Airborne inflammatory factors: "From the nose to the brain"

Frontiers in Bioscience - Scholar

Volumn 2 S, Issue 1, 2010, Pages 135-152

  Tonelli, Leonardo H ^a   Postolache, Teodor T ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Anxiety; Bacteria; Behavior; Brain; Cytokines; Depression; Frontal cortex; Inflammation; Intranasal; Neurodegeneration; Neurotropic Viruses; Olfaction; Particulate Matter; Pollution; Respiratory epithelium

Indexed keywords

ALLERGEN;

AIR POLLUTANT; BRAIN; COMMUNICABLE DISEASE; DISEASE TRANSMISSION; HUMAN; IMMUNOLOGY; INFLAMMATION; MICROBIOLOGY; NASOPHARYNX; NEUROLOGIC DISEASE; NOSE MUCOSA; REVIEW; VIROLOGY;

AIR POLLUTANTS; ALLERGENS; BRAIN; COMMUNICABLE DISEASES; HUMANS; INFLAMMATION; NASAL MUCOSA; NASOPHARYNX; NERVOUS SYSTEM DISEASES;

EID: 77957318938     PISSN: 19450516     EISSN: 19450524     Source Type: Journal    
DOI: 10.2741/s52     Document Type: Article

References (216)

1. Langmuir AD. Changing concepts of airborne infection of acute contagious diseases: a reconsideration of classic epidemiologic theories Ann N Y Acad Sci 353: 35-44 (1980) (Pubitemid 11185043)
2. Kinney PL. Climate change, air quality, and human health Am J Prev Med 35: 459-67 (2008)
3. Bartra J, Mullol J, del Cuvillo A, Davila I, Ferrer M, Jauregui I, Montoro J, Sastre J, Valero A. Air pollution and allergens J Investig Allergol Clin Immunol 17 Suppl 2: 3-8 (2007) (Pubitemid 351252751)
4. Ebi KL, McGregor G. Climate change, tropospheric ozone and particulate matter, and health impacts Environ Health Perspect 116: 1449-55 (2008)
5. Glezen WP. The changing epidemiology of respiratory syncytial virus and influenza: impetus for new control measures Pediatr Infect Dis J 2004; 23: S202-6. (Pubitemid 44146414)
6. Weiss N, Miller F, Cazaubon S, Couraud PO. The blood-brain barrier in brain homeostasis and neurological diseases Biochim Biophys Acta (2008)
7. Quan N, Banks WA. Brain-immune communication pathways Brain Behav Immun 21: 727-35 (2007) (Pubitemid 47002217)
8. Fry M, Ferguson AV. The sensory circumventricular organs: brain targets for circulating signals controlling ingestive behavior Physiol Behav 91: 413-23 (2007) (Pubitemid 47016535)
9. Harkema JR, Carey SA, Wagner JG. The nose revisited: a brief review of the comparative structure, function, and toxicologic pathology of the nasal epithelium Toxicol Pathol 34: 252-69 (2006)
10. Ross TM, Zuckermann RN, Reinhard C, Frey WH 2nd. Intranasal administration delivers peptoids to the rat central nervous system Neurosci Lett 439: 30-3 (2008)
11. Thorne RG, Pronk GJ, Padmanabhan V, Frey WH 2nd. Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration Neuroscience 127: 481-96 (2004) (Pubitemid 38950662)
12. Hanson LR, Frey WH 2nd. Intranasal delivery bypasses the blood-brain barrier to target therapeutic agents to the central nervous system and treat neurodegenerative disease BMC Neurosci 9 Suppl 3: S5 (2008)
13. Ross TM, Martinez PM, Renner JC, Thorne RG, Hanson LR, Frey WH 2nd. Intranasal administration of interferon beta bypasses the blood-brain barrier to target the central nervous system and cervical lymph nodes: a non-invasive treatment strategy for multiple sclerosis J Neuroimmunol 151: 66-77 (2004) (Pubitemid 38624401)
14. Gozes I, Giladi E, Pinhasov A, Bardea A, Brenneman DE. Activity-dependent neurotrophic factor: intranasal administration of femtomolar-acting peptides improve performance in a water maze J Pharmacol Exp Ther 293:1091-8 (2000) (Pubitemid 30417880)
15. Deretzi G, Zou LP, Pelidou SH, Nennesmo I, Levi M, Wahren B, Mix E, Zhu J. Nasal administration of recombinant rat IL-4 ameliorates ongoing experimental autoimmune neuritis and inhibits demyelination J Autoimmun 12: 81-9 (1999) (Pubitemid 29130585)
16. Kalueff AV, Lehtimaki KA, Ylinen A, Honkaniemi J, Peltola J. Intranasal administration of human IL-6 increases the severity of chemically induced seizures in rats Neurosci Lett 365: 106-10 (2004) (Pubitemid 38881634)
17. Pelidou SH, Zou LP, Deretzi G, Nennesmo I, Wei L, Mix E, Van Der Meide PH, Zhu J. Intranasal administration of recombinant mouse interleukin-12 increases inflammation and demyelination in chronic experimental autoimmune neuritis in Lewis rats Scand J Immunol 51: 29-35 (2000) (Pubitemid 30074300)
18. Benedict C, Hallschmid M, Schmitz K, Schultes B, Ratter F, Fehm HL, Born J, Kern W. Intranasal insulin improves memory in humans: superiority of insulin aspart Neuropsychopharmacology 32: 239-43 (2007) (Pubitemid 44967803)
19. Benedict C, Hallschmid M, Hatke A, Schultes B, Fehm HL, Born J, Kern W. Intranasal insulin improves memory in humans Psychoneuroendocrinology 29: 1326-34 (2004) (Pubitemid 39024358)
20. Reger MA, Watson GS, Frey WH 2nd, Baker LD, Cholerton B, Keeling ML, Belongia DA, Fishel MA, Plymate SR, Schellenberg GD, Cherrier MM, Craft S. Effects of intranasal insulin on cognition in memory-impaired older adults: modulation by APOE genotype Neurobiol Aging 27: 451-8 (2006) (Pubitemid 43185331)
21. Burri A, Heinrichs M, Schedlowski M, Kruger TH. The acute effects of intranasal oxytocin administration on endocrine and sexual function in males Psychoneuroendocrinology 33: 591-600 (2008)
22. Ditzen B, Schaer M, Gabriel B, Bodenmann G, Ehlert U, Heinrichs M. Intranasal Oxytocin Increases Positive Communication and Reduces Cortisol Levels During Couple Conflict Biol Psychiatry (2008)
