Renal tubular hyperplasia, polycystic disease, and glomerulosclerosis in transgenic mice overexpressing hepatocyte growth factor/scatter factor

Laboratory Investigation

Volumn 77, Issue 2, 1997, Pages 131-138

  Takayama, Hisashi ^a,c   LaRochelle, William J ^a   Sabnis, Sharda G ^b   Otsuka, Toshiyuki ^a   Merlino, Glenn ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b ARMED FORCES INSTITUTE OF PATHOLOGY   (United States)

^c GUNMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

SCATTER FACTOR;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; FEMALE; GENE EXPRESSION; GLOMERULOSCLEROSIS; HISTOPATHOLOGY; KIDNEY DISEASE; KIDNEY FUNCTION; KIDNEY POLYCYSTIC DISEASE; KIDNEY TUBULE EPITHELIUM; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSGENIC MOUSE;

ANIMALS; FEMALE; HEPATOCYTE GROWTH FACTOR; HYPERPLASIA; KIDNEY GLOMERULUS; KIDNEY TUBULES; MALE; MICE; MICE, TRANSGENIC; POLYCYSTIC KIDNEY DISEASES;

EID: 0030738188     PISSN: 00236837     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Antonovych TT, Sabnis SG, Tuur SM, Sesterhenn IA, and Balow JE (1989). Morphologic differences between polyarteritis and Wegener's granulomatosis using light, electron and immunohistochemical techniques. Mod Pathol 2:349-359.
2. Bladt F, Rlethmacher D, Isenmann S, Aguzzi A, and Birchmeier C (1995). Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud. Nature 376:768-771.
3. Dickie P, Felser J, Eckhaus M, Bryant J, Silver J, Marinos N, and Notkins AL (1991). HIV-associated nephropathy in transgenic mice expressing HIV-1 genes. Virology 185:109-119.
4. Doi T, Striker LJ, Quaife CJ, Conti FG, Palmiter RD, Behringer RR, Brinster RL, and Striker GE (1988). Progressive glomerulosclerosis develops in transgenic mice chronically expressing growth hormone and growth hormone releasing factor but not in those expressing insulin-like growth factor-1. Am J Pathol 131:398-403.
5. Fattori E, Della Rocca C, Costa P, Giorgio M, Dente B, Pozzi L, and Ciliberto G (1994). Development of progressive kidney damage and myeloma kidney in Interleukin-6 transgenic mice. Blood 83:2570-2579.
6. Gherardi E and Stoker M (1991). Hepatocyte growth factor-scatter factor: Mitogen, motogen, amd Met. Cancer Cells 3:227-232.
7. Harding MA, Gattone VH, Grantham JJ, and Calvet JP (1992). Localization of overexpressed c-myc mRNA in polycystic kidneys of the cpk mouse. Kidney Int 41:317-325.
8. Harris RC, Burns KD, Alattar M, Homma T, and Nakamura T (1993). Hepatocyte growth factor stimulates phosphoinositide hydrolysis and mitogenesis in cultured renal epithelial cells. Life Sci 52:1091-1100.
9. Igawa T, Kanda S, Kanetake H, Saitoh Y, Ichihara A, Tomita Y, and Nakamura T (1991). Hepatocyte growth factor is a potent mitogen for cultured rabbit renal tubular epithelial cells. Biochem Biophys Res Commun 174:831-838.
10. Igawa T, Matsumoto K, Kanda S, Saito Y, and Nakamura T (1993). Hepatocyte growth factor may function as a renotropic factor for regeneration in rats with acute renal injury. Am J Phyiol 265:F61-F69.
11. Ishibashi K, Sasaki S, Sakamoto H, Nakamura Y, Hata T, Nakamura T, and Marumo F (1992). Hepatocyte growth factor is a paracrine factor for renal epithelial cells: Stimulation of DNA synthesis and Na, K-ATPase activity. Biochem Biophys Res Commun 182:960-965.
12. Jhappan C, Takayama H, Dickson RB, and Merlino G (1994). Transgenic mice provide genetic evidence that transforming growth factor α promotes skin tumorigenesis via H-Rasdependent and H-Ras-independent pathways. Cell Growth Diff 5:385-395.
13. Kan M, Zhang G, Zarnegar R, Michalopoulos G, Myoken Y, MacKeehan WL, and Stevens JI (1991). Hepatocyte growth factor/hepatopoietin A stimulates the growth of rat kidney proximal tubule epithelial cells (RPTE), rat nonparenchymal liver cells, mouse keratinocytes and stimulates anchorage-independent growth of SV-40 transformed RPTE. Biochem Biophys Res Commun 174:331-337.
14. Kawaida K, Matsumoto K, Shimazu H, and Nakamura T (1994). Hepatocyte growth factor prevents acute renal failure and accelerates renal regeneration in mice. Proc Natl Acad Sci U S A 91:4357-4361.
15. Kopp JB, Factor VM, Mozes M, Nagy P, Sanderson N, Böttinger EP, Klotman PE, and Thorgeirsson SS (1996). Transgenic mice with increased plasma levels of TGFβ1 develop progressive renal disease. Lab Invest 74:991-1003.
16. Kreidberg JA, Sariola H, Loring JM, Maeda M, Pelletier J, Housman D, and Jaenisch R (1993). WT-1 is required for early kidney development. Cell 74:679-691.
17. Liu ZZ, Wada J, Kumar A, Carone FA, Takahashi M, and Kanwar YS (1996). Comparative role of phophotyrosine kinase domains of c-ros and c-ret protooncogenes in metanephric development with respect to growth factors and matrix morphogens. Dev Biol 178:133-148.
