Nutraceutical use in late-stage cancer

Cancer and Metastasis Reviews

Volumn 29, Issue 3, 2010, Pages 503-510

  Wargovich, Michael J ^a   Morris, Jay ^a   Brown, Vondina ^a   Ellis, Jane ^b   Logothetis, Britt ^c   Weber, Rebecca ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b PRESBYTERIAN COLLEGE   (United States)

^c UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Cancer treatment; Dietary supplements; Metastasis; Nutraceuticals

Indexed keywords

ALKALOID; CAPSAICIN; CURCUMIN; DIOSGENIN; EPIGALLOCATECHIN GALLATE; ESTROGEN RECEPTOR; EUGENOL; FLUOROURACIL; GENISTEIN; GINGEROL; NONSTEROID ANTIINFLAMMATORY AGENT; NUTRACEUTICAL; PIPERINE; PIPLARTINE; RESVERATROL; SIRTUIN; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TURMERIC; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; BLADDER CANCER; CANCER CELL; CANCER CHEMOTHERAPY; CANCER MODEL; CANCER PATIENT; CANCER PREVENTION; CANCER RADIOTHERAPY; CANCER STAGING; CLOVE; COLON CANCER; DIET SUPPLEMENTATION; DRUG ABSORPTION; DRUG MEGADOSE; DRUG METABOLISM; DRUG POTENTIATION; FENUGREEK; GINGER; GRAPE; HEAD AND NECK CANCER; HUMAN; IMMUNOMODULATION; KIDNEY INJURY; MELANOMA; MULTIPLE MYELOMA; NAUSEA AND VOMITING; NEUROPATHY; NONHUMAN; PANCREAS CANCER; PEPPER; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; REVIEW; SOYBEAN; STOMACH CANCER; TEA; TUMOR GROWTH;

ANIMALS; DIETARY SUPPLEMENTS; HUMANS; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; NEOPLASMS;

EID: 77957571290     PISSN: 01677659     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10555-010-9240-5     Document Type: Review

References (83)

1. VA Rhodes RW McDaniel 2001 Nausea, vomiting, and retching: complex problems in palliative care CA: A Cancer Journal for Clinicians 51 232 248 1:STN:280:DC%2BD3MrjtFCqtA%3D%3D 10.3322/canjclin.51.4.232 quiz 249-252
2. R Di Luzio S Moscatiello G Marchesini 2010 Role of nutrition in gastrointestinal oncological patients European Review for Medical and Pharmacological Sciences 14 277 284 20496536
3. NM Aziz JH Rowland 2003 Trends and advances in cancer survivorship research: challenge and opportunity Seminars in Radiation Oncology 13 248 266 10.1016/S1053-4296(03)00024-9 12903014 (Pubitemid 36962648)
4. JH Rowland N Aziz G Tesauro EJ Feuer 2001 The changing face of cancer survivorship Seminars in Oncology Nursing 17 236 240 1:STN:280: DC%2BD38%2FjtFOhsA%3D%3D 10.1053/sonu.2001.27912 11764706
5. E Ernst BR Cassileth 1998 The prevalence of complementary/alternative medicine in cancer: a systematic review Cancer 83 777 782
6. MA Richardson T Sanders JL Palmer A Greisinger SE Singletary 2000 Complementary/alternative medicine use in a comprehensive cancer center and the implications for oncology Journal of Clinical Oncology 18 2505 2514 1:STN:280:DC%2BD3czlt1SnsA%3D%3D 10893280
7. Rausch, S. M., Winegardner, F., Kruk, K. M., Phatak, V., Wahner-Roedler, D. L., Bauer, B., et al. (2010) Complementary and alternative medicine: use and disclosure in radiation oncology community practice. Support Care Cancer.(in press)
