Anti-inflammatory effects of α-melanocyte-stimulating hormone in celiac intestinal mucosa

NeuroImmunoModulation

Volumn 10, Issue 4, 2002, Pages 208-216

  Colombo, Gualtiero ^a   Buffa, Roberto ^b   Bardella, Maria Teresa ^a   Garofalo, Letizia ^a   Carlin, Andrea ^a   Lipton, James M ^c   Catania, Anna ^a  

^a FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

^b UNIVERSITY OF MILANO BICOCCA   (Italy)

^c Zengen Inc   (United States)

Author keywords

Melanocyte stimulating hormone; Celiac disease; Duodenal mucosa; Gliadin; Interleukin 6; Melanocortin receptors

Indexed keywords

ALPHA INTERMEDIN; ANTIINFLAMMATORY AGENT; CYTOKINE; GLIADIN; GLUTEN; INTERLEUKIN 6; MELANOCORTIN 1 RECEPTOR; MELANOCORTIN 5 RECEPTOR; PEPTIDE HORMONE; PROOPIOMELANOCORTIN; PROTEIN PRECURSOR;

ADULT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELIAC DISEASE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; DUODENUM BIOPSY; DUODENUM MUCOSA; FEMALE; FRACTIONATION; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; IN VITRO STUDY; INTESTINE MUCOSA; MAJOR CLINICAL STUDY; MALE; MUCOSAL IMMUNITY; PRIORITY JOURNAL; PROTEIN SYNTHESIS; STIMULATION;

ADULT; ALPHA-MSH; ANTI-INFLAMMATORY AGENTS; CELIAC DISEASE; DUODENUM; FEMALE; GLIADIN; HUMANS; IMMUNOHISTOCHEMISTRY; INFLAMMATION; INTERLEUKIN-6; INTESTINAL MUCOSA; MALE; MIDDLE AGED; PRO-OPIOMELANOCORTIN; RECEPTORS, PITUITARY HORMONE;

EID: 12244308531     PISSN: 10217401     EISSN: None     Source Type: Journal    
DOI: 10.1159/000068323     Document Type: Article

References (32)

