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Volumn 1, Issue 3, 2010, Pages 260-263

A newly discovered role of telomeres in an ancient organism

Author keywords

Antigenic variation; Gene silencing; Microbial pathogen virulence; Monoallelic expression; RAP1; Telomere position effect; Trypanosoma brucei; Variant surface glycoprotein

Indexed keywords

RAP1 PROTEIN; VARIANT SURFACE GLYCOPROTEIN;

EID: 77957671534     PISSN: 19491034     EISSN: 19491042     Source Type: Journal    
DOI: 10.4161/nucl.11742     Document Type: Article
Times cited : (4)

References (42)
  • 1
    • 0035222844 scopus 로고    scopus 로고
    • Antigenic variation in trypanosomes: Enhanced phenotypic variation in a eukaryotic parasite
    • Barry JD, McCulloch R. Antigenic variation in trypanosomes: enhanced phenotypic variation in a eukaryotic parasite. Adv Parasitol 2001; 49:1-70.
    • (2001) Adv Parasitol , vol.49 , pp. 1-70
    • Barry, J.D.1    McCulloch, R.2
  • 2
    • 0016809286 scopus 로고
    • Identification, purification and properties of clone-specific glycoprotein antigens constituting the surface coat of trypanosoma brucei
    • Cross GAM. Identification, purification and properties of clone-specific glycoprotein antigens constituting the surface coat of Trypanosoma brucei. Parasitology 1975; 71:393-417.
    • (1975) Parasitology , vol.71 , pp. 393-417
    • Cross, G.A.M.1
  • 4
    • 0019965322 scopus 로고
    • Genomic environment of the expression-linked extra copies of genes for surface antigens of trypanosoma brucei resembles the end of a chromosome
    • de Lange T, Borst P. Genomic environment of the expression-linked extra copies of genes for surface antigens of Trypanosoma brucei resembles the end of a chromosome. Nature 1982; 299:451-3.
    • (1982) Nature , vol.299 , pp. 451-453
    • de Lange, T.1    Borst, P.2
  • 5
    • 18844462890 scopus 로고    scopus 로고
    • RNA polymerase I transcribes procyclin genes and variant surface glycoprotein gene expression sites in Trypanosoma brucei
    • Gunzl A, Bruderer T, Laufer G, Schimanski B, Tu LC, Chung HM, et al. RNA polymerase I transcribes procyclin genes and variant surface glycoprotein gene expression sites in Trypanosoma brucei. Eukaryot Cell 2003; 2:542-51.
    • (2003) Eukaryot Cell , vol.2 , pp. 542-551
    • Gunzl, A.1    Bruderer, T.2    Laufer, G.3    Schimanski, B.4    Tu, L.C.5    Chung, H.M.6
  • 7
    • 33845605494 scopus 로고    scopus 로고
    • Telomere structure and function in trypanosomes: A proposal
    • Dreesen O, Li B, Cross GAM. Telomere structure and function in trypanosomes: a proposal. Nat Rev Microbiol 2007; 5:70-5.
    • (2007) Nat Rev Microbiol , vol.5 , pp. 70-75
    • Dreesen, O.1    Li, B.2    Cross, G.A.M.3
  • 8
    • 0025201982 scopus 로고
    • Position effect at S. cerevisiae telomeres: Reversible repression of pol II transcription
    • Gottschling DE, Aparicio OM, Billington BL, Zakian VA. Position effect at S. cerevisiae telomeres: reversible repression of pol II transcription. Cell 1990; 63:751-62.
    • (1990) Cell , vol.63 , pp. 751-762
    • Gottschling, D.E.1    Aparicio, O.M.2    Billington, B.L.3    Zakian, V.A.4
  • 9
    • 0027965291 scopus 로고
    • Telomereassociated chromosome breakage in fission yeast results in variegated expression of adjacent genes
    • Nimmo ER, Cranston G, Allshire RC. Telomereassociated chromosome breakage in fission yeast results in variegated expression of adjacent genes. EMBO J 1994; 13:3801-11.
    • (1994) EMBO J , vol.13 , pp. 3801-3811
    • Nimmo, E.R.1    Cranston, G.2    Allshire, R.C.3
  • 10
    • 0028881923 scopus 로고
    • A developmentally regulated position effect at a telomeric locus in Trypanosoma brucei
    • Horn D, Cross GAM. A developmentally regulated position effect at a telomeric locus in Trypanosoma brucei. Cell 1995; 83:555-61.
