The cardiovascular effects of methylxanthines

Handbook of Experimental Pharmacology

Volumn 200, Issue , 2011, Pages 413-437

  Riksen, Niels P ^a   Smits, Paul ^a   Rongen, Gerard A ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Adenosine; Blood pressure; Caffeine; Cardiovascular effects

Indexed keywords

ADENOSINE; ADENOSINE RECEPTOR; ATORVASTATIN; CAFFEINE; CHOLESTEROL; ENPROFYLLINE; HOMOCYSTEINE; METHYLXANTHINE; PARAXANTHINE; PENTOXIFYLLINE; THEOBROMINE; THEOPHYLLINE;

ACUTE HEART INFARCTION; ADRENERGIC SYSTEM; AMINO ACID BLOOD LEVEL; AUTONOMIC NERVOUS SYSTEM; BLOOD PRESSURE FLUCTUATION; BLOOD VESSEL TONE; BRADYCARDIA; CARDIOVASCULAR EFFECT; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; COFFEE; CORONARY ARTERY DILATATION; DRUG EFFECT; DRUG MECHANISM; FOOD DRUG INTERACTION; HEART ARRHYTHMIA; HEART BLOOD VESSEL; HEART HEMODYNAMICS; HEART PERFUSION; HEART RATE; HUMAN; IN VITRO STUDY; IN VIVO STUDY; ISCHEMIC HEART DISEASE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PERCUTANEOUS CORONARY INTERVENTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REVIEW;

ANIMALS; AUTONOMIC NERVOUS SYSTEM; CAFFEINE; COFFEE; HEART; HEMODYNAMICS; HUMANS; RENIN-ANGIOTENSIN SYSTEM;

EID: 77957557709     PISSN: 01712004     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-642-13443-2_16     Document Type: Review

References (165)

1. Agwunobi J, Abedin M, Young M, Beeram M, Sinkford S (1996) Impact of theophylline use in Wolff-Parkinson-White syndrome. J Natl Med Assoc 88:450-452
2. Ammon HP, Bieck PR, Mandalaz D, Verspohl EJ (1983) Adaptation of blood pressure to continuous heavy coffee drinking in young volunteers. A double-blind crossover study. Br J Clin Pharmacol 15:701-706
3. Andreas S, Reiter H, Luthje L et al (2004) Differential effects of theophylline on sympathetic excitation, hemodynamics, and breathing in congestive heart failure. Circulation 110:2157-2162
4. Bak AA, Grobbee DE (1990) A randomized study on coffee and blood pressure. J Hum Hypertens 4:259-264
5. Bardou M, Goirand F, Bernard A et al (2002) Relaxant effects of selective phosphodiesterase inhibitors on U46619 precontracted human intralobar pulmonary arteries and role of potassium channels. J Cardiovasc Pharmacol 40:153-161
6. 2A receptors associated with norepinephrine release and their desensitization in the rat nucleus tractus solitarius. J Neurochem 65:1604-1611
7. Baylin A, Hernandez-Diaz S, Kabagambe EK, Siles X, Campos H (2006) Transient exposure to coffee as a trigger of a first nonfatal myocardial infarction. Epidemiology 17:506-511
8. Belardinelli L, Linden J, Berne RM (1989) The cardiac effects of adenosine. Prog Cardiovasc Dis 32:73-97
9. 2A adenosine receptor mediates coronary vasodilation. J Pharmacol Exp Ther 284:1066-1073 (Pubitemid 28130836)
10. Belardinelli L, Shryock JC, Song Y, Wang D, Srinivas M (1995) Ionic basis of the electrophysiological actions of adenosine on cardiomyocytes. FASEB J 9:359-365
11. Biaggioni I, Olafsson B, Robertson RM, Hollister AS, Robertson D (1987) Cardiovascular and respiratory effects of adenosine in conscious man. Evidence for chemoreceptor activation. Circ Res 61:779-786
12. Biaggioni I, Onrot J, Hollister AS, Robertson D (1986) Cardiovascular effects of adenosine infusion in man and their modulation by dipyridamole. Life Sci 39:2229-2236
13. Biaggioni I, Paul S, Puckett A, Arzubiaga C (1991) Caffeine and theophylline as adenosine receptor antagonists in humans. J Pharmacol Exp Ther 258:588-593
14. Bijlstra P, van Ginneken EE, Huls M, van Dijk R, Smits P, Rongen GA (2004) Glyburide inhibits dipyridamole-induced forearm vasodilation but not adenosine-induced forearm vasodilation. Clin Pharmacol Ther 75:147-156
