Robust parameter estimation during logistic modeling of batch and fed-batch culture kinetics

Biotechnology Progress

Volumn 25, Issue 3, 2009, Pages 801-806

  Goudar, Chetan T ^a   Konstantinov, Konstantinov B ^b   Piret, James M ^c  

^a Global Biological Development   (United States)

^b GENZYME CORPORATION   (United States)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Batch; Fed batch; Logistic equation; Mammalian cell culture; Modeling; Nonlinear optimization

Indexed keywords

BATCH; FED-BATCH; LOGISTIC EQUATION; MAMMALIAN CELL CULTURE; MODELING; NONLINEAR OPTIMIZATION;

ANIMAL CELL CULTURE; CELL CULTURE; CELL MEMBRANES; LINEARIZATION; MAMMALS; NONLINEAR EQUATIONS; OPTIMIZATION; PARAMETER ESTIMATION; SENSITIVITY ANALYSIS;

BATCH CELL CULTURE;

ANIMAL; ARTICLE; BIOLOGICAL MODEL; BIOREACTOR; CHEMISTRY; CHO CELL; CRICETULUS; CULTURE TECHNIQUE; HAMSTER; KINETICS; METHODOLOGY; PHYSIOLOGY;

ANIMALS; BIOREACTORS; CELL CULTURE TECHNIQUES; CHO CELLS; CRICETINAE; CRICETULUS; KINETICS; MODELS, BIOLOGICAL;

MAMMALIA;

EID: 67651093767     PISSN: 87567938     EISSN: None     Source Type: Journal    
DOI: 10.1002/btpr.154     Document Type: Article

References (15)

1. Pörtner R. Schäfer T. Modeling hybridoma cell growth and metabolism-A comparison of selected models and data. J Biotechnol. 1996;49:119-135.
2. Tziampazis E., Sambanis A. Modeling of cell culture processes. Cytotechnology 1994;14:191-204.
3. Linz M., Zeng A.P., Wagner R., Deckwer W.D. Stoichiometry, kinetics and regulation of glucose and amino acid metabolism of a recombinant BHK cell line in batch and continuous culture. Biotechnol Prog. 1997;13:453-463.
4. Ljumggren J., Häggström L. Catabolic control of hybridoma cells by glucose and glutamine limited fed batch cultures. Biotechnol Bioeng. 1994;44:808-818.
5. Goudar C.T., Joeris K., Konstantinov K., Piret J.M. Logistic equations effectively model mammalian cell batch and fed-batch kinetics by logically constraining the fit. Biotechnol Prog. 2005;21:1109-1118.
6. Press W.H., Teukolsky S.A., Vellerling W.T., Flannery B.P. Numerical Recipies in FORTRAN. The Art of Scientific Computing, 2nd ed. Cambridge: Cambridge University Press; 1992.
7. Bree M.A., Dhurjati P., Geoghegan R.F., Robnett B. Kinetic modeling of hybridoma cell growth and immunoglobulin production in a large-scale suspension culture. Biotechnol Bioeng. 1988;32:1067-1072.
8. Dalili M., Sayles G.D., Ollis D.F. Glutamine-limited batch hybridoma growth and antibody production: experiment and model. Biotechnol Bioeng. 1990;36:74-82.
9. Dowd J.E., Kwok K.E., Piret J.M. Increased t-PA yields using ultrafiltration of an inhibitory product fron CHO fed-batch culture. Biotechnol Prog. 2000;16:786-794.
10. Robinson J.A. Determining microbial kinetic parameters using nonlinear regression analysis. Advantages and limitations in microbial ecology. Adv Microb Ecol. 1985;8:61-110.
11. Marquardt D.W. An algorithm for least-squares estimation of nonlinear parameters. SIAM J Appl Math. 1963;11:431-441.
12. Nelder J.A., Mead R. A simplex method for function minimization. Comput J. 1965;7:308-313.
13. Lasdon L.S., Smith S. Solving large spare nonlinear programs using GRG. ORSA J Comput. 1992;4:2-15.
14. Lasdon L.S., Waren A., Jain A., Ratner M. Design and testing of a generalized reduced gradient code for nonlinear programming. ACM Trans Math Softw. 1978;4:34-50.
15. Goudar C.T., Ellis T.G. Explicit oxygen concentration expression for estimating extant biodegradation kinetics from respirometric experiments. Biotechnol Bioeng. 2001;75:74-81.