    • (1995) Cell , vol.83 , pp. 555-561
    • Horn, D.1    Cross, G.A.M.2
  • 11
    • 0035874977 scopus 로고    scopus 로고
    • Telomere position effect in human cells
    • Baur JA, Zou Y, Shay JW, Wright WE. Telomere position effect in human cells. Science 2001; 292:2075-207.
    • (2001) Science , vol.292 , pp. 2075-2207
    • Baur, J.A.1    Zou, Y.2    Shay, J.W.3    Wright, W.E.4
  • 12
    • 33646204183 scopus 로고    scopus 로고
    • Repression of polymerase I-mediated gene expression at Trypanosoma brucei telomeres
    • Glover L, Horn D. Repression of polymerase I-mediated gene expression at Trypanosoma brucei telomeres. EMBO Rep 2006; 7:93-9.
    • (2006) EMBO Rep , vol.7 , pp. 93-99
    • Glover, L.1    Horn, D.2
  • 13
    • 23344454718 scopus 로고    scopus 로고
    • Telomere structure and shortening in telomerase-deficient Trypanosoma brucei
    • Dreesen O, Li B, Cross GAM. Telomere structure and shortening in telomerase-deficient Trypanosoma brucei. Nuc Acids Res 2005; 33:4536-43.
    • (2005) Nuc Acids Res , vol.33 , pp. 4536-4543
    • Dreesen, O.1    Li, B.2    Cross, G.A.M.3
  • 14
    • 13544275919 scopus 로고    scopus 로고
    • Telomere length regulation and transcriptional silencing in KU80-deficient Trypanosoma brucei
    • Janzen CJ, Lander F, Dreesen O, Cross GAM. Telomere length regulation and transcriptional silencing in KU80-deficient Trypanosoma brucei. Nuc Acids Res 2004; 32:6575-84.
    • (2004) Nuc Acids Res , vol.32 , pp. 6575-6584
    • Janzen, C.J.1    Lander, F.2    Dreesen, O.3    Cross, G.A.M.4
  • 15
    • 0037077206 scopus 로고    scopus 로고
    • Ku is important for telomere maintenance, but not for differential expression of telomeric VSG genes, in African trypanosomes
    • Conway C, McCulloch R, Ginger ML, Robinson NP, Browitt A, Barry JD. Ku is important for telomere maintenance, but not for differential expression of telomeric VSG genes, in African trypanosomes. J Biol Chem 2002; 277:21269-77.
    • (2002) J Biol Chem , vol.277 , pp. 21269-21277
    • Conway, C.1    McCulloch, R.2    Ginger, M.L.3    Robinson, N.P.4    Browitt, A.5    Barry, J.D.6
  • 16
    • 0242556798 scopus 로고    scopus 로고
    • A chromosomal SIR2 homologue with both histone NAD-dependent ADP-ribosyltransferase and deacetylase activities is involved in DNA repair in Trypanosoma brucei
    • Garcia-Salcedo JA, Gijon P, Nolan DP, Tebabi P, Pays E. A chromosomal SIR2 homologue with both histone NAD-dependent ADP-ribosyltransferase and deacetylase activities is involved in DNA repair in Trypanosoma brucei. EMBO J 2003; 22:5851-62.
    • (2003) EMBO J , vol.22 , pp. 5851-5862
    • Garcia-Salcedo, J.A.1    Gijon, P.2    Nolan, D.P.3    Tebabi, P.4    Pays, E.5
  • 17
    • 33846194528 scopus 로고    scopus 로고
    • A sirtuin in the African trypanosome is involved in both DNA repair and telomeric gene silencing but is not required for antigenic variation
    • Alsford S, Kawahara T, Isamah C, Horn D. A sirtuin in the African trypanosome is involved in both DNA repair and telomeric gene silencing but is not required for antigenic variation. Mol Microbiol 2007; 63:724-36.
    • (2007) Mol Microbiol , vol.63 , pp. 724-736
    • Alsford, S.1    Kawahara, T.2    Isamah, C.3    Horn, D.4
  • 18
    • 33847372924 scopus 로고    scopus 로고
    • Deletion of a trypanosome telomere leads to loss of silencing and progressive loss of terminal DNA in the absence of cell cycle arrest
    • Glover L, Alsford S, Beattie C, Horn D. Deletion of a trypanosome telomere leads to loss of silencing and progressive loss of terminal DNA in the absence of cell cycle arrest. Nuc Acids Res 2007; 35:872-80.
