SCOPUS 정보 검색 플랫폼

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 17, 2005, Pages 3891-3895

Ketoheterocycle-based inhibitors of cathepsin K: A novel entry into the synthesis of peptidic ketoheterocycles

(5) Tavares, Francis X a Deaton, David N a Miller, Aaron B a Miller, Larry R a Wright, Lois L a

a GLAXOSMITHKLINE (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE; CARBAMIC ACID; CATHEPSIN K INHIBITOR; PEPTIDE DERIVATIVE; PROTEINASE INHIBITOR; THIAZOLE DERIVATIVE; THIOAMIDE;

ARTICLE; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; STRUCTURE ACTIVITY RELATION;

BINDING SITES; CATHEPSIN B; CATHEPSINS; CYSTEINE ENDOPEPTIDASES; HETEROCYCLIC COMPOUNDS; HUMANS; HYDROGEN BONDING; INHIBITORY CONCENTRATION 50; PROTEIN BINDING; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 23244456258 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/j.bmcl.2005.05.091 Document Type: Article

Times cited : (17)

References (24)

1
- 0003486796
- R. Marcus D. Feldman J. Kelsey Academic Press San Diego, CA
- T.A. Einhorn R. Marcus D. Feldman J. Kelsey Osteoporosis 1996 Academic Press San Diego, CA 3
- (1996) Osteoporosis , pp. 3
- Einhorn, T.A.¹

2
- 15844422855
- F.H. Drake, R.A. Dodds, I.E. James, J.R. Connor, C. Debouck, S. Richardson, E. Lee-Rykaczewski, L. Coleman, D. Rieman, R. Barthlow, G. Hastings, and M. Gowen J. Biol. Chem. 271 1996 12511
- (1996) J. Biol. Chem. , vol.271 , pp. 12511
- Drake, F.H.¹ Dodds, R.A.² James, I.E.³ Connor, J.R.⁴ Debouck, C.⁵ Richardson, S.⁶ Lee-Rykaczewski, E.⁷ Coleman, L.⁸ Rieman, D.⁹ Barthlow, R.¹⁰ Hastings, G.¹¹ Gowen, M.¹²

3
- 0030984531
- T. Inui, O. Ishibashi, T. Inaoka, Y. Origane, M. Kumegawa, T. Kokubo, and T. Yamamura J. Biol. Chem. 272 1997 8109
- (1997) J. Biol. Chem. , vol.272 , pp. 8109
- Inui, T.¹ Ishibashi, O.² Inaoka, T.³ Origane, Y.⁴ Kumegawa, M.⁵ Kokubo, T.⁶ Yamamura, T.⁷

4
- 0029809357
- B.D. Gelb, G.-P. Shi, H.A. Chapman, and R.J. Desnick Science 273 1996 1236
- (1996) Science , vol.273 , pp. 1236
- Gelb, B.D.¹ Shi, G.-P.² Chapman, H.A.³ Desnick, R.J.⁴

5
- 0029800843
- M.R. Johnson, M.H. Polymeropoulos, H.L. Vos, R.I. Ortiz de Luna, and C.A. Francomano Genome Res. 6 1996 1050
- (1996) Genome Res. , vol.6 , pp. 1050
- Johnson, M.R.¹ Polymeropoulos, M.H.² Vos, H.L.³ Ortiz De Luna, R.I.⁴ Francomano, C.A.⁵

6
- 0345580617
- W.-S. Hou, D. Bromme, Y. Zhao, E. Mehler, C. Dushey, H. Weinstein, C.S. Miranda, C. Fraga, F. Greig, J. Carey, D.L. Rimoin, R.J. Desnick, and B.D. Gelb J. Clin. Invest. 103 1999 731
- (1999) J. Clin. Invest. , vol.103 , pp. 731
- Hou, W.-S.¹ Bromme, D.² Zhao, Y.³ Mehler, E.⁴ Dushey, C.⁵ Weinstein, H.⁶ Miranda, C.S.⁷ Fraga, C.⁸ Greig, F.⁹ Carey, J.¹⁰ Rimoin, D.L.¹¹ Desnick, R.J.¹² Gelb, B.D.¹³

7
- 0032506007
- P. Saftig, E. Hunziker, O. Wehmeyer, S. Jones, A. Boyde, W. Rommerskirch, J.D. Moritz, P. Schu, and K. Von Figura Proc. Natl. Acad. Sci. U.S.A. 95 1998 13453
- (1998) Proc. Natl. Acad. Sci. U.S.A. , vol.95 , pp. 13453
- Saftig, P.¹ Hunziker, E.² Wehmeyer, O.³ Jones, S.⁴ Boyde, A.⁵ Rommerskirch, W.⁶ Moritz, J.D.⁷ Schu, P.⁸ Von Figura, K.⁹