8. DL Wahner-Roedler PL Elkin A Vincent JM Thompson TH Oh LL Loehrer, et al. 2005 Use of complementary and alternative medical therapies by patients referred to a fibromyalgia treatment program at a tertiary care center Mayo Clinic Proceedings 80 55 60 10.4065/80.1.55 15667030
9. BR Cassileth M Heitzer K Wesa 2009 The public health impact of herbs and nutritional supplements Le Pharmacien Biologiste 47 761 767 10.1080/ 13880200902991581
10. Z Hu X Yang PC Ho SY Chan PW Heng E Chan, et al. 2005 Herb-drug interactions: a literature review Drugs 65 1239 1282 1:CAS:528: DC%2BD2MXhtVekurfL 10.2165/00003495-200565090-00005 15916450 (Pubitemid 41038418)
11. PR Gwilt CL Lear MA Tempero DD Birt AC Grandjean RW Ruddon, et al. 1994 The effect of garlic extract on human metabolism of acetaminophen Cancer Epidemiology, Biomarkers & Prevention 3 155 160 1:CAS:528:DyaK2cXkt1Kitbw%3D
12. LP Vaes PA Chyka 2000 Interactions of warfarin with garlic, ginger, ginkgo, or ginseng: nature of the evidence The Annals of Pharmacotherapy 34 1478 1482 1:STN:280:DC%2BD3M7jslCqtg%3D%3D 11144706
13. KI Block MN Mead 2003 Immune system effects of echinacea, ginseng, and astragalus: a review Integrative Cancer Therapies 2 247 267 10.1177/ 1534735403256419 15035888 (Pubitemid 37138611)
14. F Borrelli AA Izzo 2009 Herb-drug interactions with St John's wort (Hypericum perforatum): an update on clinical observations The AAPS Journal 11 710 727 1:CAS:528:DC%2BD1MXhsFGmurzK 10.1208/s12248-009-9146-8 19859815
15. AA Oyagbemi AB Saba OI Azeez 2010 Capsaicin: a novel chemopreventive molecule and its underlying molecular mechanisms of action Indian Journal of Cancer 47 53 58 1:STN:280:DC%2BC3c%2Fitl2mtw%3D%3D 10.4103/0019-509X.58860 20071791
16. SH Lee C Krisanapun SJ Baek 2010 NSAID-activated gene-1 as a molecular target for capsaicin-induced apoptosis through a novel molecular mechanism involving GSK3beta, C/EBPbeta and ATF3 Carcinogenesis 31 719 728 1:CAS:528:DC%2BC3cXkt1Olsr4%3D 10.1093/carcin/bgq016 20110283
17. KM Yang JO Pyo GY Kim R Yu IS Han SA Ju, et al. 2009 Capsaicin induces apoptosis by generating reactive oxygen species and disrupting mitochondrial transmembrane potential in human colon cancer cell lines Cellular & Molecular Biology Letters 14 497 510 1:CAS:528:DC%2BC3cXisVGrtLw%3D 10.2478/s11658-009-0016-2
18. R Zhang I Humphreys RP Sahu Y Shi SK Srivastava 2008 In vitro and in vivo induction of apoptosis by capsaicin in pancreatic cancer cells is mediated through ROS generation and mitochondrial death pathway Apoptosis 13 1465 1478 1:CAS:528:DC%2BD1cXhtlylu7vK 10.1007/s10495-008-0278-6 19002586
19. A Berger M Henderson W Nadoolman V Duffy D Cooper L Saberski, et al. 1995 Oral capsaicin provides temporary relief for oral mucositis pain secondary to chemotherapy/radiation therapy Journal of Pain and Symptom Management 10 243 248 1:STN:280:DyaK2MzlsFOntQ%3D%3D 10.1016/0885-3924(94)00130-D 7629418
20. BB Aggarwal AB Kunnumakkara KB Harikumar ST Tharakan B Sung P Anand, et al. 2008 Potential of spice-derived phytochemicals for cancer prevention Planta Medica 74 1560 1569 1:CAS:528:DC%2BD1cXhtl2hsb3P 10.1055/s-2008-1074578 18612945
