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Volumn 7, Issue 10, 2007, Pages 750-762

Genetic and molecular pathogenesis of mantle cell lymphoma: Perspectives for new targeted therapeutics

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 6 BROMO 4 (1 CYANO 2 ETHOXY 2 OXOETHYL) 4H CHROMENE 3 CARBOXYLIC ACID ETHYL ESTER; 4 [4 (4' CHLORO 2 BIPHENYLYLMETHYL) 1 PIPERAZINYL] N [4 [3 DIMETHYLAMINO 1 (PHENYLTHIOMETHYL)PROPYLAMINO] 3 NITROBENZENESULFONYL]BENZAMIDE; ANTINEOPLASTIC AGENT; BMS 345541; BORTEZOMIB; CURCUMIN; CYCLIN D1; EVEROLIMUS; FLAVOPIRIDOL; GELDANAMYCIN; GX 15 070; HISTONE DEACETYLASE INHIBITOR; LENALIDOMIDE; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; OBATOCLAX; OBLIMERSEN; ON 013100; ON 01370; PD 0332991; PROTEASOME INHIBITOR; PROTEIN ANTIBODY; PROTEIN BCL 2; PROTEIN INHIBITOR; RITUXIMAB; ROSCOVITINE; SULFONE DERIVATIVE; TEMSIROLIMUS; THALIDOMIDE; TRAIL DR4 ANTIBODY; TRAIL DR5 ANTIBODY; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UNCLASSIFIED DRUG; UNINDEXED DRUG; VORINOSTAT;

EID: 34648824397     PISSN: 1474175X     EISSN: 14741768     Source Type: Journal    
DOI: 10.1038/nrc2230     Document Type: Review
Times cited : (405)

References (140)
  • 2
    • 0142169921 scopus 로고    scopus 로고
    • Indolent mantle cell lymphoma with nodal involvement and mutated immunoglobulin heavy chain genes
    • Nodit, L., Bahler, D. W., Jacobs, S. A., Locker, J. & Swerdlow, S. H. Indolent mantle cell lymphoma with nodal involvement and mutated immunoglobulin heavy chain genes. Hum. Pathol. 34, 1030-1034 (2003).
    • (2003) Hum. Pathol , vol.34 , pp. 1030-1034
    • Nodit, L.1    Bahler, D.W.2    Jacobs, S.A.3    Locker, J.4    Swerdlow, S.H.5
  • 3
    • 27544452570 scopus 로고    scopus 로고
    • Clonal proliferation of cyclin D1-positive mantle lymphocytes in an asymptomatic patient: An early-stage event in the development or an indolent form of a mantle cell lymphoma?
    • Espinet, B. et al. Clonal proliferation of cyclin D1-positive mantle lymphocytes in an asymptomatic patient: an early-stage event in the development or an indolent form of a mantle cell lymphoma? Hum. Pathol. 36, 1232-1237 (2005).
    • (2005) Hum. Pathol , vol.36 , pp. 1232-1237
    • Espinet, B.1
  • 4
    • 10744227172 scopus 로고    scopus 로고
    • Orchard, J. et al. A subset of t(11;14) lymphoma with mantle cell features displays mutated IgVH genes and includes patients with good prognosis, nonnodal disease. Blood 101, 4975-4981 (2003). Recognized a subset of MCL patients with long survival, some of them without need for treatment.
    • Orchard, J. et al. A subset of t(11;14) lymphoma with mantle cell features displays mutated IgVH genes and includes patients with good prognosis, nonnodal disease. Blood 101, 4975-4981 (2003). Recognized a subset of MCL patients with long survival, some of them without need for treatment.
  • 5
    • 0025836326 scopus 로고
    • bcl-1, t(11;14), and mantle cell-derived lymphomas
    • Raffeld, M. & Jaffe, E. S. bcl-1, t(11;14), and mantle cell-derived lymphomas. Blood 78, 259-263 (1991).
    • (1991) Blood , vol.78 , pp. 259-263
    • Raffeld, M.1    Jaffe, E.S.2
  • 6
    • 16844381831 scopus 로고    scopus 로고
    • Mechanisms of B-cell lymphoma pathogenesis
    • Kuppers, R. Mechanisms of B-cell lymphoma pathogenesis. Nature Rev. Cancer 5, 251-262 (2005).
    • (2005) Nature Rev. Cancer , vol.5 , pp. 251-262
    • Kuppers, R.1
  • 7
    • 33947581390 scopus 로고    scopus 로고
    • The impact of translocations and gene fusions on cancer causation
    • Mitelman, F., Johansson, B. & Mertens, F. The impact of translocations and gene fusions on cancer causation. Nature Rev. Cancer 7, 233-245 (2007).
    • (2007) Nature Rev. Cancer , vol.7 , pp. 233-245
    • Mitelman, F.1    Johansson, B.2    Mertens, F.3
  • 9
    • 0035866359 scopus 로고    scopus 로고
    • Templated nucleotide addition and immunoglobulin JH-gene utilization in t(11;14) junctions: Implications for the mechanism of translocation and the origin of mantle cell lymphoma
    • Welzel, N. et al. Templated nucleotide addition and immunoglobulin JH-gene utilization in t(11;14) junctions: implications for the mechanism of translocation and the origin of mantle cell lymphoma. Cancer Res. 61, 1629-1636 (2001).
    • (2001) Cancer Res , vol.61 , pp. 1629-1636
    • Welzel, N.1
  • 10
    • 0038054340 scopus 로고    scopus 로고
    • Spatial proximity of translocationprone gene loci in human lymphomas
    • Roix, J. J., McQueen, P. G., Munson, P. J., Parada, L. A. & Misteli, T. Spatial proximity of translocationprone gene loci in human lymphomas. Nature Genet. 34, 287-291 (2003).
    • (2003) Nature Genet , vol.34 , pp. 287-291
    • Roix, J.J.1    McQueen, P.G.2    Munson, P.J.3    Parada, L.A.4    Misteli, T.5
  • 11
    • 0017751925 scopus 로고
    • Alkline phosphatase-positive malignant lymphomas. A subset of B-cell lymphomas
    • Nanba, K., Jaffe, E. S., Braylan, R. C., Soban, E. J. & Berard, C. Alkline phosphatase-positive malignant lymphomas. A subset of B-cell lymphomas. Am. J. Clin. Pathol. 68, 535-542 (1977).
    • (1977) Am. J. Clin. Pathol , vol.68 , pp. 535-542
    • Nanba, K.1    Jaffe, E.S.2    Braylan, R.C.3    Soban, E.J.4    Berard, C.5
  • 12
    • 85143008490 scopus 로고    scopus 로고
    • Banks, P. M. et al. Mantle cell lymphoma: A proposal for unification of morphologic, immunologic, and molecular data. Am. J. Surg. Pathol. 16, 637-640 (1992). Defines MCL as a clinicopathological entity associated with the t(11;14) translocation.
    • Banks, P. M. et al. Mantle cell lymphoma: A proposal for unification of morphologic, immunologic, and molecular data. Am. J. Surg. Pathol. 16, 637-640 (1992). Defines MCL as a clinicopathological entity associated with the t(11;14) translocation.
  • 14
    • 0012605914 scopus 로고    scopus 로고
    • Molecular heterogeneity in MCL defined by the use of specific VH genes and the frequency of somatic mutations
    • Camacho, F. I. et al. Molecular heterogeneity in MCL defined by the use of specific VH genes and the frequency of somatic mutations. Blood 101, 4042-4046 (2003).
    • (2003) Blood , vol.101 , pp. 4042-4046
    • Camacho, F.I.1
  • 15
    • 0141889260 scopus 로고    scopus 로고
    • VH mutation status and VDJ rearrangement structure in mantle cell lymphoma: Correlation with genomic aberrations, clinical characteristics, and outcome
    • Kienle, D. et al. VH mutation status and VDJ rearrangement structure in mantle cell lymphoma: correlation with genomic aberrations, clinical characteristics, and outcome. Blood 102, 3003-3009 (2003).
    • (2003) Blood , vol.102 , pp. 3003-3009
    • Kienle, D.1
  • 16
    • 0033567907 scopus 로고    scopus 로고
    • Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia
    • Hamblin, T. J., Davis, Z., Gardiner, A., Oscier, D. G. & Stevenson, F. K. Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood 94, 1848-1854 (1999).
    • (1999) Blood , vol.94 , pp. 1848-1854
    • Hamblin, T.J.1    Davis, Z.2    Gardiner, A.3    Oscier, D.G.4    Stevenson, F.K.5
  • 17
    • 0037406968 scopus 로고    scopus 로고
    • ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia
    • Crespo, M. et al. ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia. N. Engl. J. Med. 348, 1764-1775 (2003).
