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Volumn 67, Issue 11, 2010, Pages 1307-1315

Translational research in neurology and neuroscience 2010: Multiple sclerosis

(17)  Stüve, Olaf a,b   Kieseier, Bernd C e   Hemmer, Bernhard f   Hartung, Hans Peter e   Awad, Amer i   Frohman, Elliot M b   Greenberg, Benjamin M b   Racke, Michael K j   Zamvil, Scott S k   Phillips, J Theodore d   Gold, Ralf g   Chan, Andrew g   Zettl, Uwe h   Milo, Ron c,l   Marder, Ellen a   Khan, Omar m   Eagar, Todd N b,c,l  


Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; BETA1A INTERFERON; DACLIZUMAB; FLECAINIDE ACETATE; GLATIRAMER; LAMOTRIGINE; MITOXANTRONE; NATALIZUMAB; PHENYTOIN; PLACEBO; RILUZOLE;

EID: 77957949997     PISSN: 00039942     EISSN: 15383687     Source Type: Journal    
DOI: 10.1001/archneurol.2010.158     Document Type: Review
Times cited : (15)

References (135)
  • 1
    • 34547907306 scopus 로고
    • Observations on attempts to produce acute disseminated encephalomyelitis
    • Rivers TM, Sprunt DH, Berry GP. Observations on attempts to produce acute disseminated encephalomyelitis. J Exp Med. 1933;58(1):39-53.
    • (1933) J Exp Med , vol.58 , Issue.1 , pp. 39-53
    • Rivers, T.M.1    Sprunt, D.H.2    Berry, G.P.3
  • 2
    • 84959827843 scopus 로고
    • Encephalomyelitis accompanied by myelin destruction experimentally produced in monkeys
    • Rivers TM, Schwentker FF. Encephalomyelitis accompanied by myelin destruction experimentally produced in monkeys. J Exp Med. 1935;61(5):689-702.
    • (1935) J Exp Med , vol.61 , Issue.5 , pp. 689-702
    • Rivers, T.M.1    Schwentker, F.F.2
  • 3
    • 0025246367 scopus 로고
    • The T lymphocyte in experimental allergic encephalomyelitis
    • Zamvil SS, Steinman L. The T lymphocyte in experimental allergic encephalomyelitis. Annu Rev Immunol. 1990;8:579-621.
    • (1990) Annu Rev Immunol , vol.8 , pp. 579-621
    • Zamvil, S.S.1    Steinman, L.2
  • 4
    • 28544450761 scopus 로고    scopus 로고
    • Experimental allergic encephalomyelitis: A misleading model of multiple sclerosis
    • Sriram S, Steiner I. Experimental allergic encephalomyelitis: a misleading model of multiple sclerosis. Ann Neurol. 2005;58(6):939-945.
    • (2005) Ann Neurol , vol.58 , Issue.6 , pp. 939-945
    • Sriram, S.1    Steiner, I.2
  • 5
    • 0034231339 scopus 로고    scopus 로고
    • Selective loss of type I interferon-induced STAT4 activation caused by a minisatellite insertion in mouse Stat2
    • Farrar JD, Smith JD, Murphy TL, Leung S, Stark GR, Murphy KM. Selective loss of type I interferon-induced STAT4 activation caused by a minisatellite insertion in mouse Stat2. Nat Immunol. 2000;1(1):65-69.
    • (2000) Nat Immunol , vol.1 , Issue.1 , pp. 65-69
    • Farrar, J.D.1    Smith, J.D.2    Murphy, T.L.3    Leung, S.4    Stark, G.R.5    Murphy, K.M.6
  • 6
    • 0030013545 scopus 로고    scopus 로고
    • The development of Cop 1 (Copaxone), an innovative drug for the treatment of multiple sclerosis: Personal reflections
    • Arnon R. The development of Cop 1 (Copaxone), an innovative drug for the treatment of multiple sclerosis: personal reflections. Immunol Lett. 1996;50(1-2):1-15.
    • (1996) Immunol Lett , vol.50 , Issue.1-2 , pp. 1-15
    • Arnon, R.1
  • 7
    • 0030799763 scopus 로고    scopus 로고
    • Copolymer 1: From basic research to clinical application
    • Teitelbaum D, Arnon R, Sela M. Copolymer 1: from basic research to clinical application. Cell Mol Life Sci. 1997;53(1):24-28.
    • (1997) Cell Mol Life Sci , vol.53 , Issue.1 , pp. 24-28
    • Teitelbaum, D.1    Arnon, R.2    Sela, M.3
  • 8
    • 0015103005 scopus 로고
    • Suppression of experimental allergic encephalomyelitis by a synthetic polypeptide
    • Teitelbaum D, Meshorer A, Hirshfeld T, Arnon R, Sela M. Suppression of experimental allergic encephalomyelitis by a synthetic polypeptide. Eur J Immunol. 1971;1(4):242-248.
    • (1971) Eur J Immunol , vol.1 , Issue.4 , pp. 242-248
    • Teitelbaum, D.1    Meshorer, A.2    Hirshfeld, T.3    Arnon, R.4    Sela, M.5
  • 9
    • 0015529001 scopus 로고
    • Protection against experimental allergic encephalomyelitis
    • Teitelbaum D, Webb C, Meshorer A, Arnon R, Sela M. Protection against experimental allergic encephalomyelitis. Nature. 1972;240(5383):564-566.
    • (1972) Nature , vol.240 , Issue.5383 , pp. 564-566
    • Teitelbaum, D.1    Webb, C.2    Meshorer, A.3    Arnon, R.4    Sela, M.5
  • 10
    • 0015795775 scopus 로고
    • Suppression by several synthetic polypeptides of experimental allergic encephalomyelitis induced in guinea pigs and rabbits with bovine and human basic encephalitogen
    • Teitelbaum D, Webb C, Meshorer A, Arnon R, Sela M. Suppression by several synthetic polypeptides of experimental allergic encephalomyelitis induced in guinea pigs and rabbits with bovine and human basic encephalitogen. Eur J Immunol. 1973;3(5):273-279.
    • (1973) Eur J Immunol , vol.3 , Issue.5 , pp. 273-279
    • Teitelbaum, D.1    Webb, C.2    Meshorer, A.3    Arnon, R.4    Sela, M.5
  • 11
    • 0013798175 scopus 로고
    • Genetic control of the antibody response, I: Demonstration of determinant-specific differences in response to synthetic polypeptide antigens in two strains of inbred mice
    • McDevitt HO, Sela M. Genetic control of the antibody response, I: demonstration of determinant-specific differences in response to synthetic polypeptide antigens in two strains of inbred mice. J Exp Med. 1965;122(3):517-531.
    • (1965) J Exp Med , vol.122 , Issue.3 , pp. 517-531
    • McDevitt, H.O.1    Sela, M.2
  • 12
    • 0009573338 scopus 로고    scopus 로고
    • A complete genomic screen for multiple sclerosis underscores a role for the major histocompatibility complex
    • The Multiple Sclerosis Genetics Group
    • Haines JL, Ter Minassian M, Bazyk A, et al; The Multiple Sclerosis Genetics Group. A complete genomic screen for multiple sclerosis underscores a role for the major histocompatibility complex. Nat Genet. 1996;13(4):469-471.
    • (1996) Nat Genet , vol.13 , Issue.4 , pp. 469-471
    • Haines, J.L.1    Ter Minassian, M.2    Bazyk, A.3
  • 14
    • 0016290415 scopus 로고
    • Suppression of experimental allergic encephalomyelitis in Rhesus monkeys by a synthetic basic copolymer
    • Teitelbaum D, Webb C, Bree M, Meshorer A, Arnon R, Sela M. Suppression of experimental allergic encephalomyelitis in Rhesus monkeys by a synthetic basic copolymer. Clin Immunol Immunopathol. 1974;3(2):256-262.
    • (1974) Clin Immunol Immunopathol , vol.3 , Issue.2 , pp. 256-262
    • Teitelbaum, D.1    Webb, C.2    Bree, M.3    Meshorer, A.4    Arnon, R.5    Sela, M.6
  • 15
    • 0018357704 scopus 로고
    • The effect of Cop 1, a synthetic polypeptide, on chronic relapsing experimental allergic encephalomyelitis in guinea pigs
    • Keith AB, Arnon R, Teitelbaum D, Caspary EA, Wisniewski HM. The effect of Cop 1, a synthetic polypeptide, on chronic relapsing experimental allergic encephalomyelitis in guinea pigs. J Neurol Sci. 1979;42(2):267-274.