15. Brodmann M, Lischnig U, Lueger A, Pilger E, Stark G (2003) The effect of caffeine on peripheral vascular resistance in isolated perfused guinea pig hind limbs. J Cardiovasc Pharmacol 42:506-510
16. Brown NJ, Ryder D, Nadeau J (1993) Caffeine attenuates the renal vascular response to angiotensin II infusion. Hypertension 22:847-852
17. Burr ML, Gallacher JE, Butland BK, Bolton CH, Downs LG (1989) Coffee, blood pressure and plasma lipids: a randomized controlled trial. Eur J Clin Nutr 43:477-483
18. Butcher RW, Sutherland EW (1962) Adenosine 3′, 5′-phosphate in biological materials. I. Purification and properties of cyclic 3′, 5′-nucleotide phosphodiesterase and use of this enzyme to characterize adenosine 3′, 5′-phosphate in human urine. J Biol Chem 237:1244-1250
19. Cannon ME, Cooke CT, McCarthy JS (2001) Caffeine-induced cardiac arrhythmia: an unrecognised danger of healthfood products. Med J Aust 174:520-521
20. 3 receptors in protection of isolated human atrial muscle against simulated ischaemia. Cardiovasc Res 36:52-59
21. Casiglia E, Bongiovi S, Paleari CD et al (1991) Haemodynamic effects of coffee and caffeine in normal volunteers: a placebo-controlled clinical study. J Intern Med 229:501-504
22. Cawley MJ, Al-Jazairi AS, Stone EA (2001) Intravenous theophylline-an alternative to temporary pacing in the management of bradycardia secondary to AV nodal block. Ann Pharmacother 35:303-307
23. Christensen B, Mosdol A, Retterstol L, Landaas S, Thelle DS (2001) Abstention from filtered coffee reduces the concentrations of plasma homocysteine and serum cholesterol: a randomized controlled trial. Am J Clin Nutr 74:302-307
24. Conlay LA, Conant JA, deBros F, Wurtman R (1997) Caffeine alters plasma adenosine levels. Nature 389:136
25. Cornelis MC, El-Sohemy A, Kabagambe EK, Campos H (2006) Coffee, CYP1A2 genotype, and risk of myocardial infarction. JAMA 295:1135-1141
26. Costa F, Biaggioni I (1994) Role of adenosine in the sympathetic activation produced by isometric exercise in humans. J Clin Invest 93:1654-1660
27. Cox DA, Vita JA, Treasure CB, Fish RD, Selwyn AP, Ganz P (1989) Reflex increase in blood pressure during the intracoronary administration of adenosine in man. J Clin Invest 84:592-596
28. Daniels JW, Mole PA, Shaffrath JD, Stebbins CL (1998) Effects of caffeine on blood pressure, heart rate, and forearm blood flow during dynamic leg exercise. J Appl Physiol 85:154-159
29. DeLago A, El-Hajjar M, Kirnus M (2008) Aminophylline for prevention of bradyarrhythmias induced by rheolytic thrombectomy. J Invasive Cardiol 20:9A-11A
30. Dimarco AF, Nochomovitz M, DiMarco MS, Altose MD, Kelsen SG (1985) Comparative effects of aminophylline on diaphragm and cardiac contractility. Am Rev Respir Dis 132:800-805
31. 3 receptors on the differential modulation of norepinephrine and neuropeptide Y release from peripheral sympathetic nerve terminals. J Neurochem 96:1680-1695
32. Edlund A, Conradsson T, Sollevi A (1995) A role for adenosine in coronary vasoregulation in man. Effects of theophylline and enprofylline. Clin Physiol 15:623-636
33. Edlund A, Sollevi A (1995) Theophylline increases coronary vascular tone in humans: evidence for a role of endogenous adenosine in flow regulation. Acta Physiol Scand 155:303-311
34. Eppel GA, Ventura S, Evans RG (2006) Regional vascular responses to ATP and ATP analogues in the rabbit kidney in vivo: roles for adenosine receptors and prostanoids. Br J Pharmacol 149:523-531
35. Farag NH, Vincent AS, McKey BS, Whitsett TL, Lovallo WR (2005) Hemodynamic mechanisms underlying the incomplete tolerance to caffeine's pressor effects. Am J Cardiol 95:1389-1392
