Mice heterozygous for both A1 and A2A adenosine receptor genes show similarities to mice given long-term caffeine

Journal of Applied Physiology

Volumn 106, Issue 2, 2009, Pages 631-639

  Yang, Jiang Ning ^a   Björklund, Olga ^a   Lindström Törnqvist, Karin ^a   Lindgren, Eva ^a   Eriksson, Therese M ^a   Kahlström, Johan ^a   Chen, Jiang Fan ^b   Schwarzschild, Michael A ^c   Tobler, Irene ^d   Fredholm, Bertil B ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Knockout; Lipolysis; Locomotor activity; Receptor binding; Tolerance

Indexed keywords

ADENOSINE A1 RECEPTOR; ADENOSINE A2 RECEPTOR; CAFFEINE; CENTRAL STIMULANT AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY TEMPERATURE; CONTROLLED STUDY; FEMALE; GENE DELETION; HEART RATE; HETEROZYGOSITY; KNOCKOUT MOUSE; LOCOMOTION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; ADIPOCYTE; ANIMAL; C57BL MOUSE; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; GENOTYPE; HETEROZYGOTE; INTRAPERITONEAL DRUG ADMINISTRATION; LIPOLYSIS; METABOLISM; MOTOR ACTIVITY; MOUSE MUTANT; ORAL DRUG ADMINISTRATION; PHENOTYPE; TIME;

ADIPOCYTES; ADMINISTRATION, ORAL; ANIMALS; BODY TEMPERATURE; CAFFEINE; CENTRAL NERVOUS SYSTEM STIMULANTS; DOSE-RESPONSE RELATIONSHIP, DRUG; GENOTYPE; HEART RATE; HETEROZYGOTE; INJECTIONS, INTRAPERITONEAL; LIPOLYSIS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOTOR ACTIVITY; PHENOTYPE; RECEPTOR, ADENOSINE A1; RECEPTORS, ADENOSINE A2; TIME FACTORS;

EID: 61949343322     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.90971.2008     Document Type: Article

References (37)