    • (2003) N. Engl. J. Med , vol.348 , pp. 1764-1775
    • Crespo, M.1
  • 18
    • 20144363564 scopus 로고    scopus 로고
    • Immunohistochemical analysis of ZAP-70 expression in B-cell lymphoid neoplasms
    • Carreras, J. et al. Immunohistochemical analysis of ZAP-70 expression in B-cell lymphoid neoplasms. J. Pathol. 205, 507-513 (2005).
    • (2005) J. Pathol , vol.205 , pp. 507-513
    • Carreras, J.1
  • 19
    • 0028104979 scopus 로고
    • PRAD-1/Cyclin D1 gene overexpression in chronic lymphoproliferative disorders: A highly specific marker of mantle cell lymphoma
    • Bosch, F. et al. PRAD-1/Cyclin D1 gene overexpression in chronic lymphoproliferative disorders: a highly specific marker of mantle cell lymphoma. Blood 84, 2726-2732 (1994).
    • (1994) Blood , vol.84 , pp. 2726-2732
    • Bosch, F.1
  • 20
    • 85177008968 scopus 로고    scopus 로고
    • de Boer, C. J., van Krieken, J. H. J. M., Kluin-Nelemans, H. C., Kluin, P. M. & Schuuring, E. Cyclin D1 messenger RNA overexpression as a marker for mantle cell lymphoma. Oncogene 10, 1833-1840 (1995). References 19 and 20 showed that cyclin D1 overexpression in lymphoid neoplasms was a highly specific characteristic for MCL.
    • de Boer, C. J., van Krieken, J. H. J. M., Kluin-Nelemans, H. C., Kluin, P. M. & Schuuring, E. Cyclin D1 messenger RNA overexpression as a marker for mantle cell lymphoma. Oncogene 10, 1833-1840 (1995). References 19 and 20 showed that cyclin D1 overexpression in lymphoid neoplasms was a highly specific characteristic for MCL.
  • 21
    • 0029746275 scopus 로고    scopus 로고
    • Characterization of t(11;14) translocation in mantle cell lymphoma by fluorescent in situ hybridization
    • Bigoni, R. et al. Characterization of t(11;14) translocation in mantle cell lymphoma by fluorescent in situ hybridization. Oncogene 13, 797-802 (1996).
    • (1996) Oncogene , vol.13 , pp. 797-802
    • Bigoni, R.1
  • 22
    • 0029934207 scopus 로고    scopus 로고
    • Molecular diagnosis of t(11;14) in mantle cell lymphoma using two- colour interphase fluorescence in situ hybridization
    • Monteil, M., Callanan, M., Dascalescu, C., Sotto, J. J. & Leroux, D. Molecular diagnosis of t(11;14) in mantle cell lymphoma using two- colour interphase fluorescence in situ hybridization. Br. J. Haematol. 93, 656-660 (1996).
    • (1996) Br. J. Haematol , vol.93 , pp. 656-660
    • Monteil, M.1    Callanan, M.2    Dascalescu, C.3    Sotto, J.J.4    Leroux, D.5
  • 23
    • 9444286481 scopus 로고    scopus 로고
    • Vaandrager, J. W. et al. Direct visualization of dispersed 11q13 chromosomal translocations in mantle cell lymphoma by multicolor DNA fiber fluorescence in situ hybridization. Blood 88, 1177-1182 (1996). Showed that virtually all MCL carry the t(11;14) translocation.
    • Vaandrager, J. W. et al. Direct visualization of dispersed 11q13 chromosomal translocations in mantle cell lymphoma by multicolor DNA fiber fluorescence in situ hybridization. Blood 88, 1177-1182 (1996). Showed that virtually all MCL carry the t(11;14) translocation.
  • 24
    • 0026693984 scopus 로고
    • Gene rearrangement and overexpression of PRAD1 in lymphoid malignancy with t(11;14)(q13;q32) translocation
    • Seto, M. et al. Gene rearrangement and overexpression of PRAD1 in lymphoid malignancy with t(11;14)(q13;q32) translocation. Oncogene 7, 1401-1406 (1992).
    • (1992) Oncogene , vol.7 , pp. 1401-1406
    • Seto, M.1
  • 25
    • 0030667493 scopus 로고    scopus 로고
    • Visualization of mono-allelic chromosomal aberrations 3′ and 5′ of the cyclin D1 gene in mantle cell lymphoma using DNA fiber fluorescence in situ hybridization
    • de Boer, C. J. et al. Visualization of mono-allelic chromosomal aberrations 3′ and 5′ of the cyclin D1 gene in mantle cell lymphoma using DNA fiber fluorescence in situ hybridization. Oncogene 15, 1599-1603 (1997).
    • (1997) Oncogene , vol.15 , pp. 1599-1603
    • de Boer, C.J.1
  • 26
    • 0028065439 scopus 로고
    • A variant chromosome translocation at 11q13 identifying PRAD1/Cyclin D1 as the bcl-1 gene
    • Komatsu, H. et al. A variant chromosome translocation at 11q13 identifying PRAD1/Cyclin D1 as the bcl-1 gene. Blood 84, 1226-1231 (1994).
    • (1994) Blood , vol.84 , pp. 1226-1231
    • Komatsu, H.1
  • 27
    • 0028270019 scopus 로고
    • Detection of the chromosomal translocation t(11;14) by polymerase chain reaction in mantle cell lymphomas
    • Rimokh, R. et al. Detection of the chromosomal translocation t(11;14) by polymerase chain reaction in mantle cell lymphomas. Blood 83, 1871-1875 (1994).
    • (1994) Blood , vol.83 , pp. 1871-1875
    • Rimokh, R.1
  • 28
    • 34249723211 scopus 로고    scopus 로고
    • Point mutations and genomic deletions in CCND1 create stable truncated cyclin D1 mRNAs that are associated with increased proliferation rate and shorter survival
    • Wiestner, A. et al. Point mutations and genomic deletions in CCND1 create stable truncated cyclin D1 mRNAs that are associated with increased proliferation rate and shorter survival. Blood 109, 4599-4606 (2007).
    • (2007) Blood , vol.109 , pp. 4599-4606
    • Wiestner, A.1
  • 29
    • 0013224058 scopus 로고    scopus 로고
    • The proliferation gene expression signature is a quantitative integrator of oncogenic events that predicts survival in mantle cell lymphoma
    • Showed the global expression profile of MCL and recognized a subset of these tumours negative for cyclin D1
    • Rosenwald, A. et al. The proliferation gene expression signature is a quantitative integrator of oncogenic events that predicts survival in mantle cell lymphoma. Cancer Cell 3, 185-197 (2003). Showed the global expression profile of MCL and recognized a subset of these tumours negative for cyclin D1.
    • (2003) Cancer Cell , vol.3 , pp. 185-197
    • Rosenwald, A.1
  • 30
    • 26444621360 scopus 로고    scopus 로고
    • Mantle cell lymphomas with low levels of cyclin D1 long mRNA transcripts are highly proliferative and can be discriminated by elevated cyclin A2 and cyclin B1
    • Sander, B. et al. Mantle cell lymphomas with low levels of cyclin D1 long mRNA transcripts are highly proliferative and can be discriminated by elevated cyclin A2 and cyclin B1. Int. J. Cancer 117, 418-430 (2005).
    • (2005) Int. J. Cancer , vol.117 , pp. 418-430
    • Sander, B.1
  • 31
    • 0032930674 scopus 로고    scopus 로고
    • Cyclin D1/PRAD1/BCL-1 alternative transcript [B] protein product in B-lymphoid malignancies with t(11;14)(q13;q32) translocation
    • Hosokawa, Y., Joh, T., Maeda, Y., Arnold, A. & Seto, M. Cyclin D1/PRAD1/BCL-1 alternative transcript [B] protein product in B-lymphoid malignancies with t(11;14)(q13;q32) translocation. Int. J. Cancer 81, 616-619 (1999).
    • (1999) Int. J. Cancer , vol.81 , pp. 616-619
    • Hosokawa, Y.1    Joh, T.2    Maeda, Y.3    Arnold, A.4    Seto, M.5
  • 32
    • 0029083790 scopus 로고
    • Alternate splicing produces a novel cyclin D1 transcript
    • Betticher, D. C. et al. Alternate splicing produces a novel cyclin D1 transcript. Oncogene 11, 1005-1011 (1995).
    • (1995) Oncogene , vol.11 , pp. 1005-1011
    • Betticher, D.C.1
  • 33
    • 0034671768 scopus 로고    scopus 로고
    • Phosphorylation-dependent regulation of cyclin D1 nuclear export and cyclin D1-dependent cellular transformation
    • Alt, J. R., Cleveland, J. L., Hannink, M. & Diehl, J. A. Phosphorylation-dependent regulation of cyclin D1 nuclear export and cyclin D1-dependent cellular transformation. Genes Dev. 14, 3102-3114 (2000).
