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Volumn 18, Issue 17, 1999, Pages 4846-4855

Control of variant surface glycoprotein gene-expression sites in Trypanosoma brucei

Author keywords

Allelic exclusion; Antigenic variation; Expression site switching; Mono allelic expression; Telomeric silencing

Indexed keywords

AGAROSE; VARIANT SURFACE GLYCOPROTEIN;

EID: 0033199568     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/18.17.4846     Document Type: Article
Times cited : (95)

References (45)
  • 1
    • 0022589129 scopus 로고
    • Stable expression of two variable surface glycoproteins by cloned Trypanosoma equiperdum
    • Baltz, T., Giroud, C., Baltz, D., Roth, C., Raibaud, A. and Eisen, H. (1986) Stable expression of two variable surface glycoproteins by cloned Trypanosoma equiperdum. Nature, 319, 602-604.
    • (1986) Nature , vol.319 , pp. 602-604
    • Baltz, T.1    Giroud, C.2    Baltz, D.3    Roth, C.4    Raibaud, A.5    Eisen, H.6
  • 2
    • 0030900089 scopus 로고    scopus 로고
    • The relative significance of mechanisms of antigenic variation in African trypanosomes
    • Barry, J.D. (1997) The relative significance of mechanisms of antigenic variation in African trypanosomes. Parasitol. Today, 13, 212-218.
    • (1997) Parasitol. Today , vol.13 , pp. 212-218
    • Barry, J.D.1
  • 3
    • 0032576751 scopus 로고    scopus 로고
    • The role of transferrin receptor variation in the host range of Trypanosoma brucei
    • Bitter, W., Gerrits, H., Kieft, R. and Borst, P. (1998) The role of transferrin receptor variation in the host range of Trypanosoma brucei. Nature, 391, 499-502.
    • (1998) Nature , vol.391 , pp. 499-502
    • Bitter, W.1    Gerrits, H.2    Kieft, R.3    Borst, P.4
  • 5
    • 0032029340 scopus 로고    scopus 로고
    • Control of VSG gene expression sites in Trypanosoma brucei
    • Borst, P. et al. (1998) Control of VSG gene expression sites in Trypanosoma brucei. Mol. Biochem. Parasitol., 91, 67-76.
    • (1998) Mol. Biochem. Parasitol. , vol.91 , pp. 67-76
    • Borst, P.1
  • 6
    • 0028223427 scopus 로고
    • Expression of a glycosylphosphatidylinositol-anchored Trypanosoma brucei transferrin-binding protein complex in insect cells
    • Chaudhri, M., Steverding, D., Kittelberger, D., Tjia, S. and Overath, P. (1994) Expression of a glycosylphosphatidylinositol-anchored Trypanosoma brucei transferrin-binding protein complex in insect cells. Proc. Natl Acad. Sci. USA, 91, 6443-6447.
    • (1994) Proc. Natl Acad. Sci. USA , vol.91 , pp. 6443-6447
    • Chaudhri, M.1    Steverding, D.2    Kittelberger, D.3    Tjia, S.4    Overath, P.5
  • 7
    • 0032514625 scopus 로고    scopus 로고
    • Subnuclear localization of the active variant surface glycoprotein gene expression site in Trypanosoma brucei
    • Chaves, I., Zomerdijk, J.C., Dirks-Mulder, A., Dirks, R.W., Raap, A.K. and Borst, P. (1998) Subnuclear localization of the active variant surface glycoprotein gene expression site in Trypanosoma brucei. Proc. Natl Acad. Sci. USA, 95, 12328-12333.
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , pp. 12328-12333
    • Chaves, I.1    Zomerdijk, J.C.2    Dirks-Mulder, A.3    Dirks, R.W.4    Raap, A.K.5    Borst, P.6
  • 8
    • 0032571410 scopus 로고    scopus 로고
    • Expansion of the allelic exclusion principle?
    • Chess, A. (1998) Expansion of the allelic exclusion principle? Science, 279, 2067-2068.