36. 2B receptors evoke interleukin-8 secretion in human mast cells. An enprofylline-sensitive mechanism with implications for asthma. J Clin Invest 96:1979-1986
37. Francis SH, Sekhar KR, Ke H, Corbin JD (2010) Inhibition of cyclic nucleotide phosphodiesterases by methylxanthines and related compounds. In: Fredholm BB (ed) Methylxanthines. Springer, Heidelberg
38. Fredholm BB (1980) Are methylxanthine effects due to antagonism of endogenous adenosine? Trends Pharmacol Sci 1:129-132
39. Fredholm BB (1984) Cardiovascular and renal actions of methylxanthines. Prog Clin Biol Res 158:303-330
40. Fredholm BB, Battig K, Holmen J, Nehlig A, Zvartau EE (1999) Actions of caffeine in the brain with special reference to factors that contribute to its widespread use. Pharmacol Rev 51:83-133
41. Fredholm BB, Hedqvist P, Vernet L (1978) Effect of theophylline and other drugs on rabbit renal cyclic nucleotide phosphodiesterase, 5′- nucleotidase and adenosine deaminase. Biochem Pharmacol 27:2845-2850
42. Fredholm BB, IJzerman AP, Jacobson KA, Klotz KN, Linden J (2001a) International union of pharmacology. XXV. Nomenclature and classification of adenosine receptors. Pharmacol Rev 53:527-552
43. Fredholm BB, Irenius E, Kull B, Schulte G (2001b) Comparison of the potency of adenosine as an agonist at human adenosine receptors expressed in Chinese hamster ovary cells. Biochem Pharmacol 61:443-448
44. Fredholm BB, Persson CG (1982) Xanthine derivatives as adenosine receptor antagonists. Eur J Pharmacol 81:673-676
45. Frost L, Vestergaard P (2005) Caffeine and risk of atrial fibrillation or flutter: the Danish diet, cancer, and health study. Am J Clin Nutr 81:578-582
46. Greenland S (1993) A meta-analysis of coffee, myocardial infarction, and coronary death. Epidemiology 4:366-374
47. Grossmann M, Braune J, Ebert U, Kirch W (1998) Dilatory effects of phosphodiesterase inhibitors on human hand veins in vivo. Eur J Clin Pharmacol 54:35-39 (Pubitemid 28189397)
48. Grubben MJ, Boers GH, Blom HJ et al (2000) Unfiltered coffee increases plasma homocysteine concentrations in healthy volunteers: a randomized trial. Am J Clin Nutr 71:480-484
49. Guerreiro S, Marien M, Michel PP (2010) Methylxanthines and ryanodine receptor channels. In: Fredholm BB (ed) Methylxanthines. Springer, Heidelberg
50. Happonen P, Voutilainen S, Tuomainen TP, Salonen JT (2006) Catechol-O-methyltransferase gene polymorphism modifies the effect of coffee intake on incidence of acute coronary events. PLoS ONE 1: e117
51. Harada K, Ohashi K, Kumagai Y, Fujimura A (1995) Comparison of venodilatory effect of amrinone and theophylline in human subjects. J Clin Pharmacol 35:1067-1070
52. Hasko G, Linden J, Cronstein B, Pacher P (2008) Adenosine receptors: therapeutic aspects for inflammatory and immune diseases. Nat Rev Drug Discov 7:759-770
53. Hausenloy DJ, Yellon DM (2007) Preconditioning and postconditioning: united at reperfusion. Pharmacol Ther 116:173-191
54. Hinschen AK, Rose'Meyer RB, Headrick JP (2003) Adenosine receptor subtypes mediating coronary vasodilation in rat hearts. J Cardiovasc Pharmacol 41:73-80
55. Hu G, Jousilahti P, Nissinen A, Bidel S, Antikainen R, Tuomilehto J (2007) Coffee consumption and the incidence of antihypertensive drug treatment in Finnish men and women. Am J Clin Nutr 86:457-464
56. Ishibashi Y, Duncker DJ, Zhang J, Bache RJ (1998) ATP-sensitive K+ channels, adenosine, and nitric oxide-mediated mechanisms account for coronary vasodilation during exercise. Circ Res 82:346-359
57. Ishida S, Ito M, Takahashi N, Fujino T, Akimitsu T, Saikawa T (1996) Caffeine induces ventricular tachyarrhythmias possibly due to triggered activity in rabbits in vivo. Jpn Circ J 60:157-165
