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Volumn 15, Issue 9, 2010, Pages 6598-6618

Kinin receptor antagonists as potential neuroprotective agents in central nervous system injury

Author keywords

Brain injury; Kinins; Neuropeptides; Neurotrauma; Stroke

Indexed keywords

BRADYKININ RECEPTOR; NEUROKININ 1 RECEPTOR; NEUROPROTECTIVE AGENT;

EID: 77957314877     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules15096598     Document Type: Review
Times cited : (38)

References (116)
  • 1
    • 57849136110 scopus 로고    scopus 로고
    • Multifunctional drugs for head injury
    • Vink, R.; Nimmo, A. J. Multifunctional drugs for head injury. Neurotherapeutics 2009, 6, 28-42.
    • (2009) Neurotherapeutics , vol.6 , pp. 28-42
    • Vink, R.1    Nimmo, A.J.2
  • 2
    • 14144251086 scopus 로고    scopus 로고
    • International union of pharmacology. XLV. Classification of the kinin receptor family: From molecular mechanisms to pathophysiological consequences
    • Leeb-Lundberg, L. M.; Marceau, F.; Muller-Esterl, W.; Pettibone, D. J.; Zuraw, B. L. International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Pharmacol. Rev. 2005, 57, 27-77.
    • (2005) Pharmacol. Rev. , vol.57 , pp. 27-77
    • Leeb-Lundberg, L.M.1    Marceau, F.2    Muller-Esterl, W.3    Pettibone, D.J.4    Zuraw, B.L.5
  • 3
    • 68849118781 scopus 로고    scopus 로고
    • Recent patents in CNS drug discovery: The management of inflammation in the central nervous system
    • Nimmo, A. J.; Vink, R. Recent patents in CNS drug discovery: the management of inflammation in the central nervous system. Recent Pat CNS Drug Discov. 2009, 4, 86-95.
    • (2009) Recent Pat CNS Drug Discov. , vol.4 , pp. 86-95
    • Nimmo, A.J.1    Vink, R.2
  • 4
    • 0031850773 scopus 로고    scopus 로고
    • Pathophysiology of the kallikrein-kinin system in mammalian nervous tissue
    • Raidoo, D. M.; Bhoola, K. D. Pathophysiology of the kallikrein-kinin system in mammalian nervous tissue. Pharmacol. Ther. 1998, 79, 105-127.
    • (1998) Pharmacol. Ther. , vol.79 , pp. 105-127
    • Raidoo, D.M.1    Bhoola, K.D.2
  • 5
    • 16244385015 scopus 로고    scopus 로고
    • Targeting kinin receptors for the treatment of neurological diseases
    • Rodi, D.; Couture, R.; Ongali, B.; Simonato, M. Targeting kinin receptors for the treatment of neurological diseases. Curr. Pharm. Design 2005, 11, 1313-1326.
    • (2005) Curr. Pharm. Design , vol.11 , pp. 1313-1326
    • Rodi, D.1    Couture, R.2    Ongali, B.3    Simonato, M.4
  • 6
    • 0035137002 scopus 로고    scopus 로고
    • Substance P: A pioneer amongst neuropeptides
    • Hokfelt, T.; Pernow, B.; Wahren, J. Substance P: a pioneer amongst neuropeptides. J. Int. Med. 2001, 249, 27-40.
    • (2001) J. Int. Med. , vol.249 , pp. 27-40
    • Hokfelt, T.1    Pernow, B.2    Wahren, J.3
  • 7
    • 0026331697 scopus 로고
    • Human substance P receptor (NK-1): Organisation of the gene, chromosome localization, and functional expression of cDNA clones
    • Gerard, N. P.; Garraway, L. A.; Eddy, J. R. L.; Shows, T. B.; Iijima, H.; Paquet, J.-L.; Gerard, C. Human substance P receptor (NK-1): Organisation of the gene, chromosome localization, and functional expression of cDNA clones. Biochemistry 1991, 30, 10640-10646.
    • (1991) Biochemistry , vol.30 , pp. 10640-10646
    • Gerard, N.P.1    Garraway, L.A.2    Eddy, J.R.L.3    Shows, T.B.4    Iijima, H.5    Paquet, J.-L.6    Gerard, C.7
  • 14
    • 0036509936 scopus 로고    scopus 로고
    • Expression of functional NK-1 receptors in murine microglia
    • Rasley, A.; Bost, K. L.; Olson, J. K.; Miller, S. D.; Marriott, I. Expression of functional NK-1 receptors in murine microglia. Glia 2002, 37, 258-267.
    • (2002) Glia , vol.37 , pp. 258-267
    • Rasley, A.1    Bost, K.L.2    Olson, J.K.3    Miller, S.D.4    Marriott, I.5
  • 15
    • 0035112614 scopus 로고    scopus 로고
    • Adaptive plasticity in tachykinin and tachykinin receptor expression after focal cerebral ischemia is differentially linked to gabaergic and glutamatergic cerebrocortical circuits and cerebrovenular endothelium
    • Stumm, R.; Culmsee, C.; Schafer, M. K.; Krieglstein, J.; Weihe, E. Adaptive plasticity in tachykinin and tachykinin receptor expression after focal cerebral ischemia is differentially linked to gabaergic and glutamatergic cerebrocortical circuits and cerebrovenular endothelium. J. Neurosci. 2001, 21, 798-811.