8
- 0032859323
- M. Gowen, F. Lazner, R. Dodds, R. Kapadia, J. Feild, M. Tavaria, I. Bertoncello, F. Drake, S. Zavarselk, I. Tellis, P. Hertzog, C. Debouck, and I. Kola J. Bone Miner. Res. 14 1999 1654
- (1999) J. Bone Miner. Res. , vol.14 , pp. 1654
- Gowen, M.¹ Lazner, F.² Dodds, R.³ Kapadia, R.⁴ Feild, J.⁵ Tavaria, M.⁶ Bertoncello, I.⁷ Drake, F.⁸ Zavarselk, S.⁹ Tellis, I.¹⁰ Hertzog, P.¹¹ Debouck, C.¹² Kola, I.¹³

9
- 0034041529
- D.S. Yamashita, and R.A. Dodds Curr. Pharm. Des. 1 2000 1
- (2000) Curr. Pharm. Des. , vol.1 , pp. 1
- Yamashita, D.S.¹ Dodds, R.A.²

10
- 4444344451
- D.N. Deaton, and S. Kumar Prog. Med. Chem. 42 2004 245
- (2004) Prog. Med. Chem. , vol.42 , pp. 245
- Deaton, D.N.¹ Kumar, S.²

11
- 13544254618
- J. Cai, C. Jamieson, J. Moir, and Z. Rankovic Expert Opin. Ther. Pat. 15 2005 33
- (2005) Expert Opin. Ther. Pat. , vol.15 , pp. 33
- Cai, J.¹ Jamieson, C.² Moir, J.³ Rankovic, Z.⁴

12
- 0348143469
- J.G. Catalano, D.N. Deaton, E.S. Furfine, A.M. Hassell, R.B. McFadyen, A.B. Miller, L.R. Miller, L.M. Shewchuk, D.H. Willard, and L.L. Wright Bioorg. Med. Chem. Lett. 14 2004 275
- (2004) Bioorg. Med. Chem. Lett. , vol.14 , pp. 275
- Catalano, J.G.¹ Deaton, D.N.² Furfine, E.S.³ Hassell, A.M.⁴ McFadyen, R.B.⁵ Miller, A.B.⁶ Miller, L.R.⁷ Shewchuk, L.M.⁸ Willard, D.H.⁹ Wright, L.L.¹⁰

13
- 2942620830
- E.E. Boros, D.N. Deaton, A.M. Hassell, R.B. McFadyen, A.B. Miller, L.R. Miller, M.G. Paulick, L.M. Shewchuk, J.B. Thompson, D.H. Willard, and L.L. Wright Bioorg. Med. Chem. Lett. 14 2004 3425
- (2004) Bioorg. Med. Chem. Lett. , vol.14 , pp. 3425
- Boros, E.E.¹ Deaton, D.N.² Hassell, A.M.³ McFadyen, R.B.⁴ Miller, A.B.⁵ Miller, L.R.⁶ Paulick, M.G.⁷ Shewchuk, L.M.⁸ Thompson, J.B.⁹ Willard, D.H.¹⁰ Wright, L.L.¹¹

14
- 15044351879
- D.N. Deaton, A.M. Hassell, R.B. McFadyen, A.B. Miller, L.R. Miller, L.M. Shewchuk, F.X. Tavares, D.H. Willard Jr., and L.L. Wright Bioorg. Med. Chem. Lett. 15 2005 1815
- (2005) Bioorg. Med. Chem. Lett. , vol.15 , pp. 1815
- Deaton, D.N.¹ Hassell, A.M.² McFadyen, R.B.³ Miller, A.B.⁴ Miller, L.R.⁵ Shewchuk, L.M.⁶ Tavares, F.X.⁷ Willard Jr., D.H.⁸ Wright, L.L.⁹

15
- 1642436650
- J.G. Catalano, D.N. Deaton, S.T. Long, R.B. McFadyen, L.R. Miller, J.A. Payne, K.J. Wells-Knecht, and L.L. Wright Bioorg. Med. Chem. Lett. 14 2004 719
- (2004) Bioorg. Med. Chem. Lett. , vol.14 , pp. 719
- Catalano, J.G.¹ Deaton, D.N.² Long, S.T.³ McFadyen, R.B.⁴ Miller, L.R.⁵ Payne, J.A.⁶ Wells-Knecht, K.J.⁷ Wright, L.L.⁸