    • (1998) Science , vol.279 , pp. 2067-2068
    • Chess, A.1
  • 9
    • 0021971538 scopus 로고
    • Two simultaneously active VSG gene transcription units in a single Trypanosoma brucei variant
    • Cornelissen, A.W., Johnson, P.J., Kooter, J.M., Van der Ploeg, L.H. and Borst, P. (1985) Two simultaneously active VSG gene transcription units in a single Trypanosoma brucei variant. Cell, 41, 825-832.
    • (1985) Cell , vol.41 , pp. 825-832
    • Cornelissen, A.W.1    Johnson, P.J.2    Kooter, J.M.3    Van Der Ploeg, L.H.4    Borst, P.5
  • 10
    • 0016809286 scopus 로고
    • Identification, purification and properties of clone-specific glycoprotein antigens constituting the surface coat of Trypanosoma brucei
    • Cross, G.A. (1975) Identification, purification and properties of clone-specific glycoprotein antigens constituting the surface coat of Trypanosoma brucei. Parasitology, 71, 393-417.
    • (1975) Parasitology , vol.71 , pp. 393-417
    • Cross, G.A.1
  • 11
    • 0032029361 scopus 로고    scopus 로고
    • Regulation of vsg expression site transcription and switching in Trypanosoma brucei
    • Cross, G.A., Wirtz, L.E. and Navarro, M. (1998) Regulation of vsg expression site transcription and switching in Trypanosoma brucei. Mol. Biochem. Parasitol., 91, 77-91.
    • (1998) Mol. Biochem. Parasitol. , vol.91 , pp. 77-91
    • Cross, G.A.1    Wirtz, L.E.2    Navarro, M.3
  • 12
    • 0026040201 scopus 로고
    • Analysis of small nuclear ribonucleoproteins (RNPs) in Trypanosoma brucei: Structural organization and protein components of the spliced leader RNP
    • Cross, M., Gunzl, A., Palfi, Z. and Bindereif, A. (1991) Analysis of small nuclear ribonucleoproteins (RNPs) in Trypanosoma brucei: structural organization and protein components of the spliced leader RNP. Mol. Cell. Biol., 11, 5516-5526.
    • (1991) Mol. Cell. Biol. , vol.11 , pp. 5516-5526
    • Cross, M.1    Gunzl, A.2    Palfi, Z.3    Bindereif, A.4
  • 13
    • 0031961882 scopus 로고    scopus 로고
    • Frequent loss of the active site during variant surface glycprotein expression site switching in vitro in Trypanosoma brucei
    • Cross, M.A., Taylor, M.C. and Borst, P. (1998) Frequent loss of the active site during variant surface glycprotein expression site switching in vitro in Trypanosoma brucei. Mol. Cell. Biol., 18, 198-205.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 198-205
    • Cross, M.A.1    Taylor, M.C.2    Borst, P.3
  • 14
    • 0030911625 scopus 로고    scopus 로고
    • Manipulation of the vsg co-transposed region increases expression-site switching in Trypanosoma brucei
    • Davies, K.P., Carruthers, V.B. and Cross, G.A. (1997) Manipulation of the vsg co-transposed region increases expression-site switching in Trypanosoma brucei. Mol. Biochem. Parasitol., 86, 163-177.
    • (1997) Mol. Biochem. Parasitol. , vol.86 , pp. 163-177
    • Davies, K.P.1    Carruthers, V.B.2    Cross, G.A.3
  • 15
    • 0020616957 scopus 로고
    • Tandem repetition of the 5′ mini-exon of variant surface glycoprotein genes: A multiple promoter for VSG gene transcription?
    • de Lange, T., Liu, A.Y., Van der Ploeg, L.H., Borst, P., Tromp, M.C. and van Boom, J.H. (1983) Tandem repetition of the 5′ mini-exon of variant surface glycoprotein genes: a multiple promoter for VSG gene transcription? Cell 34, 891-900.