    • (2001) J. Neurosci. , vol.21 , pp. 798-811
    • Stumm, R.1    Culmsee, C.2    Schafer, M.K.3    Krieglstein, J.4    Weihe, E.5
  • 16
    • 0026331697 scopus 로고
    • Human substance P receptor (NK-1): Organization of the gene, chromosome localization, and functional expression of cDNA clones
    • Gerard, N. P.; Garraway, L. A.; Eddy, R. L., Jr.; Shows, T. B.; Iijima, H.; Paquet, J. L.; Gerard, C. Human substance P receptor (NK-1): organization of the gene, chromosome localization, and functional expression of cDNA clones. Biochemistry 1991, 30, 10640-10646.
    • (1991) Biochemistry , vol.30 , pp. 10640-10646
    • Gerard, N.P.1    Garraway, L.A.2    Eddy Jr., R.L.3    Shows, T.B.4    Iijima, H.5    Paquet, J.L.6    Gerard, C.7
  • 17
    • 0032587925 scopus 로고    scopus 로고
    • 1 receptor in the brain: Pharmacology and putative functions
    • 1 receptor in the brain: pharmacology and putative functions. Eur. J. Pharmacol. 1999, 375, 51-60.
    • (1999) Eur. J. Pharmacol. , vol.375 , pp. 51-60
    • Saria, A.1
  • 18
    • 0028869860 scopus 로고
    • Kinins and kinin receptors in the nervous system
    • Walker, K.; Perkins, M.; Dray, A. Kinins and kinin receptors in the nervous system. Neurochem. Int. 1995, 26, 1-16.
    • (1995) Neurochem. Int. , vol.26 , pp. 1-16
    • Walker, K.1    Perkins, M.2    Dray, A.3
  • 19
    • 0026544583 scopus 로고
    • Bradykinin and neuronal injury
    • Francel, P. C. Bradykinin and neuronal injury. J. Neurotrauma 1992, 9, S27-S45.
    • (1992) J. Neurotrauma , vol.9
    • Francel, P.C.1
  • 20
    • 0020676334 scopus 로고
    • Agonist-induced endothelium-dependent relaxation in rat thoracic aorta may be mediated through cGMP
    • Rapoport, R. M.; Murad, F. Agonist-induced endothelium-dependent relaxation in rat thoracic aorta may be mediated through cGMP. Circ. Res. 1983, 52, 352-357. (Pubitemid 13158751)
    • (1983) Circulation Research , vol.52 , Issue.3 , pp. 352-357
    • Rapoport, R.M.1    Murad, F.2
  • 21
    • 0037144171 scopus 로고    scopus 로고
    • Effects of LF 16-0687 Ms, a bradykinin B (2) receptor antagonist, on brain edema formation and tissue damage in a rat model of temporary focal cerebral ischemia
    • Zausinger, S.; Lumenta, D. B.; Pruneau, D.; Schmid-Elsaesser, R.; Plesnila, N.; Baethmann, A. Effects of LF 16-0687 Ms, a bradykinin B (2) receptor antagonist, on brain edema formation and tissue damage in a rat model of temporary focal cerebral ischemia. Brain Res. 2002, 950, 268-278.
    • (2002) Brain Res. , vol.950 , pp. 268-278
    • Zausinger, S.1    Lumenta, D.B.2    Pruneau, D.3    Schmid-Elsaesser, R.4    Plesnila, N.5    Baethmann, A.6
  • 23
    • 33747494572 scopus 로고    scopus 로고
    • Microglia as a pharmacological target in infectious and inflammatory diseases of the brain
    • Rock, R. B.; Peterson, P. K. Microglia as a pharmacological target in infectious and inflammatory diseases of the brain. J. Neuroimmune Pharmacol. 2006, 1, 117-126.
    • (2006) J. Neuroimmune Pharmacol. , vol.1 , pp. 117-126
    • Rock, R.B.1    Peterson, P.K.2
  • 25
    • 33646947850 scopus 로고    scopus 로고
    • Induction of glial fibrillary acidic protein expression in astrocytes by nitric oxide
    • Brahmachari, S.; Fung, Y. K.; Pahan, K. Induction of glial fibrillary acidic protein expression in astrocytes by nitric oxide. J. Neurosci. 2006, 26, 4930-4939.
    • (2006) J. Neurosci. , vol.26 , pp. 4930-4939
    • Brahmachari, S.1    Fung, Y.K.2    Pahan, K.3
  • 26
    • 50949116628 scopus 로고    scopus 로고
    • Neurogenic exacerbation of microglial and astrocyte responses to Neisseria meningitidis and Borrelia burgdorferi
    • Chauhan, V. S.; Sterka, D. G., Jr.; Gray, D. L.; Bost, K. L.; Marriott, I. Neurogenic exacerbation of microglial and astrocyte responses to Neisseria meningitidis and Borrelia burgdorferi. J. Immunol. 2008, 180, 8241-8249.
    • (2008) J. Immunol. , vol.180 , pp. 8241-8249
    • Chauhan, V.S.1    Sterka Jr., D.G.2    Gray, D.L.3    Bost, K.L.4    Marriott, I.5
  • 27
    • 9144269103 scopus 로고    scopus 로고
    • Interleukin-1beta upregulates functional expression of neurokinin-1 receptor (NK-1R) via NF-kappaB in astrocytes
    • Guo, C. J.; Douglas, S. D.; Gao, Z.; Wolf, B. A.; Grinspan, J.; Lai, J. P.; Riedel, E.; Ho, W. Z. Interleukin-1beta upregulates functional expression of neurokinin-1 receptor (NK-1R) via NF-kappaB in astrocytes. Glia 2004, 48, 259-266.