    • (2000) Genes Dev , vol.14 , pp. 3102-3114
    • Alt, J.R.1    Cleveland, J.L.2    Hannink, M.3    Diehl, J.A.4
  • 34
    • 0032533225 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization
    • Diehl, J. A., Cheng, M., Roussel, M. F. & Sherr, C. J. Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization. Genes Dev. 12, 3499-3511 (1998).
    • (1998) Genes Dev , vol.12 , pp. 3499-3511
    • Diehl, J.A.1    Cheng, M.2    Roussel, M.F.3    Sherr, C.J.4
  • 35
    • 0041528506 scopus 로고    scopus 로고
    • Cyclin D1 splice variants. Differential effects on localization, RB phosphorylation, and cellular transformation
    • Solomon, D. A. et al. Cyclin D1 splice variants. Differential effects on localization, RB phosphorylation, and cellular transformation. J. Biol. Chem. 278, 30339-30347 (2003).
    • (2003) J. Biol. Chem , vol.278 , pp. 30339-30347
    • Solomon, D.A.1
  • 36
    • 0027938209 scopus 로고
    • Cyclins and cancer II: Cyclin D and CDK inhibitors come of age
    • Hunter, T. & Pines, J. Cyclins and cancer II: cyclin D and CDK inhibitors come of age. Cell 79, 573-582 (1994).
    • (1994) Cell , vol.79 , pp. 573-582
    • Hunter, T.1    Pines, J.2
  • 37
    • 0027229136 scopus 로고
    • Fuctional interactions of the retinoblastoma protein with mammalian D-type cyclins
    • Ewen, M. E. et al. Fuctional interactions of the retinoblastoma protein with mammalian D-type cyclins. Cell 73, 487-497 (1993).
    • (1993) Cell , vol.73 , pp. 487-497
    • Ewen, M.E.1
  • 38
    • 0029979182 scopus 로고    scopus 로고
    • Expression of retinoblastoma gene product (pRb) in mantle cell lymphomas. Correlation with cyclin D1 (PRAD1/CCND1) mRNA levels and proliferative activity
    • Jares, P. et al. Expression of retinoblastoma gene product (pRb) in mantle cell lymphomas. Correlation with cyclin D1 (PRAD1/CCND1) mRNA levels and proliferative activity. Am. J. Pathol. 148, 1591-1600 (1996).
    • (1996) Am. J. Pathol , vol.148 , pp. 1591-1600
    • Jares, P.1
  • 39
    • 34250028203 scopus 로고    scopus 로고
    • Inactivation of RB1 in mantle-cell lymphoma detected by nonsense-mediated mRNA decay pathway inhibition and microarray analysis
    • Pinyol, M. et al. Inactivation of RB1 in mantle-cell lymphoma detected by nonsense-mediated mRNA decay pathway inhibition and microarray analysis. Blood 109, 5422-5429 (2007).
    • (2007) Blood , vol.109 , pp. 5422-5429
    • Pinyol, M.1
  • 40
    • 0038281327 scopus 로고    scopus 로고
    • Sequestration of p27Kip1 protein by cyclin D1 in typical and blastic variants of mantle cell lymphoma (MCL): Implications for pathogenesis
    • Quintanilla-Martinez, L. et al. Sequestration of p27Kip1 protein by cyclin D1 in typical and blastic variants of mantle cell lymphoma (MCL): implications for pathogenesis. Blood 101, 3181-3187 (2003).
    • (2003) Blood , vol.101 , pp. 3181-3187
    • Quintanilla-Martinez, L.1
  • 41
    • 28844504755 scopus 로고    scopus 로고
    • Expression of the cyclin-dependent kinase inhibitor p27 and its deregulation in mouse B cell lymphomas
    • Qi, C. F. et al. Expression of the cyclin-dependent kinase inhibitor p27 and its deregulation in mouse B cell lymphomas. Leuk. Res. 30, 153-163 (2006).
    • (2006) Leuk. Res , vol.30 , pp. 153-163
    • Qi, C.F.1
  • 42
    • 12944283204 scopus 로고    scopus 로고
    • Increased proteasome degradation of cyclin-dependent kinase inhibitor p27 is associated with a decreased overall survival in mantle cell lymphoma
    • Chiarle, R. et al. Increased proteasome degradation of cyclin-dependent kinase inhibitor p27 is associated with a decreased overall survival in mantle cell lymphoma. Blood 95, 619-626 (2000).
    • (2000) Blood , vol.95 , pp. 619-626
    • Chiarle, R.1
  • 43
    • 9444236895 scopus 로고    scopus 로고
    • Minireview: Cyclin D1: normal and abnormal functions
    • Fu, M., Wang, C., Li, Z., Sakamaki, T. & Pestell, R. G. Minireview: Cyclin D1: normal and abnormal functions. Endocrinology 145, 5439-5447 (2004).
    • (2004) Endocrinology , vol.145 , pp. 5439-5447
    • Fu, M.1    Wang, C.2    Li, Z.3    Sakamaki, T.4    Pestell, R.G.5
  • 44
    • 0037121081 scopus 로고    scopus 로고
    • Linking cyclins to transcriptional control
    • Coqueret, O. Linking cyclins to transcriptional control. Gene 299, 35-55 (2002).
    • (2002) Gene , vol.299 , pp. 35-55
    • Coqueret, O.1
  • 45
    • 28844449677 scopus 로고    scopus 로고
    • Cyclin D1-negative mantle cell lymphoma: A clinicopathologic study based on gene expression profiling
    • Fu, K. et al. Cyclin D1-negative mantle cell lymphoma: a clinicopathologic study based on gene expression profiling. Blood 106, 4315-4321 (2005).
    • (2005) Blood , vol.106 , pp. 4315-4321
    • Fu, K.1
  • 46
    • 34247116019 scopus 로고    scopus 로고
    • Specific secondary genetic alterations in mantle cell lymphoma provide prognostic information independent of the gene expression-based proliferation signature
    • Salaverria, I. et al. Specific secondary genetic alterations in mantle cell lymphoma provide prognostic information independent of the gene expression-based proliferation signature. J. Clin. Oncol. 25, 1216-1222 (2007).
    • (2007) J. Clin. Oncol , vol.25 , pp. 1216-1222
    • Salaverria, I.1
  • 47
    • 33746605975 scopus 로고    scopus 로고
    • A chromosomal translocation in cyclin D1-negative/cyclin D2-positive mantle cell lymphoma fuses the CCND2 gene to the IGK locus
    • Gesk, S. et al. A chromosomal translocation in cyclin D1-negative/cyclin D2-positive mantle cell lymphoma fuses the CCND2 gene to the IGK locus. Blood 108, 1109-1110 (2006).
    • (2006) Blood , vol.108 , pp. 1109-1110
    • Gesk, S.1
  • 49
    • 0028274940 scopus 로고
    • Cyclin D1 transgene impedes lymphocyte maturation and collaborates in lymphomagenesis with the myc gene
    • Bodrug, S. E. et al. Cyclin D1 transgene impedes lymphocyte maturation and collaborates in lymphomagenesis with the myc gene. EMBO J. 13, 2124 (1994).
    • (1994) EMBO J , vol.13 , pp. 2124
    • Bodrug, S.E.1
  • 50
    • 0028049592 scopus 로고
    • Cyclin D1/bcl-1 cooperates with myc genes in the generation of B- cell lymphomas in transgenic mice
    • Lovec, H., Grzeschiczek, A., Kowalski, M.-B. & Moroy, T. Cyclin D1/bcl-1 cooperates with myc genes in the generation of B- cell lymphomas in transgenic mice. EMBO J. 13, 3487-3495 (1994).
    • (1994) EMBO J , vol.13 , pp. 3487-3495
    • Lovec, H.1    Grzeschiczek, A.2    Kowalski, M.-B.3    Moroy, T.4
  • 51
    • 33244481730 scopus 로고    scopus 로고
    • Expression of constitutively nuclear cyclin D1 in murine lymphocytes induces B-cell lymphoma
    • Gladden, A. B., Woolery, R., Aggarwal, P., Wasik, M. A. & Diehl, J. A. Expression of constitutively nuclear cyclin D1 in murine lymphocytes induces B-cell lymphoma. Oncogene 25, 998-1007 (2006).
    • (2006) Oncogene , vol.25 , pp. 998-1007
    • Gladden, A.B.1    Woolery, R.2    Aggarwal, P.3    Wasik, M.A.4    Diehl, J.A.5
  • 52
    • 33748184149 scopus 로고    scopus 로고
    • Mantle cell lymphoma cells express predominantly cyclin D1a isoform and are highly sensitive to selective inhibition of CDK4 kinase activity
    • Marzec, M. et al. Mantle cell lymphoma cells express predominantly cyclin D1a isoform and are highly sensitive to selective inhibition of CDK4 kinase activity. Blood 108, 1744-1750 (2006).