21. P Manikandan G Vinothini R Vidya Priyadarsini D Prathiba S Nagini 2009 Eugenol inhibits cell proliferation via NF-kappaB suppression in a rat model of gastric carcinogenesis induced by MNNG Investigational New Drugs 23 23
22. D Slamenova E Horvathova L Wsolova M Sramkova J Navarova P Manikandan, et al. 2009 Investigation of anti-oxidative, cytotoxic, DNA-damaging and DNA-protective effects of plant volatiles eugenol and borneol in human-derived HepG2, Caco-2 and VH10 cell lines Mutation Research 677 46 52 1:CAS:528:DC%2BD1MXoslamsL0%3D 19501671
23. Manikandan, P., Murugan, R. S., Priyadarsini, R. V., Vinothini, G., Nagini, S. (2010) Eugenol induces apoptosis and inhibits invasion and angiogenesis in a rat model of gastric carcinogenesis induced by MNNG. Life sciences. (in press)
24. JK Kundu HK Na YJ Surh 2009 Ginger-derived phenolic substances with cancer preventive and therapeutic potential Forum of Nutrition 61 182 192 1:CAS:528:DC%2BD1MXhtFegtr%2FP 10.1159/000212750 19367122
25. S Dugasani MR Pichika VD Nadarajah MK Balijepalli S Tandra JN Korlakunta 2010 Comparative antioxidant and anti-inflammatory effects of [6]-gingerol, [8]-gingerol, [10]-gingerol and [6]-shogaol Journal of Ethnopharmacology 127 515 520 1:CAS:528:DC%2BC3cXot12mtw%3D%3D 10.1016/j.jep.2009.10.004 19833188
26. HS Lee EY Seo NE Kang WK Kim 2008 [6]-Gingerol inhibits metastasis of MDA-MB-231 human breast cancer cells The Journal of Nutritional Biochemistry 19 313 319 1:CAS:528:DC%2BD1cXks1Gjtbw%3D 10.1016/j.jnutbio.2007.05.008 17683926 (Pubitemid 351503763)
27. N Nigam K Bhui S Prasad J George Y Shukla 2009 [6]-Gingerol induces reactive oxygen species regulated mitochondrial cell death pathway in human epidermoid carcinoma A431 cells Chemico-Biological Interactions 181 77 84 1:CAS:528:DC%2BD1MXptValur8%3D 10.1016/j.cbi.2009.05.012 19481070
28. J Rhode S Fogoros S Zick H Wahl K Griffith J Huang, et al. 2007 Ginger inhibits cell growth and modulates angiogenic factors in ovarian cancer cells BMC Complementary and Alternative Medicine 7 44 10.1186/1472-6882-7-44 18096028 (Pubitemid 351250514)
29. T Hoffman 2007 Ginger: an ancient remedy and modern miracle drug Hawaii Medical Journal 66 326 327 18269091
30. S Zick M Ruffin J Lee D Normolle R Siden S Alrawi, et al. 2009 Phase II trial of encapsulated ginger as a treatment for chemotherapy-induced nausea and vomiting Supportive Care in Cancer 17 563 572 10.1007/s00520-008-0528-8 19005687
31. WG Taylor JL Elder PR Chang KW Richards 2000 Microdetermination of diosgenin from fenugreek (Trigonella foenum-graecum) seeds Journal of Agricultural and Food Chemistry 48 5206 5210 1:CAS:528:DC%2BD3cXntVehu7w%3D 10.1021/jf000467t 11087460
32. J Raju RP Bird 2007 Diosgenin, a naturally occurring steroid [corrected] saponin suppresses 3-hydroxy-3-methylglutaryl CoA reductase expression and induces apoptosis in HCT-116 human colon carcinoma cells Cancer Letters 255 194 204 1:CAS:528:DC%2BD2sXpsFKqurc%3D 10.1016/j.canlet.2007.04.011 17555873 (Pubitemid 47268640)