    • (2004) Glia , vol.48 , pp. 259-266
    • Guo, C.J.1    Douglas, S.D.2    Gao, Z.3    Wolf, B.A.4    Grinspan, J.5    Lai, J.P.6    Riedel, E.7    Ho, W.Z.8
  • 30
    • 0030801207 scopus 로고    scopus 로고
    • Upregulation of substance P receptor in angiogenesis associated with chronic airway inflammation in rats
    • Baluk, P.; Bowden, J. J.; Lefevre, P. M.; McDonald, D. M. Upregulation of substance P receptor in angiogenesis associated with chronic airway inflammation in rats. Am. J. Physiol. 1997, 27, L567-L571.
    • (1997) Am. J. Physiol. , vol.27
    • Baluk, P.1    Bowden, J.J.2    Lefevre, P.M.3    McDonald, D.M.4
  • 31
    • 0027366775 scopus 로고
    • Neurogenic inflammation in rat trachea is accompanied by increased negativity of interstitial fluid pressure
    • Woie, K.; Koller, M. E.; Heyeraas, K. J.; Reed, R. K. Neurogenic inflammation in rat trachea is accompanied by increased negativity of interstitial fluid pressure. Circ. Res. 1993, 73, 839-845. (Pubitemid 23306129)
    • (1993) Circulation Research , vol.73 , Issue.5 , pp. 839-845
    • Woie, K.1    Koller, M.-E.2    Heyeraas, K.J.3    Reed, R.K.4
  • 33
    • 0032875597 scopus 로고    scopus 로고
    • Receptor subtypes involved in tachykinin-mediated edema formation
    • Alves, R. V.; Campos, M. M.; Santos, A. R. S.; Calixto, J. B. Receptor subtypes involved in tachykinin-mediated edema formation. Peptides 1999, 20, 921-927.
    • (1999) Peptides , vol.20 , pp. 921-927
    • Alves, R.V.1    Campos, M.M.2    Santos, A.R.S.3    Calixto, J.B.4
  • 34
    • 77249125330 scopus 로고    scopus 로고
    • Quantitative analysis of cellular inflammation after traumatic spinal cord injury: Evidence for a multiphasic inflammatory response in the acute to chronic environment
    • Beck, K. D.; Nguyen, H. X.; Galvan, M. D.; Salazar, D. L.; Woodruff, T. M.; Anderson, A. J. Quantitative analysis of cellular inflammation after traumatic spinal cord injury: evidence for a multiphasic inflammatory response in the acute to chronic environment. Brain 2010, 133, 433-447.
    • (2010) Brain , vol.133 , pp. 433-447
    • Beck, K.D.1    Nguyen, H.X.2    Galvan, M.D.3    Salazar, D.L.4    Woodruff, T.M.5    Anderson, A.J.6
  • 35
    • 27944434592 scopus 로고    scopus 로고
    • Aprepitant (EMEND): The role of substance P in nausea and vomiting
    • Prommer, E. Aprepitant (EMEND): the role of substance P in nausea and vomiting. J. Pain Palliative Care Pharmacother. 2005, 19, 31-39.
    • (2005) J. Pain Palliative Care Pharmacother. , vol.19 , pp. 31-39
    • Prommer, E.1
  • 36
    • 0032748934 scopus 로고    scopus 로고
    • Bradykinin antagonists: Present progress and future prospects
    • Stewart, J. M.; Gera, L.; York, E. J.; Chan, D. C.; Bunn, P. Bradykinin antagonists: present progress and future prospects. Immunopharmacology 1999, 43, 155-161.
    • (1999) Immunopharmacology , vol.43 , pp. 155-161
    • Stewart, J.M.1    Gera, L.2    York, E.J.3    Chan, D.C.4    Bunn, P.5
  • 37
    • 0029023066 scopus 로고
    • Quantitative autoradiographic localization of [125I-Tyr8]bradykinin receptor binding sites in the rat spinal cord: Effects of neonatal capsaicin, noradrenergic deafferentation, dorsal rhizotomy and peripheral axotomy
    • Lopes, P.; Kar, S.; Chretien, L.; Regoli, D.; Quirion, R.; Couture, R. Quantitative autoradiographic localization of [125I-Tyr8]bradykinin receptor binding sites in the rat spinal cord: effects of neonatal capsaicin, noradrenergic deafferentation, dorsal rhizotomy and peripheral axotomy. Neuroscience 1995, 68, 867-881.
    • (1995) Neuroscience , vol.68 , pp. 867-881
    • Lopes, P.1    Kar, S.2    Chretien, L.3    Regoli, D.4    Quirion, R.5    Couture, R.6
  • 40
    • 72949092495 scopus 로고    scopus 로고
    • Involvement of pro- and anti-inflammatory cytokines and chemokines in the pathophysiology of traumatic brain injury
    • Ziebell, J. M.; Morganti-Kossmann, M. C. Involvement of pro- and anti-inflammatory cytokines and chemokines in the pathophysiology of traumatic brain injury. Neurotherapeutics 2010, 7, 22-30.
