Ginger inhibits cell growth and modulates angiogenic factors in ovarian cancer cells

BMC Complementary and Alternative Medicine

Volumn 7, Issue , 2007, Pages

  Rhode, Jennifer ^a   Fogoros, Sarah ^b   Zick, Suzanna ^c   Wahl, Heather ^c   Griffith, Kent A ^d   Huang, Jennifer ^c   Rebecca, J Rebecca ^c  

^a WRIGHT PATTERSON AIR FORCE BASE   (United States)

^b NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 SHOGAOL; ANGIOGENIC FACTOR; GINGER EXTRACT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; SHOGAOL; UNCLASSIFIED DRUG; VASCULOTROPIN; ANTINEOPLASTIC AGENT; ANTIOXIDANT; FATTY ALCOHOL; GINGEROL; VASCULOTROPIN A;

ANTIANGIOGENIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CANCER PREVENTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ENZYME ACTIVATION; EPITHELIUM CELL; GROWTH INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; OVARY CANCER; CELL CULTURE; DOSE RESPONSE; FEMALE; METABOLISM; OVARY TUMOR; SECRETION; TUMOR CELL LINE;

ANGIOGENESIS INDUCING AGENTS; ANTICARCINOGENIC AGENTS; ANTIOXIDANTS; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; FATTY ALCOHOLS; FEMALE; HUMANS; INTERLEUKIN-8; NF-KAPPA B; OVARIAN NEOPLASMS; TUMOR CELLS, CULTURED; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 39149108129     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/1472-6882-7-44     Document Type: Article

References (51)