    • (1983) Cell , vol.34 , pp. 891-900
    • De Lange, T.1    Liu, A.Y.2    Van Der Ploeg, L.H.3    Borst, P.4    Tromp, M.C.5    Van Boom, J.H.6
  • 17
    • 0025201982 scopus 로고
    • Position effect at S. cerevisiae telomeres: Reversible repression of Pol II transcription
    • Gottschling, D.E., Aparicio, O.M., Billington, B.L. and Zakian, V.A. (1990) Position effect at S. cerevisiae telomeres: reversible repression of Pol II transcription. Cell, 63, 751-762.
    • (1990) Cell , vol.63 , pp. 751-762
    • Gottschling, D.E.1    Aparicio, O.M.2    Billington, B.L.3    Zakian, V.A.4
  • 18
    • 0024948840 scopus 로고
    • Continuous cultivation of Trypanosoma brucei blood stream forms in a medium containing a low concentration of serum protein without feeder cell layers
    • Hirumi, H. and Hirumi, K. (1989) Continuous cultivation of Trypanosoma brucei blood stream forms in a medium containing a low concentration of serum protein without feeder cell layers. J. Parasitol., 75, 985-989.
    • (1989) J. Parasitol. , vol.75 , pp. 985-989
    • Hirumi, H.1    Hirumi, K.2
  • 19
    • 0028881923 scopus 로고
    • A developmentally regulated position effect at a telomeric locus in Trypanosoma brucei
    • Horn, D. and Cross, G.A. (1995) A developmentally regulated position effect at a telomeric locus in Trypanosoma brucei. Cell, 83, 555-561.
    • (1995) Cell , vol.83 , pp. 555-561
    • Horn, D.1    Cross, G.A.2
  • 20
    • 0031043358 scopus 로고    scopus 로고
    • Analysis of Trypanosoma brucei vsg expression site switching in vitro
    • Horn, D. and Cross, G.A. (1997a) Analysis of Trypanosoma brucei vsg expression site switching in vitro. Mol. Biochem. Parasitol., 84, 189-201.
    • (1997) Mol. Biochem. Parasitol. , vol.84 , pp. 189-201
    • Horn, D.1    Cross, G.A.2
  • 21
    • 0031464010 scopus 로고    scopus 로고
    • Position-dependent and promoter-specific regulation of gene expression in Trypanosoma brucei
    • Horn, D. and Cross, G.A. (1997b) Position-dependent and promoter-specific regulation of gene expression in Trypanosoma brucei. EMBO J., 16, 7422-7431.
    • (1997) EMBO J. , vol.16 , pp. 7422-7431
    • Horn, D.1    Cross, G.A.2
  • 22
    • 0023663094 scopus 로고
    • Inactivation of transcription by UV irradiation of T. brucei provides evidence for a multicistronic transcription unit including a VSG gene
    • Johnson, P.J., Kooter, J.M. and Borst, P. (1987) Inactivation of transcription by UV irradiation of T. brucei provides evidence for a multicistronic transcription unit including a VSG gene. Cell, 51, 273-281.
    • (1987) Cell , vol.51 , pp. 273-281
    • Johnson, P.J.1    Kooter, J.M.2    Borst, P.3
  • 23
    • 0023663089 scopus 로고
    • The anatomy and transcription of a telomeric expression site for variant-specific surface antigens in T. brucei
    • Kooter, J.M., van der Spek, H.J., Wagter, R., d'Oliveira, C.E., van der Hoeven, F., Johnson, P.J. and Borst, P. (1987) The anatomy and transcription of a telomeric expression site for variant-specific surface antigens in T. brucei. Cell. 51, 261-272.
    • (1987) Cell , vol.51 , pp. 261-272
    • Kooter, J.M.1    Van Der Spek, H.J.2    Wagter, R.3    D'Oliveira, C.E.4    Van Der Hoeven, F.5    Johnson, P.J.6    Borst, P.7
  • 24
    • 0028362270 scopus 로고
    • Reconstitution of a surface transferrin binding complex in insect form Trypanosoma brucei
    • Ligtenberg, M.J., Bitter, W., Kieft, R., Steverding, D., Janssen, H., Calafat, J. and Borst, P. (1994) Reconstitution of a surface transferrin binding complex in insect form Trypanosoma brucei. EMBO J., 13, 2565-2573.
