Persistent penetration of MPTP through the nasal route induces Parkinson's disease in mice

European Journal of Neuroscience

Volumn 24, Issue 7, 2006, Pages 1874-1884

  Rojo, Ana I ^a   Montero, Celia ^a   Salazar, María ^a   Close, Ryan M ^b   Fernández Ruiz, Javier ^c   Sánchez González, Miguel A ^d   De Sagarra, María Rosa ^a   Jackson Lewis, Vernice ^b   Cavada, Carmen ^d   Cuadrado, Antonio ^a  

^a INSTITUTO DE INVESTIGACIONES BIOMÉDICAS ALBERTO SOLS   (Spain)

^b Och Spine at New York Presbyterian Hospitals   (United States)

^c UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^d UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

Intranasal delivery; Neurotoxins

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; ACETYLCHOLINESTERASE; ALPHA SYNUCLEIN; DOPAMINE; DOPAMINE TRANSPORTER; MANGANESE SUPEROXIDE DISMUTASE; TYROSINE 3 MONOOXYGENASE;

AGGRESSION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTOSIS; CONTROLLED STUDY; CORPUS STRIATUM; DISEASE MODEL; DISEASE SEVERITY; DOPAMINE BLOOD LEVEL; DRUG PENETRATION; ENVIRONMENTAL FACTOR; MALE; MOTOR DYSFUNCTION; MOUSE; NEUROTOXICITY; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN AGGREGATION; RISK ASSESSMENT; SUBSTANTIA NIGRA;

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; 3,4-DIHYDROXYPHENYLACETIC ACID; ACETYLCHOLINESTERASE; ADMINISTRATION, INTRANASAL; ANIMALS; BEHAVIOR, ANIMAL; BLOTTING, WESTERN; BRAIN; DISEASE MODELS, ANIMAL; DOPAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION ROUTES; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, INBRED C57BL; MOTOR ACTIVITY; NERVE TISSUE PROTEINS; NEUROTOXINS; PARKINSON DISEASE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SYNUCLEINS; TIME FACTORS; TYROSINE 3-MONOOXYGENASE;

EID: 33750068268     PISSN: 0953816X     EISSN: 14609568     Source Type: Journal    
DOI: 10.1111/j.1460-9568.2006.05060.x     Document Type: Article

References (24)