    • (1979) J Neurol Sci , vol.42 , Issue.2 , pp. 267-274
    • Keith, A.B.1    Arnon, R.2    Teitelbaum, D.3    Caspary, E.A.4    Wisniewski, H.M.5
  • 16
    • 0017341548 scopus 로고
    • Effect of a synthetic polypeptide (COP 1) on patients with multiple sclerosis and with acute disseminated encephalomyelitis: Preliminary report
    • Abramsky O, Teitelbaum D, Arnon R. Effect of a synthetic polypeptide (COP 1) on patients with multiple sclerosis and with acute disseminated encephalomyelitis: preliminary report. J Neurol Sci. 1977;31(3):433-438.
    • (1977) J Neurol Sci , vol.31 , Issue.3 , pp. 433-438
    • Abramsky, O.1    Teitelbaum, D.2    Arnon, R.3
  • 17
    • 0023248694 scopus 로고
    • A pilot trial of cop 1 in exacerbating-remitting multiple sclerosis
    • Bornstein MB, Miller A, Slagle S, et al. A pilot trial of Cop 1 in exacerbating-remitting multiple sclerosis. N Engl J Med. 1987;317(7):408-414. (Pubitemid 17131177)
    • (1987) New England Journal of Medicine , vol.317 , Issue.7 , pp. 408-414
    • Bornstein, M.B.1    Miller, A.2    Slagle, S.3
  • 18
    • 0029082566 scopus 로고
    • Copolymer 1 reduces relapse rate and improves disability in relapsing-remitting multiple sclerosis: Results of a phase III multicenter, double-blind placebo-controlled trial
    • the Copolymer 1 Multiple Sclerosis Study Group
    • Johnson KP, Brooks BR, Cohen JA, et al; the Copolymer 1 Multiple Sclerosis Study Group. Copolymer 1 reduces relapse rate and improves disability in relapsing-remitting multiple sclerosis: results of a phase III multicenter, double-blind placebo-controlled trial. Neurology. 1995;45(7):1268-1276.
    • (1995) Neurology , vol.45 , Issue.7 , pp. 1268-1276
    • Johnson, K.P.1    Brooks, B.R.2    Cohen, J.A.3
  • 19
    • 77949885488 scopus 로고    scopus 로고
    • Continuous long-term immunomodulatory therapy in relapsing multiple sclerosis: Results from the 15-year analysis of the US prospective open-label study of glatiramer acetate
    • Ford C, Goodman AD, Johnson K, et al. Continuous long-term immunomodulatory therapy in relapsing multiple sclerosis: results from the 15-year analysis of the US prospective open-label study of glatiramer acetate. Mult Scler. 2010;16(3):342-350.
    • (2010) Mult Scler , vol.16 , Issue.3 , pp. 342-350
    • Ford, C.1    Goodman, A.D.2    Johnson, K.3
  • 20
    • 0035091667 scopus 로고    scopus 로고
    • European/Canadian multicenter, double-blind, randomized, placebo-controlled study of the effects of glatiramer acetate on magnetic resonance imaging - Measured disease activity and burden in patients with relapsing multiple sclerosis
    • European/Canadian Glatiramer Acetate Study Group
    • Comi G, Filippi M, Wolinsky JS; European/Canadian Glatiramer Acetate Study Group. European/Canadian multicenter, double-blind, randomized, placebo-controlled study of the effects of glatiramer acetate on magnetic resonance imaging - measured disease activity and burden in patients with relapsing multiple sclerosis. Ann Neurol. 2001;49(3):290-297.
    • (2001) Ann Neurol , vol.49 , Issue.3 , pp. 290-297
    • Comi, G.1    Filippi, M.2    Wolinsky, J.S.3
  • 21
    • 70350786389 scopus 로고    scopus 로고
    • Effect of glatiramer acetate on conversion to clinically definite multiple sclerosis in patients with clinically isolated syndrome (PreCISe study): A randomised, double-blind, placebo-controlled trial
    • PreCISe Study Group
    • Comi G, Martinelli V, Rodegher M, et al; PreCISe Study Group. Effect of glatiramer acetate on conversion to clinically definite multiple sclerosis in patients with clinically isolated syndrome (PreCISe study): a randomised, double-blind, placebo-controlled trial. Lancet. 2009;374(9700):1503-1511.
    • (2009) Lancet , vol.374 , Issue.9700 , pp. 1503-1511
    • Comi, G.1    Martinelli, V.2    Rodegher, M.3
  • 22
    • 0027418515 scopus 로고
    • Interferon beta-1b is effective in relapsing-remitting multiple sclerosis, I: Clinical results of a multicenter, randomized, double-blind, placebo-controlled trial
    • The IFNB Multiple Sclerosis Study Group
    • The IFNB Multiple Sclerosis Study Group. Interferon beta-1b is effective in relapsing-remitting multiple sclerosis, I: clinical results of a multicenter, randomized, double-blind, placebo-controlled trial. Neurology. 1993;43(4):655-661.
    • (1993) Neurology , vol.43 , Issue.4 , pp. 655-661
  • 23
    • 30044447736 scopus 로고    scopus 로고
    • Immune cell migration in inflammation: Present and future therapeutic targets
    • Luster AD, Alon R, von Andrian UH. Immune cell migration in inflammation: present and future therapeutic targets. Nat Immunol. 2005;6(12):1182-1190.
    • (2005) Nat Immunol , vol.6 , Issue.12 , pp. 1182-1190
    • Luster, A.D.1    Alon, R.2    Von Andrian, U.H.3
  • 24
    • 85047682713 scopus 로고    scopus 로고
    • Alpha4-integrin-VCAM-1 binding mediates G protein-independent capture of encephalitogenic T cell blasts to CNS white matter microvessels
    • Vajkoczy P, Laschinger M, Engelhardt B. Alpha4-integrin-VCAM-1 binding mediates G protein-independent capture of encephalitogenic T cell blasts to CNS white matter microvessels. J Clin Invest. 2001;108(4):557-565.
    • (2001) J Clin Invest , vol.108 , Issue.4 , pp. 557-565
    • Vajkoczy, P.1    Laschinger, M.2    Engelhardt, B.3
  • 25
    • 0025307161 scopus 로고
    • + T cells by the interaction of VLA-4 and VLA-5 with fibronectin or VLA-6 with laminin
    • Shimizu Y, van Seventer GA, Horgan KJ, Shaw S. Costimulation of proliferative responses of resting CD4+ T cells by the interaction of VLA-4 and VLA-5 with fibronectin or VLA-6 with laminin. J Immunol. 1990;145(1):59-67. (Pubitemid 20217383)
    • (1990) Journal of Immunology , vol.145 , Issue.1 , pp. 59-67
    • Shimizu, Y.1    Van Seventer, G.A.2    Horgan, K.J.3    Shaw, S.4
  • 26
    • 0026506799 scopus 로고
    • Prevention of experimental autoimmune encephalomyelitis by antibodies against alpha 4 beta 1 integrin
    • Yednock TA, Cannon C, Fritz LC, Sanchez-Madrid F, Steinman L, Karin N. Prevention of experimental autoimmune encephalomyelitis by antibodies against alpha 4 beta 1 integrin. Nature. 1992;356(6364):63-66.
    • (1992) Nature , vol.356 , Issue.6364 , pp. 63-66
    • Yednock, T.A.1    Cannon, C.2    Fritz, L.C.3    Sanchez-Madrid, F.4    Steinman, L.5    Karin, N.6
  • 27
    • 0035052096 scopus 로고    scopus 로고
    • Discordant effects of anti-VLA-4 treatment before and after onset of relapsing experimental autoimmune encephalomyelitis
    • Theien BE, Vanderlugt CL, Eagar TN, et al. Discordant effects of anti-VLA-4 treatment before and after onset of relapsing experimental autoimmune encephalomyelitis. J Clin Invest. 2001;107(8):995-1006.
    • (2001) J Clin Invest , vol.107 , Issue.8 , pp. 995-1006
    • Theien, B.E.1    Vanderlugt, C.L.2    Eagar, T.N.3
  • 28
    • 0033622029 scopus 로고    scopus 로고
    • Beta7 integrins contribute to demyelinating disease of the central nervous system
    • Kanwar JR, Harrison JE, Wang D, et al. Beta7 integrins contribute to demyelinating disease of the central nervous system. J Neuroimmunol. 2000;103(2):146-152.