16
- 9144241615
- F.X. Tavares, V. Boncek, D.N. Deaton, A.M. Hassell, S.T. Long, A.B. Miller, A.A. Payne, L.R. Miller, L.M. Shewchuk, K. Wells-Knecht, D.H. Willard Jr., L.L. Wright, and H.-Q. Zhou J. Med. Chem. 47 2004 588
- (2004) J. Med. Chem. , vol.47 , pp. 588
- Tavares, F.X.¹ Boncek, V.² Deaton, D.N.³ Hassell, A.M.⁴ Long, S.T.⁵ Miller, A.B.⁶ Payne, A.A.⁷ Miller, L.R.⁸ Shewchuk, L.M.⁹ Wells-Knecht, K.¹⁰ Willard Jr., D.H.¹¹ Wright, L.L.¹² Zhou, H.-Q.¹³

17
- 1942444360
- D.G. Barrett, J.G. Catalano, D.N. Deaton, S.T. Long, L.R. Miller, F.X. Tavares, K.J. Wells-Knecht, L.L. Wright, and H.-Q.Q. Zhou Bioorg. Med. Chem. Lett. 14 2004 2543
- (2004) Bioorg. Med. Chem. Lett. , vol.14 , pp. 2543
- Barrett, D.G.¹ Catalano, J.G.² Deaton, D.N.³ Long, S.T.⁴ Miller, L.R.⁵ Tavares, F.X.⁶ Wells-Knecht, K.J.⁷ Wright, L.L.⁸ Zhou, H.-Q.Q.⁹

18
- 4444281995
- D.G. Barrett, J.G. Catalano, D.N. Deaton, A.M. Hassell, S.T. Long, A.B. Miller, L.R. Miller, L.M. Shewchuk, K.J. Wells-Knecht, D.H. Willard Jr., and L.L. Wright Bioorg. Med. Chem. Lett. 14 2004 4897
- (2004) Bioorg. Med. Chem. Lett. , vol.14 , pp. 4897
- Barrett, D.G.¹ Catalano, J.G.² Deaton, D.N.³ Hassell, A.M.⁴ Long, S.T.⁵ Miller, A.B.⁶ Miller, L.R.⁷ Shewchuk, L.M.⁸ Wells-Knecht, K.J.⁹ Willard Jr., D.H.¹⁰ Wright, L.L.¹¹

19
- 4744369975
- F.X. Tavares, D.N. Deaton, A.B. Miller, L.R. Miller, L.L. Wright, and H.-Q. Zhou J. Med. Chem. 47 2004 5049
- (2004) J. Med. Chem. , vol.47 , pp. 5049
- Tavares, F.X.¹ Deaton, D.N.² Miller, A.B.³ Miller, L.R.⁴ Wright, L.L.⁵ Zhou, H.-Q.⁶

20
- 4744350185
- F.X. Tavares, D.N. Deaton, L.R. Miller, and L.L. Wright J. Med. Chem. 47 2004 5057
- (2004) J. Med. Chem. , vol.47 , pp. 5057
- Tavares, F.X.¹ Deaton, D.N.² Miller, L.R.³ Wright, L.L.⁴

21
- 0026546559
- P.D. Edwards, E.F. Meyer Jr., J. Vijayalakshmi, P.A. Tuthill, D.A. Andisik, B. Gomes, and A. Strimpler J. Am. Chem. Soc. 114 1992 1854
- (1992) J. Am. Chem. Soc. , vol.114 , pp. 1854
- Edwards, P.D.¹ Meyer Jr., E.F.² Vijayalakshmi, J.³ Tuthill, P.A.⁴ Andisik, D.A.⁵ Gomes, B.⁶ Strimpler, A.⁷

22
- 0029742578
- M.J. Costanzo, B. Maryanoff, L.R. Hecker, M.R. Schott, S.C. Yabut, H.-C. Zhang, P. Andrade-Gordon, J.A. Kauffman, and J.M. Lewis J. Med. Chem. 39 1996 3039
- (1996) J. Med. Chem. , vol.39 , pp. 3039
- Costanzo, M.J.¹ Maryanoff, B.² Hecker, L.R.³ Schott, M.R.⁴ Yabut, S.C.⁵ Zhang, H.-C.⁶ Andrade-Gordon, P.⁷ Kauffman, J.A.⁸ Lewis, J.M.⁹

23
- 0030591856
- M. Tao, R. Bihovsky, and J.C. Kauer Bioorg. Med. Chem. Lett. 6 1996 3009
- (1996) Bioorg. Med. Chem. Lett. , vol.6 , pp. 3009
- Tao, M.¹ Bihovsky, R.² Kauer, J.C.³

24
- 0346333386
- M.E. McGrath, P.A. Sprengeler, C.M. Hill, V. Martichonok, H. Cheung, J.R. Somoza, J.T. Palmer, and J.W. Janc Biochemistry 42 2003 15018
- (2003) Biochemistry , vol.42 , pp. 15018
- McGrath, M.E.¹ Sprengeler, P.A.² Hill, C.M.³ Martichonok, V.⁴ Cheung, H.⁵ Somoza, J.R.⁶ Palmer, J.T.⁷ Janc, J.W.⁸

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.