1. Schuppan D: Current concepts of celiac disease pathogenesis. Gastroenterology 2000;119:234-242.
2. Paulley LW: Observations on the aetiology of idiopathic steatorrhoea. BMJ 1954;2:1318-1321.
3. Yardley JH, Bayless TM, Norton JH, Hendrix TR: Celiac disease: A study of the jejunal epithelium before and after a gluten-free diet. New Engl J Med 1962;267:1173-1179.
4. Ferguson A, Murray D: Quantitation of intra-epithelial lymphocytes in human jejunum. Gut 1971;12:988-994.
5. Ferguson A, MacDonald TT, McClure JP, Holden RJ: Cell-mediated immunity to gliadin within the small-intestinal mucosa in coeliac disease. Lancet 1975;i:895-897.
6. Nilsen EM, Jahnsen FL, Lundin KE, Johansen FE, Fausa O, Sollid LM, Jahnsen J, Scott H, Brandtzaeg P: Gluten induces an intestinal cy-tokine response strongly dominated by interferon-γ in patients with celiac disease. Gastroenterology 1998;115:551-563.
7. Przemioslo RT, Kontakou M, Nobili V, Ciclitira PJ: Raised pro-inflammatory cytokines interleukin-6 and tumor necrosis factor-α in coeliac disease mucosa detected by immunohistochemistry. Gut 1994;35:1398-1403.
8. Beckett CG, Dell'Olio D, Shidrawi RG, Rosen-Bronson S, Ciclitira PJ: Gluten-induced nitric oxide and pro-inflammatory cytokine release by cultured coeliac small intestinal biopsies. Eur J Gastroenterol Hepatol 1999;11:529-535.
9. Catania A, Lipton JM: α-Melanocyte stimulating hormone in the modulation of host reactions. Endocr Rev 1993;14:564-576.
10. Catania A, Airaghi L, Colombo G, Lipton JM: α-MSH in normal human physiology and disease states. Trends Endocrinol Metab 2000;11:304-308.
11. Eberle AN: The Melanotropins. Basel, Karger, 1988.
12. Lipton JM, Ceriani G, Macaluso A, McCoy D, Carnes K, Biltz J, Catania A: Antiinflammatory effects of the neuropeptide α-MSH in acute, chronic, and systemic inflammation. Ann NY Acad Sci 1994;741:137-148.
13. Lipton JM, Catania A: Anti-inflammatory actions of the neuroimmunomodulator α-MSH. Immunol Today 1997;18:140-145.
14. Macaluso A, McCoy D, Ceriani G, Watanabe T, Biltz J, Catania A, Lipton JM: Antiinflammatory influences of α-MSH molecules: Central neurogenic and peripheral actions. J Neurosci 1994;14:2377-2382.
15. Catania A, Gerloni V, Procaccia S, Airaghi L, Manfredi MG, Lomater C, Grossi L, Lipton JM: The neuropeptide α-MSH in synovial fluid of patients with rheumatic diseases: Comparisons with other anticytokine molecules. Neuroimmunomodulation 1994;1:321-328.
16. Chomczynski P, Sacchi N: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987;162:156-159.
17. Star RA, Rajora N, Huang J, Stock RC, Catania A, Lipton JM: Evidence of autocrine modulation of macrophage nitric oxide synthase by α-melanocyte-stimulating hormone. Proc Natl Acad Sci USA 1995;92:8016-8020.
18. Chiao H, Foster S, Thomas R, Lipton J, Star R: α-Melanocyte-stimulating hormone reduces endotoxin-induced liver inflammation. J Clin Invest 1996;97:2038-2044.
19. Mason MJ, Van Epps D: Modulation of IL-1, tumor necrosis factor, and C5a-mediated murine neutrophil migration by α-melanocyte-stimulating hormone. J Immunol 1989;142:1646-1651.
20. Catania A, Rajora N, Capsoni F, Minonzio F, Star RA, Lipton JM: The neuropeptide α-MSH has specific receptors on neutrophils and reduces chemotaxis in vitro. Peptides 1996;17:675-679.
21. Grabbe S, Bhardwaj RS, Mahnke K, Simon MM, Schwarz T Luger TA: α-Melanocyte-stimulating hormone induces hapten-specific tolerance in mice. J Immunol 1996;156:473-478.
22. Manna SK, Aggarwal BB: α-Melanocyte-stimulating hormone inhibits the nuclear transcription factor NF-κB activation induced by various inflammatory agents. J Immunol 1998;161:2873-2880.
23. Ichiyama T, Zhao H, Catania A, Furukawa S, Lipton JM: α-Melanocyte-stimulating hormone inhibits NF-κB activation and IκBα degradation in human glioma cells and in experimental brain inflammation. Exp Neurol 1999;157:359-365.
24. Abdel-Malek ZA: Melanocortin receptors: Their functions and regulation by physiological agonists and antagonists. Cell Mol Life Sci 2001;58:434-441.
25. Taherzadeh S, Sharma S, Chhajlani V, Gantz I, Rajora N, Demitri MT, Kelly L, Zhao H, Catania A, Lipton JM: α-MSH and its receptors in regulation of inflammatory tumor necrosis factor-α by human monocyte/macrophages. Am J Physiol 1999;276:R1289-R1294.
26. van der Kraan M, Adan RA, Entwistle ML, Gispen WH, Burbach JP, Tatro JB: Expression of melanocortin-5 receptor in secretory epithelia supports a functional role in exocrine and endocrine glands. Endocrinology 1998;139:2348-2355.
27. Chen W, Kelly MA, Opitz-Araya X, Thomas RE, Low MJ, Cone RD: Exocrine gland dysfunction in MC5-R-deficient mice: Evidence for coordinated regulation of exocrine gland function by melanocortin peptides. Cell 1997;91:789-798.
28. Taylor AW, Namba K: In vitro induction of CD25+ CD4+ regulatory T cells by the neuro-peptideα-melanocyte-stimulating hormone (α-MSH). Immunol Cell Biol 2001;79:358-367.
29. Benjannet S, Rondeau N, Day R, Chrétien M, Seidah NG: PC1 and PC2 are pro-protein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues. Proc Natl Acad Sci USA 1991;88:3564-3568.
30. Taylor A, Streilen J, Cousins S: Identification of α-melanocyte stimulating hormone as a potential immunosuppressive factor in aqueous humor. Curr Eye Res 1992;1:1199-1206.
31. Rajora N, Boccoli G, Catania A, Lipton JM: α-MSH modulates experimental inflammatory bowel disease. Peptides 1997;18:381-385.
32. Oktar BK, Ercan F, Yegen BC, Alican I: The effect of α-melanocyte-stimulating hormone on colonic inflammation in the rat. Peptides 2000;21:1271-1277.