58. Jansen DF, Nedeljkovic S, Feskens EJ et al (1995) Coffee consumption, alcohol use, and cigarette smoking as determinants of serum total and HDL cholesterol in two Serbian cohorts of the Seven Countries Study. Arterioscler Thromb Vasc Biol 15:1793-1797
59. Jee SH, He J, Appel LJ, Whelton PK, Suh I, Klag MJ (2001) Coffee consumption and serum lipids: a meta-analysis of randomized controlled clinical trials. Am J Epidemiol 153:353-362
60. Jee SH, He J, Whelton PK, Suh I, Klag MJ (1999) The effect of chronic coffee drinking on blood pressure: a meta-analysis of controlled clinical trials. Hypertension 33:647-652
61. Kabagambe EK, Baylin A, Campos H (2007) Nonfatal acute myocardial infarction in Costa Rica: modifiable risk factors, population-attributable risks, and adherence to dietary guidelines. Circulation 115:1075-1081
62. Kamphuis J, Smits P, Thien T (1994) Vascular effects of pentoxifylline in humans. J Cardiovasc Pharmacol 24:648-654
63. Karatzis E, Papaioannou TG, Aznaouridis K et al (2005) Acute effects of caffeine on blood pressure and wave reflections in healthy subjects: should we consider monitoring central blood pressure? Int J Cardiol 98:425-430
64. Kawachi I, Colditz GA, Stone CB (1994) Does coffee drinking increase the risk of coronary heart disease? Results from a meta-analysis. Br Heart J 72:269-275
65. 2B receptors. Br J Pharmacol 126:1796-1800
66. Klag MJ, Wang NY, Meoni LA et al (2002) Coffee intake and risk of hypertension: the Johns Hopkins precursors study. Arch Intern Med 162:657-662
67. Klatsky AL, Koplik S, Kipp H, Friedman GD (2008) The confounded relation of coffee drinking to coronary artery disease. Am J Cardiol 101:825-827
68. Klotz KN, Hessling J, Hegler J et al (1998) Comparative pharmacology of human adenosine receptor subtypes - characterization of stably transfected receptors in CHO cells. Naunyn Schmiedebergs Arch Pharmacol 357:1-9
69. 2+ activation of the ryanodine receptor. Biochem J 414:441-452
70. Lai EY, Patzak A, Steege A et al (2006) Contribution of adenosine receptors in the control of arteriolar tone and adenosine-angiotensin II interaction. Kidney Int 70:690-698
71. 2A adenosine receptor agonist, causes dose-dependent increases in coronary blood flow velocity in humans. J Nucl Cardiol 14:514-520
72. Lindahl B, Johansson I, Huhtasaari F, Hallmans G, Asplund K (1991) Coffee drinking and blood cholesterol: effects of brewing method, food intake and life style. J Intern Med 230:299-305
73. Little JA, Shanoff HM, Csima A, Toronto MA, Yano R (1966) Coffee and serum-lipids in coronary heart-disease. Lancet 1:732-734
74. Lo YC, Tsou HH, Lin RJ et al (2005) Endothelium-dependent and-independent vasorelaxation by a theophylline derivative MCPT: roles of cyclic nucleotides, potassium channel opening and phosphodiesterase inhibition. Life Sci 76:931-944
75. Lopez-Garcia E, van Dam RM, Li TY, Rodriguez-Artalejo F, Hu FB (2008) The relationship of coffee consumption with mortality. Ann Intern Med 148:904-914
76. Lovallo WR, Wilson MF, Vincent AS, Sung BH, McKey BS, Whitsett TL (2004) Blood pressure response to caffeine shows incomplete tolerance after short-term regular consumption. Hypertension 43:760-765
77. MacDonald TM, Sharpe K, Fowler G et al (1991) Caffeine restriction: effect on mild hypertension. BMJ 303:1235-1238
78. Mahmud A, Feely J (2001) Acute effect of caffeine on arterial stiffness and aortic pressure waveform. Hypertension 38:227-231
79. McNamara R, Maginn M, Harkin A (2007) Caffeine induces a profound and persistent tachycardia in response to MDMA ("Ecstasy") administration. Eur J Pharmacol 555:194-198
80. McPherson PS, Kim YK, Valdivia H et al (1991) The brain ryanodine receptor: a caffeinesensitive calcium release channel. Neuron 7:17-25