23. Perras B, Schultes B, Behn B, Dodt C, Born J, Fehm HL. Intranasal atrial natriuretic peptide acts as central nervous inhibitor of the hypothalamo-pituitary-adrenal stress system in humans J Clin Endocrinol Metab 89: 4642-8 (2004) (Pubitemid 39244482)
24. Perras B, Marshall L, Kohler G, Born J, Fehm HL. Sleep and endocrine changes after intranasal administration of growth hormone-releasing hormone in young and aged humans Psychoneuroendocrinology 24: 743-57 (1999) (Pubitemid 29378501)
25. van Wingen GA, Zylicz SA, Pieters S, Mattern C, Verkes RJ, Buitelaar JK, Fernandez G. Testosterone increases amygdala reactivity in middle-aged women to a young adulthood level Neuropsychopharmacology 34: 539-47 (2009)
26. Mori I, Goshima F, Ito H, Koide N, Yoshida T, Yokochi T, Kimura Y, Nishiyama Y. The vomeronasal chemosensory system as a route of neuroinvasion by herpes simplex virus Virology 334: 51-8 (2005) (Pubitemid 40320734)
27. Iwasaki T, Itamura S, Nishimura H, Sato Y, Tashiro M, Hashikawa T, Kurata T. Productive infection in the murine central nervous system with avian influenza virus A (H5N1) after intranasal inoculation Acta Neuropathol 108: 485-92 (2004) (Pubitemid 39534590)
28. Sauder CJ, Vandenburgh KM, Iskow RC, Malik T, Carbone KM, Rubin SA. Changes in mumps virus neurovirulence phenotype associated with quasispecies heterogeneity Virology 350: 48-57 (2006) (Pubitemid 44209083)
29. Sellin CI, Davoust N, Guillaume V, Baas D, Belin MF, Buckland R, Wild TF, Horvat B. High pathogenicity of wild-type measles virus infection in CD150 (SLAM) transgenic mice J Virol 80: 6420-9 (2006) (Pubitemid 43927445)
30. Shankar V, Kao M, Hamir AN, Sheng H, Koprowski H, Dietzschold B. Kinetics of virus spread and changes in levels of several cytokine mRNAs in the brain after intranasal infection of rats with Borna disease virus J Virol 66: 992-8 (1992)
31. Pedras-Vasconcelos JA, Goucher D, Puig M, Tonelli LH, Wang V, Ito S, Verthelyi D. CpG oligodeoxynucleotides protect newborn mice from a lethal challenge with the neurotropic Tacaribe arenavirus J Immunol 176: 4940-9 (2006)
32. Pedras-Vasconcelos JA, Puig M, Sauder C, Wolbert C, Ovanesov M, Goucher D, Verthelyi D. Immunotherapy with CpG oligonucleotides and antibodies to TNF-alpha rescues neonatal mice from lethal arenavirus-induced meningoencephalitis J Immunol 180: 8231-40 (2008)
33. Soucy G, Boivin G, Labrie F, Rivest S. Estradiol is required for a proper immune response to bacterial and viral pathogens in the female brain J Immunol 174: 6391-8 (2005) (Pubitemid 40663832)
34. Morawska L. Droplet fate in indoor environments, or can we prevent the spread of infection? Indoor Air 16: 335-47 (2006) (Pubitemid 44327686)
35. Griffin DW. Atmospheric movement of microorganisms in clouds of desert dust and implications for human health Clin Microbiol Rev 20: 459-77, table of contents. (2007) (Pubitemid 47175014)
36. Enria DA, Pinheiro F. Rodent-borne emerging viral zoonosis. Hemorrhagic fevers and hantavirus infections in South America Infect Dis Clin North Am 14: 167-84, x. (2000) (Pubitemid 30158546)
37. Krautkramer E, Zeier M. Hantavirus causing hemorrhagic fever with renal syndrome enters from the apical surface and requires decay-accelerating factor (DAF/CD55) J Virol 82: 4257-64 (2008) (Pubitemid 351563663)
38. Simonsen L, Clarke MJ, Schonberger LB, Arden NH, Cox NJ, Fukuda K. Pandemic versus epidemic influenza mortality: a pattern of changing age distribution J Infect Dis 178: 53-60 (1998) (Pubitemid 28328076)
39. Brammer L, Fukuda K, Arden N, Schmeltz LM, Simonsen L, Khan A, Regnery HL, Schonberger LB, Cox NJ. Influenza surveillance-United States, 1992-93 and 1993-94 MMWR CDC Surveill Summ 46: 1-12 (1997)
40. Simonsen L, Fukuda K, Schonberger LB, Cox NJ. The impact of influenza epidemics on hospitalizations J Infect Dis 181: 831-7 (2000) (Pubitemid 30194462)
41. Griffin MR, Coffey CS, Neuzil KM, Mitchel EF Jr, Wright PF, Edwards KM. Winter viruses: influenza- and respiratory syncytial virus-related morbidity in chronic lung disease Arch Intern Med 162: 1229-36 (2002) (Pubitemid 34595028)
42. de Souza AL, Seguro AC. Two centuries of meningococcal infection: from Vieusseux to the cellular and molecular basis of disease J Med Microbiol 57: 1313-21 (2008)
43. Noakes CJ, Beggs CB, Sleigh PA, Kerr KG. Modelling the transmission of airborne infections in enclosed spaces Epidemiol Infect 134: 1082-91 (2006) (Pubitemid 44336386)
44. Dowell SF, Ho MS. Seasonality of infectious diseases and severe acute respiratory syndrome-what we don't know can hurt us Lancet Infect Dis 4: 704-8 (2004) (Pubitemid 39452524)
45. Barker WH, Mullooly JP. "A study of excess mortality during influenza epidemics in the United States, 1968-1976" Am J Epidemiol 115: 479-80 (1982)
46. Glezen WP, Payne AA, Snyder DN, Downs TD. Mortality and influenza J Infect Dis 146: 313-21 (1982) (Pubitemid 12031206)
47. Sande MA, Gwaltney JM. Acute community-acquired bacterial sinusitis: continuing challenges and current management Clin Infect Dis 39 Suppl 3: S151-8 (2004)
48. Kaliner MA, Osguthorpe JD, Fireman P, Anon J, Georgitis J, Davis ML, Naclerio R, Kennedy D. Sinusitis: bench to bedside. Current findings, future directions Otolaryngol Head Neck Surg 116: S1-20 (1997)
49. Nadadur SS, Miller CA, Hopke PK, Gordon T, Vedal S, Vandenberg JJ, Costa DL. The complexities of air pollution regulation: the need for an integrated research and regulatory perspective Toxicol Sci 100: 318-27 (2007) (Pubitemid 350131359)
