A novel 18β-glycyrrhetinic acid analogue as a potent and selective inhibitor of 11β-hydroxysteroid dehydrogenase 2

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 12, 2004, Pages 3263-3267

  Vicker, Nigel ^a   Su, Xiangdong ^a   Lawrence, Harshani ^a   Cruttenden, Adrian ^b   Purohit, Atul ^b   Reed, Michael J ^b   Potter, Barry V L ^a  

^a UNIVERSITY OF BATH   (United Kingdom)

^b ST MARY S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; GLYCYRRHETINIC ACID; GLYCYRRHETINIC ACID DERIVATIVE; N (2 HYDROXYETHYL) 3 BETA HYDROXY 11 OXO 18 BETA OLEAN 12 EN 30 OIC ACID AMIDE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 2; ANIMALS; ENZYME INHIBITORS; GLUCURONIDES; GLYCYRRHETINIC ACID; RATS; RATS, WISTAR;

EID: 2442604248     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.03.107     Document Type: Article

References (29)

1. Jörnvall H., Persson B., Krook M., Atrian S., Gonzalez-Duarte R., Jeffery J., Ghosh D. Biochemistry. 34:1995;6003-6013
2. Edwards C.R., Stewart P.M., Burt D., Brett L., McIntyre M.A., Sutano W.S. Lancet. 2:1988;986-989
3. Seckl J.R., Walker B.R. Endocrinology. 142:2001;1371-1376
4. Davani B., Kahn A., Måartensson E., Efendic S., Jörnvall H., Oppermann U.C.T. J. Biol. Chem. 275:2000;34841-34844
5. Kotelevtsev Y.V., Brown R.W., Fleming S., Kenyon C., Edwards C.R.W., Seckl J.R., Mullins J.J. J. Clin. Invest. 103:1999;683-689
6. Alberts P., Engblom L., Edling N., Forsgren M., Kilngström G., Larsson C., Rönquist-Nii Y., Öhman B., Abrahmsén L. Diabetalogica. 45:2002;1528-1532
7. Andrews R.C., Rooyackers O., Walker B.R. J. Clin. Endocrinol. Metab. 88:2003;285-291
8. Barf T., Vallgårda J., Emond R., Häggström C., Kurz G., Nygren A., Larwood V., Mosialou E., Axelsson K., Olsson R., Engblom L., Edling N., Rönquist-Nii Y., Öhman B., Alberts P., Abrahmsén L. J. Med. Chem. 45:2002;3813-3815
9. Sandeep T.C., Walker B.R. Trends Endocrinol. Metab. 12:2001;446-453
10. Kotelevtsev Y.V., Holmes M.C., Burchell A., Houston P.M., Schmoll D., Jamieson P., Best R., Brown R., Edwards C.R.W., Seckl J.R., Mullins J.J. Proc. Natl. Acad. Sci. U.S.A. 94:1997;14924-14929
11. Masusaki H., Paterson J., Shinyama H., Morton N.M., Mullins J.J., Seckl J.R., Flier J.S. Science. 294:2001;2166-2170
12. Monder C., Stewart P.M., Laksmi V., Valentino R., Burt D., Edwards C.R.W. Endocrinology. 125:1989;1046-1053
13. Diederich S., Grossmann C., Hanke B., Quinkler M., Herrmann M., Bähr V., Oelkers W. Eur. J. Endocrinol. 142:2000;200-207
14. Stewart P.M., Valentino R., Wallace A.M., Burt D., Shackleton C.H.L., Edwards C.R.W. Lancet. 2:1987;281-284
15. Stewart P.M., Wallace A.M., Atherton S.M., Shearing C.H., Edwards C.R.W. Clin. Sci. 78:1990;49-54
16. Dave-Sharma S., Wilson R.C., Harbison M.D., Newfield R., Azar M.R., Krozowski M.R., Funder J.W., Shackleton C.L., Bradlow H.L., Wei J.-Q., Hertecant J., Moran A., Neiberger R.E., Balfe J.W., Fattah A., Daneman D., Akkurt H.I., de Santis C. J. Clin. Endocrinol. Metab. 83:1998;2244-2254
17. Walker E.A., Stewart P.M. Trends Endocrinol. Metab. 14:2003;334-339
18. Coulter C.L., Smith R.E., Stowaser M., Sasano H., Krozowski Z.S., Gordon R.D. Endocr. Res. 24:1998;875-876
19. Korbonits M., Bujalska I., Shimojo M., Nobes J., Kordan S., Grossman A.B., Stewart P.M. J. Clin. Endocrinol. Metab. 86:2001;2728-2733
20. Rabbitt E.H., Ayuk J., Boelaert K., Sheppard M.C., Hewison M., Stewart P.M., Gittoes N.J.L. Oncogene. 22:2003;1663-1667
21. Sasano H., Frost A.R., Saitoh R., Matsunaga G., Nagura H., Krozowski Z.S., Silverberg S.G. Anticancer Res. 17:1997;2001-2007
22. Rabbitt E.H., Lavery G.C., Walker E.A., Cooper M.S., Stewart P.M., Hewison M. FASEB J. 16:2002;36-44
23. Rabbitt E.H., Gittoes N.J.L., Stewart P.M., Hewison M. J. Steroid. Biochem. Mol. Biol. 85:2003;415-421
24. Hult M., Jörnvall H., Oppermann U.C.T. FEBS Lett. 441:1998;25-28
25. Guo J., Reidenberg M.M. J. Lab. Clin. Med. 132:1998;32-38
26. Potter, B. V. L.; Purohit, A.; Reed, M. J.; Vicker, N. WO 02072084, 2002
27. Sheehan J.C., Ledis S.L. J. Am. Chem. Soc. 95:1973;875-879
28. Bradford M.M. Anal. Biochem. 72:1976;248-254
29. Arnold P., Tam S., Yan L., Baker M.E., Frey J.F., Odermatt A. Mol. Cell. Endocrinol. 201:2003;177-187