81. Mehta MC, Jain AC, Billie M (2004) Effects of cocaine and caffeine alone and in combination on cardiovascular performance: an experimental hemodynamic and coronary flow reserve study in a canine model. Int J Cardiol 97:225-232
82. Meijer P, Oyen WJ, Dekker D et al (2009) Rosuvastatin increases extracellular adenosine formation in humans in vivo: a new perspective on cardiovascular protection. Arterioscler Thromb Vasc Biol 29:963-968
83. Melchert PJ, Duncker DJ, Traverse JH, Bache RJ (1999) Role of K (+) (ATP) channels and adenosine in regulation of coronary blood flow in the hypertrophied left ventricle. Am J Physiol 277: H617-H625
84. Müller C, Jacobson KA (2010) Xanthines as adenosine receptor antagonists. In: Fredholm BB (ed) Methylxanthines. Springer, Heidelberg
85. Myers MG, Basinski A (1992) Coffee and coronary heart disease. Arch Intern Med 152:1767-1772
86. Newton GE, Azevedo ER, Parker JD (1999) Inotropic and sympathetic responses to the intracoronary infusion of a beta2-receptor agonist: a human in vivo study. Circulation 99:2402-2407
87. Noordzij M, Uiterwaal CS, Arends LR, Kok FJ, Grobbee DE, Geleijnse JM (2005) Blood pressure response to chronic intake of coffee and caffeine: a meta-analysis of randomized controlled trials. J Hypertens 23:921-928
88. Notarius CF, Atchison DJ, Rongen GA, Floras JS (2001) Effect of adenosine receptor blockade with caffeine on sympathetic response to handgrip exercise in heart failure. Am J Physiol Heart Circ Physiol 281: H1312-H1318
89. Notarius CF, Rongen GA, Floras JS (2003) Caffeine and coffee tolerance. Circulation 108: e38-e40
90. Nurminen ML, Niittynen L, Korpela R, Vapaatalo H (1999) Coffee, caffeine and blood pressure: a critical review. Eur J Clin Nutr 53:831-839
91. Nygard O, Nordrehaug JE, Refsum H, Ueland PM, Farstad M, Vollset SE (1997) Plasma homocysteine levels and mortality in patients with coronary artery disease. N Engl J Med 337:230-236 (Pubitemid 27310438)
92. Olthof MR, Hollman PC, Zock PL, Katan MB (2001) Consumption of high doses of chlorogenic acid, present in coffee, or of black tea increases plasma total homocysteine concentrations in humans. Am J Clin Nutr 73:532-538
93. Panagiotakos DB, Pitsavos C, Zampelas A et al (2004) The association between coffee consumption and plasma total homocysteine levels: the "ATTICA" study. Heart Vessels 19:280-286 (Pubitemid 39600420)
94. Paoloni HJ, Wilcken DE (1975) The action of aminophylline on the acutely transplanted dog heart: effect of alpha-and beta-adrenoceptor blockade. Br J Pharmacol 53:163-171
95. Papamichael CM, Aznaouridis KA, Karatzis EN et al (2005) Effect of coffee on endothelial function in healthy subjects. The role of caffeine. Clin Sci (Lond) 109:55-60
96. Patti G, Pasceri V, Colonna G et al (2007) Atorvastatin pretreatment improves outcomes in patients with acute coronary syndromes undergoing early percutaneous coronary intervention: results of the ARMYDA-ACS randomized trial. J Am Coll Cardiol 49:1272-1278
97. Paynter NP, Yeh HC, Voutilainen S et al (2006) Coffee and sweetened beverage consumption and the risk of type 2 diabetes mellitus: the atherosclerosis risk in communities study. Am J Epidemiol 164:1075-1084
98. Pereira MA, Parker ED, Folsom AR (2006) Coffee consumption and risk of type 2 diabetes mellitus: an 11-year prospective study of 28 812 postmenopausal women. Arch Intern Med 166:1311-1316
99. Persson PB (2001) Tubuloglomerular feedback in adenosine A1 receptor-deficient mice. Am J Physiol Regul Integr Comp Physiol 281: R1361
100. Phillis JW, Song D, O'Regan MH (1998) The role of adenosine in rat coronary flow regulation during respiratory and metabolic acidosis. Eur J Pharmacol 356:199-206