    • (2010) Neurotherapeutics , vol.7 , pp. 22-30
    • Ziebell, J.M.1    Morganti-Kossmann, M.C.2
  • 41
    • 0034011224 scopus 로고    scopus 로고
    • Significant reduction in brain swelling by administration of nonpeptide kinin B2 receptor antagonist LF 16-0687Ms after controlled cortical impact injury in rats
    • Stover, J. F.; Dohse, N. K.; Unterberg, A. W. Significant reduction in brain swelling by administration of nonpeptide kinin B2 receptor antagonist LF 16-0687Ms after controlled cortical impact injury in rats. J. Neurosurg. 2000, 92, 853-859.
    • (2000) J. Neurosurg. , vol.92 , pp. 853-859
    • Stover, J.F.1    Dohse, N.K.2    Unterberg, A.W.3
  • 42
    • 0030029495 scopus 로고    scopus 로고
    • Neuroligand-evoked calcium-dependent release of excitatory amino acids from cultured astrocytes
    • Jeftinija, S. D.; Jeftinija, K. V.; Stefanovic, G.; Liu, F. Neuroligand-evoked calcium-dependent release of excitatory amino acids from cultured astrocytes. J. Neurochem. 1996, 66, 676-684.
    • (1996) J. Neurochem. , vol.66 , pp. 676-684
    • Jeftinija, S.D.1    Jeftinija, K.V.2    Stefanovic, G.3    Liu, F.4
  • 43
    • 0022548862 scopus 로고
    • Endothelial dependent relaxation demonstrated in vivo in cerebral arterioles
    • Rosenblum, W. I. Endothelial dependent relaxation demonstrated in vivo in cerebral arterioles. Stroke 1986, 17, 494-497.
    • (1986) Stroke , vol.17 , pp. 494-497
    • Rosenblum, W.I.1
  • 45
    • 33646567103 scopus 로고    scopus 로고
    • Autoradiographic analysis of mouse brain kinin B1 and B2 receptors after closed head trauma and ability of Anatibant mesylate to cross the blood-brain barrier
    • Ongali, B.; Hellal, F.; Rodi, D.; Plotkine, M.; Marchand-Verrecchia, C.; Pruneau, D.; Couture, R. Autoradiographic analysis of mouse brain kinin B1 and B2 receptors after closed head trauma and ability of Anatibant mesylate to cross the blood-brain barrier. J. Neurotrauma 2006, 23, 696-707.
    • (2006) J. Neurotrauma , vol.23 , pp. 696-707
    • Ongali, B.1    Hellal, F.2    Rodi, D.3    Plotkine, M.4    Marchand-Verrecchia, C.5    Pruneau, D.6    Couture, R.7
  • 48
    • 0022573581 scopus 로고
    • The kallikrein-kinin system as mediator in vasogenic brain edema. Part 3: Inhibition of the kallikrein-kinin system in traumatic brain swelling
    • Unterberg, A.; Dautermann, C.; Baethmann, A.; Muller-Esterl, W. The kallikrein-kinin system as mediator in vasogenic brain edema. Part 3: Inhibition of the kallikrein-kinin system in traumatic brain swelling. J. Neurosurg. 1986, 64, 269-276.
    • (1986) J. Neurosurg. , vol.64 , pp. 269-276
    • Unterberg, A.1    Dautermann, C.2    Baethmann, A.3    Muller-Esterl, W.4
  • 49
    • 0018706308 scopus 로고
    • Proteolytic enzyme activity in patients with severe head injury and the effect of a proteinase inhibitor
    • Auer, L. M.; Marth, E.; Heppner, F.; Holasek, A. Proteolytic enzyme activity in patients with severe head injury and the effect of a proteinase inhibitor. Acta Neurochir. (Wien) 1979, 49, 207-217.
    • (1979) Acta Neurochir. (Wien) , vol.49 , pp. 207-217
    • Auer, L.M.1    Marth, E.2    Heppner, F.3    Holasek, A.4
  • 50
    • 0032747821 scopus 로고    scopus 로고
    • Effect of LF 16-0687MS, a new nonpeptide bradykinin B2 receptor antagonist, in a rat model of closed head trauma
    • Pruneau, D.; Chorny, I.; Benkovitz, V.; Artru, A.; Roitblat, L.; Shapira, Y. Effect of LF 16-0687MS, a new nonpeptide bradykinin B2 receptor antagonist, in a rat model of closed head trauma. J. Neurotrauma 1999, 16, 1057-1065.
    • (1999) J. Neurotrauma , vol.16 , pp. 1057-1065
    • Pruneau, D.1    Chorny, I.2    Benkovitz, V.3    Artru, A.4    Roitblat, L.5    Shapira, Y.6
  • 51
    • 0034570543 scopus 로고    scopus 로고
    • LF 16-0687 a novel non-peptide bradykinin B2 receptor antagonist reduces vasogenic brain edema from a focal lesion in rats
    • Schulz, J.; Plesnila, N.; Eriskat, J.; Stoffel, M.; Pruneau, D.; Baethmann, A. LF 16-0687 a novel non-peptide bradykinin B2 receptor antagonist reduces vasogenic brain edema from a focal lesion in rats. Acta Neurochir. Suppl. 2000, 76, 137-139.
    • (2000) Acta Neurochir. Suppl. , vol.76 , pp. 137-139
    • Schulz, J.1    Plesnila, N.2    Eriskat, J.3    Stoffel, M.4    Pruneau, D.5    Baethmann, A.6
  • 52
    • 0034740664 scopus 로고    scopus 로고
    • Role of bradykinin B2 receptors in the formation of vasogenic brain edema in rats
    • Plesnila, N.; Schulz, J.; Stoffel, M.; Eriskat, J.; Pruneau, D.; Baethmann, A. Role of bradykinin B2 receptors in the formation of vasogenic brain edema in rats. J. Neurotrauma 2001, 18, 1049-1058.
