α-ketoheterocycles as inhibitors of Leishmania mexicana cysteine protease CPB

ChemMedChem

Volumn 5, Issue 10, 2010, Pages 1734-1748

  Steert, Koen ^a   Berg, Maya ^a   Mottram, Jeremy C ^b   Westrop, Gareth D ^c   Coombs, Graham H ^c   Cos, Paul ^a   Maes, Louis ^a   Joossens, Jurgen ^a   Van Der Veken, Pieter ^a   Haemers, Achiel ^a   Augustyns, Koen ^a  

^a UNIVERSITY OF ANTWERP   (Belgium)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

^c UNIVERSITY OF STRATHCLYDE   (United Kingdom)

Author keywords

Cysteine proteases; Inhibitors; Ketoheterocycles; Parasite CPB; Trypanosomas

Indexed keywords

4 METHYL N [1 OXO 1 [1 OXO 4 PHENYL 1 (5 PHENYLISOXAZOL 3 YL)BUTAN 2 YLAMINO] 3 PHENYLPROPAN 2 YL]PIPERAZINE 1 CARBOXAMIDE; ALPHA KETOHETEROCYCLE DERIVATIVE; ANTILEISHMANIAL AGENT; CYSTEINE PROTEINASE; CYSTEINE PROTEINASE INHIBITOR; ISOXAZOLE DERIVATIVE; K11777; MU K11777; N [1 [(D) 1 (5 BENZYLISOXAZOL 3 YL) 1 OXO 4 PHENYLBUTAN 2 YLAMINO] 1 OXO 3 PHENYLPROPAN 2 YL]MORPHOLINE 4 CARBOXAMIDE; N [1 [1 (BENZO[D]OXAZOL 2 YL) 1 OXO 3 PHENYLPROPAN 2 YLAMINO] 1 OXO 3 PHENYLPROPAN 2 YL]MORPHOLINE 4 CARBOXAMIDE; N [1 [1 (BENZO[D]THIAZOL 2 YL) 1 OXO 3 PHENYLPROPAN 2 YLAMINO] 1 OXO 3 PHENYLPROPAN 2 YL]MORPHOLINE 4 CARBOXAMIDE; N [1 [1 [1 (BENZYLOXYMETHYL) 1H 1,2,3 TRIAZOL 4 YL] 1 OXO 3 PHENYLPROPAN 2 YLAMINO] 1 OXO 3 PHENYLPROPAN 2 YL]MORPHOLINE 4 CARBOXAMIDE; N [1 [1 HYDROXY 3 PHENYL 1 (5 PHENYL 1,2,4 OXADIAZOL 3 YL)PROPAN 2 YLAMINO] 1 OXO 3 PHENYLPROPAN 2 YL]MORPHOLINE 4 CARBOXAMIDE; N [1 OXO 1 [1 OXO 3 PHENYL 1 (1 PHENYL 1H 1,2,3 TRIAZOL 4 YL)PROPAN 2 YLAMINO] 3 PHENYLPROPAN 2 YL]MORPHOLINE 4 CARBOXAMIDE; N [1 OXO 1 [1 OXO 3 PHENYL 1 (1H 1,2,3 TRIAZOL 4 YL)PROPAN 2 YLAMINO] 3 PHENYLPROPAN 2 YL]MORPHOLINE 4 CARBOXAMIDE; N [1 OXO 1 [1 OXO 3 PHENYL 1 (3 PHENYLISOXAZOL 5 YL)PROPAN 2 YLAMINO] 3 PHENYLPROPAN 2 YL]MORPHOLINE 4 CARBOXAMIDE; N [1 OXO 1 [1 OXO 3 PHENYL 1 (5 PHENYLOXAZOL 2 YL)PROPAN 2 YLAMINO] 3 PHENYLPROPAN 2 YL]MORPHOLINE 4 CARBOXAMIDE; N [1 OXO 1 [1 OXO 3 PHENYL 1 (5 PHENYLTHIAZOL 2 YL)PROPAN 2 YLAMINO] 3 PHENYLPROPAN 2 YL]MORPHOLINE 4 CARBOXAMIDE; N [1 OXO 1 [1 OXO 3 PHENYL 1 (THIAZOL 2 YL)PROPAN 2 YLAMINO] 3 PHENYLPROPAN 2 YL]MORPHOLINE 4 CARBOXAMIDE; N [1 OXO 1 [1 OXO 3 PHENYL 1 [5 (TRIMETHYLSILYL)ISOXAZOL 3 YL]PROPAN 2 YLAMINO] 3 PHENYLPROPAN 2 YL]MORPHOLINE 4 CARBOXAMIDE; N [1 OXO 1 [1 OXO 4 PHENYL 1 (5 PHENYLISOXAZOL 3 YL)BUTAN 2 YLAMINO] 3 PHENYLPROPAN 2 YL]MORPHOLINE 4 CARBOXAMIDE; N [1 OXO 1 [[1 OXO 3 PHENYL 1 (5 PHENYLISOXAZOL 3 YL)PROPAN 2 YLAMINO] 3 PHENYLPROPAN 2 YL]MORPHOLINE 4 CARBOXAMIDE; OXADIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CYTOTOXICITY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; LEISHMANIA INFANTUM; LEISHMANIA MEXICANA; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; TRYPANOSOMA BRUCEI; TRYPANOSOMA CRUZI;

ANTIPROTOZOAL AGENTS; CELL LINE; CYSTEINE PROTEASES; CYSTEINE PROTEINASE INHIBITORS; HETEROCYCLIC COMPOUNDS; HUMANS; KINETICS; LEISHMANIA INFANTUM; LEISHMANIA MEXICANA; PLASMODIUM FALCIPARUM; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMA CRUZI;

EID: 77957688564     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201000265     Document Type: Article

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