    • (2007) Nuc Acids Res , vol.35 , pp. 872-880
    • Glover, L.1    Alsford, S.2    Beattie, C.3    Horn, D.4
  • 19
    • 20344388067 scopus 로고    scopus 로고
    • Trypanosome telomeres are protected by a homologue of mammalian TRF2
    • Li B, Espinal A, Cross GAM. Trypanosome telomeres are protected by a homologue of mammalian TRF2. Mol Cell Biol 2005; 25:5011-21.
    • (2005) Mol Cell Biol , vol.25 , pp. 5011-5021
    • Li, B.1    Espinal, A.2    Cross, G.A.M.3
  • 20
    • 63049115947 scopus 로고    scopus 로고
    • RAP1 is essential for silencing telomeric variant surface glycoprotein genes in Trypanosoma brucei
    • Yang X, Figueiredo LM, Espinal A, Okubo E, Li B. RAP1 is essential for silencing telomeric variant surface glycoprotein genes in Trypanosoma brucei. Cell 2009; 137:99-109.
    • (2009) Cell , vol.137 , pp. 99-109
    • Yang, X.1    Figueiredo, L.M.2    Espinal, A.3    Okubo, E.4    Li, B.5
  • 21
    • 0029963828 scopus 로고    scopus 로고
    • The crystal structure of the DNA-binding domain of yeast RAP1 in complex with telomeric DNA
    • Konig P, Giraldo R, Chapman L, Rhodes D. The crystal structure of the DNA-binding domain of yeast RAP1 in complex with telomeric DNA. Cell 1996; 85:125-36.
    • (1996) Cell , vol.85 , pp. 125-1236
    • Konig, P.1    Giraldo, R.2    Chapman, L.3    Rhodes, D.4
  • 22
    • 0027326367 scopus 로고
    • RAP1 and telomere structure regulate telomere position effects in Saccharomyces cerevisiae
    • Kyrion G, Liu K, Liu C, Lustig AJ. RAP1 and telomere structure regulate telomere position effects in Saccharomyces cerevisiae. Genes Dev 1993; 7:1146-59.
    • (1993) Genes Dev , vol.7 , pp. 1146-1159
    • Kyrion, G.1    Liu, K.2    Liu, C.3    Lustig, A.J.4
  • 23
    • 0037097940 scopus 로고    scopus 로고
    • Rap1-Sir4 binding independent of other Sir, yKu, or histone interactions initiates the assembly of telomeric heterochromatin in yeast
    • Luo K, Vega-Palas MA, Grunstein M. Rap1-Sir4 binding independent of other Sir, yKu, or histone interactions initiates the assembly of telomeric heterochromatin in yeast. Genes Dev 2002; 16:1528-39.
    • (2002) Genes Dev , vol.16 , pp. 1528-1539
    • Luo, K.1    Vega-Palas, M.A.2    Grunstein, M.3
  • 24
    • 0028004378 scopus 로고
    • Evidence that a complex of SIR proteins interacts with the silencer and telomere-binding protein RAP1
    • Moretti P, Freeman K, Coodly L, Shore D. Evidence that a complex of SIR proteins interacts with the silencer and telomere-binding protein RAP1. Genes Dev 1994; 8:2257-69.
    • (1994) Genes Dev , vol.8 , pp. 2257-2269
    • Moretti, P.1    Freeman, K.2    Coodly, L.3    Shore, D.4
  • 25
    • 0033533699 scopus 로고    scopus 로고
    • Yeast Ku protein plays a direct role in telomeric silencing and counteracts inhibition by Rif proteins
    • Mishra K, Shore D. Yeast Ku protein plays a direct role in telomeric silencing and counteracts inhibition by Rif proteins. Curr Biol 1999; 9:1123-6.
    • (1999) Curr Biol , vol.9 , pp. 1123-1126
    • Mishra, K.1    Shore, D.2
  • 26
    • 3943054839 scopus 로고    scopus 로고
    • The Sir2 family of protein deacetylases
    • Blander G, Guarente L. The Sir2 family of protein deacetylases. Annu Rev Biochem 2004; 73:417-35.