    • (1994) EMBO J. , vol.13 , pp. 2565-2573
    • Ligtenberg, M.J.1    Bitter, W.2    Kieft, R.3    Steverding, D.4    Janssen, H.5    Calafat, J.6    Borst, P.7
  • 25
    • 0031053120 scopus 로고    scopus 로고
    • Gene conversions mediating antigenic variation in Trypanosoma brucei can occur in variant surface glycoprotein expression sites lacking 70-base-pair repeat sequences
    • McCulloch, R., Rudenko, G. and Borst, P. (1997) Gene conversions mediating antigenic variation in Trypanosoma brucei can occur in variant surface glycoprotein expression sites lacking 70-base-pair repeat sequences. Mol. Cell Biol., 17, 833-843.
    • (1997) Mol. Cell Biol. , vol.17 , pp. 833-843
    • McCulloch, R.1    Rudenko, G.2    Borst, P.3
  • 26
    • 0030037305 scopus 로고    scopus 로고
    • Stable expression of mosaic coats of variant surface glycoproteins in Trypanosoma brucei
    • Muñoz-Jordan, J.L., Davies, K.P. and Cross, G.A. (1996) Stable expression of mosaic coats of variant surface glycoproteins in Trypanosoma brucei. Science, 272, 1795-1797.
    • (1996) Science , vol.272 , pp. 1795-1797
    • Muñoz-Jordan, J.L.1    Davies, K.P.2    Cross, G.A.3
  • 27
    • 0033561049 scopus 로고    scopus 로고
    • Trypanosoma brucei variant surface glycoprotein regulation involves coupled activation/ inactivation and chromatin remodelling of expression sites
    • Navarro, M., Cross, G.A. and Wirtz, E. (1999) Trypanosoma brucei variant surface glycoprotein regulation involves coupled activation/ inactivation and chromatin remodelling of expression sites. EMBO J., 18, 2265-2272.
    • (1999) EMBO J. , vol.18 , pp. 2265-2272
    • Navarro, M.1    Cross, G.A.2    Wirtz, E.3
  • 28
    • 0020841302 scopus 로고
    • Sequences homologous to the variant antigen mRNA spliced leader are located in tandem repeats and variable orphons in Trypanosoma brucei
    • Nelson, R.G., Parsons, M., Barr, P.J., Stuart, K., Selkirk, M. and Agabian, N. (1983) Sequences homologous to the variant antigen mRNA spliced leader are located in tandem repeats and variable orphons in Trypanosoma brucei. Cell, 34, 901-9.
    • (1983) Cell , vol.34 , pp. 901-909
    • Nelson, R.G.1    Parsons, M.2    Barr, P.J.3    Stuart, K.4    Selkirk, M.5    Agabian, N.6
  • 29
    • 0031736335 scopus 로고    scopus 로고
    • Monoallelic expression: 'There can only be one'
    • Ohlsson, R., Tycko, B. and Sapienza, C. (1998) Monoallelic expression: 'there can only be one'. Trends Genet., 14, 435-438.
    • (1998) Trends Genet. , vol.14 , pp. 435-438
    • Ohlsson, R.1    Tycko, B.2    Sapienza, C.3
  • 30
    • 0030742660 scopus 로고    scopus 로고
    • Expression of a variant surface glycoprotein of Trypanosoma gambiense in procyclic forms of Trypanosoma brucei shows that the cell type dictates the nature of the glycosylphosphatidylinositol membrane anchor attached to the glycoprotein
    • Paturiaux-Hanocq, F., Zitzmann, N., Hanocq-Quertier, J., Vanhamme, L., Rolin, S., Geuskens, M., Ferguson, M.A. and Pays, E. (1997) Expression of a variant surface glycoprotein of Trypanosoma gambiense in procyclic forms of Trypanosoma brucei shows that the cell type dictates the nature of the glycosylphosphatidylinositol membrane anchor attached to the glycoprotein. Biochem. J., 324, 885-895.