    • (2000) J Neuroimmunol , vol.103 , Issue.2 , pp. 146-152
    • Kanwar, J.R.1    Harrison, J.E.2    Wang, D.3
  • 29
    • 33644584352 scopus 로고    scopus 로고
    • A randomized, placebo-controlled trial of natalizumab for relapsing multiple sclerosis
    • AFFIRM Investigators
    • Polman CH, O'Connor PW, Havrdova E, et al; AFFIRM Investigators. A randomized, placebo-controlled trial of natalizumab for relapsing multiple sclerosis. N Engl J Med. 2006;354(9):899-910.
    • (2006) N Engl J Med , vol.354 , Issue.9 , pp. 899-910
    • Polman, C.H.1    O'Connor, P.W.2    Havrdova, E.3
  • 30
    • 33644608613 scopus 로고    scopus 로고
    • Natalizumab plus interferon beta-1a for relapsing multiple sclerosis
    • SENTINEL Investigators
    • Rudick RA, Stuart WH, Calabresi PA, et al; SENTINEL Investigators. Natalizumab plus interferon beta-1a for relapsing multiple sclerosis. N Engl J Med. 2006;354(9):911-923.
    • (2006) N Engl J Med , vol.354 , Issue.9 , pp. 911-923
    • Rudick, R.A.1    Stuart, W.H.2    Calabresi, P.A.3
  • 31
    • 0043022062 scopus 로고    scopus 로고
    • New and emerging treatment options for multiple sclerosis
    • Polman CH, Uitdehaag BM. New and emerging treatment options for multiple sclerosis. Lancet Neurol. 2003;2(9):563-566.
    • (2003) Lancet Neurol , vol.2 , Issue.9 , pp. 563-566
    • Polman, C.H.1    Uitdehaag, B.M.2
  • 32
    • 0008376732 scopus 로고    scopus 로고
    • Interferon beta in the treatment of multiple sclerosis: Mechanisms of action
    • Yong VW, Chabot S, Stuve O, Williams G. Interferon beta in the treatment of multiple sclerosis: mechanisms of action. Neurology. 1998;51(3):682-689. (Pubitemid 28449243)
    • (1998) Neurology , vol.51 , Issue.3 , pp. 682-689
    • Yong, V.W.1    Chabot, S.2    Stuve, O.3    Williams, G.4
  • 33
    • 74249112995 scopus 로고    scopus 로고
    • Interferon-beta mechanisms of action in multiple sclerosis
    • Dhib-Jalbut S, Marks S. Interferon-beta mechanisms of action in multiple sclerosis. Neurology. 2010;74(suppl 1):S17-S24.
    • (2010) Neurology , vol.74 , Issue.SUPPL. 1
    • Dhib-Jalbut, S.1    Marks, S.2
  • 34
    • 34848885871 scopus 로고    scopus 로고
    • Mechanism of action of glatiramer acetate in treatment of multiple sclerosis
    • Weber MS, Hohlfeld R, Zamvil SS. Mechanism of action of glatiramer acetate in treatment of multiple sclerosis. Neurotherapeutics. 2007;4(4):647-653.
    • (2007) Neurotherapeutics , vol.4 , Issue.4 , pp. 647-653
    • Weber, M.S.1    Hohlfeld, R.2    Zamvil, S.S.3
  • 35
    • 74249111385 scopus 로고    scopus 로고
    • The mechanism of action of glatiramer acetate treatment in multiple sclerosis
    • Racke MK, Lovett-Racke AE, Karandikar NJ. The mechanism of action of glatiramer acetate treatment in multiple sclerosis. Neurology. 2010;74(suppl 1):S25-S30.
    • (2010) Neurology , vol.74 , Issue.SUPPL. 1
    • Racke, M.K.1    Lovett-Racke, A.E.2    Karandikar, N.J.3
  • 36
    • 77949307503 scopus 로고    scopus 로고
    • Anticipated benefits and surprising effects of daclizumab in multiple sclerosis
    • Stüve O, Greenberg BM. Anticipated benefits and surprising effects of daclizumab in multiple sclerosis. Lancet Neurol. 2010;9(4):337-338.
    • (2010) Lancet Neurol , vol.9 , Issue.4 , pp. 337-338
    • Stüve, O.1    Greenberg, B.M.2
  • 37
    • 33645812129 scopus 로고    scopus 로고
    • Regulatory CD56(bright) natural killer cells mediate immunomodulatory effects of IL-2Ralpha-targeted therapy (daclizumab) in multiple sclerosis
    • Bielekova B, Catalfamo M, Reichert-Scrivner S, et al. Regulatory CD56(bright) natural killer cells mediate immunomodulatory effects of IL-2Ralpha-targeted therapy (daclizumab) in multiple sclerosis. Proc Natl Acad Sci U S A. 2006;103(15):5941-5946.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , Issue.15 , pp. 5941-5946
    • Bielekova, B.1    Catalfamo, M.2    Reichert-Scrivner, S.3
  • 38
    • 33646788719 scopus 로고    scopus 로고
    • Progressive multifocal leukoencephalopathy: Lessons from AIDS and natalizumab
    • Berger JR, Houff S. Progressive multifocal leukoencephalopathy: lessons from AIDS and natalizumab. Neurol Res. 2006;28(3):299-305.
    • (2006) Neurol Res , vol.28 , Issue.3 , pp. 299-305
    • Berger, J.R.1    Houff, S.2
  • 39
    • 77949279537 scopus 로고    scopus 로고
    • Natalizumab-associated progressive multifocal leukoencephalopathy in patients with multiple sclerosis: Lessons from 28 cases
    • published correction appears in Lancet Neurol. 2010;9(5):463
    • Clifford DB, De Luca A, DeLuca A, et al. Natalizumab-associated progressive multifocal leukoencephalopathy in patients with multiple sclerosis: lessons from 28 cases [published correction appears in Lancet Neurol. 2010;9(5):463]. Lancet Neurol. 2010;9(4):438-446.
    • (2010) Lancet Neurol , vol.9 , Issue.4 , pp. 438-446
    • Clifford, D.B.1    De Luca, A.2    DeLuca, A.3
  • 40
    • 57149117126 scopus 로고    scopus 로고
    • New cases of progressive multifocal leukoencephalopathy after treatment with natalizumab
    • Hartung HP. New cases of progressive multifocal leukoencephalopathy after treatment with natalizumab. Lancet Neurol. 2009;8(1):28-31.
    • (2009) Lancet Neurol , vol.8 , Issue.1 , pp. 28-31
    • Hartung, H.P.1
  • 42
    • 33749588466 scopus 로고    scopus 로고
    • Altered CD4+/CD8+ T-cell ratios in cerebrospinal fluid of natalizumab-treated patients with multiple sclerosis
    • Stüve O, Marra CM, Bar-Or A, et al. Altered CD4+/CD8+ T-cell ratios in cerebrospinal fluid of natalizumab-treated patients with multiple sclerosis. Arch Neurol. 2006;63(10):1383-1387.
    • (2006) Arch Neurol , vol.63 , Issue.10 , pp. 1383-1387
    • Stüve, O.1    Marra, C.M.2    Bar-Or, A.3
  • 43
    • 33646347357 scopus 로고    scopus 로고
    • Natalizumab effects on immune cell responses in multiple sclerosis
    • Niino M, Bodner C, Simard ML, et al. Natalizumab effects on immune cell responses in multiple sclerosis. Ann Neurol. 2006;59(5):748-754.
    • (2006) Ann Neurol , vol.59 , Issue.5 , pp. 748-754
    • Niino, M.1    Bodner, C.2    Simard, M.L.3
  • 44
    • 61449227381 scopus 로고    scopus 로고
    • Decrease in the numbers of dendritic cells and CD4+ T cells in cerebral perivascular spaces due to natalizumab
    • del Pilar Martin M, Cravens PD, Winger R, et al. Decrease in the numbers of dendritic cells and CD4+ T cells in cerebral perivascular spaces due to natalizumab. Arch Neurol. 2008;65(12):1596-1603.
    • (2008) Arch Neurol , vol.65 , Issue.12 , pp. 1596-1603
    • Del Pilar Martin, M.1    Cravens, P.D.2    Winger, R.3
  • 45
    • 43549090004 scopus 로고    scopus 로고
    • The monoclonal anti-VLA-4 antibody natalizumab mobilizes CD34+ hematopoietic progenitor cells in humans
    • Zohren F, Toutzaris D, Klarner V, Hartung HP, Kieseier B, Haas R. The monoclonal anti-VLA-4 antibody natalizumab mobilizes CD34+ hematopoietic progenitor cells in humans. Blood. 2008;111(7):3893-3895.