    • (2001) J. Neurotrauma , vol.18 , pp. 1049-1058
    • Plesnila, N.1    Schulz, J.2    Stoffel, M.3    Eriskat, J.4    Pruneau, D.5    Baethmann, A.6
  • 53
    • 31044440134 scopus 로고    scopus 로고
    • A single dose, three-arm, placebo-controlled, phase I study of the bradykinin B2 receptor antagonist Anatibant (LF16-0687Ms) in patients with severe traumatic brain injury
    • Marmarou, A.; Guy, M.; Murphey, L.; Roy, F.; Layani, L.; Combal, J. P.; Marquer, C. A single dose, three-arm, placebo-controlled, phase I study of the bradykinin B2 receptor antagonist Anatibant (LF16-0687Ms) in patients with severe traumatic brain injury. J. Neurotrauma 2005, 22, 1444-1455.
    • (2005) J. Neurotrauma , vol.22 , pp. 1444-1455
    • Marmarou, A.1    Guy, M.2    Murphey, L.3    Roy, F.4    Layani, L.5    Combal, J.P.6    Marquer, C.7
  • 55
    • 73249153460 scopus 로고    scopus 로고
    • Response to: The BRAIN TRIAL: A randomised, placebo controlled trial of a Bradykinin B2 receptor antagonist (Anatibant) in patients with traumatic brain injury
    • Simmon, V. F. Response to: The BRAIN TRIAL: a randomised, placebo controlled trial of a Bradykinin B2 receptor antagonist (Anatibant) in patients with traumatic brain injury. Trials 2009, 10, 110.
    • (2009) Trials , vol.10 , pp. 110
    • Simmon, V.F.1
  • 56
    • 0033034999 scopus 로고    scopus 로고
    • Effects of the bradykinin antagonist Bradycor (deltibant, CP-1027) in severe traumatic brain injury: Results of a multi-center, randomized, placebo-controlled trial. American brain injury consortium study group
    • Marmarou, A.; Nichols, J.; Burgess, J.; Newell, D.; Troha, J.; Burnham, D.; Pitts, L. Effects of the bradykinin antagonist Bradycor (deltibant, CP-1027) in severe traumatic brain injury: results of a multi-center, randomized, placebo-controlled trial. American Brain Injury Consortium Study Group. J. Neurotrauma 1999, 16, 431-444.
    • (1999) J. Neurotrauma , vol.16 , pp. 431-444
    • Marmarou, A.1    Nichols, J.2    Burgess, J.3    Newell, D.4    Troha, J.5    Burnham, D.6    Pitts, L.7
  • 57
    • 44949186520 scopus 로고    scopus 로고
    • Beta-2 receptor antagonists for acute traumatic brain injury
    • Ker, K.; Blackhall, K. Beta-2 receptor antagonists for acute traumatic brain injury. Cochrane Database Syst. Rev. 2008, CD006686.
    • (2008) Cochrane Database Syst. Rev.
    • Ker, K.1    Blackhall, K.2
  • 58
    • 68249125831 scopus 로고    scopus 로고
    • Substance P is associated with the development of brain edema and functional deficits after traumatic brain injury
    • Donkin, J. J.; Nimmo, A. J.; Cernak, I.; Blumbergs, P. C.; Vink, R. Substance P is associated with the development of brain edema and functional deficits after traumatic brain injury. J. Cerebr. Blood Flow Metabol. 2009, 29, 1388-1398.
    • (2009) J. Cerebr. Blood Flow Metabol. , vol.29 , pp. 1388-1398
    • Donkin, J.J.1    Nimmo, A.J.2    Cernak, I.3    Blumbergs, P.C.4    Vink, R.5
  • 59
    • 77951971088 scopus 로고    scopus 로고
    • Mechanisms of cerebral edema in traumatic brain injury: Therapeutic developments
    • Donkin, J. J.; Vink, R. Mechanisms of cerebral edema in traumatic brain injury: therapeutic developments. Curr. Opin. Neurol. 2010, 23, 293-299.
    • (2010) Curr. Opin. Neurol. , vol.23 , pp. 293-299
    • Donkin, J.J.1    Vink, R.2
  • 61
    • 0026052491 scopus 로고
    • Characterization of neuronal and endothelial forms of angiotensin converting enzyme in pig brain
    • Williams, T. A.; Hooper, N. M.; Turner, A. J. Characterization of neuronal and endothelial forms of angiotensin converting enzyme in pig brain. J. Neurochem. 1991, 57, 193-199.
    • (1991) J. Neurochem. , vol.57 , pp. 193-199
    • Williams, T.A.1    Hooper, N.M.2    Turner, A.J.3
  • 62
    • 77955090446 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme (ACE) inhibitors exacerbate histological damage and motor deficits after experimental traumatic brain injury
    • Harford-Wright, E.; Thornton, E.; Vink, R. Angiotensin-converting enzyme (ACE) inhibitors exacerbate histological damage and motor deficits after experimental traumatic brain injury. Neurosci. Lett. 2010, 481, 26-29.