1. Armstrong LE, Casa DJ, Maresh CM, Ganio MS. Caffeine, fluidelectrolyte balance, temperature regulation, and exercise-heat tolerance. Exerc Sport Sci Rev 35: 135-140, 2007.
2. Arslan G, Kull B, Fredholm BB. Signaling via A2A adenosine receptor in four PC12 cell clones. Naunyn Schmiedebergs Arch Pharmacol 359: 28-32, 1999. (Pubitemid 29142566)
3. Barraco RA, Campbell WR, Schoener EP, Shehin SE, Parizon M. Cardiovascular effects of microinjections of adenosine analogs into the fourth ventricle of rats. Brain Res 424: 17-25, 1987. (Pubitemid 18043558)
4. Barraco RA, Janusz CJ, Polasek PM, Parizon M, Roberts PA. Cardiovascular effects of microinjection of adenosine into the nucleus tractus solitarius. Brain Res Bull 20: 129-132, 1988. (Pubitemid 18048383)
5. Bjorklund O, Kahlstrom J, Salmi P, Ogren SO, Vahter M, Chen JF, Fredholm BB, Dare E. The effects of methylmercury on motor activity are sex- and age-dependent, and modulated by genetic deletion of adenosine receptors and caffeine administration. Toxicology 241: 119-133, 2007. (Pubitemid 47600465)
6. 2A adenosine receptor deficiency attenuates brain injury induced by transient focal ischemia in mice. J Neurosci 19: 9192-9200, 1999.
7. Chunn JL, Young HW, Banerjee SK, Colasurdo GN, Blackburn MR. Adenosine-dependent airway inflammation and hyperresponsiveness in partially adenosine deaminase-deficient mice. J Immunol 167: 4676-4685, 2001.
8. Conlay LA, Conant JA, deBros F, Wurtman R. Caffeine alters plasma adenosine levels. Nature 389: 136, 1997.
9. Corti R, Binggeli C, Sudano I, Spieker L, Hanseler E, Ruschitzka F, Chaplin WF, Luscher TF, Noll G. Coffee acutely increases sympathetic nerve activity and blood pressure independently of caffeine content: role of habitual versus nonhabitual drinking. Circulation 106: 2935-2940, 2002. (Pubitemid 35424745)
10. El Yacoubi M, Ledent C, Menard JF, Parmentier M, Costentin J, Vaugeois JM. The stimulant effects of caffeine on locomotor behaviour in mice are mediated through its blockade of adenosine A2A receptors. Br J Pharmacol 129: 1465-1473, 2000. (Pubitemid 30175720)
11. Fastbom J, Fredholm BB. Effects of long-term theophylline treatment on adenosine A1-receptors in rat brain: autoradiographic evidence for increased receptor number and altered coupling to G-proteins. Brain Res 507: 195-199, 1990. (Pubitemid 20054099)
12. Fredholm B. Are methylxanthine effects due to antagonism of endogenous adenosine? Trends Pharmacol Sci 1: 129-132, 1980.
13. Fredholm BB. Adenosine actions and adenosine receptors after 1 week treatment with caffeine. Acta Physiol Scand 115: 283-286, 1982.
14. Fredholm BB, APIJ, Jacobson KA, Klotz KN, Linden J. International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors. Pharmacol Rev 53: 527-552, 2001. (Pubitemid 33136237)
15. Fredholm BB, Battig K, Holmen J, Nehlig A, Zvartau EE. Actions of caffeine in the brain with special reference to factors that contribute to its widespread use. Pharmacol Rev 51: 83-133, 1999. (Pubitemid 29113867)
16. Fredholm BB, Herrera-Marschitz M, Jonzon B, Lindstrom K, Ungerstedt U. On the mechanism by which methylxanthines enhance apomorphine-induced rotation behaviour in the rat. Pharmacol Biochem Behav 19: 535-541, 1983.
17. Fredholm BB, Lindstrom K, Dionisotti S, Ongini E. [3H]SCH 58261, a selective adenosine A2A receptor antagonist, is a useful ligand in autoradiographic studies. J Neurochem 70: 1210-1216, 1998. (Pubitemid 28113656)
18. Hawkins M, Dugich MM, Porter NM, Urbancic M, Radulovacki M. Effects of chronic administration of caffeine on adenosine A1 and A2 receptors in rat brain. Brain Res Bull 21: 479-482, 1988. (Pubitemid 19269165)
19. Holtzman SG, Mante S, Minneman KP. Role of adenosine receptors in caffeine tolerance. J Pharmacol Exp Ther 256: 62-68, 1991.
20. Huang ZL, Qu WM, Eguchi N, Chen JF, Schwarzschild MA, Fredholm BB, Urade Y, Hayaishi O. Adenosine A2A, but not A1, receptors mediate the arousal effect of caffeine. Nat Neurosci 8: 858-859, 2005.
21. Johansson B, Georgiev V, Kuosmanen T, Fredholm BB. Long-term treatment with some methylxanthines decreases the susceptibility to bicuculline-and pentylenetetrazol-induced seizures in mice. Relationship to c-fos expression and receptor binding. Eur J Neurosci 8: 2447-2458, 1996. (Pubitemid 27011321)
22. Johansson B, Halldner L, Dunwiddie TV, Masino SA, Poelchen W, Gimenez-Llort L, Escorihuela RM, Fernandez-Teruel A, Wiesenfeld-Hallin Z, Xu XJ, Hardemark A, Betsholtz C, Herlenius E, Fredholm BB. Hyperalgesia, anxiety, and decreased hypoxic neuroprotection in mice lacking the adenosine A1 receptor. Proc Natl Acad Sci USA 98: 9407-9412, 2001. (Pubitemid 32743930)
23. Johansson SM, Yang JN, Lindgren E, Fredholm BB. Eliminating the antilipolytic adenosine A1 receptor does not lead to compensatory changes in the antilipolytic actions of PGE2 and nicotinic acid. Acta Physiol (Oxf) 190: 87-96, 2007. (Pubitemid 46570175)
24. Kalant H. Research on tolerance: what can we learn from history? Alcohol Clin Exp Res 22: 67-76, 1998. (Pubitemid 28139197)
25. Kuzmin A, Johansson B, Semenova S, Fredholm BB. Differences in the effect of chronic and acute caffeine on self-administration of cocaine in mice. Eur J Neurosci 12: 3026-3032, 2000.
26. Laurell S, Tibbling G. An enzymatic fluorometric micromethod for the determination of glycerol. Clin Chim Acta 13: 317-322, 1966.
27. Ledent C, Vaugeois JM, Schiffmann SN, Pedrazzini T, El Yacoubi M, Vanderhaeghen JJ, Costentin J, Heath JK, Vassart G, Parmentier M. Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor. Nature 388: 674-678, 1997. (Pubitemid 27366438)
28. Marangos PJ, Boulenger JP, Patel J. Effects of chronic caffeine on brain adenosine receptors: regional and ontogenetic studies. Life Sci 34: 899-907, 1984. (Pubitemid 14186789)
29. Notarius CF, Atchison DJ, Rongen GA, Floras JS. Effect of adenosine receptor blockade with caffeine on sympathetic response to handgrip exercise in heart failure. Am J Physiol Heart Circ Physiol 281: H1312-H1318, 2001.
30. Robertson D, Wade D, Workman R, Woosley RL, Oates JA. Tolerance to the humoral and hemodynamic effects of caffeine in man. J Clin Invest 67: 1111-1117, 1981. (Pubitemid 11090551)
31. 3 adenosine receptor gene in mice and its effect on stimulated inflammatory cells. J Biol Chem 275: 4429-4434, 2000.
32. Snyder SH. Adenosine as a neuromodulator. Annu Rev Neurosci 8: 103-124, 1985.
33. Svenningsson P, Nomikos GG, Fredholm BB. The stimulatory action and the development of tolerance to caffeine is associated with alterations in gene expression in specific brain regions. J Neurosci 19: 4011-4022, 1999. (Pubitemid 29222274)
34. Svenningsson P, Nomikos GG, Ongini E, Fredholm BB. Antagonism of adenosine A2A receptors underlies the behavioural activating effect of caffeine and is associated with reduced expression of messenger RNA for NGFI-A and NGFI-B in caudate-putamen and nucleus accumbens. Neuroscience 79: 753-764, 1997. (Pubitemid 27292672)
35. Von Borstel RW, Wurtman RJ, Conlay LA. Chronic caffeine consumption potentiates the hypotensive action of circulating adenosine. Life Sci 32: 1151-1158, 1983.
36. Whitsett TL, Manion CV, Christensen HD. Cardiovascular effects of coffee and caffeine. Am J Cardiol 53: 918-922, 1984.
37. Yang JN, Tiselius C, Dare E, Johansson B, Valen G, Fredholm BB. Sex differences in mouse heart rate and body temperature and in their regulation by adenosine A1 receptors. Acta Physiol (Oxf) 190: 63-75, 2007. (Pubitemid 46570173)