50. Gwaltney JM Jr. Acute community-acquired sinusitis Clin Infect Dis 23: 1209-23; quiz 1224-5 (1996) (Pubitemid 26423154)
51. Nakaji S, Parodi S, Fontana V, Umeda T, Suzuki K, Sakamoto J, Fukuda S, Wada S, Sugawara K. Seasonal changes in mortality rates from main causes of death in Japan (1970-1999) Eur J Epidemiol 19: 905-13. (2004) (Pubitemid 39434546)
52. Talbot TR, Poehling KA, Hartert TV, Arbogast PG, Halasa NB, Edwards KM, Schaffner W, Craig AS, Griffin MR. Seasonality of invasive pneumococcal disease: temporal relation to documented influenza and respiratory syncytial viral circulation Am J Med 118: 285-91 (2005) (Pubitemid 40312640)
53. Cooper DL, Smith GE, Edmunds WJ, Joseph C, Gerard E, George RC. The contribution of respiratory pathogens to the seasonality of NHS Direct calls J Infect 55: 240-8 (2007) (Pubitemid 47260302)
54. Dowell SF, Whitney CG, Wright C, Rose CE Jr, Schuchat A. Seasonal patterns of invasive pneumococcal disease Emerg Infect Dis 9: 573-9 (2003) (Pubitemid 36529516)
55. Lowen AC, Mubareka S, Steel J, Palese P. Influenza virus transmission is dependent on relative humidity and temperature PLoS Pathog 3: 1470-6 (2007) (Pubitemid 350085611)
56. Blaiss MS. Allergic rhinoconjunctivitis: burden of disease Allergy Asthma Proc 28: 393-7 (2007)
57. Meltzer EO. The prevalence and medical and economic impact of allergic rhinitis in the United States J Allergy Clin Immunol 99: S805-28 (1997)
58. Meltzer EO, Szwarcberg J, Pill MW. Allergic rhinitis, asthma, and rhinosinusitis: diseases of the integrated airway J Manag Care Pharm 10: 310-7 (2004)
59. Nathan RA. The burden of allergic rhinitis Allergy Asthma Proc 28: 3-9 (2007)
60. Galli SJ, Tsai M, Piliponsky AM. The development of allergic inflammation Nature 454: 445-54 (2008)
61. Frenz DA. Interpreting atmospheric pollen counts for use in clinical allergy: allergic symptomology Ann Allergy Asthma Immunol 86: 150-7, quiz 158 (2001)
62. Kosisky SE, Carpenter GB. Predominant tree aeroallergens of the Washington, DC area: a six year survey (1989-1994) Ann Allergy Asthma Immunol 78: 381-92 (1997) (Pubitemid 27175057)
63. Mallia P, Johnston SL. How viral infections cause exacerbation of airway diseases Chest 130: 1203-10 (2006) (Pubitemid 44583754)
64. Cirillo I, Marseglia G, Klersy C, Ciprandi G. Allergic patients have more numerous and prolonged respiratory infections than nonallergic subjects Allergy 62: 1087-90 (2007) (Pubitemid 47220967)
65. Zeldin Y, Weiler Z, Cohen A, Kalinin M, Schlesinger M, Kidon M, Magen E. Efficacy of nasal Staphylococcus aureus eradication by topical nasal mupirocin in patients with perennial allergic rhinitis Ann Allergy Asthma Immunol 100: 608-11 (2008) (Pubitemid 351829862)
66. Tamay Z, Akcay A, Ones U, Guler N, Kilic G, Zencir M. Prevalence and risk factors for allergic rhinitis in primary school children Int J Pediatr Otorhinolaryngol 71: 463-71 (2007) (Pubitemid 46123584)
67. Wold LE, Simkhovich BZ, Kleinman MT, Nordlie MA, Dow JS, Sioutas C, Kloner RA. In vivo and in vitro models to test the hypothesis of particle-induced effects on cardiac function and arrhythmias Cardiovasc Toxicol 2006; 6: 69-78. (Pubitemid 44127954)
68. Simkhovich BZ, Kleinman MT, Kloner RA. Air pollution and cardiovascular injury epidemiology, toxicology, and mechanisms J Am Coll Cardiol 52: 719-26 (2008)
69. Michel O, Nagy AM, Schroeven M, Duchateau J, Neve J, Fondu P, Sergysels R. Dose-response relationship to inhaled endotoxin in normal subjects Am J Respir Crit Care Med 156: 1157-64 (1997)
70. Davila I, Mullol J, Bartra J, Del Cuvillo A, Ferrer M, Jauregui I, Montoro J, Sastre J, Valero A. Effect of pollutants upon patients with respiratory allergies J Investig Allergol Clin Immunol 17 Suppl 2: 9-20 (2007) (Pubitemid 351252752)
71. Mundandhara SD, Becker S, Madden MC. Effects of diesel exhaust particles on human alveolar macrophage ability to secrete inflammatory mediators in response to lipopolysaccharide Toxicol In vitro 20: 614-24 (2006) (Pubitemid 43948879)
72. Gyan K, Henry W, Lacaille S, Laloo A, Lamsee-Ebanks C, McKay S, Antoine RM, Monteil MA. African dust clouds are associated with increased paediatric asthma accident and emergency admissions on the Caribbean island of Trinidad Int J Biometeorol 49: 371-6 (2005) (Pubitemid 41116466)
73. Monteil MA. Saharan dust clouds and human health in the English-speaking Caribbean: what we know and don't know Environ Geochem Health 30: 339-43 (2008)
74. Sigsgaard T, Bonefeld-Jorgensen EC, Hoffmann HJ, Bonlokke J, Kruger T. Microbial cell wall agents as an occupational hazard Toxicol Appl Pharmacol 207: 310-9 (2005)
75. Michel O. Role of lipopolysaccharide (LPS) in asthma and other pulmonary conditions J Endotoxin Res 9: 293-300 (2003) (Pubitemid 37193036)
76. McCarthy M. Viral infections. In: Richard T. Johnson JWGJCM, ed.
77. Watson-Creed G, Saunders A, Scott J, Lowe L, Pettipas J, Hatchette TF. Two successive outbreaks of mumps in Nova Scotia among vaccinated adolescents and young adults CMAJ 175: 483-8 (2006) (Pubitemid 44492298)
78. Boyd M, Clezy K, Lindley R, Pearce R. Pandemic influenza: clinical issues Med J Aust 185: S44-7 (2006)
79. Norrby E, Kristensson K. Measles virus in the brain Brain Res Bull 44: 213-20. (1997) (Pubitemid 27413722)
80. Aksamit Jr A. Nonviral Infectious Disease. In: Johnson R, Griffin J, McArthur Justin, eds. Current therapy in neurologic diseases.
