Synthesis and biochemical evaluation of guanidino-alkyl-ribitol derivatives as nucleoside hydrolase inhibitors

European Journal of Medicinal Chemistry

Volumn 43, Issue 2, 2008, Pages 315-326

  Goeminne, A ^a   McNaughton, M ^a   Bal, G ^a   Surpateanu, G ^a   Van Der Veken, P ^a   De Prol, S ^b   Versees W ^b   Steyaert, J ^b   Haemers, A ^a   Augustyns, K ^a  

^a UNIVERSITY OF ANTWERP   (Belgium)

^b VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

Author keywords

Cation stacking interactions; Guanidino alkyl ribitol; Inhibitor; Nucleoside hydrolase

Indexed keywords

GUANIDINE DERIVATIVE; HYDROLASE INHIBITOR; NUCLEOSIDE HYDROLASE INHIBITOR; RIBITOL; RIBITOL DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DRUG ACTIVITY; DRUG DESIGN; DRUG SCREENING; DRUG SPECIFICITY; DRUG SYNTHESIS; MOLECULAR INTERACTION; NONHUMAN; TRYPANOSOMA VIVAX;

ANIMALS; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; N-GLYCOSYL HYDROLASES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TRYPANOSOMA VIVAX;

EID: 38949212483     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2007.03.027     Document Type: Article

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