Dose and time effects of caffeine intake on human platelet adenosine A(2A) receptors: Functional and biochemical aspects

Circulation

Volumn 102, Issue 3, 2000, Pages 285-289

  Varani, Katia ^d   Portaluppi, Francesco ^d   Gessi, Stefania ^d   Merighi, Stefania ^d   Ongini, Ennio ^a   Belardinelli, Luiz ^b   Borea, Pier Andrea ^c  

^a Schering Plough Research Institute   (Italy)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF FERRARA   (Italy)

^d NONE

Author keywords

Adenosine; Caffeine; Platelets; Receptors

Indexed keywords

ADENOSINE A2A RECEPTOR; CAFFEINE; CYCLIC AMP;

ARTICLE; CALCIUM CELL LEVEL; DOSE TIME EFFECT RELATION; DRUG MECHANISM; FEMALE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PRIORITY JOURNAL; RECEPTOR UPREGULATION; THROMBOCYTE AGGREGATION INHIBITION;

EID: 0034682597     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.102.3.285     Document Type: Article

References (28)

1. Daly JW, Fredholm BB. Caffeine: an atypical drag of dependence. Drug Alcohol Depend. 1998;51:199-206.
2. Nehlig A, Daval J-L, Denry G. Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effects. Brain Res Brain Res Rev. 1992;17:139-170.
3. Fredholm BB, Bättig K, Holmèn J, et al. Actions of caffeine in the brain with special reference to factors that contribute to its widespread use. Phamacol Rev. 1999;51:83-133.
4. Daly JW. Mechanism of action of caffeine. In: Garattini S, ed. Caffeine, Coffee, and Health. New York, NY: Raven Press; 1993:97-150.
5. 2A receptors. Trends Pharmacol Sci. 1996;17:364-372.
6. Klotz K-N, Hessling J, Hegler J, et al. Comparative pharmacology of human adenosine receptor subtypes: characterization of stably transfected receptors in CHO cells. Naunyn Schmiedebergs Arch Pharmacol. 1998; 357:1-9.
7. Fredholm BB. Adenosine, adenosine receptors and the actions of caffeine. Pharmacol Toxicol. 1995;76:93-101.
8. 2A receptor. Nature. 1997;388:674-678.
9. Sawynok J. Pharmacological rationale for the clinical use of caffeine. Drugs. 1995;49:37-50.
10. Grobbee DE, Rimm EB, Giovannucci E, et al. Coffee, caffeine, and cardiovascular disease in men. N Engl J Med. 1990;323:1026-1032.
11. Jee SH, He J, Whelton PK, et al. The effect of chronic coffee drinking on blood pressure: a meta-analysis of controlled clinical trials. Hypertension. 1999;33:647-652.
12. Franceschi S. Coffee and myocardial infarction: review of epidemiological evidence. In: Garattini S, ed. Caffeine, Coffee, and Health. New York, NY: Raven Press; 1993:195-211.
13. Heyden S. Coffee and cardiovascular diseases. In: Garattini S, ed. Caffeine, Coffee, and Health. New York, NY: Raven Press; 1993: 177-193.
14. Biaggioni I, Paul S, Puckett A, et al. Caffeine and theophylline as adenosine receptor antagonists in humans. J Pharmacol Exp Ther. 1991; 258:588-593.
15. 2A adenosine receptors and their function in human platelets. Circulation. 1999;99: 2499-2502.
16. 3H]-CGS 21680 binding. Br J Pharmacol. 1996;117: 1693-1701.
17. 2A adenosine receptors in human neutrophil membranes. Br J Pharmacol. 1998;123:1723-1731.
18. Munson PJ, Rodbard D. Ligand: a versatile computerized approach for the characterization of ligand binding systems. Anal Biochem. 1980;107: 220-239.
19. Finney DJ. Statistical Methods in Biological Assay. 3rd ed. London, UK: Griffin; 1978:80-82.
20. Born GVR, Cross MJ. The aggregation of blood platelets. J Physiol. 1963;168:178-195.
21. Dionisotti S, Zocchi C, Varani K, et al. Effects of adenosine derivatives on human and rabbit platelet aggregation. Naunyn Schmiedebergs Arch Pharmacol. 1992;346:673-676.
22. Paul S, Feoktistov I, Hollister AS, et al. Adenosine inhibits the rise in intracellular calcium and platelet aggregation produced by thrombin: evidence that both effects are coupled to adenylate cyclase. Mol Pharmacol. 1990;37:870-875.
23. Nikodijevi O, Jacobsen KA, Daly JW. Locomotor activity in mice during chronic treatment with caffeine and withdrawal. Pharmacol Biochem Behav. 1993;44:199-216.
24. 1 mRNA in mouse brain: effect of long-term caffeine treatment. Brain Res. 1997;762:153-164.
25. Holtzman SG, Mante S, Minneman KP. Role of adenosine receptors in caffeine tolerance. J Pharmacol Exp Ther. 1991;256:62-68.
26. 1 adenosine receptor binding. J Pharmacol Exp Ther. 1993;266: 1563-1572.
27. Conlay AL, Conant AJ, deBros F, et al. Caffeine alters plasma adenosine levels. Nature. 1997;389:136.
28. Rudolphi KA, Schubert P, Jacobson KA, et al. Adenosine and brain ischemia. Cerebrovasc Brain Metab Rev. 1992;4:346-369.