81. Toovey S. Influenza-associated central nervous system dysfunction: a literature review Travel Med Infect Dis 6: 114-24. (2008)
82. Misra UK, Tan CT, Kalita J. Viral encephalitis and epilepsy Epilepsia 49 Suppl 6: 13-8 (2008)
83. Chauhan VS, Sterka DG Jr, Gray DL, Bost KL, Marriott I. Neurogenic exacerbation of microglial and astrocyte responses to Neisseria meningitidis and Borrelia burgdorferi J Immunol 180: 8241-9 (2008)
84. Konat GW, Kielian T, Marriott I. The role of Toll-like receptors in CNS response to microbial challenge J Neurochem 99: 1-12 (2006) (Pubitemid 44395125)
85. Mitchell L, Smith SH, Braun JS, Herzog KH, Weber JR, Tuomanen EI. Dual phases of apoptosis in pneumococcal meningitis J Infect Dis 190: 2039-46 (2004) (Pubitemid 39564711)
86. Urbanska EM, Chambers BJ, Ljunggren HG, Norrby E, Kristensson K. Spread of measles virus through axonal pathways into limbic structures in the brain of TAP1-/mice J Med Virol 52: 362-9 (1997) (Pubitemid 27356180)
87. Marques CP, Cheeran MC, Palmquist JM, Hu S, Lokensgard JR. Microglia are the major cellular source of inducible nitric oxide synthase during experimental herpes encephalitis J Neurovirol 14: 229-38 (2008) (Pubitemid 351895544)
88. Bright RA, Cho DS, Rowe T, Katz JM. Mechanisms of pathogenicity of influenza A (H5N1) viruses in mice Avian Dis 47: 1131-4 (2003) (Pubitemid 37143900)
89. Nimmerjahn A, Kirchhoff F, Helmchen F. Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo Science 308: 1314-8 (2005) (Pubitemid 40746128)
90. Aloisi F. Immune function of microglia Glia 36: 165-79 (2001) (Pubitemid 33055905)
91. Neher JJ, Brown GC. Neurodegeneration in models of Gram-positive bacterial infections of the central nervous system Biochem Soc Trans 35: 1166-7 (2007) (Pubitemid 350206452)
92. Klein M, Obermaier B, Angele B, Pfister HW, Wagner H, Koedel U, Kirschning CJ. Innate immunity to pneumococcal infection of the central nervous system depends on toll-like receptor (TLR) 2 and TLR4 J Infect Dis 198: 1028-36 (2008)
93. Klein M, Koedel U, Pfister HW. Oxidative stress in pneumococcal meningitis: a future target for adjunctive therapy? Prog Neurobiol 80: 269-80 (2006) (Pubitemid 46107738)
94. Hornig M, Weissenbock H, Horscroft N, Lipkin WI. An infection-based model of neurodevelopmental damage Proc Natl Acad Sci U S A 96: 12102-7 (1999) (Pubitemid 29502865)
95. Hornig M, Solbrig M, Horscroft N, Weissenbock H, Lipkin WI. Borna disease virus infection of adult and neonatal rats: models for neuropsychiatric disease Curr Top Microbiol Immunol 253: 157-77 (2001) (Pubitemid 32416664)
96. Rubin SA, Sylves P, Vogel M, Pletnikov M, Moran TH, Schwartz GJ, Carbone KM. Borna disease virus-induced hippocampal dentate gyrus damage is associated with spatial learning and memory deficits Brain Res Bull 48: 23-30 (1999) (Pubitemid 29165984)
97. Bauer S, Kerr BJ, Patterson PH. The neuropoietic cytokine family in development, plasticity, disease and injury Nat Rev Neurosci 8: 221-32 (2007) (Pubitemid 46294661)
98. Shi L, Smith SE, Malkova N, Tse D, Su Y, Patterson PH. Activation of the maternal immune system alters cerebellar development in the offspring Brain Behav Immun 23: 116-23 (2009)
99. Shi L, Fatemi SH, Sidwell RW, Patterson PH. Maternal influenza infection causes marked behavioral and pharmacological changes in the offspring J Neurosci 23: 297-302 (2003) (Pubitemid 36050430)
100. Lipkin WI, Hornig M. Psychotropic viruses Curr Opin Microbiol 7: 420-5 (2004) (Pubitemid 39091129)
101. Peters CJ. Emerging infections: lessons from the viral hemorrhagic fevers Trans Am Clin Climatol Assoc 117: 189-97 (2006)
102. Carballal G, Videla CM, Merani MS. Epidemiology of Argentine hemorrhagic fever Eur J Epidemiol 4: 259-74 (1988)
103. Kenyon RH, McKee KT Jr, Zack PM, Rippy MK, Vogel AP, York C, Meegan J, Crabbs C, Peters CJ. Aerosol infection of rhesus macaques with Junin virus Intervirology 33: 23-31 (1992)
104. Hornig M, Briese T, Lipkin WI. Borna disease virus J Neurovirol 2003; 9: 259-73. (Pubitemid 36656460)
105. Morales JA, Herzog S, Kompter C, Frese K, Rott R. Axonal transport of Borna disease virus along olfactory pathways in spontaneously and experimentally infected rats Med Microbiol Immunol 177: 51-68 (1988) (Pubitemid 18057798)
106. Mori I, Nishiyama Y, Yokochi T, Kimura Y. Olfactory transmission of neurotropic viruses J Neurovirol 11: 129-37 (2005) (Pubitemid 40852420)
107. Mori I, Goshima F, Mizuno T, Imai Y, Kohsaka S, Ito H, Koide N, Yoshida T, Yokochi T, Kimura Y, Nishiyama Y. Axonal injury in experimental herpes simplex encephalitis Brain Res 1057: 186-90 (2005) (Pubitemid 41341367)
108. Ando Y, Kitayama H, Kawaguchi Y, Koyanagi Y. Primary target cells of herpes simplex virus type 1 in the hippocampus Microbes Infect 10: 1514-1523. (2008)
109. Boivin G, Coulombe Z, Rivest S. Intranasal herpes simplex virus type 2 inoculation causes a profound thymidine kinase dependent cerebral inflammatory response in the mouse hindbrain Eur J Neurosci 16: 29-43 (2002) (Pubitemid 35463595)
110. Volmer R, Monnet C, Gonzalez-Dunia D. Borna disease virus blocks potentiation of presynaptic activity through inhibition of protein kinase C signaling PLoS Pathog 2: e19. (2006)