    • (2008) Blood , vol.111 , Issue.7 , pp. 3893-3895
    • Zohren, F.1    Toutzaris, D.2    Klarner, V.3    Hartung, H.P.4    Kieseier, B.5    Haas, R.6
  • 46
    • 71549134054 scopus 로고    scopus 로고
    • ABC-transporter gene-polymorphisms are potential pharmacogenetic markers for mitoxantrone response in multiple sclerosis
    • Cotte S, von Ahsen N, Kruse N, et al. ABC-transporter gene-polymorphisms are potential pharmacogenetic markers for mitoxantrone response in multiple sclerosis. Brain. 2009;132(pt 9):2517-2530.
    • (2009) Brain , vol.132 , Issue.PART 9 , pp. 2517-2530
    • Cotte, S.1    Von Ahsen, N.2    Kruse, N.3
  • 47
    • 34249781999 scopus 로고    scopus 로고
    • Pathogenesis of axonal and neuronal damage in multiple sclerosis
    • DOI 10.1212/01.wnl.0000275229.13012.32, PII 0000611420070529300005
    • Dutta R, Trapp BD. Pathogenesis of axonal and neuronal damage in multiple sclerosis. Neurology. 2007;68(22)(suppl 3):S22-S31. (Pubitemid 46848608)
    • (2007) Neurology , vol.68 , Issue.22 SUPPL. 3
    • Dutta, R.1    Trapp, B.D.2
  • 48
    • 0029730733 scopus 로고    scopus 로고
    • Accumulation of hypointense lesions ("black holes") on T1 spin-echo MRI correlates with disease progression in multiple sclerosis
    • Truyen L, van Waesberghe JH, van Walderveen MA, et al. Accumulation of hypointense lesions ("black holes") on T1 spin-echo MRI correlates with disease progression in multiple sclerosis. Neurology. 1996;47(6):1469-1476.
    • (1996) Neurology , vol.47 , Issue.6 , pp. 1469-1476
    • Truyen, L.1    Van Waesberghe, J.H.2    Van Walderveen, M.A.3
  • 49
    • 0035964157 scopus 로고    scopus 로고
    • Glatiramer acetate reduces the proportion of new MS lesions evolving into "black holes"
    • European/Canadian Glatiramer Acetate Study Group
    • Filippi M, Rovaris M, Rocca MA, Sormani MP, Wolinsky JS, Comi G; European/Canadian Glatiramer Acetate Study Group. Glatiramer acetate reduces the proportion of new MS lesions evolving into "black holes." Neurology. 2001;57(4):731-733.
    • (2001) Neurology , vol.57 , Issue.4 , pp. 731-733
    • Filippi, M.1    Rovaris, M.2    Rocca, M.A.3    Sormani, M.P.4    Wolinsky, J.S.5    Comi, G.6
  • 50
    • 3042753418 scopus 로고    scopus 로고
    • Effect of natalizumab on conversion of gadolinium enhancing lesions to T1 hypointense lesions in relapsing multiple sclerosis
    • Dalton CM, Miszkiel KA, Barker GJ, et al. Effect of natalizumab on conversion of gadolinium enhancing lesions to T1 hypointense lesions in relapsing multiple sclerosis. J Neurol. 2004;251(4):407-413.
    • (2004) J Neurol , vol.251 , Issue.4 , pp. 407-413
    • Dalton, C.M.1    Miszkiel, K.A.2    Barker, G.J.3
  • 51
    • 77950258250 scopus 로고    scopus 로고
    • Ibudilast in relapsing-remitting multiple sclerosis: A neuroprotectant?
    • MN166-001 Investigators
    • Barkhof F, Hulst HE, Drulovic J, Uitdehaag BM, Matsuda K, Landin R; MN166-001 Investigators. Ibudilast in relapsing-remitting multiple sclerosis: a neuroprotectant? Neurology. 2010;74(13):1033-1040.
    • (2010) Neurology , vol.74 , Issue.13 , pp. 1033-1040
    • Barkhof, F.1    Hulst, H.E.2    Drulovic, J.3    Uitdehaag, B.M.4    Matsuda, K.5    Landin, R.6
  • 52
    • 30844464790 scopus 로고    scopus 로고
    • The measurement and clinical relevance of brain atrophy in multiple sclerosis
    • DOI 10.1016/S1474-4422(06)70349-0, PII S1474442206703490
    • Bermel RA, Bakshi R. The measurement and clinical relevance of brain atrophy in multiple sclerosis. Lancet Neurol. 2006;5(2):158-170. (Pubitemid 43107851)
    • (2006) Lancet Neurology , vol.5 , Issue.2 , pp. 158-170
    • Bermel, R.A.1    Bakshi, R.2
  • 53
    • 33846330213 scopus 로고    scopus 로고
    • Brain atrophy in multiple sclerosis: What we know and would like to know
    • Simon JH. Brain atrophy in multiple sclerosis: what we know and would like to know. Mult Scler. 2006;12(6):679-687.
    • (2006) Mult Scler , vol.12 , Issue.6 , pp. 679-687
    • Simon, J.H.1
  • 54
    • 54849431592 scopus 로고    scopus 로고
    • Gray matter atrophy is related to long-term disability in multiple sclerosis
    • Fisniku LK, Chard DT, Jackson JS, et al. Gray matter atrophy is related to long-term disability in multiple sclerosis. Ann Neurol. 2008;64(3):247-254.
    • (2008) Ann Neurol , vol.64 , Issue.3 , pp. 247-254
    • Fisniku, L.K.1    Chard, D.T.2    Jackson, J.S.3
  • 55
    • 77954819068 scopus 로고    scopus 로고
    • Improved in vivo detection of cortical lesions in multiple sclerosis using double inversion recovery MR imaging at 3 Tesla
    • published online January 22, 2010 doi:10.1007/s00330-009-1705-y
    • Simon B, Schmidt S, Lukas C, et al. Improved in vivo detection of cortical lesions in multiple sclerosis using double inversion recovery MR imaging at 3 Tesla [published online January 22, 2010]. Eur Radiol. doi:10.1007/s00330-009-1705-y.
    • Eur Radiol
    • Simon, B.1    Schmidt, S.2    Lukas, C.3
  • 56
    • 77950534279 scopus 로고    scopus 로고
    • A 3-year magnetic resonance imaging study of cortical lesions in relapse-onset multiple sclerosis
    • Calabrese M, Rocca MA, Atzori M, et al. A 3-year magnetic resonance imaging study of cortical lesions in relapse-onset multiple sclerosis. Ann Neurol. 2010;67(3):376-383.
    • (2010) Ann Neurol , vol.67 , Issue.3 , pp. 376-383
    • Calabrese, M.1    Rocca, M.A.2    Atzori, M.3
  • 57
    • 29444431598 scopus 로고    scopus 로고
    • Magnetic resonance spectroscopy in the monitoring of multiple sclerosis
    • Narayana PA. Magnetic resonance spectroscopy in the monitoring of multiple sclerosis. J Neuroimaging. 2005;15(4)(suppl):46S-57S.
    • (2005) J Neuroimaging , vol.15 , Issue.4 SUPPL.
    • Narayana, P.A.1
  • 58
    • 28044444326 scopus 로고    scopus 로고
    • Axonal metabolic recovery and potential neuroprotective effect of glatiramer acetate in relapsing-remitting multiple sclerosis
    • Khan O, Shen Y, Caon C, et al. Axonal metabolic recovery and potential neuroprotective effect of glatiramer acetate in relapsing-remitting multiple sclerosis. Mult Scler. 2005;11(6):646-651.
    • (2005) Mult Scler , vol.11 , Issue.6 , pp. 646-651
    • Khan, O.1    Shen, Y.2    Caon, C.3
  • 59
    • 0027968745 scopus 로고
    • Magnetization transfer imaging: Practical aspects and clinical applications
    • Wolff SD, Balaban RS. Magnetization transfer imaging: practical aspects and clinical applications. Radiology. 1994;192(3):593-599.