33. S Shishodia BB Aggarwal J Raju RP Bird S Srinivasan S Koduru, et al. 2006 Diosgenin inhibits osteoclastogenesis, invasion, and proliferation through the downregulation of Akt, I kappa B kinase activation and NF-kappa B-regulated gene expression Oncogene 25 1463 1473 1:CAS:528:DC%2BD28XitFGht78%3D 10.1038/sj.onc.1209194 16331273 (Pubitemid 43361932)
34. S Srinivasan S Koduru R Kumar G Venguswamy N Kyprianou C Damodaran 2009 Diosgenin targets Akt-mediated prosurvival signaling in human breast cancer cells International Journal of Cancer 125 961 967 1:CAS:528:DC%2BD1MXnsFeltbs%3D 10.1002/ijc.24419
35. J Raju R Mehta 2009 Cancer chemopreventive and therapeutic effects of diosgenin, a food saponin Nutrition and Cancer 61 27 35 1:CAS:528: DC%2BD1MXjt1Shsbg%3D 10.1080/01635580802357352 19116873
36. W Hummer P Schreier 2008 Analysis of proanthocyanidins Molecular Nutrition & Food Research 52 1381 1398 10.1002/mnfr.200700463
37. M Nassiri-Asl H Hosseinzadeh 2009 Review of the pharmacological effects of Vitis vinifera (Grape) and its bioactive compounds Phytotherapy Research 23 1197 1204 1:CAS:528:DC%2BD1MXht1CqtrrP 10.1002/ptr.2761 19140172
38. AK Sandhu L Gu 2010 Antioxidant capacity, phenolic content, and profiling of phenolic compounds in the seeds, skin, and pulp of Vitis rotundifolia (Muscadine Grapes) As determined by HPLC-DAD-ESI-MS(n) Journal of Agricultural and Food Chemistry 58 4681 4692 1:CAS:528:DC%2BC3cXjslant78%3D 10.1021/jf904211q 20334341
39. Hsieh, T-c., & Wu, J. M. (2010) Resveratrol: biological and pharmaceutical properties as anticancer molecule. BioFactors (in press)
40. DR Yance SM Sagar 2006 Targeting angiogenesis with integrative cancer therapies Integrative Cancer Therapies 5 9 29 1:CAS:528:DC%2BD28Xis1arsLo%3D 10.1177/1534735405285562 16484711 (Pubitemid 43260791)
41. P Guha A Dey B Sarkar MV Dhyani S Chattopadhyay SK Bandyopadhyay 2009 Improved antiulcer and anticancer properties of a trans-resveratrol analog in mice The Journal of Pharmacology and Experimental Therapeutics 328 829 838 1:CAS:528:DC%2BD1MXislals7c%3D 10.1124/jpet.108.145334 19066340
42. ClinicalTrials.gov. (2010). A clinical study to assess the safety and activity of srt501 alone or in combination with bortezomib in patients with multiple myeloma. Bethesda: National Institutes of Health.
43. Liu, P. L., Tsai, J. R., Charles, A. L., Hwang, J. J., Chou, S. H., Ping, Y. H., et al. (2010) Resveratrol inhibits human lung adenocarcinoma cell metastasis by suppressing heme oxygenase 1-mediated nuclear factor-kappaB pathway and subsequently downregulating expression of matrix metalloproteinases. Molecular Nutrition & Food Research (in press)
44. T Uchiyama K Toda S Takahashi 2010 Resveratrol inhibits angiogenic response of cultured endothelial F-2 cells to vascular endothelial growth factor, but not to basic fibroblast growth factor Biological & Pharmaceutical Bulletin 33 1095 1100 10.1248/bpb.33.1095
45. N Gagliano G Aldini G Colombo R Rossi R Colombo M Gioia, et al. 2010 The potential of resveratrol against human gliomas Anti-Cancer Drugs 21 140 150 1:CAS:528:DC%2BD1MXhsFyktb%2FO 10.1097/CAD.0b013e32833498f1 20010425
