Structure and mechanism of the 6-oxopurine nucleosidase from trypanosoma brucei brucei

Biochemistry

Volumn 49, Issue 41, 2010, Pages 8999-9010

  Vandemeulebroucke, An ^a,d   Minici, Claudia ^c   Bruno, Ilaria ^c   Muzzolini, Laura ^c   Tornaghi, Paola ^c   Parkin, David W ^b   Versées, Wim ^a   Steyaert, Jan ^a   Degano, Massimo ^c,d  

^a VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^b ADELPHI UNIVERSITY   (United States)

^c SAN RAFFAELE HOSPITAL   (Italy)

^d ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMOLECULES; LEAD COMPOUNDS; NUCLEIC ACIDS;

COFACTORS; DIFFUSION LIMITED; DISTINCTIVE FEATURES; GUANOSINES; INOSINE; NANOMOLAR; NUCLEOSIDASE; NUCLEOSIDE HYDROLASES; PRE-STEADY-STATE KINETIC ANALYSIS; PRODUCT RELEASE; RATE LIMITING; STRUCTURAL CHARACTERIZATION; STRUCTURAL REARRANGEMENT; THERAPEUTIC STRATEGY; TRYPANOSOMA BRUCEI;

CRYSTAL STRUCTURE;

6 OXOPURINE NUCLEOSIDASE; GUANINE; INOSINE; ISOENZYME; NUCLEOSIDASE; PURINE; PYRIMIDINE; RIBOSE; UNCLASSIFIED DRUG; GLYCOSIDASE; NUCLEOSIDE; PROTOZOAL PROTEIN; PURINE DERIVATIVE;

ARTICLE; CATALYSIS; CRYSTAL STRUCTURE; ENZYME STRUCTURE; ENZYME SUBSTRATE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FOLDING; STEADY STATE; TRYPANOSOMA BRUCEI; ANIMAL; CHEMISTRY; ENZYMOLOGY; KINETICS; METABOLISM; STRUCTURE ACTIVITY RELATION; TRYPANOSOMA BRUCEI BRUCEI; X RAY CRYSTALLOGRAPHY;

TRYPANOSOMA BRUCEI BRUCEI;

ANIMALS; CRYSTALLOGRAPHY, X-RAY; KINETICS; N-GLYCOSYL HYDROLASES; NUCLEOSIDES; PROTOZOAN PROTEINS; PURINONES; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPANOSOMA BRUCEI BRUCEI;

EID: 77957915467     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi100697d     Document Type: Article

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