101. Pietinen P, Aro A, Tuomilehto J, Uusitalo U, Korhonen H (1990) Consumption of boiled coffee is correlated with serum cholesterol in Finland. Int J Epidemiol 19:586-590
102. Pincomb GA, Lovallo WR, Passey RB, Whitsett TL, Silverstein SM, Wilson MF (1985) Effects of caffeine on vascular resistance, cardiac output and myocardial contractility in young men. Am J Cardiol 56:119-122
103. Plagemann PG, Wohlhueter RM (1984) Inhibition of the transport of adenosine, other nucleosides and hypoxanthine in Novikoff rat hepatoma cells by methylxanthines, papaverine, N6-cyclohexyladenosine and N6- phenylisopropyladenosine. Biochem Pharmacol 33:1783-1788
104. Rakic V, Burke V, Beilin LJ (1999) Effects of coffee on ambulatory blood pressure in older men and women: a randomized controlled trial. Hypertension 33:869-873
105. Ramakers BP, Pickkers P, Deussen A et al (2008) Measurement of the endogenous adenosine concentration in humans in vivo: methodological considerations. Curr Drug Metab 9:679-685
106. Rasmussen CA Jr, Sutko JL, Barry WH (1987) Effects of ryanodine and caffeine on contractility, membrane voltage, and calcium exchange in cultured heart cells. Circ Res 60:495-504
107. Riksen NP, Rongen GA, Smits P (2009) Acute and long-term cardiovascular effects of coffee: implications for coronary heart disease. Pharmacol Ther 121:185-191
108. Riksen NP, Rongen GA, Yellon D, Smits P (2008) Human in vivo research on the vascular effects of adenosine. Eur J Pharmacol 585:220-227
109. Riksen NP, Zhou Z, Oyen WJ et al (2006) Caffeine prevents protection in two human models of ischemic preconditioning. J Am Coll Cardiol 48:700-707
110. Robertson D, Frolich JC, Carr RK et al (1978) Effects of caffeine on plasma renin activity, catecholamines and blood pressure. N Engl J Med 298:181-186
111. Robertson D, Wade D, Workman R, Woosley RL, Oates JA (1981) Tolerance to the humoral and hemodynamic effects of caffeine in man. J Clin Invest 67:1111-1117
112. Rongen GA, Brooks SC, Ando S, Abramson BL, Floras JS (1998a) Angiotensin AT1 receptor blockade abolishes the reflex sympatho-excitatory response to adenosine. J Clin Invest 101:769-776
113. Rongen GA, Brooks SC, Ando S, Notarius CF, Floras JS (1998b) Caffeine abstinence augments the systolic blood pressure response to adenosine in humans. Am J Cardiol 81:1382-1385
114. Rongen GA, Floras JS, Lenders JW, Thien T, Smits P (1997) Cardiovascular pharmacology of purines. Clin Sci (Lond) 92:13-24
115. Rongen GA, Lenders JW, Lambrou J et al (1996) Presynaptic inhibition of norepinephrine release from sympathetic nerve endings by endogenous adenosine. Hypertension 27:933-938
116. Rongen GA, Smits P, Verdonck K et al (1995) Hemodynamic and neurohumoral effects of various grades of selective adenosine transport inhibition in humans. Implications for its future role in cardioprotection. J Clin Invest 95:658-668
117. Rosmarin PC, Applegate WB, Somes GW (1990) Coffee consumption and blood pressure: a randomized, crossover clinical trial. J Gen Intern Med 5:211-213
118. Rosner SA, Akesson A, Stampfer MJ, Wolk A (2007) Coffee consumption and risk of myocardial infarction among older Swedish women. Am J Epidemiol 165:288-293
119. Rutherford JD, Vatner SF, Braunwald E (1981) Effects and mechanism of action of aminophylline on cardiac function and regional blood flow distribution in conscious dogs. Circulation 63:378-387
120. Sanada S, Asanuma H, Minamino T et al (2004) Optimal windows of statin use for immediate infarct limitation: 5′-nucleotidase as another downstream molecule of phosphatidylinositol 3-kinase. Circulation 110:2143-2149