    • (1994) Radiology , vol.192 , Issue.3 , pp. 593-599
    • Wolff, S.D.1    Balaban, R.S.2
  • 60
    • 4444310685 scopus 로고    scopus 로고
    • Magnetization transfer ratio and myelin in postmortem multiple sclerosis brain
    • DOI 10.1002/ana.20202
    • Schmierer K, Scaravilli F, Altmann DR, Barker GJ, Miller DH. Magnetization transfer ratio and myelin in postmortem multiple sclerosis brain. Ann Neurol. 2004;56(3):407-415. (Pubitemid 39166560)
    • (2004) Annals of Neurology , vol.56 , Issue.3 , pp. 407-415
    • Schmierer, K.1    Scaravilli, F.2    Altmann, D.R.3    Barker, G.J.4    Miller, D.H.5
  • 61
    • 33749488304 scopus 로고    scopus 로고
    • Magnetization transfer MRI metrics predict the accumulation of disability 8 years later in patients with multiple sclerosis
    • Agosta F, Rovaris M, Pagani E, Sormani MP, Comi G, Filippi M. Magnetization transfer MRI metrics predict the accumulation of disability 8 years later in patients with multiple sclerosis. Brain. 2006;129(pt 10):2620-2627.
    • (2006) Brain , vol.129 , Issue.PART 10 , pp. 2620-2627
    • Agosta, F.1    Rovaris, M.2    Pagani, E.3    Sormani, M.P.4    Comi, G.5    Filippi, M.6
  • 62
    • 0033773333 scopus 로고    scopus 로고
    • Magnetic resonance diffusion tensor imaging for characterizing diffuse and focal white matter abnormalities in multiple sclerosis
    • Bammer R, Augustin M, Strasser-Fuchs S, et al. Magnetic resonance diffusion tensor imaging for characterizing diffuse and focal white matter abnormalities in multiple sclerosis. Magn Reson Med. 2000;44(4):583-591.
    • (2000) Magn Reson Med , vol.44 , Issue.4 , pp. 583-591
    • Bammer, R.1    Augustin, M.2    Strasser-Fuchs, S.3
  • 63
    • 34249813370 scopus 로고    scopus 로고
    • Diffusion-weighted imaging predicts cognitive impairment in multiple sclerosis
    • Benedict RH, Bruce J, Dwyer MG, et al. Diffusion-weighted imaging predicts cognitive impairment in multiple sclerosis. Mult Scler. 2007;13(6):722-730.
    • (2007) Mult Scler , vol.13 , Issue.6 , pp. 722-730
    • Benedict, R.H.1    Bruce, J.2    Dwyer, M.G.3
  • 64
    • 0025821265 scopus 로고
    • Alterations in the levels of iron, ferritin and other trace metals in Parkinson's disease and other neurodegenerative diseases affecting the basal ganglia
    • Dexter DT, Carayon A, Javoy-Agid F, et al. Alterations in the levels of iron, ferritin and other trace metals in Parkinson's disease and other neurodegenerative diseases affecting the basal ganglia. Brain. 1991;114(pt 4):1953-1975.
    • (1991) Brain , vol.114 , Issue.PART 4 , pp. 1953-1975
    • Dexter, D.T.1    Carayon, A.2    Javoy-Agid, F.3
  • 65
    • 34250783638 scopus 로고    scopus 로고
    • Iron in Chronic Brain Disorders: Imaging and Neurotherapeutic Implications
    • DOI 10.1016/j.nurt.2007.05.006, PII S1933721307000906
    • Stankiewicz J, Panter SS, Neema M, Arora A, Batt CE, Bakshi R. Iron in chronic brain disorders: imaging and neurotherapeutic implications. Neurotherapeutics. 2007;4(3):371-386. (Pubitemid 46962416)
    • (2007) Neurotherapeutics , vol.4 , Issue.3 , pp. 371-386
    • Stankiewicz, J.1    Panter, S.S.2    Neema, M.3    Arora, A.4    Batt, C.E.5    Bakshi, R.6
  • 66
    • 0029092802 scopus 로고
    • A quantitative analysis of isoferritins in select regions of aged, parkinsonian, and Alzheimer's diseased brains
    • Connor JR, Snyder BS, Arosio P, Loeffler DA, LeWitt P. A quantitative analysis of isoferritins in select regions of aged, parkinsonian, and Alzheimer's diseased brains. J Neurochem. 1995;65(2):717-724.
    • (1995) J Neurochem , vol.65 , Issue.2 , pp. 717-724
    • Connor, J.R.1    Snyder, B.S.2    Arosio, P.3    Loeffler, D.A.4    LeWitt, P.5
  • 67
    • 58149237714 scopus 로고    scopus 로고
    • Quantitative in vivo magnetic resonance imaging of multiple sclerosis at 7 Tesla with sensitivity to iron
    • Hammond KE, Metcalf M, Carvajal L, et al. Quantitative in vivo magnetic resonance imaging of multiple sclerosis at 7 Tesla with sensitivity to iron. Ann Neurol. 2008;64(6):707-713.
    • (2008) Ann Neurol , vol.64 , Issue.6 , pp. 707-713
    • Hammond, K.E.1    Metcalf, M.2    Carvajal, L.3
  • 68
    • 58249111546 scopus 로고    scopus 로고
    • Characterizing iron deposition in multiple sclerosis lesions using susceptibility weighted imaging
    • Haacke EM, Makki M, Ge Y, et al. Characterizing iron deposition in multiple sclerosis lesions using susceptibility weighted imaging. J Magn Reson Imaging. 2009;29(3):537-544.
    • (2009) J Magn Reson Imaging , vol.29 , Issue.3 , pp. 537-544
    • Haacke, E.M.1    Makki, M.2    Ge, Y.3
  • 69
    • 50049104744 scopus 로고    scopus 로고
    • MRI in multiple sclerosis: Current status and future prospects
    • Bakshi R, Thompson AJ, Rocca MA, et al. MRI in multiple sclerosis: current status and future prospects. Lancet Neurol. 2008;7(7):615-625.
    • (2008) Lancet Neurol , vol.7 , Issue.7 , pp. 615-625
    • Bakshi, R.1    Thompson, A.J.2    Rocca, M.A.3
  • 71
    • 0020031692 scopus 로고
    • Quantitative studies of retinal nerve fiber layer defects
    • Quigley HA, Addicks EM. Quantitative studies of retinal nerve fiber layer defects. Arch Ophthalmol. 1982;100(5):807-814.
    • (1982) Arch Ophthalmol , vol.100 , Issue.5 , pp. 807-814
    • Quigley, H.A.1    Addicks, E.M.2
  • 72
    • 0019479134 scopus 로고
    • Experimental allergic encephalomyelitis, I: Optic nerve and central nervous system manifestations
    • Hayreh SS, Massanari RM, Yamada T, Hayreh SM. Experimental allergic encephalomyelitis, I: optic nerve and central nervous system manifestations. Invest Ophthalmol Vis Sci. 1981;21(2):256-269.
    • (1981) Invest Ophthalmol Vis Sci , vol.21 , Issue.2 , pp. 256-269
    • Hayreh, S.S.1    Massanari, R.M.2    Yamada, T.3    Hayreh, S.M.4
  • 73
    • 0024522649 scopus 로고
    • Quantitative analysis of labelled inner retinal proteins in experimental optic neuritis
    • Guy J, Ellis EA, Kelley K, Hope GM, Rao NA. Quantitative analysis of labelled inner retinal proteins in experimental optic neuritis. Curr Eye Res. 1989;8(3):253-260.
    • (1989) Curr Eye Res , vol.8 , Issue.3 , pp. 253-260
    • Guy, J.1    Ellis, E.A.2    Kelley, K.3    Hope, G.M.4    Rao, N.A.5
  • 74
    • 0024511631 scopus 로고
    • Axonal transport reductions in acute experimental allergic encephalomyelitis: Qualitative analysis of the optic nerve
    • Guy J, Ellis EA, Tark EF III, Hope GM, Rao NA. Axonal transport reductions in acute experimental allergic encephalomyelitis: qualitative analysis of the optic nerve. Curr Eye Res. 1989;8(3):261-269.