111. Hans A, Bajramovic JJ, Syan S, Perret E, Dunia I, Brahic M, Gonzalez-Dunia D. Persistent, noncytolytic infection of neurons by Borna disease virus interferes with ERK 1/2 signaling and abrogates BDNF-induced synaptogenesis FASEB J 18: 863-5 (2004)
112. Volmer R, Prat CM, Le Masson G, Garenne A, Gonzalez-Dunia D. Borna disease virus infection impairs synaptic plasticity J Virol 81: 8833-7 (2007) (Pubitemid 47242857)
113. Sauder C, Wolfer DP, Lipp HP, Staeheli P, Hausmann J. Learning deficits in mice with persistent Borna disease virus infection of the CNS associated with elevated chemokine expression Behav Brain Res 120: 189-201 (2001) (Pubitemid 32140986)
114. Guillot L, Le Goffic R, Bloch S, Escriou N, Akira S, Chignard M, Si-Tahar M. Involvement of toll-like receptor 3 in the immune response of lung epithelial cells to double-stranded RNA and influenza A virus J Biol Chem 280: 5571-80 (2005) (Pubitemid 40280035)
115. Sant AJ, Chaves FA, Krafcik FR, Lazarski CA, Menges P, Richards K, Weaver JM. Immunodominance in CD4 T-cell responses: implications for immune responses to influenza virus and for vaccine design Expert Rev Vaccines 6: 357-68 (2007) (Pubitemid 46911599)
116. Grayson MH, Holtzman MJ. Emerging role of dendritic cells in respiratory viral infection J Mol Med 85: 1057-68 (2007) (Pubitemid 47476728)
117. Mori I, Goshima F, Imai Y, Kohsaka S, Sugiyama T, Yoshida T, Yokochi T, Nishiyama Y, Kimura Y. Olfactory receptor neurons prevent dissemination of neurovirulent influenza A virus into the brain by undergoing virus-induced apoptosis J Gen Virol 83: 2109-16 (2002) (Pubitemid 34993715)
118. Peng T, Kotla S, Bumgarner RE, Gustin KE. Human rhinovirus attenuates the type I interferon response by disrupting activation of interferon regulatory factor 3 J Virol 80: 5021-31 (2006)
119. Kotla S, Peng T, Bumgarner RE, Gustin KE. Attenuation of the type I interferon response in cells infected with human rhinovirus Virology 374: 399-410 (2008)
120. Dreschers S, Dumitru CA, Adams C, Gulbins E. The cold case: are rhinoviruses perfectly adapted pathogens? Cell Mol Life Sci 64: 181-91 (2007) (Pubitemid 46156886)
121. Sajjan U, Wang Q, Zhao Y, Gruenert DC, Hershenson MB. Rhinovirus disrupts the barrier function of polarized airway epithelial cells Am J Respir Crit Care Med 178: 1271-81 (2008)
122. Foxwell AR, Kyd JM, Cripps AW. Nontypeable Haemophilus influenzae: pathogenesis and prevention Microbiol Mol Biol Rev 62: 294-308 (1998) (Pubitemid 28270276)
123. Foxwell AR, Kyd JM, Cripps AW. Kinetics of inflammatory cytokines in the clearance of non-typeable Haemophilus influenzae from the lung Immunol Cell Biol 76: 556-9 (1998) (Pubitemid 29003059)
124. Zhang N, Van Zele T, Perez-Novo C, Van Bruaene N, Holtappels G, DeRuyck N, Van Cauwenberge P, Bachert C. Different types of T-effector cells orchestrate mucosal inflammation in chronic sinus disease J Allergy Clin Immunol 122: 961-8 (2008)
125. Didierlaurent A, Goulding J, Hussell T. The impact of successive infections on the lung microenvironment Immunology 122: 457-65 (2007) (Pubitemid 350075963)
126. Didierlaurent A, Goulding J, Patel S, Snelgrove R, Low L, Bebien M, Lawrence T, van Rijt LS, Lambrecht BN, Sirard JC, Hussell T. Sustained desensitization to bacterial Toll-like receptor ligands after resolution of respiratory influenza infection J Exp Med 205: 323-9 (2008) (Pubitemid 351281598)
127. Goulding J, Snelgrove R, Saldana J, Didierlaurent A, Cavanagh M, Gwyer E, Wales J, Wissinger EL, Hussell T. Respiratory infections: do we ever recover? Proc Am Thorac Soc 4: 618-25 (2007) (Pubitemid 350291624)
128. Gleich GJ, Kita H. Bronchial asthma: lessons from murine models Proc Natl Acad Sci U SA 94: 2101-2 (1997) (Pubitemid 27136833)
129. Galli SJ, Nakae S, Tsai M. Mast cells in the development of adaptive immune responses Nat Immunol 6: 135-42 (2005) (Pubitemid 40268194)
130. Finkelman FD. Anaphylaxis: lessons from mouse models J Allergy Clin Immunol 120: 506-15; quiz 516-7 (2007) (Pubitemid 47334841)
131. Pawankar R, Lee KH, Nonaka M, Takizawa R. Role of mast cells and basophils in chronic rhinosinusitis Clin Allergy Immunol 20: 93-101 (2007)
132. Finnerty K, Choi JE, Lau A, Davis-Gorman G, Diven C, Seaver N, Linak WP, Witten M, McDonagh PF. Instillation of coarse ash particulate matter and lipopolysaccharide produces a systemic inflammatory response in mice J Toxicol Environ Health A 70: 1957-66 (2007) (Pubitemid 350034919)
133. Kleinman MT, Araujo JA, Nel A, Sioutas C, Campbell A, Cong PQ, Li H, Bondy SC. Inhaled ultrafine particulate matter affects CNS inflammatory processes and may act via MAP kinase signaling pathways Toxicol Lett 178: 127-30 (2008)
134. Campbell A, Oldham M, Becaria A, Bondy SC, Meacher D, Sioutas C, Misra C, Mendez LB, Kleinman M. Particulate matter in polluted air may increase biomarkers of inflammation in mouse brain Neurotoxicology 26: 133-40 (2005) (Pubitemid 39440973)
135. Steerenberg PA, Dormans JA, van Doorn CC, Middendorp S, Vos JG, van Loveren H. A pollen model in the rat for testing adjuvant activity of air pollution components Inhal Toxicol 11: 1109-22 (1999) (Pubitemid 30023324)
136. Steerenberg PA, Withagen CE, Dormans JA, van Dalen WJ, van Loveren H, Casee FR. Adjuvant activity of various diesel exhaust and ambient particles in two allergic models J Toxicol Environ Health A 66: 1421-39 (2003) (Pubitemid 36976207)