121. Sattin A, Rall TW (1970) The effect of adenosine and adenine nucleotides on the cyclic adenosine 3′, 5′-phosphate content of guinea pig cerebral cortex slices. Mol Pharmacol 6:13-23
122. 2 adenosine receptors. Naunyn Schmiedebergs Arch Pharmacol 330:212-221 (Pubitemid 15003581)
123. Sekiguchi F, Miyake Y, Kashimoto T, Sunano S (2002) Unaltered caffeine-induced relaxation in the aorta of stroke-prone spontaneously hypertensive rats (SHRSP). J Smooth Muscle Res 38:11-22 (Pubitemid 34988301)
124. Smits P, Boekema P, De Abreu R, Thien T, van't Laar A (1987) Evidence for an antagonism between caffeine and adenosine in the human cardiovascular system. J Cardiovasc Pharmacol 10:136-143
125. Smits P, Lenders JW, Thien T (1990) Caffeine and theophylline attenuate adenosine-induced vasodilation in humans. Clin Pharmacol Ther 48:410-418
126. Smits P, Pieters G, Thien T (1986) The role of epinephrine in the circulatory effects of coffee. Clin Pharmacol Ther 40:431-437
127. Smits P, Schouten J, Thien T (1989) Cardiovascular effects of two xanthines and the relation to adenosine antagonism. Clin Pharmacol Ther 45:593-599
128. Smits P, Thien T, Van't Laar A (1985a) The cardiovascular effects of regular and decaffeinated coffee. Br J Clin Pharmacol 19:852-854
129. Smits P, Thien T, Laar A (1985b) Circulatory effects of coffee in relation to the pharmacokinetics of caffeine. Am J Cardiol 56:958-963
130. Sofi F, Conti AA, Gori AM et al (2007) Coffee consumption and risk of coronary heart disease: a meta-analysis. Nutr Metab Cardiovasc Dis 17:209-223
131. Song Y, Shryock JC, Knot HJ, Belardinelli L (2001) Selective attenuation by adenosine of arrhythmogenic action of isoproterenol on ventricular myocytes. Am J Physiol Heart Circ Physiol 280: H2789-H2795
132. Stolzenberg-Solomon RZ, Miller ER III, Maguire MG, Selhub J, Appel LJ (1999) Association of dietary protein intake and coffee consumption with serum homocysteine concentrations in an older population. Am J Clin Nutr 69:467-475
133. Strandhagen E, Thelle DS (2003) Filtered coffee raises serum cholesterol: results from a controlled study. Eur J Clin Nutr 57:1164-1168
134. Strandhagen E, Zetterberg H, Aires N et al (2004) The methylenetetrahydrofolate reductase C677T polymorphism is a major determinant of coffee-induced increase of plasma homocysteine: a randomized placebo controlled study. Int J Mol Med 13:811-815
135. Superko HR, Bortz W Jr, Williams PT, Albers JJ, Wood PD (1991) Caffeinated and decaffeinated coffee effects on plasma lipoprotein cholesterol, apolipoproteins, and lipase activity: a controlled, randomized trial. Am J Clin Nutr 54:599-605
136. Superko HR, Myll J, DiRicco C, Williams PT, Bortz WM, Wood PD (1994) Effects of cessation of caffeinated-coffee consumption on ambulatory and resting blood pressure in men. Am J Cardiol 73:780-784
137. Sutton-Tyrrell K, Najjar SS, Boudreau RM et al (2005) Elevated aortic pulse wave velocity, a marker of arterial stiffness, predicts cardiovascular events in well-functioning older adults. Circulation 111:3384-3390
138. Taddei S, Virdis A, Mattei P, Favilla S, Salvetti A (1991) Adenosine causes angiotensin II release in human forearm arterioles. J Hypertens Suppl 9: S232-S233
139. Tawfik HE, Schnermann J, Oldenburg PJ, Mustafa SJ (2005) Role of A1 adenosine receptors in regulation of vascular tone. Am J Physiol Heart Circ Physiol 288: H1411-H1416
140. Thelle DS, Heyden S, Fodor JG (1987) Coffee and cholesterol in epidemiological and experimental studies. Atherosclerosis 67:97-103
141. Timmers HJ, Rongen GA, Karemaker JM, Wieling WW, Marres HA, Lenders JW (2004) The role of carotid chemoreceptors in the sympathetic activation by adenosine in humans. Clin Sci (Lond) 106:75-82