    • (2010) Neurosci. Lett. , vol.481 , pp. 26-29
    • Harford-Wright, E.1    Thornton, E.2    Vink, R.3
  • 63
    • 1642305688 scopus 로고    scopus 로고
    • Neurogenic inflammation is associated with development of edema and functional deficits following traumatic brain injury in rats
    • Nimmo, A. J.; Cernak, I.; Heath, D. L.; Hu, X.; Bennett, C. J.; Vink, R. Neurogenic inflammation is associated with development of edema and functional deficits following traumatic brain injury in rats. Neuropeptides 2004, 38, 40-47.
    • (2004) Neuropeptides , vol.38 , pp. 40-47
    • Nimmo, A.J.1    Cernak, I.2    Heath, D.L.3    Hu, X.4    Bennett, C.J.5    Vink, R.6
  • 64
    • 16644368140 scopus 로고    scopus 로고
    • A substance P antagonist increases brain intracellular free magnesium concentration after diffuse traumatic brain injury in rats
    • Vink, R.; Donkin, J. J.; Cruz, M. I.; Nimmo, A. J.; Cernak, I. A substance P antagonist increases brain intracellular free magnesium concentration after diffuse traumatic brain injury in rats. J. Amer. Coll. Nutr. 2004, 23, 538S-540S.
    • (2004) J. Amer. Coll. Nutr. , vol.23
    • Vink, R.1    Donkin, J.J.2    Cruz, M.I.3    Nimmo, A.J.4    Cernak, I.5
  • 65
    • 70349524697 scopus 로고    scopus 로고
    • Magnesium in acute and chronic brain injury: An update
    • Vink, R.; Cook, N. L.; van den Heuvel, C. Magnesium in acute and chronic brain injury: an update. Magnes. Res. 2009, 22, 158S-162S.
    • (2009) Magnes. Res. , vol.22
    • Vink, R.1    Cook, N.L.2    Van Den Heuvel, C.3
  • 66
    • 72949094390 scopus 로고    scopus 로고
    • Substance P antagonists as a therapeutic approach to improving outcome following traumatic brain injury
    • Vink, R.; van den Heuvel, C. Substance P antagonists as a therapeutic approach to improving outcome following traumatic brain injury. Neurotherapeutics 2010, 7, 74-80.
    • (2010) Neurotherapeutics , vol.7 , pp. 74-80
    • Vink, R.1    Van Den Heuvel, C.2
  • 68
    • 0014757558 scopus 로고
    • The blood-brain barrier to proteins under normal and pathological conditions
    • Brightman, M. W.; Klatzo, I.; Olsson, Y.; Reese, T. S. The blood-brain barrier to proteins under normal and pathological conditions. J. Neurol. Sci. 1970, 10, 215-239.
    • (1970) J. Neurol. Sci. , vol.10 , pp. 215-239
    • Brightman, M.W.1    Klatzo, I.2    Olsson, Y.3    Reese, T.S.4
  • 69
    • 17844378527 scopus 로고    scopus 로고
    • Pathophysiology of blood-spinal cord barrier in traumatic injury and repair
    • Sharma, H. S. Pathophysiology of blood-spinal cord barrier in traumatic injury and repair. Curr. Pharm. Design 2005, 11, 1353-1389.
    • (2005) Curr. Pharm. Design , vol.11 , pp. 1353-1389
    • Sharma, H.S.1
  • 70
    • 0030560684 scopus 로고    scopus 로고
    • A quantitative spatial analysis of the blood-spinal cord barrier. I. Permeability changes after experimental spinal contusion injury
    • Popovich, P. G.; Horner, P. J.; Mullin, B. B.; Stokes, B. T. A quantitative spatial analysis of the blood-spinal cord barrier. I. Permeability changes after experimental spinal contusion injury. Exp. Neurol. 1996, 142, 258-275.
    • (1996) Exp. Neurol. , vol.142 , pp. 258-275
    • Popovich, P.G.1    Horner, P.J.2    Mullin, B.B.3    Stokes, B.T.4
  • 71
    • 65949095026 scopus 로고    scopus 로고
    • Tamoxifen attenuates inflammatory-mediated damage and improves functional outcome after spinal cord injury in rats
    • Tian, D. S.; Liu, J. L.; Xie, M. J.; Zhan, Y.; Qu, W. S.; Yu, Z. Y.; Tang, Z. P.; Pan, D. J.; Wang, W. Tamoxifen attenuates inflammatory-mediated damage and improves functional outcome after spinal cord injury in rats. J. Neurochem. 2009, 109, 1658-1667.
    • (2009) J. Neurochem. , vol.109 , pp. 1658-1667
    • Tian, D.S.1    Liu, J.L.2    Xie, M.J.3    Zhan, Y.4    Qu, W.S.5    Yu, Z.Y.6    Tang, Z.P.7    Pan, D.J.8    Wang, W.9
  • 72
    • 34249069211 scopus 로고    scopus 로고
    • Comparative neuroprotective effect of sodium channel blockers after experimental spinal cord injury
    • Ates, O.; Cayli, S. R.; Gurses, I.; Turkoz, Y.; Tarim, O.; Cakir, C. O.; Kocak, A. Comparative neuroprotective effect of sodium channel blockers after experimental spinal cord injury. J. Clin. Neurosci. 2007, 14, 658-665.
