Synthesis of glycyrrhetinic acid derivatives for the treatment of metabolic diseases

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 1, 2010, Pages 433-454

  Beseda, Igor ^a   Czollner, Laszlo ^a   Shah, Priti S ^b   Khunt, Rupesh ^a   Gaware, Rawindra ^a   Kosma, Paul ^c   Stanetty, Christian ^c   Ruiz Ruiz, Maria Carmen del ^c   Amer, Hassan ^c   Mereiter, Kurt ^a   Cunha, Thierry Da ^d   Odermatt, Alex ^d   Claßen Houben, Dirk ^e   Jordis, Ulrich ^a  

^a VIENNA UNIVERSITY OF TECHNOLOGY   (Austria)

^b SAURASHTRA UNIVERSITY   (India)

^c UNIVERSITY OF NATURAL RESOURCES AND LIFE SCIENCES   (Austria)

^d UNIVERSITY OF BASEL   (Switzerland)

^e Onepharm Research and Development GmbH   (Austria)

Author keywords

11 HSD1; 11 HSD2; Hydroxysteroid dehydrogenase (HSD); Inhibitors; Metabolic diseases; X ray

Indexed keywords

(18BETA,20BETA) 3 (HYDROXYIMINO) 11 OXO OLEAN 12 EN 29 OIC ACID DIPHENYLMETHYL ESTER; (18BETA,20BETA) 3 (HYDROXYIMINO) 11 OXO OLEAN 12 EN 29 OIC ACID METHYL ESTER; (18BETA,20BETA) 3 (METHOXYIMINO) 11 OXO OLEAN 12 EN 29 OIC ACID; (18BETA,20BETA) 3 (METHOXYIMINO) 11 OXO OLEAN 12 EN 29 OIC ACID DIPHENYLMETHYL ESTER; (18BETA,20BETA) 3,11 DIOXO OLEAN 12 EN 29 OIC ACID DIPHENYLMETHYL ESTER; (18BETA,20BETA) 3,11 DIOXO OLEAN 12 EN 29 OIC ACID METHYL ESTER; (3BETA,18BETA,20BETA) 2 [(4 METHYLPHENYL)SULFONYL]HYDRAZIDE 3 (ACETYLOXY) 11 OXO OLEAN 12 EN 29 OIC ACID; (3BETA,18BETA,20BETA) 29 (ALLYLAMINO) 11,29 DIOXO OLEAN 12 EN 3 YL ACETATE; (3BETA,18BETA,20BETA) 29 [(2 AMINOETHYL)AMINO] 11,29 DIOXO OLEAN 12 EN 3 YL ACETATE; (3BETA,18BETA,20BETA) 29 AMINO 11,29 DIOXO OLEAN 12 EN 3 YL ACETATE; (3BETA,18BETA,20BETA) 29 HYDRAZINO 11,29 DIOXO OLEAN 12 EN 3 YL ACETATE; (3BETA,18BETA,20BETA) 3 (3 CARBOXY 1 OXOPROPOXY) 11 OXO OLEAN 12 EN 29 OIC ACID; (3BETA,18BETA,20BETA) 3 (4 HYDROXY 3,3 DIMETHYL 1,4 DIOXOBUTOXY) 11 OXO OLEAN 12 EN 29 OIC ACID; (3BETA,18BETA,20BETA) 3 (ACETYLOXY) 11 OXO OLEAN 12 EN 29 AL; (3BETA,18BETA,20BETA) 3 (ACETYLOXY) 11 OXO OLEAN 12 EN 29 OIC ACID; (3BETA,18BETA,20BETA) 3 (ACETYLOXY) 11 OXO OLEAN 12 EN 29 OIC ACID DIPHENYLMETHYL ESTER; (3BETA,18BETA,20BETA) 3 (ACETYLOXY) 11 OXO OLEAN 12 EN 29 OIC ACID METHYL ESTER; (3BETA,18BETA,20BETA) 3 (ACETYLOXY) 11 OXO OLEAN 12 EN 29 OYL CHLORIDE; (3BETA,18BETA,20BETA) 3 [(PHOSPHONO)OXY] 11 OXO OLEAN 12 EN 29 OIC ACID; (3BETA,18BETA,20BETA) 3 [(TRIMETHYLSILYL)OXY] 11 OXO OLEAN 12 EN 29 OIC ACID; (3BETA,18BETA,20BETA) 3 AMINO 11 OXO OLEAN 12 EN 29 OIC ACID METHYL ESTER; (3BETA,18BETA,20BETA) 3 HYDROXY 11 OXO OLEAN 12 EN 29 AL OXIME; (3BETA,18BETA,20BETA) 3 HYDROXY 11 OXO OLEAN 12 EN 29 OIC ACID ALLYL ESTER; (3BETA,18BETA,20BETA) 3 HYDROXY 11 OXO OLEAN 12 EN 29 OIC ACID BENZYL ESTER; (3BETA,18BETA,20BETA) 3 HYDROXY 11 OXO OLEAN 12 EN 29 OIC ACID DIPHENYLMETHYL ESTER; (3BETA,18BETA,20BETA) 3 HYDROXY 11 OXO OLEAN 12 EN 29 OIC ACID ETHYL ESTER; (3BETA,18BETA,20BETA) 3 HYDROXY 11 OXO OLEAN 12 EN 29 OIC ACID METHYL ESTER; ETHYL 1 [(3BETA,18ALPHA,20BETA 3 HYDROXY 11,29 DIOXOOLEAN 12 EN 29 YL]PIPERIDINE 4 CARBOXYLATE; GLYCYRRHETINIC ACID DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG EFFECT; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; METABOLIC DISORDER; X RAY DIFFRACTION;

11-BETA-HYDROXYSTEROID DEHYDROGENASES; CRYSTALLOGRAPHY, X-RAY; GLYCYRRHETINIC ACID; HUMANS; METABOLIC DISEASES; MODELS, MOLECULAR;

EID: 72049109415     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.10.036     Document Type: Article

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