    • (1989) Curr Eye Res , vol.8 , Issue.3 , pp. 261-269
    • Guy, J.1    Ellis, E.A.2    Tark III, E.F.3    Hope, G.M.4    Rao, N.A.5
  • 75
    • 0024318188 scopus 로고
    • Local enhancement of major histocompatibility complex (MHC) class I and II expression and cell infiltration in experimental allergic encephalomyelitis around axotomized motor neurons
    • DOI 10.1016/0165-5728(89)90031-3
    • Maehlen J, Olsson T, Zachau A, Klareskog L, Kristensson K. Local enhancement of major histocompatibility complex (MHC) class I and II expression and cell infiltration in experimental allergic encephalomyelitis around axotomized motor neurons. J Neuroimmunol. 1989;23(2):125-132. (Pubitemid 19144793)
    • (1989) Journal of Neuroimmunology , vol.23 , Issue.2 , pp. 125-132
    • Maehlen, J.1    Olsson, T.2    Zachau, A.3    Klareskog, L.4    Kristensson, K.5
  • 76
    • 0025035614 scopus 로고
    • Damage to bulbospinal serotonin-, tyrosine hydroxylase-, and TRH-containing axons occurs early in the development of experimental allergic encephalomyelitis in rats
    • White SR, Samathanam GK, Bowker RM, Wessendorf MW. Damage to bulbospinal serotonin-, tyrosine hydroxylase-, and TRH-containing axons occurs early in the development of experimental allergic encephalomyelitis in rats. J Neurosci Res. 1990;27(1):89-98.
    • (1990) J Neurosci Res , vol.27 , Issue.1 , pp. 89-98
    • White, S.R.1    Samathanam, G.K.2    Bowker, R.M.3    Wessendorf, M.W.4
  • 77
    • 0033541567 scopus 로고    scopus 로고
    • Axonal cytoskeleton changes in experimental optic neuritis
    • Zhu B, Moore GR, Zwimpfer TJ, et al. Axonal cytoskeleton changes in experimental optic neuritis. Brain Res. 1999;824(2):204-217.
    • (1999) Brain Res , vol.824 , Issue.2 , pp. 204-217
    • Zhu, B.1    Moore, G.R.2    Zwimpfer, T.J.3
  • 78
    • 0034710368 scopus 로고    scopus 로고
    • Restricted immune responses lead to CNS demyelination and axonal damage
    • Mancardi G, Hart BA, Capello E, et al. Restricted immune responses lead to CNS demyelination and axonal damage. J Neuroimmunol. 2000;107(2):178-183.
    • (2000) J Neuroimmunol , vol.107 , Issue.2 , pp. 178-183
    • Mancardi, G.1    Hart, B.A.2    Capello, E.3
  • 79
    • 0033870097 scopus 로고    scopus 로고
    • Multiple sclerosis and chronic autoimmune encephalomyelitis: A comparative quantitative study of axonal injury in active, inactive, and remyelinated lesions
    • Kornek B, Storch MK, Weissert R, et al. Multiple sclerosis and chronic autoimmune encephalomyelitis: a comparative quantitative study of axonal injury in active, inactive, and remyelinated lesions. Am J Pathol. 2000;157(1):267-276.
    • (2000) Am J Pathol , vol.157 , Issue.1 , pp. 267-276
    • Kornek, B.1    Storch, M.K.2    Weissert, R.3
  • 80
    • 0035865002 scopus 로고    scopus 로고
    • Demyelination and axonal damage in a non-human primate model of multiple sclerosis
    • Mancardi G, Hart B, Roccatagliata L, et al. Demyelination and axonal damage in a non-human primate model of multiple sclerosis. J Neurol Sci. 2001;184(1):41-49.
    • (2001) J Neurol Sci , vol.184 , Issue.1 , pp. 41-49
    • Mancardi, G.1    Hart, B.2    Roccatagliata, L.3
  • 81
    • 0036136532 scopus 로고    scopus 로고
    • Axon loss in the spinal cord determines permanent neurological disability in an animal model of multiple sclerosis
    • Wujek JR, Bjartmar C, Richer E, et al. Axon loss in the spinal cord determines permanent neurological disability in an animal model of multiple sclerosis. J Neuropathol Exp Neurol. 2002;61(1):23-32.
    • (2002) J Neuropathol Exp Neurol , vol.61 , Issue.1 , pp. 23-32
    • Wujek, J.R.1    Bjartmar, C.2    Richer, E.3
  • 82
    • 0037819578 scopus 로고    scopus 로고
    • Abnormal sodium channel distribution in optic nerve axons in a model of inflammatory demyelination
    • Craner MJ, Lo AC, Black JA, Waxman SG. Abnormal sodium channel distribution in optic nerve axons in a model of inflammatory demyelination. Brain. 2003;126(pt 7):1552-1561.
    • (2003) Brain , vol.126 , Issue.PART 7 , pp. 1552-1561
    • Craner, M.J.1    Lo, A.C.2    Black, J.A.3    Waxman, S.G.4
  • 83
    • 0742305831 scopus 로고    scopus 로고
    • Co-localization of sodium channel Nav1.6 and the sodium-calcium exchanger at sites of axonal injury in the spinal cord in EAE
    • Craner MJ, Hains BC, Lo AC, Black JA, Waxman SG. Co-localization of sodium channel Nav1.6 and the sodium-calcium exchanger at sites of axonal injury in the spinal cord in EAE. Brain. 2004;127(pt 2):294-303.
    • (2004) Brain , vol.127 , Issue.PART 2 , pp. 294-303
    • Craner, M.J.1    Hains, B.C.2    Lo, A.C.3    Black, J.A.4    Waxman, S.G.5
  • 85
    • 24144498784 scopus 로고    scopus 로고
    • Astrocyte-associated axonal damage in pre-onset stages of experimental autoimmune encephalomyelitis
    • DOI 10.1002/glia.20199
    • Wang D, Ayers MM, Catmull DV, Hazelwood LJ, Bernard CC, Orian JM. Astrocyte-associated axonal damage in pre-onset stages of experimental autoimmune encephalomyelitis. Glia. 2005;51(3):235-240. (Pubitemid 41297430)
    • (2005) GLIA , vol.51 , Issue.3 , pp. 235-240
    • Wang, D.1    Ayers, M.M.2    Catmull, D.V.3    Hazelwood, L.J.4    Bernard, C.C.A.5    Orian, J.M.6
  • 86
    • 33244488050 scopus 로고    scopus 로고
    • Detecting axon damage in spinal cord from a mouse model of multiple sclerosis
    • Kim JH, Budde MD, Liang HF, et al. Detecting axon damage in spinal cord from a mouse model of multiple sclerosis. Neurobiol Dis. 2006;21(3):626-632.
    • (2006) Neurobiol Dis , vol.21 , Issue.3 , pp. 626-632
    • Kim, J.H.1    Budde, M.D.2    Liang, H.F.3
  • 87
    • 0035152804 scopus 로고    scopus 로고
    • Optical coherence tomography (OCT) findings in normal retina and laser-induced choroidal neovascularization in rats
    • Fukuchi T, Takahashi K, Shou K, Matsumura M. Optical coherence tomography (OCT) findings in normal retina and laser-induced choroidal neovascularization in rats. Graefes Arch Clin Exp Ophthalmol. 2001;239(1):41-46.
    • (2001) Graefes Arch Clin Exp Ophthalmol , vol.239 , Issue.1 , pp. 41-46
    • Fukuchi, T.1    Takahashi, K.2    Shou, K.3    Matsumura, M.4
  • 88
    • 18044374091 scopus 로고    scopus 로고
    • Quantitative evaluation of ischemia-reperfusion injury by optical coherence tomography in the rat retina
    • Sho K, Takahashi K, Fukuchi T, Matsumura M. Quantitative evaluation of ischemia-reperfusion injury by optical coherence tomography in the rat retina. Jpn J Ophthalmol. 2005;49(2):109-113.
    • (2005) Jpn J Ophthalmol , vol.49 , Issue.2 , pp. 109-113
    • Sho, K.1    Takahashi, K.2    Fukuchi, T.3    Matsumura, M.4
  • 89
    • 0034759706 scopus 로고    scopus 로고
    • Noninvasive imaging by optical coherence tomography to monitor retinal degeneration in the mouse
    • Li Q, Timmers AM, Hunter K, et al. Noninvasive imaging by optical coherence tomography to monitor retinal degeneration in the mouse. Invest Ophthalmol Vis Sci. 2001;42(12):2981-2989.
    • (2001) Invest Ophthalmol Vis Sci , vol.42 , Issue.12 , pp. 2981-2989
    • Li, Q.1    Timmers, A.M.2    Hunter, K.3
  • 93
    • 33646567522 scopus 로고    scopus 로고
    • Optic nerve atrophy and retinal nerve fibre layer thinning following optic neuritis: Evidence that axonal loss is a substrate of MRI-detected atrophy
    • Trip SA, Schlottmann PG, Jones SJ, et al. Optic nerve atrophy and retinal nerve fibre layer thinning following optic neuritis: evidence that axonal loss is a substrate of MRI-detected atrophy. Neuroimage. 2006;31(1):286-293.