    • (2006) Blood , vol.108 , pp. 1744-1750
    • Marzec, M.1
  • 53
    • 33750278124 scopus 로고    scopus 로고
    • Relevance of cyclin D1b expression and CCND1 polymorphism in the pathogenesis of multiple myeloma and mantle cell lymphoma
    • Krieger, S., Gauduchon, J., Roussel, M., Troussard, X. & Sola, B. Relevance of cyclin D1b expression and CCND1 polymorphism in the pathogenesis of multiple myeloma and mantle cell lymphoma. BMC Cancer 6, 238 (2006).
    • (2006) BMC Cancer , vol.6 , pp. 238
    • Krieger, S.1    Gauduchon, J.2    Roussel, M.3    Troussard, X.4    Sola, B.5
  • 54
    • 3242791755 scopus 로고    scopus 로고
    • Low prevalence of circulating t(11;14)(q13;q32)-positive cells in the peripheral blood of healthy individuals as detected by real-time quantitative PCR
    • Hirt, C., Schuler, F., Dolken, L., Schmidt, C. A. & Dolken, G. Low prevalence of circulating t(11;14)(q13;q32)-positive cells in the peripheral blood of healthy individuals as detected by real-time quantitative PCR. Blood 104, 904-905 (2004).
    • (2004) Blood , vol.104 , pp. 904-905
    • Hirt, C.1    Schuler, F.2    Dolken, L.3    Schmidt, C.A.4    Dolken, G.5
  • 56
    • 0033564352 scopus 로고    scopus 로고
    • Bea, S. et al. Increased number of chromosomal imbalances and high-level DNA amplifications in mantle cell lymphoma are associated with blastoid variants. Blood 93, 4365-4374 (1999). Showed that MCL had a high number of secondary chromosomal imbalances with a distinctive profile different from other lymphoid neoplasms.
    • Bea, S. et al. Increased number of chromosomal imbalances and high-level DNA amplifications in mantle cell lymphoma are associated with blastoid variants. Blood 93, 4365-4374 (1999). Showed that MCL had a high number of secondary chromosomal imbalances with a distinctive profile different from other lymphoid neoplasms.
  • 57
    • 0033979127 scopus 로고    scopus 로고
    • t(11;14)-positive mantle cell lymphomas exhibit complex karyotypes and share similarities with B-cell chronic lymphocytic leukemia
    • Bentz, M. et al. t(11;14)-positive mantle cell lymphomas exhibit complex karyotypes and share similarities with B-cell chronic lymphocytic leukemia. Genes Chromosomes Cancer 27, 285-294 (2000).
    • (2000) Genes Chromosomes Cancer , vol.27 , pp. 285-294
    • Bentz, M.1
  • 58
    • 0036179121 scopus 로고    scopus 로고
    • Identification of novel regions of amplification and deletion within mantle cell lymphoma DNA by comparative genomic hybridization
    • Allen, J. E. et al. Identification of novel regions of amplification and deletion within mantle cell lymphoma DNA by comparative genomic hybridization. Br. J. Haematol. 116, 291-298 (2002).
    • (2002) Br. J. Haematol , vol.116 , pp. 291-298
    • Allen, J.E.1
  • 59
    • 3242762286 scopus 로고    scopus 로고
    • Genomic DNA-chip hybridization in t(11;14)-positive mantle cell lymphomas shows a high frequency of aberrations and allows a refined characterization of consensus regions
    • Kohlhammer, H. et al. Genomic DNA-chip hybridization in t(11;14)-positive mantle cell lymphomas shows a high frequency of aberrations and allows a refined characterization of consensus regions. Blood 104, 795-801 (2004).
    • (2004) Blood , vol.104 , pp. 795-801
    • Kohlhammer, H.1
  • 60
    • 21144446267 scopus 로고    scopus 로고
    • Mantle-cell lymphoma genotypes identified with CGH to BAC microarrays define a leukemic subgroup of disease and predict patient outcome
    • Rubio-Moscardo, F. et al. Mantle-cell lymphoma genotypes identified with CGH to BAC microarrays define a leukemic subgroup of disease and predict patient outcome. Blood 105, 4445-4454 (2005).
    • (2005) Blood , vol.105 , pp. 4445-4454
    • Rubio-Moscardo, F.1
  • 61
    • 13544260503 scopus 로고    scopus 로고
    • Novel chromosomal imbalances in mantle cell lymphoma detected by genome-wide array-based comparative genomic hybridization
    • Schraders, M. et al. Novel chromosomal imbalances in mantle cell lymphoma detected by genome-wide array-based comparative genomic hybridization. Blood 105, 1686-1693 (2005).
    • (2005) Blood , vol.105 , pp. 1686-1693
    • Schraders, M.1
  • 62
    • 34249886043 scopus 로고    scopus 로고
    • Detailed assessment of copy number alterations revealing homozygous deletions in 1p and 13q in mantle cell lymphoma
    • Flordal, T. E. et al. Detailed assessment of copy number alterations revealing homozygous deletions in 1p and 13q in mantle cell lymphoma. Leuk. Res. 31, 1227-1238 (2007).
    • (2007) Leuk. Res , vol.31 , pp. 1227-1238
    • Flordal, T.E.1
  • 63
    • 14844285335 scopus 로고    scopus 로고
    • Genome-wide array-based CGH for mantle cell lymphoma: Identification of homozygous deletions of the proapoptotic gene BIM
    • Tagawa, H. et al. Genome-wide array-based CGH for mantle cell lymphoma: identification of homozygous deletions of the proapoptotic gene BIM. Oncogene 24, 1348-1358 (2005).
    • (2005) Oncogene , vol.24 , pp. 1348-1358
    • Tagawa, H.1
  • 64
    • 33644851486 scopus 로고    scopus 로고
    • Genomic and expression profiling identifies the B-cell associated tyrosine kinase Syk as a possible therapeutic target in mantle cell lymphoma
    • Rinaldi, A. et al. Genomic and expression profiling identifies the B-cell associated tyrosine kinase Syk as a possible therapeutic target in mantle cell lymphoma. Br. J. Haematol. 132, 303-316 (2006).
    • (2006) Br. J. Haematol , vol.132 , pp. 303-316
    • Rinaldi, A.1
  • 65
    • 32544461007 scopus 로고    scopus 로고
    • Mantle cell lymphoma: From pathology and molecular pathogenesis to new therapeutic perspectives
    • Salaverria, I., Perez-Galan, P., Colomer, D. & Campo, E. Mantle cell lymphoma: from pathology and molecular pathogenesis to new therapeutic perspectives. Haematologica 91, 11-16 (2006).
    • (2006) Haematologica , vol.91 , pp. 11-16
    • Salaverria, I.1    Perez-Galan, P.2    Colomer, D.3    Campo, E.4
  • 66
    • 0031042053 scopus 로고    scopus 로고
    • Ott, G. et al. Blastoid variants of mantle cell lymphoma: frequent bcl-1 rearrangements at the major translocation cluster region and tetraploid chromosome clones. Blood 89, 1421-1429 (1997). Showed that MCL, particularly pleomorphic variants, have frequent tetraploid clones.
    • Ott, G. et al. Blastoid variants of mantle cell lymphoma: frequent bcl-1 rearrangements at the major translocation cluster region and tetraploid chromosome clones. Blood 89, 1421-1429 (1997). Showed that MCL, particularly pleomorphic variants, have frequent tetraploid clones.
  • 67
    • 0034778020 scopus 로고    scopus 로고
    • Blastic mantle cell lymphoma associated with Burkitt-type translocation and hypodiploidy
    • Vaishampayan, U. N., Mohamed, A. N., Dugan, M. C., Bloom, R. E. & Palutke, M. Blastic mantle cell lymphoma associated with Burkitt-type translocation and hypodiploidy. Br. J. Haematol. 115, 66-68 (2001).
    • (2001) Br. J. Haematol , vol.115 , pp. 66-68
    • Vaishampayan, U.N.1    Mohamed, A.N.2    Dugan, M.C.3    Bloom, R.E.4    Palutke, M.5
  • 68
    • 0033652176 scopus 로고    scopus 로고
    • 8q24 translocations in blastic transformation of mantle cell lymphoma
    • Au, W. Y. et al. 8q24 translocations in blastic transformation of mantle cell lymphoma. Haematologica 85, 1225-1227 (2000).
    • (2000) Haematologica , vol.85 , pp. 1225-1227
    • Au, W.Y.1
  • 69
    • 33646122464 scopus 로고    scopus 로고
    • Partial uniparental disomy: A recurrent genetic mechanism alternative to chromosomal deletion in malignant lymphoma
    • Nielaender, I., Martin-Subero, J. I., Wagner, F., Martinez-Climent, J. A. & Siebert, R. Partial uniparental disomy: a recurrent genetic mechanism alternative to chromosomal deletion in malignant lymphoma. Leukemia 20, 904-905 (2006).