    • (2004) Annu Rev Biochem , vol.73 , pp. 417-435
    • Blander, G.1    Guarente, L.2
  • 27
    • 0027184524 scopus 로고
    • Silent domains are assembled continuously from the telomere and are defined by promoter distance and strength, and by SIR3 dosage
    • Renauld H, Aparicio OM, Zierath PD, Billington BL, Chhablani SK, Gottschling DE. Silent domains are assembled continuously from the telomere and are defined by promoter distance and strength, and by SIR3 dosage. Genes Dev 1993; 7:1133-45.
    • (1993) Genes Dev , vol.7 , pp. 1133-1145
    • Renauld, H.1    Aparicio, O.M.2    Zierath, P.D.3    Billington, B.L.4    Chhablani, S.K.5    Gottschling, D.E.6
  • 28
    • 0033522444 scopus 로고    scopus 로고
    • Limitations of silencing at native yeast telomeres
    • Pryde FE, Louis EJ. Limitations of silencing at native yeast telomeres. EMBO J 1999; 18:2538-50.
    • (1999) EMBO J , vol.18 , pp. 2538-2550
    • Pryde, F.E.1    Louis, E.J.2
  • 30
    • 0036867444 scopus 로고    scopus 로고
    • Human telomeric position effect is determined by chromosomal context and telomeric chromatin integrity
    • Koering CE, Pollice A, Zibella MP, Bauwens S, Puisieux A, Brunori M, et al. Human telomeric position effect is determined by chromosomal context and telomeric chromatin integrity. EMBO Rep 2002; 3:1055-61.
    • (2002) EMBO Rep , vol.3 , pp. 1055-1061
    • Koering, C.E.1    Pollice, A.2    Zibella, M.P.3    Bauwens, S.4    Puisieux, A.5    Brunori, M.6
  • 31
    • 69249216410 scopus 로고    scopus 로고
    • A 'higher order' of telomere regulation: Telomere heterochromatin and telomeric RNAs
    • Schoeftner S, Blasco MA. A 'higher order' of telomere regulation: telomere heterochromatin and telomeric RNAs. EMBO J 2009; 28:2323-36.
    • (2009) EMBO J , vol.28 , pp. 2323-2336
    • Schoeftner, S.1    Blasco, M.A.2
  • 32
    • 33947317206 scopus 로고    scopus 로고
    • The epigenetic regulation of mammalian telomeres
    • Blasco MA. The epigenetic regulation of mammalian telomeres. Nat Rev Genet 2007; 8:299-309.
    • (2007) Nat Rev Genet , vol.8 , pp. 299-309
    • Blasco, M.A.1
  • 33
    • 34247572533 scopus 로고    scopus 로고
    • A novel ISWI is involved in VSG expression site downregulation in African trypanosomes
    • Hughes K, Wand M, Foulston L, Young R, Harley K, Terry S, et al. A novel ISWI is involved in VSG expression site downregulation in African trypanosomes. EMBO J 2007; 26:2400-10.
    • (2007) EMBO J , vol.26 , pp. 2400-2410
    • Hughes, K.1    Wand, M.2    Foulston, L.3    Young, R.4    Harley, K.5    Terry, S.6
  • 34
    • 48349107004 scopus 로고    scopus 로고
    • A histone methyltransferase modulates antigenic variation in African trypanosomes
    • Figueiredo LM, Janzen CJ, Cross GAM. A histone methyltransferase modulates antigenic variation in African trypanosomes. PLoS Biol 2008; 6:161.
    • (2008) PLoS Biol , vol.6 , pp. 161
    • Figueiredo, L.M.1    Janzen, C.J.2    Cross, G.A.M.3
  • 35
    • 75649140875 scopus 로고    scopus 로고
    • Active VSG expression sites in Trypanosoma brucei are depleted of nucleosomes
    • Stanne TM, Rudenko G. Active VSG expression sites in Trypanosoma brucei are depleted of nucleosomes. Eukaryot Cell 2010; 9:136-47.
    • (2010) Eukaryot Cell , vol.9 , pp. 136-147
    • Stanne, T.M.1    Rudenko, G.2
  • 36
    • 75649110809 scopus 로고    scopus 로고
    • Nucleosomes are depleted at the VSG expression site transcribed by RNA polymerase I in African trypanosomes
    • Figueiredo LM, Cross GAM. Nucleosomes are depleted at the VSG expression site transcribed by RNA polymerase I in African trypanosomes. Eukaryot Cell 2010; 9:148-54.