137. Tonelli LH, Holmes A, Postolache TT. Intranasal immune challenge induces sex-dependent depressive-like behavior and cytokine expression in the brain Neuropsychopharmacology 33: 1038-48 (2008) (Pubitemid 351367545)
138. Tin-Tin-Win-Shwe, Yamamoto S, Ahmed S, Kakeyama M, Kobayashi T, Fujimaki H. Brain cytokine and chemokine mRNA expression in mice induced by intranasal instillation with ultrafine carbon black Toxicol Lett 163: 153-60 (2006)
139. Boivin N, Sergerie Y, Rivest S, Boivin G. Effect of pretreatment with toll-like receptor agonists in a mouse model of herpes simplex virus type 1 encephalitis J Infect Dis 198: 664-72 (2008)
140. Costa-Pinto FA, Basso AS, Russo M. Role of mast cell degranulation in the neural correlates of the immediate allergic reaction in a murine model of asthma Brain Behav Immun 21: 783-90 (2007) (Pubitemid 47002204)
141. Costa-Pinto FA, Basso AS, De Sa-Rocha LC, Britto LR, Russo M, Palermo-Neto J. Neural correlates of IgE-mediated allergy Ann N Y Acad Sci 1088: 116-31 (2006) (Pubitemid 47092049)
142. Costa-Pinto FA, Basso AS, Britto LR, Malucelli BE, Russo M. Avoidance behavior and neural correlates of allergen exposure in a murine model of asthma Brain Behav Immun 19: 52-60 (2005) (Pubitemid 39592809)
143. Rosenkranz MA, Busse WW, Johnstone T, Swenson CA, Crisafi GM, Jackson MM, Bosch JA, Sheridan JF, Davidson RJ. Neural circuitry underlying the interaction between emotion and asthma symptom exacerbation Proc Natl Acad Sci U S A 102: 13319-24 (2005) (Pubitemid 41325021)
144. Tonelli LH, Katz M, Kovacsis C, Gould TD, Joppy B, Hoshino A, Hoffman GE, Komarow H, Postolache TT. Allergic rhinitis induces anxiety-like behavior and reduced social interaction in rodents. Brain Behav Immun (in press)
145. Pewter SM, Williams WH, Haslam C, Kay JM. Neuropsychological and psychiatric profiles in acute encephalitis in adults Neuropsychol Rehabil 17: 478-505 (2007) (Pubitemid 47309358)
146. Fatemi SH, Earle J, Kanodia R, Kist D, Emamian ES, Patterson PH, Shi L, Sidwell R. Prenatal viral infection leads to pyramidal cell atrophy and macrocephaly in adulthood: implications for genesis of autism and schizophrenia Cell Mol Neurobiol 22: 25-33 (2002) (Pubitemid 34579406)
147. Danaher RJ, McGarrell BS, Stromberg AJ, Miller CS. Herpes simplex virus type 1 modulates cellular gene expression during quiescent infection of neuronal cells Arch Virol 153: 1335-45 (2008)
148. Ovanesov MV, Moldovan K, Smith K, Vogel MW, Pletnikov MV. Persistent Borna Disease Virus (BDV) infection activates microglia prior to a detectable loss of granule cells in the hippocampus J Neuroinflammation 5: 16 (2008)
149. Dantzer R, O'Connor JC, Freund GG, Johnson RW, Kelley KW. From inflammation to sickness and depression: when the immune system subjugates the brain Nat Rev Neurosci 9: 46-56 (2008) (Pubitemid 350295688)
150. Anisman H, Gibb J, Hayley S. Influence of continuous infusion of interleukin-1beta on depression-related processes in mice: corticosterone, circulating cytokines, brain monoamines, and cytokine mRNA expression Psychopharmacology (Berl) 199: 231-44 (2008)
151. Anisman H, Merali Z, Hayley S. Neurotransmitter, peptide and cytokine processes in relation to depressive disorder: comorbidity between depression and neurodegenerative disorders Prog Neurobiol 85: 1-74 (2008)
152. Tonelli LH, Postolache TT. Tumor necrosis factor alpha, interleukin-1 beta, interleukin-6 and major histocompatibility complex molecules in the normal brain and after peripheral immune challenge Neurol Res 27: 679-84 (2005) (Pubitemid 41513076)
153. Goshen I, Kreisel T, Ben-Menachem-Zidon O, Licht T, Weidenfeld J, Ben-Hur T, Yirmiya R. Brain interleukin-1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression Mol Psychiatry 13: 717-28 (2008) (Pubitemid 351861529)
154. Goshen I, Yirmiya R, Iverfeldt K, Weidenfeld J. The role of endogenous interleukin-1 in stress-induced adrenal activation and adrenalectomy-induced adrenocorticotropic hormone hypersecretion Endocrinology 144: 4453-8 (2003) (Pubitemid 37204845)
155. Tonelli LH, Postolache TT, Sternberg EM. Inflammatory genes and neural activity: involvement of immune genes in synaptic function and behavior Front Biosci 10: 675-80 (2005)
156. Tonelli LH, Maeda S, Rapp KL, Sternberg EM. Differential induction of
157. Foster JA, Quan N, Stern EL, Kristensson K, Herkenham M. Induced neuronal expression of class I major histocompatibility complex mRNA in acute and chronic inflammation models J Neuroimmunol 131: 83-91 (2002)
158. Quan N, Stern EL, Whiteside MB, Herkenham M. Induction of pro-inflammatory cytokine mRNAs in the brain after peripheral injection of subseptic doses of lipopolysaccharide in the rat J Neuroimmunol 93: 72-80 (1999) (Pubitemid 29051552)
159. Doty RL. The olfactory vector hypothesis of neurodegenerative disease: is it viable? Ann Neurol 63: 7-15. (2008) (Pubitemid 351240546)
160. Itzhaki RF, Cosby SL, Wozniak MA. Herpes simplex virus type 1 and Alzheimer's disease: the autophagy connection J Neurovirol 14: 1-4. (2008) (Pubitemid 351314968)
161. Ball MJ. The essential lesion of Alzheimer disease: a surprise in retrospect J Alzheimers Dis 9: 29-33 (2006) (Pubitemid 44253295)