    • (2006) Leukemia , vol.20 , pp. 904-905
    • Nielaender, I.1    Martin-Subero, J.I.2    Wagner, F.3    Martinez-Climent, J.A.4    Siebert, R.5
  • 70
    • 27144478643 scopus 로고    scopus 로고
    • Association between acquired uniparental disomy and homozygous gene mutation in acute myeloid leukemias
    • Fitzgibbon, J. et al. Association between acquired uniparental disomy and homozygous gene mutation in acute myeloid leukemias. Cancer Res. 65, 9152-9154 (2005).
    • (2005) Cancer Res , vol.65 , pp. 9152-9154
    • Fitzgibbon, J.1
  • 71
    • 33744832429 scopus 로고    scopus 로고
    • Genomic imbalances and patterns of karyotypic variability in mantle-cell lymphoma cell lines
    • Camps, J. et al. Genomic imbalances and patterns of karyotypic variability in mantle-cell lymphoma cell lines. Leuk. Res. 30, 923-934 (2006).
    • (2006) Leuk. Res , vol.30 , pp. 923-934
    • Camps, J.1
  • 72
    • 33744787874 scopus 로고    scopus 로고
    • Mantle cell lymphoma-derived cell lines: Unique research tools
    • Drexler, H. G. & MacLeod, R. A. Mantle cell lymphoma-derived cell lines: unique research tools. Leuk. Res. 30, 911-913 (2006).
    • (2006) Leuk. Res , vol.30 , pp. 911-913
    • Drexler, H.G.1    MacLeod, R.A.2
  • 73
    • 27244434794 scopus 로고    scopus 로고
    • Pathogenesis of mantle-cell lymphoma: All oncogenic roads lead to dysregulation of cell cycle and DNA damage response pathways
    • Fernandez, V., Hartmann, E., Ott, G., Campo, E. & Rosenwald, A. Pathogenesis of mantle-cell lymphoma: all oncogenic roads lead to dysregulation of cell cycle and DNA damage response pathways. J. Clin. Oncol. 23, 6364-6369 (2005).
    • (2005) J. Clin. Oncol , vol.23 , pp. 6364-6369
    • Fernandez, V.1    Hartmann, E.2    Ott, G.3    Campo, E.4    Rosenwald, A.5
  • 74
    • 30144442233 scopus 로고    scopus 로고
    • Perez-Galan, P. et al. The proteasome inhibitor bortezomib induces apoptosis in mantle-cell lymphoma through generation of ROS and Noxa activation independent of p53 status. Blood 107, 257-264 (2006). Showed that the proteasome inhibitor bortezomib induces apoptosis through generation of ROS and NOXA overexpression.
    • Perez-Galan, P. et al. The proteasome inhibitor bortezomib induces apoptosis in mantle-cell lymphoma through generation of ROS and Noxa activation independent of p53 status. Blood 107, 257-264 (2006). Showed that the proteasome inhibitor bortezomib induces apoptosis through generation of ROS and NOXA overexpression.
  • 75
    • 34248362003 scopus 로고    scopus 로고
    • The BH3-mimetic GX15-070 synergizes with bortezomib in mantle cell lymphoma by enhancing Noxa-mediated activation of Bak
    • Perez-Galan, P., Roue, G., Villamor, N., Campo, E. & Colomer, D. The BH3-mimetic GX15-070 synergizes with bortezomib in mantle cell lymphoma by enhancing Noxa-mediated activation of Bak. Blood 109, 4441-4449 (2007).
    • (2007) Blood , vol.109 , pp. 4441-4449
    • Perez-Galan, P.1    Roue, G.2    Villamor, N.3    Campo, E.4    Colomer, D.5
  • 76
    • 9944243557 scopus 로고    scopus 로고
    • Molecular cytogenetic characterization of the mantle cell lymphoma cell line GRANTA-519
    • Rudolph, C. et al. Molecular cytogenetic characterization of the mantle cell lymphoma cell line GRANTA-519. Cancer Genet. Cytogenet. 153, 144-150 (2004).
    • (2004) Cancer Genet. Cytogenet , vol.153 , pp. 144-150
    • Rudolph, C.1
  • 77
    • 0031020805 scopus 로고    scopus 로고
    • Waf1 genes are associated with aggressive variants of mantle cell lymphomas
    • Waf1 genes are associated with aggressive variants of mantle cell lymphomas. Blood 89, 272-280 (1997).
    • (1997) Blood , vol.89 , pp. 272-280
    • Pinyol, M.1
  • 78
    • 0030882326 scopus 로고    scopus 로고
    • Alterations of the cyclin D1/p16-pRB pathway in mantle cell lymphoma
    • Dreyling, M. H. et al. Alterations of the cyclin D1/p16-pRB pathway in mantle cell lymphoma. Cancer Res. 57, 4608-4614 (1997).
    • (1997) Cancer Res , vol.57 , pp. 4608-4614
    • Dreyling, M.H.1
  • 79
    • 31944436267 scopus 로고    scopus 로고
    • Differential effect of epigenetic alterations and genomic deletions of CDK inhibitors [p16(INK4a), p15(INK4b), p14(ARF)] in mantle cell lymphoma
    • Hutter, G. et al. Differential effect of epigenetic alterations and genomic deletions of CDK inhibitors [p16(INK4a), p15(INK4b), p14(ARF)] in mantle cell lymphoma. Genes Chromosomes Cancer 45, 203-210 (2006).
    • (2006) Genes Chromosomes Cancer , vol.45 , pp. 203-210
    • Hutter, G.1
  • 80
    • 0033552813 scopus 로고    scopus 로고
    • The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus
    • Jacobs, J. J., Kieboom, K., Marino, S., DePinho, R. A. & van Lohuizen, M. The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus. Nature 397, 164-168 (1999).
    • (1999) Nature , vol.397 , pp. 164-168
    • Jacobs, J.J.1    Kieboom, K.2    Marino, S.3    DePinho, R.A.4    van Lohuizen, M.5
  • 81
    • 20144389458 scopus 로고    scopus 로고
    • CDK4 and MDM2 gene alterations mainly occur in highly proliferative and aggressive mantle cell lymphomas with wild-type INK4a/ARF locus
    • Hernandez, L. et al. CDK4 and MDM2 gene alterations mainly occur in highly proliferative and aggressive mantle cell lymphomas with wild-type INK4a/ARF locus. Cancer Res. 65, 2199-2206 (2005).
    • (2005) Cancer Res , vol.65 , pp. 2199-2206
    • Hernandez, L.1
  • 82
    • 0030014469 scopus 로고    scopus 로고
    • Expression of the retinoblastoma protein in low-grade B-cell lymphoma: Relationship to cyclin D1
    • Zukerberg, L. R. et al. Expression of the retinoblastoma protein in low-grade B-cell lymphoma: relationship to cyclin D1. Blood 88, 268-276 (1996).
    • (1996) Blood , vol.88 , pp. 268-276
    • Zukerberg, L.R.1
  • 83
    • 15844382913 scopus 로고    scopus 로고
    • p53 gene mutations and protein overexpression are associated with aggressive variants of mantle cell lymphomas
    • Hernandez, L. et al. p53 gene mutations and protein overexpression are associated with aggressive variants of mantle cell lymphomas. Blood 87, 3351-3359 (1996).
    • (1996) Blood , vol.87 , pp. 3351-3359
    • Hernandez, L.1
  • 84
    • 0029916234 scopus 로고    scopus 로고
    • p53 mutations in mantle cell lymphoma are associated with variant cytology and predict a poor prognosis
    • Greiner, T. C. et al. p53 mutations in mantle cell lymphoma are associated with variant cytology and predict a poor prognosis. Blood 87, 4302-4310 (1996).
    • (1996) Blood , vol.87 , pp. 4302-4310
    • Greiner, T.C.1
  • 85
    • 34547684836 scopus 로고    scopus 로고
    • Increased MDM2 expression is associated with inferior survival in mantle cell lymphoma, but not related to the MDM2 SNP309
    • Hartmann, E. et al. Increased MDM2 expression is associated with inferior survival in mantle cell lymphoma, but not related to the MDM2 SNP309. Haematologica 92, 574-575 (2007).
    • (2007) Haematologica , vol.92 , pp. 574-575
    • Hartmann, E.1
  • 86
    • 0033229701 scopus 로고    scopus 로고
    • Molecular characterization of 11q deletions points to a pathogenic role of the ATM gene in mantle cell lymphoma
    • Stilgenbauer, S. et al. Molecular characterization of 11q deletions points to a pathogenic role of the ATM gene in mantle cell lymphoma. Blood 94, 3262-3264 (1999).
    • (1999) Blood , vol.94 , pp. 3262-3264
    • Stilgenbauer, S.1
  • 87
    • 0037365789 scopus 로고    scopus 로고
    • ATM and related protein kinases: Safeguarding genome integrity
    • Shiloh, Y. ATM and related protein kinases: safeguarding genome integrity. Nature Rev. Cancer 3, 155-168 (2003).