46. Chatelain, K., Phippen, S., McCabe, J., Teeters, C. A., O'Malley, S., Kingsley, K. (2008) Cranberry and grape seed extracts inhibit the proliferative phenotype of oral squamous cell carcinomas. eCAM, nen047
47. Deziel, B. A., Patel, K., Neto, C., Gottschall-Pass, K., Hurta, R. A. (2010) Proanthocyanidins from the american cranberry (vaccinium macrocarpon) inhibit matrix metalloproteinase-2 and matrix metalloproteinase-9 activity in human prostate cancer cells via alterations in multiple cellular signalling pathways. Journal of Cellular Biochemistry. (epub ahead of print)
48. Boehm, K., Borrelli, F., Ernst, E., Habacher, G., Hung SK, Milazzo S, et al. (2009) Green tea (Camellia sinensis) for the prevention of cancer. Cochrane Database of Systematic Reviews CD005004
49. MS Butt MT Sultan 2009 Green tea: nature's defense against malignancies Critical Reviews in Food Science and Nutrition 49 463 473 1:CAS:528: DC%2BD1MXltFCjs7o%3D 10.1080/10408390802145310 19399671
50. SM Sagar D Yance RK Wong 2006 Natural health products that inhibit angiogenesis: a potential source for investigational new agents to treat cancer-Part 1 Curr Oncol 13 14 26 1:STN:280:DC%2BD2szmt1Whtg%3D%3D 17576437
51. S Hazgui A Bonnomet B Nawrocki-Raby M Milliot C Terryn J Cutrona, et al. 2008 Epigallocatechin-3-gallate (EGCG) inhibits the migratory behavior of tumor bronchial epithelial cells Respiratory Research 9 33 10.1186/1465-9921-9-33 18426555
52. K Kato NK Long H Makita M Toida T Yamashita D Hatakeyama, et al. 2008 Effects of green tea polyphenol on methylation status of RECK gene and cancer cell invasion in oral squamous cell carcinoma cells British Journal of Cancer 99 647 654 1:CAS:528:DC%2BD1cXpslWrt7c%3D 10.1038/sj.bjc.6604521 18665171
53. Larsen, C. A., & Dashwood, R. H. (2010) Epigallocatechin-3-gallate inhibits Met signaling, proliferation, and invasiveness in human colon cancer cells. Archives of Biochemistry and Biophysics. Corrected Proof
54. S Shankar S Ganapathy SR Hingorani RK Srivastava 2008 EGCG inhibits growth, invasion, angiogenesis and metastasis of pancreatic cancer Frontiers in Bioscience 13 440 452 10.2741/2691 17981559 (Pubitemid 351599756)
55. AY Issa SR Volate SJ Muga D Nitcheva T Smith MJ Wargovich 2007 Green tea selectively targets initial stages of intestinal carcinogenesis in the AOM-ApcMin mouse model Carcinogenesis 28 1978 1984 1:CAS:528:DC%2BD2sXhtFWhurjM 10.1093/carcin/bgm161 17638923 (Pubitemid 47500612)
56. SR Volate SJ Muga AY Issa D Nitcheva T Smith MJ Wargovich 2009 Epigenetic modulation of the retinoid X receptor alpha by green tea in the azoxymethane-Apc Min/+ mouse model of intestinal cancer Molecular Carcinogenesis 48 920 933 1:CAS:528:DC%2BD1MXhtFOkur3M 10.1002/mc.20542 19378291
57. MW Roomi JC Monterrey T Kalinovsky M Rath A Niedzwiecki 2010 Comparative effects of EGCG, green tea and a nutrient mixture on the patterns of MMP-2 and MMP-9 expression in cancer cell lines Oncology Reports 24 747 757 1:STN:280:DC%2BC3cjgs1Cjsw%3D%3D 20664983
58. IJ Park YK Lee JT Hwang DY Kwon J Ha OJ Park 2009 Green tea catechin controls apoptosis in colon cancer cells by attenuation of H2O2-stimulated COX-2 expression via the AMPK signaling pathway at low-dose H2O2 Annals of the New York Academy of Sciences 1171 538 544 1:CAS:528:DC%2BD1MXht1SntbfP 10.1111/j.1749-6632.2009.04698.x 19723101