162. Letenneur L, Peres K, Fleury H, Garrigue I, Barberger-Gateau P, Helmer C, Orgogozo JM, Gauthier S, Dartigues JF. Seropositivity to herpes simplex virus antibodies and risk of Alzheimer's disease: a population-based cohort study PLoS ONE; 3: e3637 (2008)
163. Ascherio A, Munger K. Epidemiology of multiple sclerosis: from risk factors to prevention Semin Neurol 28: 17-28 (2008) (Pubitemid 351273081)
164. Tucker WG, Andrew Paskauskas R. The MSMV hypothesis: measles virus and multiple sclerosis, etiology and treatment Med Hypotheses 71: 682-9 (2008)
165. Elbaz A, Tranchant C. Epidemiologic studies of environmental exposures in Parkinson's disease J Neurol Sci 262: 37-44 (2007) (Pubitemid 47398893)
166. Nagatsu T, Mogi M, Ichinose H, Togari A. Cytokines in Parkinson's disease J Neural Transm Suppl 143-51 (2000)
167. Pugliatti M, Harbo HF, Holmoy T, Kampman MT, Myhr KM, Riise T, Wolfson C. Environmental risk factors in multiple sclerosis Acta Neurol Scand Suppl 188: 34-40 (2008) (Pubitemid 351595271)
168. Posnett DN. Herpesviruses and autoimmunity Curr Opin Investig Drugs 9: 505-14. (2008) (Pubitemid 351677905)
169. Alvarez-Lafuente R, Garcia-Montojo M, De Las Heras V, Dominguez-Mozo MI, Bartolome M, Benito-Martin MS, Arroyo R. Herpesviruses and human endogenous retroviral sequences in the cerebrospinal fluid of multiple sclerosis patients Mult Scler 14: 595-601 (2008) (Pubitemid 351954400)
170. Soldan SS, Berti R, Salem N, Secchiero P, Flamand L, Calabresi PA, Brennan MB, Maloni HW, McFarland HF, Lin HC, Patnaik M, Jacobson S. Association of human herpes virus 6 (HHV-6) with multiple sclerosis: increased IgM response to HHV-6 early antigen and detection of serum HHV-6 DNA Nat Med 3: 1394-7 (1997) (Pubitemid 28011041)
171. Berti R, Brennan MB, Soldan SS, Ohayon JM, Casareto L, McFarland HF, Jacobson S. Increased detection of serum HHV-6 DNA sequences during multiple sclerosis (MS) exacerbations and correlation with parameters of MS disease progression J Neurovirol 8: 250-6 (2002) (Pubitemid 34732706)
172. Jarius S, Eichhorn P, Jacobi C, Wildemann B, Wick M, Voltz R. The intrathecal, polyspecific antiviral immune response: Specific for MS or a general marker of CNS autoimmunity? J Neurol Sci (2008)
173. Ascherio A, Munger KL, Lennette ET, Spiegelman D, Hernan MA, Olek MJ, Hankinson SE, Hunter DJ. Epstein-Barr virus antibodies and risk of multiple sclerosis: a prospective study JAMA 286: 3083-8 (2001) (Pubitemid 34016522)
174. Jilek S, Schluep M, Meylan P, Vingerhoets F, Guignard L, Monney A, Kleeberg J, Le Goff G, Pantaleo G, Du Pasquier RA. Strong EBV-specific CD8+ T-cell response in patients with early multiple sclerosis Brain 131: 1712-21 (2008) (Pubitemid 351957461)
175. Lindsey J, Hatfield L, Crawford M, Patel S. Quantitative PCR for Epstein-Barr virus DNA and RNA in multiple sclerosis Mult Scler (2008)
176. Rodriguez-Violante M, Ordonez G, Bermudez JR, Sotelo J, Corona T. Association of a history of varicella virus infection with multiple sclerosis Clin Neurol Neurosurg 111: 54-6 (2009)
177. Hawkes C. Olfaction in neurodegenerative disorder Mov Disord 18: 364-72 (2003) (Pubitemid 36527276)
178. Hawkes C. Olfaction in neurodegenerative disorder Adv Otorhinolaryngol 63: 133-51 (2006) (Pubitemid 44155316)
179. Mesholam RI, Moberg PJ, Mahr RN, Doty RL. Olfaction in neurodegenerative disease: a meta-analysis of olfactory functioning in Alzheimer's and Parkinson's diseases Arch Neurol 55: 84-90 (1998) (Pubitemid 28139109)
180. Wozniak MA, Mee AP, Itzhaki RF. Herpes simplex virus type 1 DNA is located within Alzheimer's disease amyloid plaques J Pathol 217: 131-8 (2009)
181. Itzhaki RF, Wozniak MA. Herpes simplex virus type 1 in Alzheimer's disease: the enemy within J Alzheimers Dis 13: 393-405 (2008) (Pubitemid 352039023)
182. Wozniak MA, Itzhaki RF, Shipley SJ, Dobson CB. Herpes simplex virus infection causes cellular beta-amyloid accumulation and secretase upregulation Neurosci Lett 429: 95-100 (2007) (Pubitemid 350161114)
183. Wozniak MA, Shipley SJ, Combrinck M, Wilcock GK, Itzhaki RF. Productive herpes simplex virus in brain of elderly normal subjects and Alzheimer's disease patients J Med Virol 75: 300-6 (2005) (Pubitemid 40053743)
184. Mori I, Goshima F, Watanabe D, Ito H, Koide N, Yoshida T, Liu B, Kimura Y, Yokochi T, Nishiyama Y. Herpes simplex virus US3 protein kinase regulates virus-induced apoptosis in olfactory and vomeronasal chemosensory neurons in vivo Microbes Infect 8: 1806-12 (2006) (Pubitemid 44128882)
185. Hawkes CH, Del Tredici K, Braak H. Parkinson's disease: a dual-hit hypothesis Neuropathol Appl Neurobiol 33: 599-614 (2007) (Pubitemid 350076090)
186. Rojo AI, Montero C, Salazar M, Close RM, Fernandez-Ruiz J, Sanchez-Gonzalez MA, de Sagarra MR, Jackson-Lewis V, Cavada C, Cuadrado A. Persistent penetration of MPTP through the nasal route induces Parkinson's disease in mice Eur J Neurosci 24: 1874-84 (2006) (Pubitemid 44583472)
187. Friedman JH, Amick MM. Rhinorrhea is increased in Parkinson's disease Mov Disord 23: 452-4 (2008)
188. Meredith GE, Sonsalla PK, Chesselet MF. Animal models of Parkinson's disease progression Acta Neuropathol 115: 385-98 (2008)