    • (2003) Nature Rev. Cancer , vol.3 , pp. 155-168
    • Shiloh, Y.1
  • 89
    • 0036090306 scopus 로고    scopus 로고
    • Camacho, E. et al. ATM gene inactivation in mantle cell lymphoma mainly occurs by truncating mutations and missense mutations involving the phosphatidylinositol-3 kinase domain and is associated with increasing numbers of chromosomal imbalances. Blood 99, 238-244 (2002).
    • Camacho, E. et al. ATM gene inactivation in mantle cell lymphoma mainly occurs by truncating mutations and missense mutations involving the phosphatidylinositol-3 kinase domain and is associated with increasing numbers of chromosomal imbalances. Blood 99, 238-244 (2002).
  • 90
    • 0037627448 scopus 로고    scopus 로고
    • Fang, N. Y. et al. Oligonucleotide microarrays demonstrate the highest frequency of ATM mutations in the mantle cell subtype of lymphoma. Proc. Natl Acad. Sci. USA 100, 5372-5377 (2003). References 88-90 showed frequent mutations of ATM in MCL compared to other lymphomas that were related to more complex karyotypes and present in the germline of occasional MCL patients.
    • Fang, N. Y. et al. Oligonucleotide microarrays demonstrate the highest frequency of ATM mutations in the mantle cell subtype of lymphoma. Proc. Natl Acad. Sci. USA 100, 5372-5377 (2003). References 88-90 showed frequent mutations of ATM in MCL compared to other lymphomas that were related to more complex karyotypes and present in the germline of occasional MCL patients.
  • 91
    • 0037103190 scopus 로고    scopus 로고
    • ATM mutations are associated with inactivation of the ARF-TP53 tumor suppressor pathway in diffuse large B-cell lymphoma
    • Gronbaek, K. et al. ATM mutations are associated with inactivation of the ARF-TP53 tumor suppressor pathway in diffuse large B-cell lymphoma. Blood 100, 1430-1437 (2002).
    • (2002) Blood , vol.100 , pp. 1430-1437
    • Gronbaek, K.1
  • 92
    • 0042346052 scopus 로고    scopus 로고
    • Variations in ATM protein expression during normal lymphoid differentiation and among B-cell-derived neoplasias
    • Starczynski, J. et al. Variations in ATM protein expression during normal lymphoid differentiation and among B-cell-derived neoplasias. Am. J. Pathol. 163, 423-432 (2003).
    • (2003) Am. J. Pathol , vol.163 , pp. 423-432
    • Starczynski, J.1
  • 93
    • 0035839959 scopus 로고    scopus 로고
    • Mechanisms of chromosomal translocations in B cell lymphomas
    • Kuppers, R. & Dalla-Favera, R. Mechanisms of chromosomal translocations in B cell lymphomas. Oncogene 20, 5580-5594 (2001).
    • (2001) Oncogene , vol.20 , pp. 5580-5594
    • Kuppers, R.1    Dalla-Favera, R.2
  • 94
    • 0034707047 scopus 로고    scopus 로고
    • The DNA damage response: Putting checkpoints in perspective
    • Zhou, B. B. & Elledge, S. J. The DNA damage response: putting checkpoints in perspective. Nature 408, 433-439 (2000).
    • (2000) Nature , vol.408 , pp. 433-439
    • Zhou, B.B.1    Elledge, S.J.2
  • 95
    • 0037114634 scopus 로고    scopus 로고
    • CHK2-decreased protein expression and infrequent genetic alterations mainly occur in aggressive types of non-Hodgkin lymphomas
    • Tort, F. et al. CHK2-decreased protein expression and infrequent genetic alterations mainly occur in aggressive types of non-Hodgkin lymphomas. Blood 100, 4602-4608 (2002).
    • (2002) Blood , vol.100 , pp. 4602-4608
    • Tort, F.1
  • 96
    • 85056036501 scopus 로고    scopus 로고
    • Mutations of Chk2 in primary hematopoietic neoplasms
    • Hangaishi, A. et al. Mutations of Chk2 in primary hematopoietic neoplasms. Blood 99, 3075-3077 (2002).
    • (2002) Blood , vol.99 , pp. 3075-3077
    • Hangaishi, A.1
  • 97
    • 11844251995 scopus 로고    scopus 로고
    • Checkpoint kinase 1 (CHK1) protein and mRNA expression is downregulated in aggressive variants of human lymphoid neoplasms
    • Tort, F. et al. Checkpoint kinase 1 (CHK1) protein and mRNA expression is downregulated in aggressive variants of human lymphoid neoplasms. Leukemia 19, 112-117 (2005).
    • (2005) Leukemia , vol.19 , pp. 112-117
    • Tort, F.1
  • 98
    • 33751574653 scopus 로고    scopus 로고
    • Unbalanced expression of licensing DNA replication factors occurs in a subset of mantle cell lymphomas with genomic instability
    • Pinyol, M. et al. Unbalanced expression of licensing DNA replication factors occurs in a subset of mantle cell lymphomas with genomic instability. Int. J. Cancer 119, 2768-2774 (2006).
    • (2006) Int. J. Cancer , vol.119 , pp. 2768-2774
    • Pinyol, M.1
  • 99
    • 0038206722 scopus 로고    scopus 로고
    • Inhibition of constitutive NF-kappa B activation in mantle cell lymphoma B cells leads to induction of cell cycle arrest and apoptosis
    • Pham, L. V., Tamayo, A. T., Yoshimura, L. C., Lo, P. & Ford, R. J. Inhibition of constitutive NF-kappa B activation in mantle cell lymphoma B cells leads to induction of cell cycle arrest and apoptosis. J. Immunol. 171, 88-95 (2003).
    • (2003) J. Immunol , vol.171 , pp. 88-95
    • Pham, L.V.1    Tamayo, A.T.2    Yoshimura, L.C.3    Lo, P.4    Ford, R.J.5
  • 100
    • 33747846726 scopus 로고    scopus 로고
    • Constitutive activation of Akt contributes to the pathogenesis and survival of mantle cell lymphoma
    • Rudelius, M. et al. Constitutive activation of Akt contributes to the pathogenesis and survival of mantle cell lymphoma. Blood 108, 1668-1676 (2006).
    • (2006) Blood , vol.108 , pp. 1668-1676
    • Rudelius, M.1
  • 101
    • 33846476267 scopus 로고    scopus 로고
    • Selective inhibition of IκB kinase sensitizes mantle cell lymphoma B cells to TRAIL by decreasing cellular FLIP level
    • Roue, G. et al. Selective inhibition of IκB kinase sensitizes mantle cell lymphoma B cells to TRAIL by decreasing cellular FLIP level. J. Immunol. 178, 1923-1930 (2007).
    • (2007) J. Immunol , vol.178 , pp. 1923-1930
    • Roue, G.1
  • 102
    • 33748350890 scopus 로고    scopus 로고
    • Treatment of mantle cell lymphoma: Current approach and future directions
    • Brody, J. & Advani, R. Treatment of mantle cell lymphoma: current approach and future directions. Crit Rev. Oncol. Hematol. 58, 257-265 (2006).
    • (2006) Crit Rev. Oncol. Hematol , vol.58 , pp. 257-265
    • Brody, J.1    Advani, R.2
  • 103
    • 34249704600 scopus 로고    scopus 로고
    • Immunochemotherapy with rituximab and overall survival in patients with indolent or mantle cell lymphoma: A systematic review and meta-analysis
    • Schulz, H. et al. Immunochemotherapy with rituximab and overall survival in patients with indolent or mantle cell lymphoma: a systematic review and meta-analysis. J. Natl Cancer Inst. 99, 706-714 (2007).
    • (2007) J. Natl Cancer Inst , vol.99 , pp. 706-714
    • Schulz, H.1
  • 104
    • 27244434474 scopus 로고    scopus 로고
    • Current treatment approaches for mantle-cell lymphoma
    • Witzig, T. E. Current treatment approaches for mantle-cell lymphoma. J. Clin. Oncol. 23, 6409-6414 (2005).
    • (2005) J. Clin. Oncol , vol.23 , pp. 6409-6414
    • Witzig, T.E.1
  • 105
    • 27244431774 scopus 로고    scopus 로고
    • Targeting histones and proteasomes: New strategies for the treatment of lymphoma
    • O'connor, O. A. Targeting histones and proteasomes: new strategies for the treatment of lymphoma. J. Clin. Oncol. 23, 6429-6436 (2005).
    • (2005) J. Clin. Oncol , vol.23 , pp. 6429-6436
    • O'connor, O.A.1
  • 106
    • 0038473927 scopus 로고    scopus 로고
    • Flavopiridol in untreated or relapsed mantle-cell lymphoma: Results of a phase II study of the National Cancer Institute of Canada Clinical Trials Group
    • Kouroukis, C. T. et al. Flavopiridol in untreated or relapsed mantle-cell lymphoma: results of a phase II study of the National Cancer Institute of Canada Clinical Trials Group. J. Clin. Oncol. 21, 1740-1745 (2003).