    • (2006) Neuroimage , vol.31 , Issue.1 , pp. 286-293
    • Trip, S.A.1    Schlottmann, P.G.2    Jones, S.J.3
  • 96
    • 0029871017 scopus 로고    scopus 로고
    • Pupillometric evaluation and analysis of light reflex in healthy subjects as a tool to study autonomic nervous system changes with aging
    • Pozzessere G, Valle E, Rossi P, et al. Pupillometric evaluation and analysis of light reflex in healthy subjects as a tool to study autonomic nervous system changes with aging. Aging (Milano). 1996;8(1):55-60.
    • (1996) Aging (Milano) , vol.8 , Issue.1 , pp. 55-60
    • Pozzessere, G.1    Valle, E.2    Rossi, P.3
  • 97
    • 0029961815 scopus 로고    scopus 로고
    • Changes in autonomic function with age: A study of pupillary kinetics in healthy young and old people
    • Bitsios P, Prettyman R, Szabadi E. Changes in autonomic function with age: a study of pupillary kinetics in healthy young and old people. Age Ageing. 1996;25(6):432-438.
    • (1996) Age Ageing , vol.25 , Issue.6 , pp. 432-438
    • Bitsios, P.1    Prettyman, R.2    Szabadi, E.3
  • 98
    • 0031011572 scopus 로고    scopus 로고
    • Altered pupillary size and darkness and light reflexes in Alzheimer's disease
    • Prettyman R, Bitsios P, Szabadi E. Altered pupillary size and darkness and light reflexes in Alzheimer's disease. J Neurol Neurosurg Psychiatry. 1997;62(6):665-668.
    • (1997) J Neurol Neurosurg Psychiatry , vol.62 , Issue.6 , pp. 665-668
    • Prettyman, R.1    Bitsios, P.2    Szabadi, E.3
  • 100
    • 0032032177 scopus 로고    scopus 로고
    • Pupil noise is a discriminator between narcoleptics and controls
    • O'Neill WD, Oroujeh AM, Merritt SL. Pupil noise is a discriminator between narcoleptics and controls. IEEE Trans Biomed Eng. 1998;45(3):314-322.
    • (1998) IEEE Trans Biomed Eng , vol.45 , Issue.3 , pp. 314-322
    • O'Neill, W.D.1    Oroujeh, A.M.2    Merritt, S.L.3
  • 101
    • 0032911474 scopus 로고    scopus 로고
    • Comparison of the effects of venlafaxine, paroxetine and desipramine on the pupillary light reflex in man
    • DOI 10.1007/s002130050949
    • Bitsios P, Szabadi E, Bradshaw CM. Comparison of the effects of venlafaxine, paroxetine and desipramine on the pupillary light reflex in man. Psychopharmacology (Berl). 1999;143(3):286-292. (Pubitemid 29204983)
    • (1999) Psychopharmacology , vol.143 , Issue.3 , pp. 286-292
    • Bitsios, P.1    Szabadi, E.2    Bradshaw, C.M.3
  • 102
    • 3042781690 scopus 로고    scopus 로고
    • The effect of daily use of brimonidine tartrate on the dark-adapted pupil diameter
    • DOI 10.1016/j.ajo.2004.02.017, PII S0002939404001436
    • Brown SM, Khanani AM, McCartney DL. The effect of daily use of brimonidine tartrate on the dark-adapted pupil diameter. Am J Ophthalmol. 2004;138(1):149-151. (Pubitemid 38850268)
    • (2004) American Journal of Ophthalmology , vol.138 , Issue.1 , pp. 149-151
    • Brown, S.M.1    Khanani, A.M.2    McCartney, D.L.3
  • 103
    • 3042651661 scopus 로고    scopus 로고
    • The pupillary effects of intravenous morphine, codeine, and tramadol in volunteers
    • Knaggs RD, Crighton IM, Cobby TF, Fletcher AJ, Hobbs GJ. The pupillary effects of intravenous morphine, codeine, and tramadol in volunteers. Anesth Analg. 2004;99(1):108-112.
    • (2004) Anesth Analg , vol.99 , Issue.1 , pp. 108-112
    • Knaggs, R.D.1    Crighton, I.M.2    Cobby, T.F.3    Fletcher, A.J.4    Hobbs, G.J.5
  • 104
    • 0035093382 scopus 로고    scopus 로고
    • Daytime variations in central nervous system activation measured by a pupillographic sleepiness test
    • Wilhelm B, Giedke H, Ludtke H, Bittner E, Hofmann A, Wilhelm H. Daytime variations in central nervous system activation measured by a pupillographic sleepiness test. J Sleep Res. 2001;10(1):1-7.
    • (2001) J Sleep Res , vol.10 , Issue.1 , pp. 1-7
    • Wilhelm, B.1    Giedke, H.2    Ludtke, H.3    Bittner, E.4    Hofmann, A.5    Wilhelm, H.6
  • 107
    • 0033748721 scopus 로고    scopus 로고
    • Pupillography as an objective indicator of fatigue
    • Morad Y, Lemberg H, Yofe N, Dagan Y. Pupillography as an objective indicator of fatigue. Curr Eye Res. 2000;21(1):535-542.
    • (2000) Curr Eye Res , vol.21 , Issue.1 , pp. 535-542
    • Morad, Y.1    Lemberg, H.2    Yofe, N.3    Dagan, Y.4
  • 109
    • 0037333252 scopus 로고    scopus 로고
    • Pain and the defense response: Structural equation modeling reveals a coordinated psychophysiological response to increasing painful stimulation
    • Donaldson GW, Chapman CR, Nakamura Y, Bradshaw DH, Jacobson RC, Chapman CN. Pain and the defense response: structural equation modeling reveals a coordinated psychophysiological response to increasing painful stimulation. Pain. 2003;102(1-2):97-108.
    • (2003) Pain , vol.102 , Issue.1-2 , pp. 97-108
    • Donaldson, G.W.1    Chapman, C.R.2    Nakamura, Y.3    Bradshaw, D.H.4    Jacobson, R.C.5    Chapman, C.N.6
  • 110
    • 0037406273 scopus 로고    scopus 로고
    • Peripheral opioid analgesia in experimental human pain models
    • Tegeder I, Meier S, Burian M, Schmidt H, Geisslinger G, Lotsch J. Peripheral opioid analgesia in experimental human pain models. Brain. 2003;126(pt 5):1092-1102.
    • (2003) Brain , vol.126 , Issue.PART 5 , pp. 1092-1102
    • Tegeder, I.1    Meier, S.2    Burian, M.3    Schmidt, H.4    Geisslinger, G.5    Lotsch, J.6
  • 111
    • 70350571645 scopus 로고    scopus 로고
    • Direct and consensual murine pupillary reflex metrics: Establishing normative values
    • Hussain RZ, Hopkins SC, Frohman EM, et al. Direct and consensual murine pupillary reflex metrics: establishing normative values. Auton Neurosci. 2009;151(2):164-167.
    • (2009) Auton Neurosci , vol.151 , Issue.2 , pp. 164-167
    • Hussain, R.Z.1    Hopkins, S.C.2    Frohman, E.M.3
  • 112
    • 0036715263 scopus 로고    scopus 로고
    • Ion channels and neuronal dysfunction in multiple sclerosis
    • Waxman SG. Ion channels and neuronal dysfunction in multiple sclerosis. Arch Neurol. 2002;59(9):1377-1380.
    • (2002) Arch Neurol , vol.59 , Issue.9 , pp. 1377-1380
    • Waxman, S.G.1
  • 113
    • 0035818320 scopus 로고    scopus 로고
    • Neurodegeneration: A failure of neuroregeneration?
    • Armstrong RJ, Barker RA. Neurodegeneration: a failure of neuroregeneration? Lancet. 2001;358(9288):1174-1176.
    • (2001) Lancet , vol.358 , Issue.9288 , pp. 1174-1176
    • Armstrong, R.J.1    Barker, R.A.2
  • 114
    • 34249775208 scopus 로고    scopus 로고
    • Can imaging techniques measure neuroprotection and remyelination in multiple sclerosis?