    • (1997) Biochem. J. , vol.324 , pp. 885-895
    • Paturiaux-Hanocq, F.1    Zitzmann, N.2    Hanocq-Quertier, J.3    Vanhamme, L.4    Rolin, S.5    Geuskens, M.6    Ferguson, M.A.7    Pays, E.8
  • 31
    • 0022343621 scopus 로고
    • Telomeric reciprocal recombination as a possible mechanism for antigenic variation in trypanosomes
    • Pays, E., Guyaux, M., Aerts, D., Van Meirvenne, N. and Steinert, M. (1985) Telomeric reciprocal recombination as a possible mechanism for antigenic variation in trypanosomes. Nature, 316, 562-564.
    • (1985) Nature , vol.316 , pp. 562-564
    • Pays, E.1    Guyaux, M.2    Aerts, D.3    Van Meirvenne, N.4    Steinert, M.5
  • 32
    • 0024400224 scopus 로고
    • The genes and transcripts of an antigen gene expression site from T. brucei
    • Pays, E., Tebabi, P., Pays, A., Coquelet, H., Revelard, P., Salmon, D. and Steinert, M. (1989) The genes and transcripts of an antigen gene expression site from T. brucei. Cell, 57, 835-845.
    • (1989) Cell , vol.57 , pp. 835-845
    • Pays, E.1    Tebabi, P.2    Pays, A.3    Coquelet, H.4    Revelard, P.5    Salmon, D.6    Steinert, M.7
  • 33
    • 0032029245 scopus 로고    scopus 로고
    • Expression and function of surface proteins in Trypanosoma brucei
    • Pays, E. and Nolan, D.P. (1998) Expression and function of surface proteins in Trypanosoma brucei. Mol. Biochem. Parasitol., 91, 3-36.
    • (1998) Mol. Biochem. Parasitol. , vol.91 , pp. 3-36
    • Pays, E.1    Nolan, D.P.2
  • 35
    • 0028050668 scopus 로고
    • VSG gene expression site control in insect form Trypanosoma brucei
    • Rudenko, G., Blundell, P.A., Taylor, M.C., Kieft, R. and Borst, P. (1994) VSG gene expression site control in insect form Trypanosoma brucei. EMBO J., 13, 5470-5482.
    • (1994) EMBO J. , vol.13 , pp. 5470-5482
    • Rudenko, G.1    Blundell, P.A.2    Taylor, M.C.3    Kieft, R.4    Borst, P.5
  • 36
    • 0028809565 scopus 로고
    • A ribosomal DNA promoter replacing the promoter of a telomeric VSG gene expression site can be efficiently switched on and off in T. brucei
    • Rudenko, G., Blundell, P.A., Dirks-Mulder, A., Kieft, R. and Borst, P. (1995) A ribosomal DNA promoter replacing the promoter of a telomeric VSG gene expression site can be efficiently switched on and off in T. brucei. Cell, 83, 547-553.
    • (1995) Cell , vol.83 , pp. 547-553
    • Rudenko, G.1    Blundell, P.A.2    Dirks-Mulder, A.3    Kieft, R.4    Borst, P.5
  • 37
    • 0030249772 scopus 로고    scopus 로고
    • Telomere exchange can be an important mechanism of variant surface glycoprotein gene switching in Trypanosoma brucei
    • Rudenko, G., McCulloch, R., Dirks-Mulder, A. and Borst, P. (1996) Telomere exchange can be an important mechanism of variant surface glycoprotein gene switching in Trypanosoma brucei. Mol. Biochem. Parasitol., 80, 65-75.
    • (1996) Mol. Biochem. Parasitol. , vol.80 , pp. 65-75
    • Rudenko, G.1    McCulloch, R.2    Dirks-Mulder, A.3    Borst, P.4
  • 38
    • 0032168225 scopus 로고    scopus 로고
    • Selection for activation of a new VSG expression site in Trypanosoma brucei can result in deletion of the old one
    • Rudenko, G., Chaves, I., Dirks-Mulder, A. and Borst, P. (1998) Selection for activation of a new VSG expression site in Trypanosoma brucei can result in deletion of the old one. Mol. Biochem. Parasitol., 95, 97-109.