18. Matsumoto K and Nakamura T (1996). Emerging multipotent aspects of hepatocyte growth factor. J Biochem 119:591-600.
19. Miller SB, Martin DR, Kissane J, and Hammerman MR (1994). Hepatocyte growth factor accelerates recovery from acute ischemic renal injury in rats. Am J Physiol 266:F129-F134.
20. Montesano R, Matsumoto K, Nakamura T, and Orci L (1991). Identification of a fibroblast-derived epithelial morphogen as hepatocyte growth factor. Cell 67:901-908.
21. Nagaike M, Hirao S, Tajima H, Noji S, Taniguchi S, Matsumoto K, and Nakamura T (1991). Renotropic functions of hepatocyte growth factor in renal regeneration after unilateral nephrectomy. J Biol Chem 266:22781-22784.
22. Nguyen HQ, Danilenko DM, Bucay N, Derose ML, Van GY, Thomason A, and Simonet WS (1996). Expression of keratinocyte growth factor in embryonic liver of transgenic mice causes changes in epithelial growth and differentiation resulting in polycystic kidneys and other organ malformation. Oncogene 12:2109-2119.
23. Palmiter RD, Sandgren EP, Koeller DM, and Brinster RL (1993). Distal regulatory elements from the mouse metallothionein locus stimulate gene expression in transgenic mice. Mol Cell Biol 13:5266-5275.
24. Rahilly MA, Samuel K, Ansell JD, Micklem HS, and Fleming S (1992). Polycystic kidney disease in the CBA/N immunodeficient mouse. J Pathol 168:335-342.
25. Rosen EM, Nigam SK, and Goldberg ID (1994). Scatter factor and the c-Met receptor. A paradigm for mesenchymal/ epithelial interaction. J Cell Biol 127:1783-1787.
26. Sabnis SG, Nandedkar MA, and Antonovych TT (1988). Antiglomerular basement membrane antibody-induced glomerulonephritis with glomerular multinucleated giant cell reaction: A case study. Am J Kidney Dis 12:544-547.
27. Sakata H, Takayama H, Sharp R, Rubin JS, Merlino G, and LaRochelle WJ (1996). Hepatocyte growth factor/scatter factor overexpression induces growth, abnormal development, and tumor formation in transgenic mouse livers. Cell Growth Diff 7:1513-1523.
28. Santos OFP, Barros EJG, Yang X-M, Matsumoto K, Nakamura T, Park M, and Nigam SK (1994). Involvement of hepatocyte growth factor in kidney development. Dev Biol 163:525-529.
29. Schmidt C, Bladt F, Goedecke S, Brinkman V, Zschiesche W, Sharpe M, Gherardi E, and Birchmeier C (1995). Scatter factor/hepatocyte growth factor is essential for liver development. Nature 373:699-702.
30. Schuchardt A, D'Agati V, Larsson-Blomberg L, Costantini F, and Pachnis V (1994). Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret. Nature 367:380-383.
31. Sonnenberg E, Meyer D, Weidner KM, and Birchmeier C (1993). Scatter factor/hepatocyte growth factor and its receptor, the c-met tyrosine kinase, can mediate a signal exchange between mesenchyme and epithelia during mouse development. J Cell Biol 123:223-235.
32. Stöcklin E, Botteri F, and Groner B (1993). An activated allele of the c-erbB-2 oncogene impairs kidney and lung function and causes early death of transgenic mice. J Cell Biol 122:199-208.
33. Striker LJ, Doi T, and Striker GE (1991). Transgenic mice in renal research. Adv Nephrol Necker Hosp 20:91-108.
34. Sugimura K, Kim T, Goto T, Kasai S, Takemoto Y, Matsuda J, Yoshimoto M, Yamagami S, and Kishimoto T (1994). Serum hepatocyte growth factor levels in patients with chronic renal failure. Nephron 70:324-328.
35. Takayama H, LaRochelle WJ, Anver M, Bockman DE, and Merlino G (1996). Scatter factor/hepatocyte growth factor as a regulator of skeletal muscle and neural crest development. Proc Natl Acad Sci U S A 93:5866-5871.
36. Takayama H, LaRochelle WJ, Sharp R, Otsuka T, Kriebel P, Anver M, Aaronson SA, and Merlino G (1997). Diverse tumorigenesis associated with aberrant development in mice overexpressing hepatocyte growth factor/scatter factor. Proc Natl Acad Sci U S A 94:701-706.
37. Trudel M, D'Agati V, and Costantini F (1991). c-myc as an inducer of polycystic kidney disease in transgenic mice. Kidney Int 39:665-671.
38. Uehara Y, Minowa O, Mori C, Shiota K, Kuno J, Noda T, and Kitamura N (1995). Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor. Nature 373:702-705.
39. Vande Woude GF (1992). Hepatocyte growth factor: Mitogen, motogen, and morphogen. Jpn J Cancer Res 83:227-232.
40. Veis DJ, Sorenson CM, Shutter JR, and Korsmeyer SJ (1993). Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair. Cell 75:229-240.
41. Woolf AS, Kolatsi-Joannou M, Hardman P, Andermarcher E, Moorby C, Fine LG, Jat PS, Noble MD, and Gherardi E (1995). Roles of hepatocyte growth factor/scatter factor and the met receptor in the early development of the metanephros. J Cell Biol 128:171-184.
42. Zarnegar R and Michalopoulos GK (1995). The many faces of hepatocyte growth factor: From hepatopoiesis to hematopoiesis. J Cell Biol 129:1177-1180.