Selective inhibition of 11β-hydroxysteroid dehydrogenase 1 by 18α-glycyrrhetinic acid but not 18β-glycyrrhetinic acid

Journal of Steroid Biochemistry and Molecular Biology

Volumn 113, Issue 3-5, 2009, Pages 248-252

  Classen Houben, Dirk ^a   Schuster, Daniela ^b,c   Da Cunha, Thierry ^d   Odermatt, Alex ^d   Wolber, Gerhard ^b,c   Jordis, Ulrich ^e   Kueenburg, Bernhard ^a  

^a Onepharm Research and Development GmbH   (Austria)

^b UNIVERSITY OF INNSBRUCK   (Austria)

^c Inte:Ligand GmbH   (Austria)

^d UNIVERSITY OF BASEL   (Switzerland)

^e VIENNA UNIVERSITY OF TECHNOLOGY   (Austria)

Author keywords

11 HSD; 11beta hydroxysteroid dehydrogenase; Glucocorticoid; Glycyrrhetinic acid; Inhibitor; LigandScout; Metabolic syndrome; Pharmacophore model

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 1; 11BETA HYDROXYSTEROID DEHYDROGENASE 2; 18ALPHA GLYCYRRHETINIC ACID; CARBENOXOLONE; GLYCYRRHETINIC ACID; 18ALPHA-GLYCYRRHETINIC ACID; DRUG DERIVATIVE;

ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG ACTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; PHARMACOPHORE; CELL LINE; CHEMICAL STRUCTURE; DOSE RESPONSE; DRUG ANTAGONISM; DRUG DESIGN; GENETICS; METABOLISM; STEREOISOMERISM; SYNTHESIS;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 2; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; GLYCYRRHETINIC ACID; HUMANS; MOLECULAR STRUCTURE; STEREOISOMERISM;

EID: 61349196161     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2009.01.009     Document Type: Article

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