1. Jemal A Murray T Ward E Samuels A Tiwari RC Ghafoor A Feuer EJ Thun MJ Cancer statistics, 2005 CA Cancer J Clin 2005, 55(1):10-30 15661684
2. Casagrande JT Louie EW Pike MC Roy S Ross RK Henderson BE "Incessant ovulation" and ovarian cancer Lancet 1979, 2(8135):170-173 10.1016/S0140-6736(79)91435-1 89281
3. Fathalla MF Incessant ovulation - a factor in ovarian neoplasia? Lancet 1971, 2(7716):163 10.1016/S0140-6736(71)92335-X 4104488
4. Cramer DW Welch WR Determinants of ovarian cancer risk. II. Inferences regarding pathogenesis J Natl Cancer Inst 1983, 71(4):717-721 6578367
5. Ness RB Grisso JA Cottreau C Klapper J Vergona R Wheeler JE Morgan M Schlesselman JJ Factors related to inflammation of the ovarian epithelium and risk of ovarian cancer Epidemiology 2000, 11(2):111-117 10.1097/00001648-200003000-00006 11021606
6. Rae MT Niven D Critchley HO Harlow CR Hillier SG Antiinflammatory steroid action in human ovarian surface epithelial cells J Clin Endocrinol Metab 2004, 89(9):4538-4544 10.1210/jc.2003-032225 15356059
7. Balkwill F Coussens LM Cancer: An inflammatory link Nature 2004, 431(7007):405-406 10.1038/431405a 15385993
8. Hanahan D Weinberg RA The hallmarks of cancer Cell 2000, 100(1):57-70 10.1016/S0092-8674(00)81683-9 10647931
9. Pacifico F Leonardi A NF-kappaB in solid tumors Biochem Pharmacol 2006, 72(9):1142-1152 10.1016/j.bcp.2006.07.032 16956585
10. Kuo JM Yeh DB Pan BS Rapid photometric assay evaluating antioxidative activity in edible plant material Journal of Agricultural & Food Chemistry 1999, 47(8):3206-3209 10.1021/jf981351o
11. Reddy AC Lokesh BR Studies on spice principles as antioxidants in the inhibition of lipid peroxidation of rat liver microsomes Mol Cell Biochem 1992, 111(1-2):117-124 1588934
12. Krishnakantha TP Lokesh BR Scavenging of superoxide anions by spice principles Indian Journal of Biochemistry & Biophysics 1993, 30(2):133-134 8394839
13. Ahmed RS Seth V Banerjee BD Influence of dietary ginger (Zingiber officinales Rosc) on antioxidant defense system in rat: Comparison with ascorbic acid Indian Journal of Experimental Biology 2000, 38(6):604-606 11116533
14. Banerjee S Bueso-Ramos C Aggarwal BB Suppression of 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis in rats by resveratrol: Role of nuclear factor-kappaB, cyclooxygenase 2, and matrix metalloprotease 9 Cancer Res 2002, 62(17):4945-4954 12208745
15. Sekiwa Y Kubota K Kobayashi A Isolation of novel glucosides related to gingerdiol from ginger and their antioxidative activities Journal of Agricultural & Food Chemistry 2000, 48(2):373-377 10.1021/jf990674x
16. Grzanna R Lindmark L Frondoza CG Ginger - an herbal medicinal product with broad anti-inflammatory actions J Med Food 2005, 8(2):125-132 10.1089/jmf.2005.8.125 16117603
17. Lantz RC Chen GJ Sarihan M Solyom AM Jolad SD Timmermann BN The effect of extracts from ginger rhizome on inflammatory mediator production Phytomedicine 2006, 16709450
18. Jolad SD Lantz RC Chen GJ Bates RB Timmermann BN Commercially processed dry ginger (Zingiber officinale): Composition and effects on LPS-induced PGE2 production Phytochemistry 2005, 66(13):1614-1635 10.1016/ j.phytochem.2005.05.007 15996695
19. Jolad SD Lantz RC Solyom AM Chen GJ Bates RB Timmermann BN Fresh organically grown ginger (Zingiber officinale): Composition and effects on LPS-induced PGE2 production Phytochemistry 2004, 65(13):1937-1954 10.1016/j.phytochem.2004.06.008 15280001
20. Shukla Y Singh M Cancer preventive properties of ginger: A brief review Food Chem Toxicol 2006, 17175086
21. Ahmad N Katiyar SK Mukhtar H Antioxidants in chemoprevention of skin cancer. [Review] [28 refs] Current Problems in Dermatology 2001, 29:128-139 11225193
22. Katiyar SK Agarwal R Mukhtar H Inhibition of tumor promotion in SENCAR mouse skin by ethanol extract of Zingiber officinale rhizome Cancer Research 1996, 56(5):1023-1030 8640756
23. Surh Y Molecular mechanisms of chemopreventive effects of selected dietary and medicinal phenolic substances. [Review] [239 refs] Mutation Research 1999, 428(1-2):305-327 10518003
24. Manju V Nalini N Chemopreventive efficacy of ginger, a naturally occurring anticarcinogen during the initiation, post-initiation stages of 1,2 dimethylhydrazine-induced colon cancer Clin Chim Acta 2005, 358(1-2):60-67 10.1016/j.cccn.2005.02.018 16018877
25. Aktan F Henness S Tran VH Duke CC Roufogalis BD Ammit AJ Gingerol metabolite and a synthetic analogue Capsarol inhibit macrophage NF-kappaB-mediated iNOS gene expression and enzyme activity Planta Med 2006, 72(8):727-734 10.1055/s-2006-931588 16732525
26. Takada Y Murakami A Aggarwal BB Zerumbone abolishes NF-kappaB and IkappaBalpha kinase activation leading to suppression of antiapoptotic and metastatic gene expression, upregulation of apoptosis, and downregulation of invasion Oncogene 2005, 24(46):6957-6969 10.1038/ sj.onc.1208845 16007145
27. Kim SO Chun KS Kundu JK Surh YJ Inhibitory effects of [6]-gingerol on PMA-induced COX-2 expression and activation of NF-kappaB and p38 MAPK in mouse skin Biofactors 2004, 21(1-4):27-31 15630166