59. KC Choi MG Jung YH Lee JC Yoon SH Kwon HB Kang, et al. 2009 Epigallocatechin-3-gallate, a histone acetyltransferase inhibitor, inhibits EBV-induced B lymphocyte transformation via suppression of RelA acetylation Cancer Research 69 583 592 1:CAS:528:DC%2BD1MXltFShtg%3D%3D 10.1158/0008-5472. CAN-08-2442 19147572
60. M Fang D Chen CS Yang 2007 Dietary polyphenols may affect DNA methylation The Journal of Nutrition 137 223S 228S 1:CAS:528:DC%2BD2sXms1egtA%3D%3D 17182830
61. K Srinivasan 2007 Black pepper and its pungent principle-piperine: a review of diverse physiological effects Critical Reviews in Food Science and Nutrition 47 735 748 1:CAS:528:DC%2BD2sXht1KmtrfO 10.1080/10408390601062054 17987447 (Pubitemid 350072517)
62. BB Aggarwal 2010 Targeting inflammation-induced obesity and metabolic diseases by curcumin and other nutraceuticals Annual Review of Nutrition 30 173 199 10.1146/annurev.nutr.012809.104755 20420526
63. DP Bezerra FO de Castro APNN Alves C Pessoa MO de Moraes ER Silveira, et al. 2008 In vitro and in vivo antitumor effect of 5-FU combined with piplartine and piperine Journal of Applied Toxicology 28 156 163 1:CAS:528: DC%2BD1cXjvVajt7c%3D 10.1002/jat.1261 17541943 (Pubitemid 351428288)
64. CR Pradeep G Kuttan 2002 Effect of piperine on the inhibition of lung metastasis induced B16F-10 melanoma cells in mice Clinical & Experimental Metastasis 19 703 708 1:CAS:528:DC%2BD38Xpt1Kqtbk%3D 10.1023/A:1021398601388 (Pubitemid 36092266)
65. M Kakarala D Brenner H Korkaya C Cheng K Tazi C Ginestier, et al. 2010 Targeting breast stem cells with the cancer preventive compounds curcumin and piperine Breast Cancer Research and Treatment 122 777 785 1:CAS:528: DC%2BC3cXoslehsLw%3D 10.1007/s10549-009-0612-x 19898931
66. S Barnes 2010 The biochemistry, chemistry and physiology of the isoflavones in soybeans and their food products Lymphatic Research and Biology 8 89 98 1:CAS:528:DC%2BC3cXjtlGhtr0%3D 10.1089/lrb.2009.0030 20235891
67. EA Rakha JS Reis-Filho IO Ellis 2010 Combinatorial biomarker expression in breast cancer Breast Cancer Research and Treatment 120 293 308 1:CAS:528:DC%2BC3cXjtlahur4%3D 10.1007/s10549-010-0746-x 20107892
68. AA Franke BM Halm K Kakazu X Li LJ Custer 2009 Phytoestrogenic isoflavonoids in epidemiologic and clinical research Drug Testing and Analysis 1 14 21 1:CAS:528:DC%2BD1MXkvFGmtLc%3D 10.1002/dta.12 20355154
69. WG Helferich JE Andrade MS Hoagland 2008 Phytoestrogens and breast cancer: a complex story Inflammopharmacology 16 219 226 1:CAS:528: DC%2BD1cXhtlOlsb3N 10.1007/s10787-008-8020-0 18815740
70. C Nagata 2010 Factors to consider in the association between soy isoflavone intake and breast cancer risk Journal of Epidemiology 20 83 89 10.2188/jea.JE20090181 20173308
71. El-Rayes, B. F., Philip, P. A., Sarkar, F. H., Shields, A. F., Ferris, A. M., Hess, K., et al. (2010) A phase II study of isoflavones, erlotinib, and gemcitabine in advanced pancreatic cancer. Investigational New Drugs. (in press).