189. Nagatsu T, Mogi M, Ichinose H, Togari A. Changes in cytokines and neurotrophins in Parkinson's disease J Neural Transm Suppl 277-90 (2000) (Pubitemid 32037200)
190. Bower JH, Maraganore DM, Peterson BJ, Ahlskog JE, Rocca WA. Immunologic diseases, anti-inflammatory drugs, and Parkinson disease: a case-control study Neurology 67: 494-6 (2006) (Pubitemid 44214979)
191. McCoy MK, Ruhn KA, Martinez TN, McAlpine FE, Blesch A, Tansey MG. Intranigral lentiviral delivery of dominant-negative TNF attenuates neurodegeneration and behavioral deficits in hemiparkinsonian rats Mol Ther 16: 1572-9 (2008)
192. Brochard V, Combadiere B, Prigent A, Laouar Y, Perrin A, Beray-Berthat V, Bonduelle O, Alvarez-Fischer D, Callebert J, Launay JM, Duyckaerts C, Flavell RA, Hirsch EC, Hunot S. Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease J Clin Invest 119: 182-92 (2009)
193. Hayley S, Poulter MO, Merali Z, Anisman H. The pathogenesis of clinical depression: stressor-and cytokine-induced alterations of neuroplasticity Neuroscience 135: 659-78 (2005) (Pubitemid 41407732)
194. Pollak Y, Yirmiya R. Cytokine-induced changes in mood and behaviour: implications for 'depression due to a general medical condition', immunotherapy and antidepressive treatment Int J Neuropsychopharmacol 5: 389-99 (2002) (Pubitemid 35470358)
195. Raison CL, Capuron L, Miller AH. Cytokines sing the blues: inflammation and the pathogenesis of depression Trends Immunol 27: 24-31 (2006) (Pubitemid 43083561)
196. Yirmiya R. Depression in medical illness: the role of the immune system West J Med 173: 333-6 (2000)
197. Raison CL, Broadwell SD, Borisov AS, Manatunga AK, Capuron L, Woolwine BJ, Jacobson IM, Nemeroff CB, Miller AH. Depressive symptoms and viral clearance in patients receiving interferon-alpha and ribavirin for hepatitis C Brain Behav Immun 19: 23-7 (2005) (Pubitemid 39592806)
198. Castanon N, Leonard BE, Neveu PJ, Yirmiya R. Effects of antidepressants on cytokine production and actions Brain Behav Immun 16: 569-74 (2002) (Pubitemid 35333736)
199. Yirmiya R, Pollak Y, Morag M, Reichenberg A, Barak O, Avitsur R, Shavit Y, Ovadia H, Weidenfeld J, Morag A, Newman ME, Pollmacher T. Illness, cytokines, and depression Ann N Y Acad Sci 917: 478-87 (2000)
200. Belmaker RH, Agam G. Major depressive disorder N Engl J Med 358: 55-68 (2008)
201. Drevets WC, Price JL, Furey ML. Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression Brain Struct Funct 213: 93-118 (2008)
202. Drevets WC, Savitz J, Trimble M. The subgenual anterior cingulate cortex in mood disorders CNS Spectr 13: 663-81 (2008)
203. Drevets WC. Orbitofrontal cortex function and structure in depression Ann N Y Acad Sci 1121: 499-527 (2007)
204. Postolache TT, Lapidus M, Sander ER, Langenberg P, Hamilton RG, Soriano JJ, McDonald JS, Furst N, Bai J, Scrandis DA, Cabassa JA, Stiller JW, Balis T, Guzman A, Togias A, Tonelli LH. Changes in allergy symptoms and depression scores are positively correlated in patients with recurrent mood disorders exposed to seasonal peaks in aeroallergens ScientificWorldJournal 7: 1968-77 (2007)
205. Guzman A, Tonelli LH, Roberts D, Stiller JW, Jackson MA, Soriano JJ, Yousufi S, Rohan KJ, Komarow H, Postolache TT. Mood-worsening with high-pollen-counts and seasonality: a preliminary report J Affect Disord 101: 269-74 (2007) (Pubitemid 46879939)
206. Goodwin RD, Buka SL. Childhood respiratory disease and the risk of anxiety disorder and major depression in adulthood Arch Pediatr Adolesc Med 162: 774-80 (2008)
207. Roy-Byrne PP, Davidson KW, Kessler RC, Asmundson GJ, Goodwin RD, Kubzansky L, Lydiard RB, Massie MJ, Katon W, Laden SK, Stein MB. Anxiety disorders and comorbid medical illness Gen Hosp Psychiatry 30: 208-25 (2008) (Pubitemid 351545834)
208. Addolorato G, Ancona C, Capristo E, Graziosetto R, Di Rienzo L, Maurizi M, Gasbarrini G. State and trait anxiety in women affected by allergic and vasomotor rhinitis J Psychosom Res 46: 283-9 (1999) (Pubitemid 29118390)
209. Buske-Kirschbaum A, Ebrecht M, Kern S, Gierens A, Hellhammer DH. Personality characteristics in chronic and non-chronic allergic conditions Brain Behav Immun 22: 762-8 (2008)
210. Barone S, Bacon SL, Campbell TS, Labrecque M, Ditto B, Lavoie KL. The association between anxiety sensitivity and atopy in adult asthmatics J Behav Med 31: 331-9 (2008)
211. Deshmukh VM, Toelle BG, Usherwood T, O'Grady B, Jenkins CR. The association of comorbid anxiety and depression with asthma-related quality of life and symptom perception in adults Respirology 13: 695-702 (2008) (Pubitemid 351977582)
212. Timonen M, Jokelainen J, Hakko H, Silvennoinen-Kassinen S, Meyer-Rochow VB, Herva A, Rasanen P. Atopy and depression: results from the Northern Finland 1966 Birth Cohort Study Mol Psychiatry 8: 738-44 (2003) (Pubitemid 36976431)
213. Goodwin RD. Self-reported hay fever and panic attacks in the community Ann Allergy Asthma Immunol 88: 556-9 (2002) (Pubitemid 36183807)
214. Rook GA. The hygiene hypothesis and the increasing prevalence of chronic inflammatory disorders Trans R Soc Trop Med Hyg 101: 1072-4 (2007) (Pubitemid 47440534)
215. Bach JF. Infections and autoimmune diseases J Autoimmun 25 Suppl: 74-80 (2005)
216. Rook GA, Lowry CA. The hygiene hypothesis and psychiatric disorders Trends Immunol 29: 150-8 (2008)