A flexible loop as a functional element in the catalytic mechanism of nucleoside hydrolase from Trypanosoma vivax

Journal of Biological Chemistry

Volumn 283, Issue 32, 2008, Pages 22272-22282

  Vandemeulebroucke, An ^a   De Vos, Stefan ^a   Van Holsbeke, Els ^a   Steyaert, Jan ^a   Versées, Wim ^a  

^a DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; CRYSTALLOGRAPHY; MUTAGENESIS; QUANTUM CHEMISTRY;

ACTIVE SITES; CATALYTIC MECHANISMS; CATALYTIC ROLES; DELETION MUTAGENESISES; FLEXIBLE LOOPS; FUNCTIONAL ELEMENTS; GLYCOSIDIC BONDS; KINETIC STUDIES; LEAVING GROUPS; LOOP DYNAMICS; NUCLEOSIDE HYDROLASE; PRODUCT RELEASES; SINGLE SITES; STEADY STATES; TRYPANOSOMA VIVAX; WATER CHANNELS; X-RAY CRYSTALLOGRAPHIES;

X RAY CRYSTALLOGRAPHY;

NUCLEOSIDASE; 7 METHYLGUANINE; 7-METHYLGUANINE; DRUG DERIVATIVE; GLYCOSIDASE; GUANINE; GUANOSINE; PROLINE; RIBOSE; SOLVENT;

ARTICLE; CATALYSIS; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME KINETICS; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; TRYPANOSOMA VIVAX; X RAY CRYSTALLOGRAPHY; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; ENZYMOLOGY; GENETICS; HYDROLYSIS; METABOLISM; MUTATION; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE;

TRYPANOSOMA VIVAX;

ANIMALS; CATALYSIS; GUANINE; GUANOSINE; HYDROLYSIS; MODELS, MOLECULAR; MUTATION; N-GLYCOSYL HYDROLASES; PROLINE; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RIBOSE; SOLVENTS; TRYPANOSOMA VIVAX;

EID: 52049126845     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M803705200     Document Type: Article

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