates IL-1 beta and IL-18 production in human macrophages by a caspase-1-dependent pathway
    • Pirhonen J, Sareneva T, Kurimoto M, et al. Virus infection activates IL-1 beta and IL-18 production in human macrophages by a caspase-1-dependent pathway. J Immunol 1999; 162:7322-7329.
    • (1999) J Immunol , vol.162 , pp. 7322-7329
    • Pirhonen, J.1    Sareneva, T.2    Kurimoto, M.3
  • 36
    • 3042800587 scopus 로고    scopus 로고
    • Phospholipases C and A2 control lysosome-mediated IL-1 beta secretion: Implications for inflammatory processes
    • Andrei C, Margiocco P, Poggi A, et al. Phospholipases C and A2 control lysosome-mediated IL-1 beta secretion: implications for inflammatory processes. Proc Natl Acad Sci \USA 2004; 101:9745-9750.
    • (2004) Proc Natl Acad Sci \USA , vol.101 , pp. 9745-9750
    • Andrei, C.1    Margiocco, P.2    Poggi, A.3
  • 37
    • 34250307119 scopus 로고    scopus 로고
    • Interleukin-1 gene complex polymorphisms in systemic sclerosis patients with severe restrictive lung pathology
    • Beretta L, Bertolotti F, Cappiello F, et al. Interleukin-1 gene complex polymorphisms in systemic sclerosis patients with severe restrictive lung pathology. Hum Immunol 2007; 68:603-609.
    • (2007) Hum Immunol , vol.68 , pp. 603-609
    • Beretta, L.1    Bertolotti, F.2    Cappiello, F.3
  • 38
    • 13244272290 scopus 로고    scopus 로고
    • \+ T cells, interleukin-1b, and tumor necrosis factor a in the bronchoalveolar lavage fluid, peripheral blood, and skin of patients with systemic sclerosis
    • \+ T cells, interleukin-1b, and tumor necrosis factor a in the bronchoalveolar lavage fluid, peripheral blood, and skin of patients with systemic sclerosis. J Clin Pathol 2005; 58:178-184.
    • (2005) J Clin Pathol , vol.58 , pp. 178-184
    • Hussein, M.R.1    Hassan, H.I.2    Hofny, E.R.M.3
  • 39
    • 9644258488 scopus 로고    scopus 로고
    • Cytokine and chemokine levels in systemic sclerosis: Relationship with cutaneous and internal organ involvement
    • Scala E, Pallotta S, Frezzolini A, et al. Cytokine and chemokine levels in systemic sclerosis: relationship with cutaneous and internal organ involvement. Clin Exp Immunol 2004; 138:540-546.
    • (2004) Clin Exp Immunol , vol.138 , pp. 540-546
    • Scala, E.1    Pallotta, S.2    Frezzolini, A.3
  • 41
    • 54449088686 scopus 로고    scopus 로고
    • Interleukin-1b induction of IL-6 is mediated by a novel phosphatidylinositol 3-kinase dependent Akt/IkB kinase alpha pathway targeting activator protein-1
    • Cahill CM, Rogers JT. Interleukin-1b induction of IL-6 is mediated by a novel phosphatidylinositol 3-kinase dependent Akt/IkB kinase alpha pathway targeting activator protein-1. J Biol Chem 2008; 283:25900-25912.
    • (2008) J Biol Chem , vol.283 , pp. 25900-25912
    • Cahill, C.M.1    Rogers, J.T.2
  • 42
    • 0028937326 scopus 로고
    • Demonstration of interleukin-2, interleukin-4 and interleukin-6 in sera from patients with localized scleroderma
    • Ihn H, Sato S, Fujimoto M, et al. Demonstration of interleukin-2, interleukin-4 and interleukin-6 in sera from patients with localized scleroderma. Arch Dermatol Res 1995; 287:193-197.
    • (1995) Arch Dermatol Res , vol.287 , pp. 193-197
    • Ihn, H.1    Sato, S.2    Fujimoto, M.3
  • 43
    • 0026767273 scopus 로고
    • Mechanisms of pathogenesis in scleroderma. I: Overproduction of interleukin-6 by fibroblasts cultured from affected skin sites of patients with scleroderma
    • Feghali CA, Bost KL, Boulware DW, Levy LS. Mechanisms of pathogenesis in scleroderma. I: Overproduction of interleukin-6 by fibroblasts cultured from affected skin sites of patients with scleroderma. J Rheumatol 1992; 19:1207-1211.
    • (1992) J Rheumatol , vol.19 , pp. 1207-1211
    • Feghali, C.A.1    Bost, K.L.2    Boulware, D.W.3    Levy, L.S.4
  • 44
    • 36849056773 scopus 로고    scopus 로고
    • IL-1R1/MyD88 signaling and the inflam-masome are essential in pulmonary inflammation and fibrosis in mice
    • Gasse P, Mary C, Guenon I, et al. IL-1R1/MyD88 signaling and the inflam-masome are essential in pulmonary inflammation and fibrosis in mice. J Clin Invest 2007; 117:3786-3799.
    • (2007) J Clin Invest , vol.117 , pp. 3786-3799
    • Gasse, P.1    Mary, C.2    Guenon, I.3
  • 45
    • 47849132947 scopus 로고    scopus 로고
    • The NALP3 inflammasome is essential for the development of silicosis
    • Cassel SL, Eisenbarth SC, Lyer SS, et al. The NALP3 inflammasome is essential for the development of silicosis. Proc Natl Acad Sci USA 2008; 105:9035-9040.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 9035-9040
    • Cassel, S.L.1    Eisenbarth, S.C.2    Lyer, S.S.3
  • 46
    • 43249125839 scopus 로고    scopus 로고
    • Innate immune activation through NALP3 inflammasome sensing of asbestos and silica
    • Dostert C, Petrilli V, van Bruggen R, et al. Innate immune activation through NALP3 inflammasome sensing of asbestos and silica. Science 2008; 320:674-677.
    • (2008) Science , vol.320 , pp. 674-677
    • Dostert, C.1    Petrilli, V.2    Van Bruggen, R.3
  • 47
    • 76249115506 scopus 로고    scopus 로고
    • IL-1R1/MyD88 signaling is critical for elastase-induced lung inflammation and emphysema
    • Couillin I, Vasseur V, Charron S, et al. IL-1R1/MyD88 signaling is critical for elastase-induced lung inflammation and emphysema. J Immunol 2009;183:8195-8202.
    • (2009) J Immunol , vol.183 , pp. 8195-8202
    • Couillin, I.1    Vasseur, V.2    Charron, S.3


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