1. Abeliovich, A., Schmitz, Y., Farinas, I., Choi-Lundberg, D., Ho, W.H., Castillo, P.E., Shinsky, N., Verdugo, J.M., Armanini, M., Ryan, A., Hynes, M., Phillips, H., Sulzer, D. & Rosenthal, A. (2000) Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system. Neuron, 25, 239-252.
2. Baldi, I., Cantagrel, A., Lebailly, P., Tison, F., Dubroca, B., Chrysostome, V., Dartigues, J.F. & Brochard, P. (2003) Association between Parkinson's disease and exposure to pesticides in southwestern France. Neuroepidemiology, 22, 305-310.
3. Ballard, P.A., Tetrud, J.W. & Langston, J.W. (1985) Permanent human parkinsonism due to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): seven cases. Neurology, 35, 949-956.
4. Barbeau, A., Roy, M. & Langston, J.W. (1985) Neurological consequence of industrial exposure to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Lancet, 1, 747.
5. Cone, E.J. (1998) Recent discoveries in pharmacokinetics of drugs of abuse. Toxicol. Lett., 102-103, 97-101.
6. Dauer, W. & Przedborski, S. (2003) Parkinson's disease mechanisms and models. Neuron, 39, 889-909.
7. Fall, P.A., Fredrikson, M., Axelson, O. & GranerusA.K. (1999) Nutritional and occupational factors influencing the risk of Parkinson's disease: a case-control study in southeastern Sweden. Mov. Disord., 14, 28-37.
8. Fornai, F., Schluter, O.M., Lenzi, P., Gesi, M., Ruffoli, R., Ferrucci, M., Lazzeri, G., Busceti, C.L., Pontarelli, F., Battaglia, G., Pellegrini, A., Nicoletti, F., Ruggieri, S., Paparelli, A. & Sudhof, T.C. (2005) Parkinson-like syndrome induced by continuous MPTP infusion: convergent roles of the ubiquitin-proteasome system and alpha-synuclein. Proc. Natl Acad. Sci. USA, 102, 3413-3418.
9. + after administration of lethal and sublethal doses of MPTP to mice. Toxicol. Lett., 54, 253-262.
10. Graff, C.L. & Pollack, G.M. (2005) Nasal drug administration: potential for targeted central nervous system delivery. J. Pharm. Sci., 94, 1187-1195.
11. Hoglinger, G.U., Rizk, P., Muriel, M.P., Duyckaerts, C., Oertel, W.H., Caille, I. & Hirsch, E.C. (2004) Dopamine depletion impairs precursor cell proliferation in Parkinson disease. Nat. Neurosci., 7, 726-735.
12. Jenner, P. (2003) Oxidative stress in Parkinson's disease. Ann. Neurol., 53 (Suppl. 3), S26-S36.
13. de Lago, E., de Miguel, R., Lastres-Becker, I., Ramos, J.A. & Fernandez-Ruiz, J. (2004) Involvement of vanilloid-like receptors in the effects of anandamide on motor behaviour and nigrostriatal dopaminergic activity: in vivo and in vitro evidence. Brain Res., 1007, 152-159.
14. Langston, J.W. & Ballard, P.A. Jr (1983) Parkinson's disease in a chemist working with 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine. N. Engl. J. Med., 309, 310.
15. Langston, J.W., Forno, L.S., Tetrud, J., Reeves, A.G., Kaplan, J.A. & Karluk, D. (1999) Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure. Ann. Neurol., 46, 598-605.
16. Liberini, P., Parola, S., Spano, P.F. & Antonini, L. (2000) Olfaction in Parkinson's disease: methods of assessment and clinical relevance. J. Neurol., 247, 88-96.
17. Mitsumoto, Y., Mori, A., Ohashi, S., Nakai, M. & Moriizumi, T. (2005) Differential effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in the olfactory bulb and the striatum in mice. Neurosci. Res., 51, 111-115.
18. Przedborski, S., Jackson-Lewis, V., Naini, A.B., Jakowec, M., Petzinger, G., Miller, R. & Akram, M. (2001) The parkinsonian toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): a technical review of its utility and safety. J. Neurochem., 76, 1265-1274.
19. Przedborski, S. & Vila, M. (2003) The 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine mouse model: a tool to explore the pathogenesis of Parkinson's disease. Ann. NY Acad. Sci., 991, 189-198.
20. Shimoji, M., Zhang, L., Mandir, A.S., Dawson, V.L. & Dawson, T.M. (2005) Absence of inclusion body formation in the MPTP mouse model of Parkinson's disease. Brain Res. Mol. Brain Res., 134, 103-108.
21. Smeyne, R.J. & Jackson-Lewis, V. (2005) The MPTP model of Parkinson's disease. Brain Res. Mol. Brain Res., 134, 57-66.
22. Thorne, R.G., Pronk, G.J., Padmanabhan, V., Frey, W.H. & 2nd (2004) Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration. Neuroscience, 127, 481-496.
23. Van Kampen, J.M., Hagg, T. & Robertson, H.A. (2004) Induction of neurogenesis in the adult rat subventricular zone and neostriatum following dopamine D receptor stimulation. Eur. J. Neurosci., 19, 2377-2387.
24. Wu, D.C., Jackson-Lewis, V., Vila, M., Tieu, K., Teismann, P., Vadseth, C., Choi, D.K., Ischiropoulos, H. & Przedborski, S. (2002) Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine mouse model of Parkinson disease. J. Neurosci., 22, 1763-1771.