    • (2003) J. Clin. Oncol , vol.21 , pp. 1740-1745
    • Kouroukis, C.T.1
  • 107
    • 0036240601 scopus 로고    scopus 로고
    • Seventy-two hour continuous infusion flavopiridol in relapsed and refractory mantle cell lymphoma
    • Lin, T. S., Howard, O. M., Neuberg, D. S., Kim, H. H. & Shipp, M. A. Seventy-two hour continuous infusion flavopiridol in relapsed and refractory mantle cell lymphoma. Leuk. Lymphoma 43, 793-797 (2002).
    • (2002) Leuk. Lymphoma , vol.43 , pp. 793-797
    • Lin, T.S.1    Howard, O.M.2    Neuberg, D.S.3    Kim, H.H.4    Shipp, M.A.5
  • 108
    • 25444502962 scopus 로고    scopus 로고
    • In vitro activity of cyclin-dependent kinase inhibitor CYC202 (Seliciclib, R-roscovitine) in mantle cell lymphomas
    • Lacrima, K. et al. In vitro activity of cyclin-dependent kinase inhibitor CYC202 (Seliciclib, R-roscovitine) in mantle cell lymphomas. Ann. Oncol. 16, 1169-1176 (2005).
    • (2005) Ann. Oncol , vol.16 , pp. 1169-1176
    • Lacrima, K.1
  • 109
    • 34547980839 scopus 로고    scopus 로고
    • Evaluation of novel cell cycle inhibitors in mantle cell lymphoma
    • Park, I. W., Reddy, M. V., Reddy, E. P. & Groopman, J. E. Evaluation of novel cell cycle inhibitors in mantle cell lymphoma. Oncogene 26, 5635-5642 (2007).
    • (2007) Oncogene , vol.26 , pp. 5635-5642
    • Park, I.W.1    Reddy, M.V.2    Reddy, E.P.3    Groopman, J.E.4
  • 110
    • 33750625445 scopus 로고    scopus 로고
    • Multicenter phase II study of bortezomib in patients with relapsed or refractory mantle cell lymphoma
    • Fisher, R. I. et al. Multicenter phase II study of bortezomib in patients with relapsed or refractory mantle cell lymphoma. J. Clin. Oncol. 24, 4867-4874 (2006).
    • (2006) J. Clin. Oncol , vol.24 , pp. 4867-4874
    • Fisher, R.I.1
  • 111
    • 20044396543 scopus 로고    scopus 로고
    • Phase II study of proteasome inhibitor bortezomib in relapsed or refractory B-cell non-Hodgkin's lymphoma
    • Goy, A. et al. Phase II study of proteasome inhibitor bortezomib in relapsed or refractory B-cell non-Hodgkin's lymphoma. J. Clin. Oncol. 23, 667-675 (2005).
    • (2005) J. Clin. Oncol , vol.23 , pp. 667-675
    • Goy, A.1
  • 112
    • 20044376092 scopus 로고    scopus 로고
    • O'connor, O. A. et al. Phase II clinical experience with the novel proteasome inhibitor bortezomib in patients with indolent non-Hodgkin's lymphoma and mantle cell lymphoma. J. Clin. Oncol. 23, 676-684 (2005). References 110-112 showed the response of MCL patients to the new proteasome inhibitor bortezomib.
    • O'connor, O. A. et al. Phase II clinical experience with the novel proteasome inhibitor bortezomib in patients with indolent non-Hodgkin's lymphoma and mantle cell lymphoma. J. Clin. Oncol. 23, 676-684 (2005). References 110-112 showed the response of MCL patients to the new proteasome inhibitor bortezomib.
  • 113
    • 22144460556 scopus 로고    scopus 로고
    • Apoptosis-based therapies for hematologic malignancies
    • Reed, J. C. & Pellecchia, M. Apoptosis-based therapies for hematologic malignancies. Blood 106, 408-418 (2005).
    • (2005) Blood , vol.106 , pp. 408-418
    • Reed, J.C.1    Pellecchia, M.2
  • 114
    • 33847328289 scopus 로고    scopus 로고
    • The Bcl-2 apoptotic switch in cancer development and therapy
    • Adams, J. M. & Cory, S. The Bcl-2 apoptotic switch in cancer development and therapy. Oncogene 26, 1324-1337 (2007).
    • (2007) Oncogene , vol.26 , pp. 1324-1337
    • Adams, J.M.1    Cory, S.2
  • 115
    • 4444365042 scopus 로고    scopus 로고
    • MCL-1 expression in B-cell non-Hodgkin's lymphomas
    • Cho-Vega, J. H. et al. MCL-1 expression in B-cell non-Hodgkin's lymphomas. Hum. Pathol. 35, 1095-1100 (2004).
    • (2004) Hum. Pathol , vol.35 , pp. 1095-1100
    • Cho-Vega, J.H.1
  • 116
    • 0037207516 scopus 로고    scopus 로고
    • Expression of Mcl-1 in mantle cell lymphoma is associated with high-grade morphology, a high proliferative state, and p53 overexpression
    • Khoury, J. D. et al. Expression of Mcl-1 in mantle cell lymphoma is associated with high-grade morphology, a high proliferative state, and p53 overexpression. J. Pathol. 199, 90-97 (2003).
    • (2003) J. Pathol , vol.199 , pp. 90-97
    • Khoury, J.D.1
  • 117
    • 33745872296 scopus 로고    scopus 로고
    • Comparison of chemical inhibitors of antiapoptotic Bcl-2-family proteins
    • Zhai, D., Jin, C., Satterthwait, A. C. & Reed, J. C. Comparison of chemical inhibitors of antiapoptotic Bcl-2-family proteins. Cell Death Differ. 13, 1419-1421 (2006).
    • (2006) Cell Death Differ , vol.13 , pp. 1419-1421
    • Zhai, D.1    Jin, C.2    Satterthwait, A.C.3    Reed, J.C.4
  • 118
    • 3342894130 scopus 로고    scopus 로고
    • Targeting death receptors in cancer with Apo2L/TRAIL
    • Kelley, S. K. & Ashkenazi, A. Targeting death receptors in cancer with Apo2L/TRAIL. Curr. Opin. Pharmacol. 4, 333-339 (2004).
    • (2004) Curr. Opin. Pharmacol , vol.4 , pp. 333-339
    • Kelley, S.K.1    Ashkenazi, A.2
  • 119
    • 29244483111 scopus 로고    scopus 로고
    • TRAIL receptor-selective mutants signal to apoptosis via TRAIL-R1 in primary lymphoid malignancies
    • MacFarlane, M., Kohlhaas, S. L., Sutcliffe, M. J., Dyer, M. J. & Cohen, G. M. TRAIL receptor-selective mutants signal to apoptosis via TRAIL-R1 in primary lymphoid malignancies. Cancer Res. 65, 11265-11270 (2005).
    • (2005) Cancer Res , vol.65 , pp. 11265-11270
    • MacFarlane, M.1    Kohlhaas, S.L.2    Sutcliffe, M.J.3    Dyer, M.J.4    Cohen, G.M.5
  • 120
    • 33947246465 scopus 로고    scopus 로고
    • Monoclonal antibodies in the treatment of non-Hodgkin's lymphoma
    • Fanale, M. A. & Younes, A. Monoclonal antibodies in the treatment of non-Hodgkin's lymphoma. Drugs 67, 333-350 (2007).
    • (2007) Drugs , vol.67 , pp. 333-350
    • Fanale, M.A.1    Younes, A.2
  • 121
    • 34248187996 scopus 로고    scopus 로고
    • Phase I pharmacokinetic and biologic correlative study of mapatumumab, a fully human monoclonal antibody with agonist activity to tumor necrosis factor-related apoptosis-inducing ligand receptor-1
    • Tolcher, A. W. et al. Phase I pharmacokinetic and biologic correlative study of mapatumumab, a fully human monoclonal antibody with agonist activity to tumor necrosis factor-related apoptosis-inducing ligand receptor-1. J. Clin. Oncol. 25, 1390-1395 (2007).
    • (2007) J. Clin. Oncol , vol.25 , pp. 1390-1395
    • Tolcher, A.W.1
  • 122
    • 33846516354 scopus 로고    scopus 로고
    • Antiproliferative activity of RAD001 (everolimus) as a single agent and combined with other agents in mantle cell lymphoma
    • Haritunians, T. et al. Antiproliferative activity of RAD001 (everolimus) as a single agent and combined with other agents in mantle cell lymphoma. Leukemia 21, 333-339 (2007).
