Dipeptidyl α-fluorovinyl Michael acceptors: Synthesis and activity against cysteine proteases

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 23, 2007, Pages 6563-6566

  Steert, Koen ^a   El Sayed, Ibrahim ^a   Van der Veken, Pieter ^a   Krishtal, Alisa ^a   Van Alsenoy, Christian ^a   Westrop, Gareth D ^b   Mottram, Jeremy C ^c   Coombs, Graham H ^b   Augustyns, Koen ^a   Haemers, Achiel ^a  

^a UNIVERSITY OF ANTWERP   (Belgium)

^b UNIVERSITY OF STRATHCLYDE   (United Kingdom)

^c UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Fluorovinyl Michael acceptors; Cysteine proteases; Inhibitors

Indexed keywords

CRUZIPAIN; CYSTEINE PROTEINASE; DIPEPTIDYL ALPHA FLUOROVINYL SULFONE DERIVATIVE; FALCIPAIN; PHENYL ALPHA FLUOROVINYL PHENYLSULFONE; SULFONE DERIVATIVE; UNCLASSIFIED DRUG; VINYL PHENYLSULFONE;

ARTICLE; BIOLOGICAL ACTIVITY; CHEMICAL STRUCTURE; DRUG ACTIVITY; ENZYME INHIBITION; HORNER WADSWORTH EMMONS REACTION; LEISHMANIA MEXICANA; MICHAEL ADDITION;

ANIMALS; BINDING SITES; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; DIPEPTIDES; LEISHMANIA MEXICANA; LEISHMANIASIS, CUTANEOUS; MODELS, MOLECULAR;

LEISHMANIA MEXICANA;

EID: 35648952198     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.09.075     Document Type: Article

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