    • (2010) Eukaryot Cell , vol.9 , pp. 148-154
    • Figueiredo, L.M.1    Cross, G.A.M.2
  • 37
    • 0035856691 scopus 로고    scopus 로고
    • A pol I transcriptional body associated with VSG mono-allelic expression in Trypanosoma brucei
    • Navarro M, Gull K. A pol I transcriptional body associated with VSG mono-allelic expression in Trypanosoma brucei. Nature 2001; 414:759-63.
    • (2001) Nature , vol.414 , pp. 759-763
    • Navarro, M.1    Gull, K.2
  • 38
    • 0033199568 scopus 로고    scopus 로고
    • Control of variant surface glycoprotein gene-expression sites in Trypanosoma brucei
    • Chaves I, Rudenko G, Dirks-Mulder A, Cross M, Borst P. Control of variant surface glycoprotein gene-expression sites in Trypanosoma brucei. EMBO J 1999; 18:4846-55.
    • (1999) EMBO J , vol.18 , pp. 4846-4855
    • Chaves, I.1    Rudenko, G.2    Dirks-Mulder, A.3    Cross, M.4    Borst, P.5
  • 39
    • 0141706832 scopus 로고    scopus 로고
    • Virulence-related surface glycoproteins in the yeast pathogen Candida glabrata are encoded in subtelomeric clusters and subject to RAP1- and SIR-dependent transcriptional silencing
    • De Las Penas A, Pan SJ, Castano I, Alder J, Cregg R, Cormack BP. Virulence-related surface glycoproteins in the yeast pathogen Candida glabrata are encoded in subtelomeric clusters and subject to RAP1- and SIR-dependent transcriptional silencing. Genes Dev 2003; 17:2245-58.
    • (2003) Genes Dev , vol.17 , pp. 2245-2258
    • de Las Penas, A.1    Pan, S.J.2    Castano, I.3    Alder, J.4    Cregg, R.5    Cormack, B.P.6
  • 40
    • 14544270961 scopus 로고    scopus 로고
    • Telomere length control and transcriptional regulation of subtelomeric adhesins in Candida glabrata
    • Castano I, Pan SJ, Zupancic M, Hennequin C, Dujon B, Cormack BP. Telomere length control and transcriptional regulation of subtelomeric adhesins in Candida glabrata. Mol Microbiol 2005; 55:1246-58.
    • (2005) Mol Microbiol , vol.55 , pp. 1246-1258
    • Castano, I.1    Pan, S.J.2    Zupancic, M.3    Hennequin, C.4    Dujon, B.5    Cormack, B.P.6
  • 41
    • 20144389331 scopus 로고    scopus 로고
    • Telomeric heterochromatin propagation and histone acetylation control mutually exclusive expression of antigenic variation genes in malaria parasites
    • Freitas-Junior LH, Hernandez-Rivas R, Ralph SA, Montiel-Condado D, Ruvalcaba-Salazar OK, Rojas-Meza AP, et al. Telomeric heterochromatin propagation and histone acetylation control mutually exclusive expression of antigenic variation genes in malaria parasites. Cell 2005; 121:25-36.
    • (2005) Cell , vol.121 , pp. 25-36
    • Freitas-Junior, L.H.1    Hernandez-Rivas, R.2    Ralph, S.A.3    Montiel-Condado, D.4    Ruvalcaba-Salazar, O.K.5    Rojas-Meza, A.P.6
  • 42
    • 20144389848 scopus 로고    scopus 로고
    • Heterochromatin silencing and locus repositioning linked to regulation of virulence genes in Plasmodium falciparum
    • Duraisingh MT, Voss TS, Marty AJ, Duffy MF, Good RT, Thompson JK, et al. Heterochromatin silencing and locus repositioning linked to regulation of virulence genes in Plasmodium falciparum. Cell 2005; 121:13-24.
    • (2005) Cell , vol.121 , pp. 13-24
    • Duraisingh, M.T.1    Voss, T.S.2    Marty, A.J.3    Duffy, M.F.4    Good, R.T.5    Thompson, J.K.6


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