142. Tsuzuki J, Newburgh RW (1975) Inhibition of 5′-nucleotidase in rat brain by methylxanthines. J Neurochem 25:895-896
143. Uiterwaal CS, Verschuren WM, Bueno-de-Mesquita HB et al (2007) Coffee intake and incidence of hypertension. Am J Clin Nutr 85:718-723
144. Umemura T, Ueda K, Nishioka K et al (2006) Effects of acute administration of caffeine on vascular function. Am J Cardiol 98:1538-1541
145. Urgert R, Katan MB (1997) The cholesterol-raising factor from coffee beans. Annu Rev Nutr 17:305-324
146. Urquhart RA, Broadley KJ (1992a) The effects of P1-and muscarinic-receptor agonists upon cAMP-dependent and independent inotropic responses of guinea-pig cardiac preparations. Gen Pharmacol 23:619-626
147. Urquhart RA, Broadley KJ (1992b) The indirect negative inotropic effects of the P1-receptor agonist, L-phenylisopropyladenosine, in guinea-pig isolated cardiac preparations: comparison with cromakalim. Can J Physiol Pharmacol 70:910-915
148. van Dam RM, Feskens EJ (2002) Coffee consumption and risk of type 2 diabetes mellitus. Lancet 360:1477-1478
149. van Dam RM, Hu FB (2005) Coffee consumption and risk of type 2 diabetes: a systematic review. JAMA 294:97-104
150. van Dam RM, Willett WC, Manson JE, Hu FB (2006) Coffee, caffeine, and risk of type 2 diabetes: a prospective cohort study in younger and middle-aged U. S. women. Diab Care 29:398-403
151. van Woudenbergh GJ, Vliegenthart R, van Rooij F J A et al (2008) Coffee consumption and coronary calcification: the Rotterdam coronary calcification study. Arterioscler Thromb Vasc Biol 28:1018-1023
152. van Dusseldorp M, Smits P, Lenders JW, Thien T, Katan MB (1991) Boiled coffee and blood pressure. A 14-week controlled trial. Hypertension 18:607-613
153. 2A receptors: functional and biochemical aspects. Circulation 102:285-289
154. 2A adenosine receptors and their function in human platelets. Circulation 99:2499-2502
155. Verhoef P, Pasman WJ, Van VT, Urgert R, Katan MB (2002) Contribution of caffeine to the homocysteine-raising effect of coffee: a randomized controlled trial in humans. Am J Clin Nutr 76:1244-1248
156. Vlachopoulos C, Hirata K, O'Rourke MF (2003) Effect of caffeine on aortic elastic properties and wave reflection. J Hypertens 21:563-570
157. Weggemans RM, Zock PL, Ordovas JM, Pedro-Botet J, Katan MB (2001a) Apoprotein E genotype and the response of serum cholesterol to dietary fat, cholesterol and cafestol. Atherosclerosis 154:547-555
158. Weggemans RM, Zock PL, Ordovas JM, Ramos-Galluzzi J, Katan MB (2001b) Genetic polymorphisms and lipid response to dietary changes in humans. Eur J Clin Invest 31:950-957
159. Wierema TK, Houben AJ, Kroon AA et al (2005) Mechanisms of adenosine-induced renal vasodilatation in hypertensive patients. J Hypertens 23:1731-1736
160. Winkelmayer WC, Stampfer MJ, Willett WC, Curhan GC (2005) Habitual caffeine intake and the risk of hypertension in women. JAMA 294:2330-2335
161. Woo OF, Pond SM, Benowitz NL, Olson KR (1984) Benefit of hemoperfusion in acute theophylline intoxication. J Toxicol Clin Toxicol 22:411-424
162. 2A adenosine receptor genes show similarities to mice given long-term caffeine. J Appl Physiol 106:631-639
163. Ye Y, Abu Said G, Lin Y et al (2008) Caffeinated coffee blunts the myocardial protective effects of statins against ischemia-reperfusion injury in the rat. Cardiovasc Drugs Ther 22:275-282
164. Yellon DM, Downey JM (2003) Preconditioning the myocardium: from cellular physiology to clinical cardiology. Physiol Rev 83:1113-1151
165. Zhang W, Lopez-Garcia E, Li TY, Hu FB, van Dam RM (2009) Coffee consumption and risk of cardiovascular diseases and all-cause mortality among men with type 2 diabetes. Diab Care 32:1043-1045