    • (2007) Leukemia , vol.21 , pp. 333-339
    • Haritunians, T.1
  • 123
    • 27144455334 scopus 로고    scopus 로고
    • Inhibition of the mammalian target of rapamycin and the induction of cell cycle arrest in mantle cell lymphoma cells
    • Hipp, S. et al. Inhibition of the mammalian target of rapamycin and the induction of cell cycle arrest in mantle cell lymphoma cells. Haematologica 90, 1433-1434 (2005).
    • (2005) Haematologica , vol.90 , pp. 1433-1434
    • Hipp, S.1
  • 124
    • 23044479821 scopus 로고    scopus 로고
    • Curcumin (diferuloylmethane) inhibits constitutive NF-?B activation, induces G1/S arrest, suppresses proliferation, and induces apoptosis in mantle cell lymphoma
    • Shishodia, S., Amin, H. M., Lai, R. & Aggarwal, B. B. Curcumin (diferuloylmethane) inhibits constitutive NF-?B activation, induces G1/S arrest, suppresses proliferation, and induces apoptosis in mantle cell lymphoma. Biochem. Pharmacol. 70, 700-713 (2005).
    • (2005) Biochem. Pharmacol , vol.70 , pp. 700-713
    • Shishodia, S.1    Amin, H.M.2    Lai, R.3    Aggarwal, B.B.4
  • 125
    • 19944431518 scopus 로고    scopus 로고
    • Retinoic acid inhibits the proliferative response induced by CD40 activation and interleukin-4 in mantle cell lymphoma
    • Guidoboni, M. et al. Retinoic acid inhibits the proliferative response induced by CD40 activation and interleukin-4 in mantle cell lymphoma. Cancer Res. 65, 587-595 (2005).
    • (2005) Cancer Res , vol.65 , pp. 587-595
    • Guidoboni, M.1
  • 126
    • 33644836549 scopus 로고    scopus 로고
    • Clinical experience with intravenous and oral formulations of the novel histone deacetylase inhibitor suberoylanilide hydroxamic acid in patients with advanced hematologic malignancies
    • O'connor, O. A. et al. Clinical experience with intravenous and oral formulations of the novel histone deacetylase inhibitor suberoylanilide hydroxamic acid in patients with advanced hematologic malignancies. J. Clin. Oncol. 24, 166-173 (2006).
    • (2006) J. Clin. Oncol , vol.24 , pp. 166-173
    • O'connor, O.A.1
  • 127
    • 12344330351 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors profoundly decrease proliferation of human lymphoid cancer cell lines
    • Sakajiri, S. et al. Histone deacetylase inhibitors profoundly decrease proliferation of human lymphoid cancer cell lines. Exp. Hematol. 33, 53-61 (2005).
    • (2005) Exp. Hematol , vol.33 , pp. 53-61
    • Sakajiri, S.1
  • 128
    • 33947313218 scopus 로고    scopus 로고
    • HDACs, histone deacetylation and gene transcription: From molecular biology to cancer therapeutics
    • Gallinari, P., Di, M. S., Jones, P., Pallaoro, M. & Steinkuhler, C. HDACs, histone deacetylation and gene transcription: from molecular biology to cancer therapeutics. Cell Res. 17, 195-211 (2007).
    • (2007) Cell Res , vol.17 , pp. 195-211
    • Gallinari, P.1    Di, M.S.2    Jones, P.3    Pallaoro, M.4    Steinkuhler, C.5
  • 129
    • 33846122993 scopus 로고    scopus 로고
    • Dimethyl sulfoxide to vorinostat: Development of this histone deacetylase inhibitor as an anticancer drug
    • Marks, P. A. & Breslow, R. Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drug. Nature Biotechnol. 25, 84-90 (2007).
    • (2007) Nature Biotechnol , vol.25 , pp. 84-90
    • Marks, P.A.1    Breslow, R.2
  • 130
    • 0141725541 scopus 로고    scopus 로고
    • INK4A
    • INK4A. Leukemia 17, 1914-1915 (2003).
    • (2003) Leukemia , vol.17 , pp. 1914-1915
    • Damaj, G.1
  • 131
    • 4944229959 scopus 로고    scopus 로고
    • Antitumor activity of rituximab plus thalidomide in patients with relapsed/refractory mantle cell lymphoma
    • Kaufmann, H. et al. Antitumor activity of rituximab plus thalidomide in patients with relapsed/refractory mantle cell lymphoma. Blood 104, 2269-2271 (2004).
    • (2004) Blood , vol.104 , pp. 2269-2271
    • Kaufmann, H.1
  • 132
    • 1542349932 scopus 로고    scopus 로고
    • Nuclear survivin expression in mantle cell lymphoma is associated with cell proliferation and survival
    • Martinez, A. et al. Nuclear survivin expression in mantle cell lymphoma is associated with cell proliferation and survival. Am. J. Pathol. 164, 501-510 (2004).
    • (2004) Am. J. Pathol , vol.164 , pp. 501-510
    • Martinez, A.1
  • 133
    • 13944249382 scopus 로고    scopus 로고
    • Coupling apoptosis resistance to the cellular stress response: The IAP-Hsp90 connection in cancer
    • Altieri, D. C. Coupling apoptosis resistance to the cellular stress response: the IAP-Hsp90 connection in cancer. Cell Cycle 3, 255-256 (2004).
    • (2004) Cell Cycle , vol.3 , pp. 255-256
    • Altieri, D.C.1
  • 134
    • 33748363502 scopus 로고    scopus 로고
    • The heat shock protein 90 inhibitor 17-AAG induces cell cycle arrest and apoptosis in mantle cell lymphoma cell lines by depleting cyclin D1, Akt, Bid and activating caspase 9
    • Georgakis, G. V., Li, Y. & Younes, A. The heat shock protein 90 inhibitor 17-AAG induces cell cycle arrest and apoptosis in mantle cell lymphoma cell lines by depleting cyclin D1, Akt, Bid and activating caspase 9. Br. J. Haematol. 135, 68-71 (2006).
    • (2006) Br. J. Haematol , vol.135 , pp. 68-71
    • Georgakis, G.V.1    Li, Y.2    Younes, A.3
  • 135
    • 0020512006 scopus 로고
    • Centrocytic lymphoma: A distinct clinicopathologic and immunologic entity. A multiparameter study of 18 cases at diagnosis and relapse
    • Swerdlow, S. H. et al. Centrocytic lymphoma: a distinct clinicopathologic and immunologic entity. A multiparameter study of 18 cases at diagnosis and relapse. Am. J. Pathol. 113, 181-197 (1983).
    • (1983) Am. J. Pathol , vol.113 , pp. 181-197
    • Swerdlow, S.H.1
  • 136
    • 2642618607 scopus 로고    scopus 로고
    • Mantle cell lymphoma: Presenting features, response to therapy, and prognostic factors
    • Bosch, F. et al. Mantle cell lymphoma: presenting features, response to therapy, and prognostic factors. Cancer 82, 567-575 (1998).
    • (1998) Cancer , vol.82 , pp. 567-575
    • Bosch, F.1
  • 137
    • 27744523816 scopus 로고    scopus 로고
    • Histopathology, cell proliferation indices and clinical outcome in 304 patients with mantle cell lymphoma (MCL): A clinicopathological study from the European MCL Network
    • Tiemann, M. et al. Histopathology, cell proliferation indices and clinical outcome in 304 patients with mantle cell lymphoma (MCL): a clinicopathological study from the European MCL Network. Br. J. Haematol. 131, 29-38 (2005).
    • (2005) Br. J. Haematol , vol.131 , pp. 29-38
    • Tiemann, M.1
  • 138
    • 15444363294 scopus 로고    scopus 로고
    • Mantle cell lymphomas with clonal immunoglobulin V(H)3-21 gene rearrangements exhibit fewer genomic imbalances than mantle cell lymphomas utilizing other immunoglobulin V(H) genes
    • Thelander, E. F. et al. Mantle cell lymphomas with clonal immunoglobulin V(H)3-21 gene rearrangements exhibit fewer genomic imbalances than mantle cell lymphomas utilizing other immunoglobulin V(H) genes. Mod. Pathol. 18, 331-339 (2005).
    • (2005) Mod. Pathol , vol.18 , pp. 331-339
    • Thelander, E.F.1
  • 139
    • 0028914585 scopus 로고
    • Lymphoma-associated translocation t(14;18) in blood B-cells of normal individuals
    • Limpens, J. et al. Lymphoma-associated translocation t(14;18) in blood B-cells of normal individuals. Blood 85, 2528-2536 (1995).
    • (1995) Blood , vol.85 , pp. 2528-2536
    • Limpens, J.1
  • 140
    • 0036566185 scopus 로고    scopus 로고
    • In situ localization of follicular lymphoma: Description and analysis by laser capture microdissection
    • Cong, P. et al. In situ localization of follicular lymphoma: description and analysis by laser capture microdissection. Blood 99, 3376-3382 (2002).
    • (2002) Blood , vol.99 , pp. 3376-3382
    • Cong, P.1


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