    • DOI 10.1212/01.wnl.0000275236.51129.d2, PII 0000611420070529300012
    • Zivadinov R. Can imaging techniques measure neuroprotection and remyelination in multiple sclerosis? Neurology. 2007;68(22)(suppl 3):S72-S82. (Pubitemid 46848615)
    • (2007) Neurology , vol.68 , Issue.22 SUPPL. 3
    • Zivadinov, R.1
  • 115
    • 20444472644 scopus 로고    scopus 로고
    • Clinical trials in multiple sclerosis: Methodological issues
    • Comi G, Filippi M. Clinical trials in multiple sclerosis: methodological issues. Curr Opin Neurol. 2005;18(3):245-252. (Pubitemid 40813750)
    • (2005) Current Opinion in Neurology , vol.18 , Issue.3 , pp. 245-252
    • Comi, G.1    Filippi, M.2
  • 117
    • 0033958462 scopus 로고    scopus 로고
    • Glutamate excitotoxicity in a model of multiple sclerosis
    • Pitt D, Werner P, Raine CS. Glutamate excitotoxicity in a model of multiple sclerosis. Nat Med. 2000;6(1):67-70.
    • (2000) Nat Med , vol.6 , Issue.1 , pp. 67-70
    • Pitt, D.1    Werner, P.2    Raine, C.S.3
  • 118
    • 0141861944 scopus 로고    scopus 로고
    • Riluzole suppresses experimental autoimmune encephalomyelitis: Implications for the treatment of multiple sclerosis
    • Gilgun-Sherki Y, Panet H, Melamed E, Offen D. Riluzole suppresses experimental autoimmune encephalomyelitis: implications for the treatment of multiple sclerosis. Brain Res. 2003;989(2):196-204.
    • (2003) Brain Res , vol.989 , Issue.2 , pp. 196-204
    • Gilgun-Sherki, Y.1    Panet, H.2    Melamed, E.3    Offen, D.4
  • 119
    • 1842845857 scopus 로고    scopus 로고
    • The effect of the neuroprotective agent riluzole on MRI parameters in primary progressive multiple sclerosis: A pilot study
    • Kalkers NF, Barkhof F, Bergers E, van Schijndel R, Polman CH. The effect of the neuroprotective agent riluzole on MRI parameters in primary progressive multiple sclerosis: a pilot study. Mult Scler. 2002;8(6):532-533.
    • (2002) Mult Scler , vol.8 , Issue.6 , pp. 532-533
    • Kalkers, N.F.1    Barkhof, F.2    Bergers, E.3    Van Schijndel, R.4    Polman, C.H.5
  • 120
    • 0037309442 scopus 로고    scopus 로고
    • Blockers of sodium and calcium entry protect axons from nitric oxide-mediated degeneration
    • Kapoor R, Davies M, Blaker PA, Hall SM, Smith KJ. Blockers of sodium and calcium entry protect axons from nitric oxide-mediated degeneration. Ann Neurol. 2003;53(2):174-180.
    • (2003) Ann Neurol , vol.53 , Issue.2 , pp. 174-180
    • Kapoor, R.1    Davies, M.2    Blaker, P.A.3    Hall, S.M.4    Smith, K.J.5
  • 122
    • 34848897836 scopus 로고    scopus 로고
    • The endocannabinoid system is dysregulated in multiple sclerosis and in experimental autoimmune encephalomyelitis
    • Centonze D, Bari M, Rossi S, et al. The endocannabinoid system is dysregulated in multiple sclerosis and in experimental autoimmune encephalomyelitis. Brain. 2007;130(pt 10):2543-2553.
    • (2007) Brain , vol.130 , Issue.PART 10 , pp. 2543-2553
    • Centonze, D.1    Bari, M.2    Rossi, S.3
  • 123
    • 33847657051 scopus 로고    scopus 로고
    • Immune control by endocannabinoids - New mechanisms of neuroprotection?
    • Ullrich O, Merker K, Timm J, Tauber S. Immune control by endocannabinoids - new mechanisms of neuroprotection? J Neuroimmunol. 2007;184(1-2):127-135.
    • (2007) J Neuroimmunol , vol.184 , Issue.1-2 , pp. 127-135
    • Ullrich, O.1    Merker, K.2    Timm, J.3    Tauber, S.4
  • 124
    • 33751166454 scopus 로고    scopus 로고
    • Long-term protection of central axons with phenytoin in monophasic and chronic-relapsing EAE
    • DOI 10.1093/brain/awl216
    • Black JA, Liu S, Hains BC, Saab CY, Waxman SG. Long-term protection of central axons with phenytoin in monophasic and chronic-relapsing EAE. Brain. 2006;129(pt 12):3196-3208. (Pubitemid 44871436)
    • (2006) Brain , vol.129 , Issue.12 , pp. 3196-3208
    • Black, J.A.1    Liu, S.2    Hains, B.C.3    Saab, C.Y.4    Waxman, S.G.5
  • 125
    • 33947546463 scopus 로고    scopus 로고
    • Sodium channels and multiple sclerosis: Roles in symptom production, damage and therapy
    • Smith KJ. Sodium channels and multiple sclerosis: roles in symptom production, damage and therapy. Brain Pathol. 2007;17(2):230-242.
    • (2007) Brain Pathol , vol.17 , Issue.2 , pp. 230-242
    • Smith, K.J.1
  • 127
    • 20444424174 scopus 로고    scopus 로고
    • Glutamate inhibition in MS: The neuroprotective properties of riluzole
    • Killestein J, Kalkers NF, Polman CH. Glutamate inhibition in MS: the neuroprotective properties of riluzole. J Neurol Sci. 2005;233(1-2):113-115.
    • (2005) J Neurol Sci , vol.233 , Issue.1-2 , pp. 113-115
    • Killestein, J.1    Kalkers, N.F.2    Polman, C.H.3
  • 128
    • 4344571664 scopus 로고    scopus 로고
    • Efficacy, safety and tolerability of an orally administered cannabis extract in the treatment of spasticity in patients with multiple sclerosis: A randomized, double-blind, placebo-controlled, crossover study
    • Vaney C, Heinzel-Gutenbrunner M, Jobin P, et al. Efficacy, safety and tolerability of an orally administered cannabis extract in the treatment of spasticity in patients with multiple sclerosis: a randomized, double-blind, placebo-controlled, crossover study. Mult Scler. 2004;10(4):417-424.
    • (2004) Mult Scler , vol.10 , Issue.4 , pp. 417-424
    • Vaney, C.1    Heinzel-Gutenbrunner, M.2    Jobin, P.3
  • 131
    • 54249124952 scopus 로고    scopus 로고
    • Remyelination in the CNS: From biology to therapy
    • Franklin RJ, Ffrench-Constant C. Remyelination in the CNS: from biology to therapy. Nat Rev Neurosci. 2008;9(11):839-855.
    • (2008) Nat Rev Neurosci , vol.9 , Issue.11 , pp. 839-855
    • Franklin, R.J.1    Ffrench-Constant, C.2
  • 132
    • 77649320806 scopus 로고    scopus 로고
    • Importance of oligodendrocyte protection, BBB breakdown and inflammation for remyelination
    • Watzlawik J, Warrington AE, Rodriguez M. Importance of oligodendrocyte protection, BBB breakdown and inflammation for remyelination. Expert Rev Neurother. 2010;10(3):441-457.
    • (2010) Expert Rev Neurother , vol.10 , Issue.3 , pp. 441-457
    • Watzlawik, J.1    Warrington, A.E.2    Rodriguez, M.3
  • 133
    • 0025892475 scopus 로고
    • Prevention and treatment of chronic relapsing experimental allergic encephalomyelitis by transforming growth factor-beta 1
    • Racke MK, Dhib-Jalbut S, Cannella B, Albert PS, Raine CS, McFarlin DE. Prevention and treatment of chronic relapsing experimental allergic encephalomyelitis by transforming growth factor-beta 1. J Immunol. 1991;146(9):3012-3017.
    • (1991) J Immunol , vol.146 , Issue.9 , pp. 3012-3017
    • Racke, M.K.1    Dhib-Jalbut, S.2    Cannella, B.3    Albert, P.S.4    Raine, C.S.5    McFarlin, D.E.6
  • 134
    • 33947535936 scopus 로고    scopus 로고
    • Effectors of demyelination and remyelination in the CNS: Implications for multiple sclerosis
    • Rodriguez M. Effectors of demyelination and remyelination in the CNS: implications for multiple sclerosis. Brain Pathol. 2007;17(2):219-229.
    • (2007) Brain Pathol , vol.17 , Issue.2 , pp. 219-229
    • Rodriguez, M.1


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