    • (2007) J. Clin. Neurosci. , vol.14 , pp. 658-665
    • Ates, O.1    Cayli, S.R.2    Gurses, I.3    Turkoz, Y.4    Tarim, O.5    Cakir, C.O.6    Kocak, A.7
  • 74
    • 0027360433 scopus 로고
    • Prostaglandins modulate alterations of microvascular permeability, blood flow, edema and serotonin levels following spinal cord injury: An experimental study in the rat
    • Sharma, H. S.; Olsson, Y.; Nyberg, F.; Dey, P. K. Prostaglandins modulate alterations of microvascular permeability, blood flow, edema and serotonin levels following spinal cord injury: an experimental study in the rat. Neuroscience 1993, 57, 443-449.
    • (1993) Neuroscience , vol.57 , pp. 443-449
    • Sharma, H.S.1    Olsson, Y.2    Nyberg, F.3    Dey, P.K.4
  • 75
    • 0025827968 scopus 로고
    • Evaluation of traumatic spinal cord edema using evoked potentials recorded from the spinal epidural space. An experimental study in the rat
    • Sharma, H. S.; Winkler, T.; Stalberg, E.; Olsson, Y.; Dey, P. K. Evaluation of traumatic spinal cord edema using evoked potentials recorded from the spinal epidural space. An experimental study in the rat. J. Neurol. Sci. 1991, 102, 150-162.
    • (1991) J. Neurol. Sci. , vol.102 , pp. 150-162
    • Sharma, H.S.1    Winkler, T.2    Stalberg, E.3    Olsson, Y.4    Dey, P.K.5
  • 76
    • 0028597549 scopus 로고
    • Opioid receptors influence spinal cord electrical activity and edema formation following spinal cord injury: Experimental observations using naloxone in the rat
    • Winkler, T.; Sharma, H. S.; Stalberg, E.; Olsson, Y.; Nyberg, F. Opioid receptors influence spinal cord electrical activity and edema formation following spinal cord injury: experimental observations using naloxone in the rat. Neurosci. Res. 1994, 21, 91-101.
    • (1994) Neurosci. Res. , vol.21 , pp. 91-101
    • Winkler, T.1    Sharma, H.S.2    Stalberg, E.3    Olsson, Y.4    Nyberg, F.5
  • 77
    • 0036562894 scopus 로고    scopus 로고
    • In vivo assessment of blood-spinal cord barrier permeability: Serial dynamic contrast enhanced MRI of spinal cord injury
    • Bilgen, M.; Dogan, B.; Narayana, P. A. In vivo assessment of blood-spinal cord barrier permeability: serial dynamic contrast enhanced MRI of spinal cord injury. Magn. Reson. Imaging 2002, 20, 337-341.
    • (2002) Magn. Reson. Imaging , vol.20 , pp. 337-341
    • Bilgen, M.1    Dogan, B.2    Narayana, P.A.3
  • 78
  • 80
    • 0035816419 scopus 로고    scopus 로고
    • Bradykinin antagonist decreases early disruption of the blood-spinal cord barrier after spinal cord injury in mice
    • Pan, W.; Kastin, A. J.; Gera, L.; Stewart, J. M. Bradykinin antagonist decreases early disruption of the blood-spinal cord barrier after spinal cord injury in mice. Neurosci. Lett. 2001, 307, 25-28.
    • (2001) Neurosci. Lett. , vol.307 , pp. 25-28
    • Pan, W.1    Kastin, A.J.2    Gera, L.3    Stewart, J.M.4
  • 81
    • 0034570633 scopus 로고    scopus 로고
    • A bradykinin BK2 receptor antagonist HOE-140 attenuates blood-spinal cord barrier permeability following a focal trauma to the rat spinal cord. An experimental study using Evans blue, [131]I-sodium and lanthanum tracers
    • Sharma, H. S. A bradykinin BK2 receptor antagonist HOE-140 attenuates blood-spinal cord barrier permeability following a focal trauma to the rat spinal cord. An experimental study using Evans blue, [131]I-sodium and lanthanum tracers. Acta Neurochir. Suppl. 2000, 76, 159-163.
    • (2000) Acta Neurochir. Suppl. , vol.76 , pp. 159-163
    • Sharma, H.S.1
  • 82
    • 0000508641 scopus 로고
    • An in vivo estimation of the potencies and halflives of synthetic bradykinin and kallidin
    • McCarthy, D. A.; Potter, D. E.; Nicolaides, E. D. An in vivo estimation of the potencies and halflives of synthetic bradykinin and kallidin. J. Pharmacol. Exp. Ther. 1965, 148, 117-122.
    • (1965) J. Pharmacol. Exp. Ther. , vol.148 , pp. 117-122
    • McCarthy, D.A.1    Potter, D.E.2    Nicolaides, E.D.3
  • 83
    • 0025130804 scopus 로고
    • Alteration of substance P after trauma to the spinal cord: an experimental study in the rat
    • DOI 10.1016/0306-4522(90)90386-I
    • Sharma, H. S.; Nyberg, F.; Olsson, Y.; Dey, P. K. Alteration of substance P after trauma to the spinal cord: an experimental study in the rat. Neuroscience 1990, 38, 205-212. (Pubitemid 20334934)
    • (1990) Neuroscience , vol.38 , Issue.1 , pp. 205-212
    • Sharma, H.S.1    Nyberg, F.2    Olsson, Y.3    Dey, P.K.4
  • 84
    • 0019491552 scopus 로고
    • Opiate antagonist improves neurologic recovery after spinal injury
    • Faden, A. I.; Jacobs, T. P.; Holaday, J. W. Opiate antagonist improves neurologic recovery after spinal injury. Science 1981, 211, 493-494.