28. Kim SO Kundu JK Shin YK Park JH Cho MH Kim TY Surh YJ [6]-Gingerol inhibits COX-2 expression by blocking the activation of p38 MAP kinase and NF-kappaB in phorbol ester-stimulated mouse skin Oncogene 2005, 24(15):2558-2567 10.1038/sj.onc.1208446 15735738
29. Nonn L Duong D Peehl DM Chemopreventive anti-inflammatory activities of curcumin and other phytochemicals mediated by MAP kinase phosphatase-5 in prostate cells Carcinogenesis 2006, 17151092
30. Kim EC Min JK Kim TY Lee SJ Yang HO Han S Kim YM Kwon YG [6]-Gingerol, a pungent ingredient of ginger, inhibits angiogenesis in vitro and in vivo Biochem Biophys Res Commun 2005, 335(2):300-308 10.1016/ j.bbrc.2005.07.076 16081047
31. Hefler LA Zeillinger R Grimm C Sood AK Cheng WF Gadducci A Tempfer CB Reinthaller A Preoperative serum vascular endothelial growth factor as a prognostic parameter in ovarian cancer Gynecol Oncol 2006, 103(2):512-517 10.1016/j.ygyno.2006.03.058 16750560
32. Neufeld G Kessler O Pro-angiogenic cytokines and their role in tumor angiogenesis Cancer Metastasis Rev 2006, 17006765
33. Xie K Interleukin-8 and human cancer biology Cytokine Growth Factor Rev 2001, 12(4):375-391 10.1016/S1359-6101(01)00016-8 11544106
34. Lokshin AE Winans M Landsittel D Marrangoni AM Velikokhatnaya L Modugno F Nolen BM Gorelik E Circulating IL-8 and anti-IL-8 autoantibody in patients with ovarian cancer Gynecol Oncol 2006, 16434085
35. Wang Y Yang J Gao Y Du Y Bao L Niu W Yao Z Regulatory effect of e2, IL-6 and IL-8 on the growth of epithelial ovarian cancer cells Cell Mol Immunol 2005, 2(5):365-372 16368063
36. Baranowska I Baranowski J Norska-Borowka I Pieszko C Separation and identification of metals in human bones, placenta and milk and in air by adsorption and ion-exchange thin-layer chromatography J Chromatogr A 1996, 725(1):199-202 10.1016/0021-9673(95)00946-9 8900519
37. Skehan P Storeng R Scudiero D Monks A McMahon J Vistica D Warren JT Bokesch H Kenney S Boyd MR New colorimetric cytotoxicity assay for anticancer-drug screening J Natl Cancer Inst 1990, 82(13):1107-1112 10.1093/jnci/82.13.1107 2359136
38. Kruk PA Maines-Bandiera SL Auersperg N A simplified method to culture human ovarian surface epithelium Lab Invest 1990, 63(1):132-136 2374399
39. Wahl H Tan L Griffith K Choi M Liu JR Curcumin enhances Apo2L/ TRAIL-induced apoptosis in chemoresistant ovarian cancer cells Gynecol Oncol 2006, 17174384
40. Hsu MH Kuo SC Chen CJ Chung JG Lai YY Huang LJ 1-(3,4-dimethoxyphenyl)-3,5-dodecenedione (I6) induces G1 arrest and apoptosis in human promyelocytic leukemia HL-60 cells Leuk Res 2005, 29(12):1399-1406 10.1016/j.leukres.2005.04.014 15927254
41. Miyoshi N Nakamura Y Ueda Y Abe M Ozawa Y Uchida K Osawa T Dietary ginger constituents, galanals A and B, are potent apoptosis inducers in Human T lymphoma Jurkat cells Cancer Lett 2003, 199(2):113-119 10.1016/ S0304-3835(03)00381-1 12969783
42. Young HY Luo YL Cheng HY Hsieh WC Liao JC Peng WH Analgesic and anti-inflammatory activities of [6]-gingerol J Ethnopharmacol 2005, 96(1-2):207-210 10.1016/j.jep.2004.09.009 15588672
43. Bode AM Ma WY Surh YJ Dong Z Inhibition of epidermal growth factor-induced cell transformation and activator protein 1 activation by [6]-gingerol Cancer Res 2001, 61(3):850-853 11221868
44. Aggarwal BB Shishodia S Takada Y Banerjee S Newman RA Bueso-Ramos CE Price JE Curcumin suppresses the paclitaxel-induced nuclear factor-kappaB pathway in breast cancer cells and inhibits lung metastasis of human breast cancer in nude mice Clin Cancer Res 2005, 11(20):7490-7498 10.1158/1078-0432.CCR-05-1192 16243823
45. Deeb D Jiang H Gao X Hafner MS Wong H Divine G Chapman RA Dulchavsky SA Gautam SC Curcumin sensitizes prostate cancer cells to tumor necrosis factor-related apoptosis-inducing ligand/Apo2L by inhibiting nuclear factor-kappaB through suppression of IkappaBalpha phosphorylation Mol Cancer Ther 2004, 3(7):803-812 15252141
46. Brew R Erikson JS West DC Flanagan BF Christmas SE Interleukin-8 as a growth factor for human colorectal carcinoma cells in vitro Biochem Soc Trans 1997, 25(2):264S 9191308
47. Brew R Erikson JS West DC Kinsella AR Slavin J Christmas SE Interleukin-8 as an autocrine growth factor for human colon carcinoma cells in vitro Cytokine 2000, 12(1):78-85 10.1006/cyto.1999.0518 10623446
48. Monk BJ Choi DC Pugmire G Burger RA Activity of bevacizumab (rhuMAB VEGF) in advanced refractory epithelial ovarian cancer Gynecol Oncol 2005, 96(3):902-905 10.1016/j.ygyno.2004.12.001 15721449
49. Dorai T Aggarwal BB Role of chemopreventive agents in cancer therapy Cancer Lett 2004, 215(2):129-140 10.1016/j.canlet.2004.07.013 15488631
50. Chen CY Liu TZ Liu YW Tseng WC Liu RH Lu FJ Lin YS Kuo SH Chen CH 6-shogaol (alkanone from ginger) induces apoptotic cell death of human hepatoma p53 mutant Mahlavu subline via an oxidative stress-mediated caspase-dependent mechanism J Agric Food Chem 2007, 55(3):948-954 10.1021/jf0624594 17263498
51. Kyung KS Gon JH Geun KY Sup JJ Suk WJ Ho KJ 6-Shogaol, a natural product, reduces cell death and restores motor function in rat spinal cord injury Eur J Neurosci 2006, 24(4):1042-1052 10.1111/ j.1460-9568.2006.04908.x 16930431