    • (1998) Mol. Biochem. Parasitol. , vol.95 , pp. 97-109
    • Rudenko, G.1    Chaves, I.2    Dirks-Mulder, A.3    Borst, P.4
  • 39
    • 0028246436 scopus 로고
    • A novel heterodimeric transferrin receptor encoded by a pair of VSG expression site-associated genes in T. brucei
    • Salmon, D., Geuskens, M., Hanocq, F., Hanocq-Quertier, J., Nolan, D., Ruben, L. and Pays, E. (1994) A novel heterodimeric transferrin receptor encoded by a pair of VSG expression site-associated genes in T. brucei. Cell, 78, 75-86.
    • (1994) Cell , vol.78 , pp. 75-86
    • Salmon, D.1    Geuskens, M.2    Hanocq, F.3    Hanocq-Quertier, J.4    Nolan, D.5    Ruben, L.6    Pays, E.7
  • 40
    • 0031435151 scopus 로고    scopus 로고
    • Characterization of the ligand-binding site of the transferrin receptor in Trypanosoma brucei demonstrates a structural relationship with the N-terminal domain of the variant surface glycoprotein
    • Salmon, D., Hanocq-Quertier, J., Paturiaux-Hanocq, F., Pays, A., Tebabi, P., Nolan, D., Michel, A. and Pays, E. (1997) Characterization of the ligand-binding site of the transferrin receptor in Trypanosoma brucei demonstrates a structural relationship with the N-terminal domain of the variant surface glycoprotein. EMBO J., 16, 7272-7278.
    • (1997) EMBO J. , vol.16 , pp. 7272-7278
    • Salmon, D.1    Hanocq-Quertier, J.2    Paturiaux-Hanocq, F.3    Pays, A.4    Tebabi, P.5    Nolan, D.6    Michel, A.7    Pays, E.8
  • 41
    • 0025847763 scopus 로고
    • A transferrin-binding protein of Trypanosoma brucei is encoded by one of the genes in the variant surface glycoprotein gene expression site
    • Schell, D., Evers, R., Preis, D., Ziegelbauer, K., Kiefer, H., Lottspeich, F., Cornelissen, A.W. and Overath, P. (1991) A transferrin-binding protein of Trypanosoma brucei is encoded by one of the genes in the variant surface glycoprotein gene expression site. EMBO J., 10, 1061-1066.
    • (1991) EMBO J. , vol.10 , pp. 1061-1066
    • Schell, D.1    Evers, R.2    Preis, D.3    Ziegelbauer, K.4    Kiefer, H.5    Lottspeich, F.6    Cornelissen, A.W.7    Overath, P.8
  • 42
    • 0032530397 scopus 로고    scopus 로고
    • Antigenic variation in malaria: In situ switching, relaxed and mutually exclusive transcription of var genes during intra-erythrocytic development in Plasmodium falciparum
    • Scherf, A., Hernandez-Rivas, R., Buffet, P., Bottius, E., Benatar, C., Pouvelle, B., Gysin, J. and Lanzer, M. (1998) Antigenic variation in malaria: in situ switching, relaxed and mutually exclusive transcription of var genes during intra-erythrocytic development in Plasmodium falciparum. EMBO J., 17, 5418-5426.
    • (1998) EMBO J. , vol.17 , pp. 5418-5426
    • Scherf, A.1    Hernandez-Rivas, R.2    Buffet, P.3    Bottius, E.4    Benatar, C.5    Pouvelle, B.6    Gysin, J.7    Lanzer, M.8
  • 45
    • 0025994368 scopus 로고
    • α-amanitin-resistant transcription units in trypanosomes: A comparison of promoter sequences for a VSG gene expression site and for the ribosomal RNA genes
    • Zomerdijk, J.C., Kieft, R., Shiels, P.G. and Borst, P. (1991) α-amanitin-resistant transcription units in trypanosomes: a comparison of promoter sequences for a VSG gene expression site and for the ribosomal RNA genes. Nucleic Acids Res., 19, 5153-5158.
    • (1991) Nucleic Acids Res. , vol.19 , pp. 5153-5158
    • Zomerdijk, J.C.1    Kieft, R.2    Shiels, P.G.3    Borst, P.4


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