72. SA Vantyghem SM Wilson CO Postenka W Al-Katib AB Tuck AF Chambers 2005 Dietary genistein reduces metastasis in a postsurgical orthotopic breast cancer model Cancer Research 65 3396 3403 1:CAS:528:DC%2BD2MXjt1yrsLY%3D 15833874
73. M Lakshman L Xu V Ananthanarayanan J Cooper CH Takimoto I Helenowski, et al. 2008 Dietary genistein inhibits metastasis of human prostate cancer in mice Cancer Research 68 2024 2032 1:CAS:528:DC%2BD1cXjtFOht7w%3D 10.1158/0008-5472. CAN-07-1246 18339885 (Pubitemid 351416590)
74. HG Farina M Pomies DF Alonso DE Gomez 2006 Antitumor and antiangiogenic activity of soy isoflavone genistein in mouse models of melanoma and breast cancer Oncology Reports 16 885 891 1:CAS:528:DC%2BD28XhtFSisrrK 16969510
75. AV Singh AA Franke GL Blackburn JR Zhou 2006 Soy phytochemicals prevent orthotopic growth and metastasis of bladder cancer in mice by alterations of cancer cell proliferation and apoptosis and tumor angiogenesis Cancer Research 66 1851 1858 1:CAS:528:DC%2BD28XpsVektw%3D%3D 10.1158/0008-5472.CAN-05-1332 16452247 (Pubitemid 43259972)
76. P Anand C Sundaram S Jhurani AB Kunnumakkara BB Aggarwal 2008 Curcumin and cancer: an "old-age" disease with an "age-old" solution Cancer Letters 267 133 164 1:CAS:528:DC%2BD1cXotlCgtbs%3D 10.1016/j.canlet.2008. 03.025 18462866
77. A Goel S Jhurani BB Aggarwal 2008 Multi-targeted therapy by curcumin: how spicy is it? Molecular Nutrition & Food Research 52 1010 1030 1:CAS:528:DC%2BD1cXht1SntrbO 10.1002/mnfr.200700354
78. BE Bachmeier P Killian U Pfeffer AG Nerlich 2010 Novel aspects for the application of Curcumin in chemoprevention of various cancers Frontiers in Bioscience: A Journal and Virtual Library (Schol Ed) 2 697 717
79. AM Kamat ST Tharakan B Sung BB Aggarwal 2009 Curcumin potentiates the antitumor effects of Bacillus Calmette-Guerin against bladder cancer through the downregulation of NF-kappaB and upregulation of TRAIL receptors Cancer Research 69 8958 8966 1:CAS:528:DC%2BD1MXhsV2itLjM 10.1158/0008-5472.CAN-09-2045 19903839
80. HJ Kang SH Lee JE Price LS Kim 2009 Curcumin suppresses the paclitaxel-induced nuclear factor-kappa beta in breast cancer cells and potentiates the growth inhibitory effect of paclitaxel in a breast cancer nude mice model The Breast Journal 15 223 229 1:CAS:528:DC%2BD1MXmtlOhtL4%3D 10.1111/j.1524-4741.2009.00709.x 19645775
81. AB Kunnumakkara P Diagaradjane P Anand KB Harikumar A Deorukhkar J Gelovani, et al. 2009 Curcumin sensitizes human colorectal cancer to capecitabine by modulation of cyclin D1, COX-2, MMP-9, VEGF and CXCR4 expression in an orthotopic mouse model International Journal of Cancer 125 2187 2197 1:CAS:528:DC%2BD1MXhtVOms7vK 10.1002/ijc.24593
82. S-S Lin K-C Lai S-C Hsu J-S Yang C-L Kuo J-P Lin, et al. 2009 Curcumin inhibits the migration and invasion of human A549 lung cancer cells through the inhibition of matrix metalloproteinase-2 and -9 and vascular endothelial growth factor (VEGF) Cancer Letters 285 127 133 1:CAS:528:DC%2BD1MXht1Ogtb%2FE 10.1016/j.canlet.2009.04.037 19477063
83. SK Sandur A Deorukhkar MK Pandey AM Pabon S Shentu S Guha, et al. 2009 Curcumin modulates the radiosensitivity of colorectal cancer cells by suppressing constitutive and inducible NF-kappaB activity International Journal of Radiation Oncology, Biology, Physics 75 534 542 1:CAS:528:DC%2BD1MXhtV2ktrbO 19735878