4-Aminoquinoline derived antimalarials: Synthesis, antiplasmodial activity and heme polymerization inhibition studies

European Journal of Medicinal Chemistry

Volumn 45, Issue 11, 2010, Pages 4990-4996

  Solomon, V R ^a   Haq, W ^a   Smilkstein, M ^b   Srivastava, Kumkum ^a   Puri, Sunil K ^a   Katti, S B ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

^b PORTLAND VA MEDICAL CENTER   (United States)

Author keywords

4 Aminoquinoline; Antimalarial agents; Heme polymerization; Thiourea

Indexed keywords

1 (4 CHLORO PHENYL) 3 [3 (7 CHLORO QUINOLIN 4 YLAMINO) PROPYL] THIOUREA; 1 [3 (7 CHLORO QUINOLIN 4 YLAMINO) PROPYL] 3 CYCLOPROPYL THIOUREA; 1 [3 (7 CHLORO QUINOLIN 4 YLAMINO) PROPYL] 3 CYCLOPROPYLTHIOUREA; 1 [3 (7 CHLORO QUINOLIN 4 YLAMINO) PROPYL] 3 METHYL THIOUREA; 1,3 BIS [3 (7 CHLORO QUINOLIN 4 YLAMINO) PROPYL] THIOUREA; 3 [3 (7 CHLORO QUINOLIN 4 YLAMINO) PROPYL] 1,1 DIETHYL THIOUREA; 3 [3 (7 CHLORO QUINOLIN 4 YLAMINO) PROPYL] 1,1 DIISOPROPYL THIOUREA; 3 [3 (7 CHLORO QUINOLIN 4 YLAMINO) PROPYL] 1,1 DIMETHYLTHIOUREA; 4 AMINOQUINOLINE; 4 METHYL PIPERAZINE 1 CARBOTHIOIC ACID [3 (7 CHLOROQUINOLIN 4 YLAMINO) PROPYL] AMIDE; 4 PHENYL PIPERAZINE 1 CARBOTHIOIC ACID [3 (7 CHLOROQUINOLIN 4 YLAMINO) PROPYL] AMIDE; AMODIAQUINE; CHLOROQUINE; HEME; MORPHOLINE 4 CARBOTHIOIC ACID [3 (7 CHLORO QUINOLIN 4 YLAMINO) PROPYL] AMIDE; N (7 CHLORO QUINOLIN 4 YL)PROPANE 1,3 DIAMINE; PIPERAZINE 1 CARBOTHIOIC ACID [3 (7 CHLORO QUINOLIN 4 YLAMINO) PROPYL] AMIDE; PIPERIDINE 1 CARBOTHIOIC ACID [3 (7 CHLORO QUINOLIN 4 YLAMINO) PROPYL] AMIDE; PYRROLIDINE 1 CARBOTHIOIC ACID [3 (7 CHLORO QUINOLIN 4 YLAMINO) PROPYL AMIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIMALARIAL ACTIVITY; ARTICLE; DRUG SYNTHESIS; IN VITRO STUDY; NONHUMAN; PLASMODIUM FALCIPARUM; POLYMERIZATION; PROTOZOON; SPECTROSCOPY;

AMINOQUINOLINES; ANIMALS; ANTIMALARIALS; DOSE-RESPONSE RELATIONSHIP, DRUG; HEME; MAGNETIC RESONANCE SPECTROSCOPY; PLASMODIUM FALCIPARUM; POLYMERS; SPECTROMETRY, MASS, FAST ATOM BOMBARDMENT;

EID: 77957843768     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.07.068     Document Type: Article

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