    • (1981) Science , vol.211 , pp. 493-494
    • Faden, A.I.1    Jacobs, T.P.2    Holaday, J.W.3
  • 85
  • 86
    • 0025145034 scopus 로고
    • Effects of experimental spinal cord transection on substance P receptors: A quantitative autoradiography study
    • Vita, G.; Haun, C. K.; Hawkins, E. F.; Engel, W. K. Effects of experimental spinal cord transection on substance P receptors: a quantitative autoradiography study. Neuropeptides 1990, 17, 147-153.
    • (1990) Neuropeptides , vol.17 , pp. 147-153
    • Vita, G.1    Haun, C.K.2    Hawkins, E.F.3    Engel, W.K.4
  • 87
    • 0022254122 scopus 로고
    • Changes in substance P and somatostatin in the spinal cord after traumatic spinal injury in the rat
    • Faden, A. I.; Jacobs, T. P.; Helke, C. J. Changes in substance P and somatostatin in the spinal cord after traumatic spinal injury in the rat. Neuropeptides 1985, 6, 215-225.
    • (1985) Neuropeptides , vol.6 , pp. 215-225
    • Faden, A.I.1    Jacobs, T.P.2    Helke, C.J.3
  • 88
    • 0020329466 scopus 로고
    • Prevention of damage in acute spinal cord injury by peptides and pharmacologic agents
    • Naftchi, N. E. Prevention of damage in acute spinal cord injury by peptides and pharmacologic agents. Peptides 1982, 3, 235-247.
    • (1982) Peptides , vol.3 , pp. 235-247
    • Naftchi, N.E.1
  • 89
  • 90
    • 0028158180 scopus 로고
    • Voltage-dependent effects of opioid peptides on hippocampal CA3 pyramidal neurons in vitro
    • Moore, S. D.; Madamba, S. G.; Schweitzer, P.; Siggins, G. R. Voltage-dependent effects of opioid peptides on hippocampal CA3 pyramidal neurons in vitro. J. Neurosci. 1994, 14, 809-820.
    • (1994) J. Neurosci. , vol.14 , pp. 809-820
    • Moore, S.D.1    Madamba, S.G.2    Schweitzer, P.3    Siggins, G.R.4
  • 91
    • 0026340608 scopus 로고
    • Kappa-opioid antagonist improves cellular bioenergetics and recovery after traumatic brain injury
    • Vink, R.; Portoghese, P. S.; Faden, A. I. Kappa-opioid antagonist improves cellular bioenergetics and recovery after traumatic brain injury. Amer. J. Physiol. 1991, 261, R1527-1532.
    • (1991) Amer. J. Physiol. , vol.261
    • Vink, R.1    Portoghese, P.S.2    Faden, A.I.3
  • 92
    • 0027737836 scopus 로고
    • Activation of kappa opioid receptors by U50488H and morphine enhances the release of substance P from rat trigeminal nucleus slices
    • Suarez-Roca, H.; Maixner, W. Activation of kappa opioid receptors by U50488H and morphine enhances the release of substance P from rat trigeminal nucleus slices. J. Pharmacol. Exp. Ther. 1993, 264, 648-653.
    • (1993) J. Pharmacol. Exp. Ther. , vol.264 , pp. 648-653
    • Suarez-Roca, H.1    Maixner, W.2
  • 93
    • 0024468523 scopus 로고
    • Naloxone blocks the formalin-induced increase of substance P in the dorsal horn
    • McCarson, K. E.; Goldstein, B. D. Naloxone blocks the formalin-induced increase of substance P in the dorsal horn. Pain 1989, 38, 339-345.
    • (1989) Pain , vol.38 , pp. 339-345
    • McCarson, K.E.1    Goldstein, B.D.2
  • 95
    • 23044478435 scopus 로고    scopus 로고
    • Release of bradykinin and expression of kinin B2 receptors in the brain: Role for cell death and brain edema formation after focal cerebral ischemia in mice
    • Groger, M.; Lebesgue, D.; Pruneau, D.; Relton, J.; Kim, S. W.; Nussberger, J.; Plesnila, N. Release of bradykinin and expression of kinin B2 receptors in the brain: role for cell death and brain edema formation after focal cerebral ischemia in mice. J. Cerebr. Blood Flow Metabol. 2005, 25, 978-989.
    • (2005) J. Cerebr. Blood Flow Metabol. , vol.25 , pp. 978-989
    • Groger, M.1    Lebesgue, D.2    Pruneau, D.3    Relton, J.4    Kim, S.W.5    Nussberger, J.6    Plesnila, N.7
  • 97
    • 0027458015 scopus 로고
    • The role of bradykinin in mediating ischemic brain edema in rats
    • Kamiya, T.; Katayama, Y.; Kashiwagi, F.; Terashi, A. The role of bradykinin in mediating ischemic brain edema in rats. Stroke 1993, 24, 571-575.
    • (1993) Stroke , vol.24 , pp. 571-575
    • Kamiya, T.1    Katayama, Y.2    Kashiwagi, F.3    Terashi, A.4
  • 98
    • 60549111207 scopus 로고    scopus 로고
    • Blockade of bradykinin receptor B1 but not bradykinin receptor B2 provides protection from cerebral infarction and brain edema
    • Austinat, M.; Braeuninger, S.; Pesquero, J. B.; Brede, M.; Bader, M.; Stoll, G.; Renne, T.; Kleinschnitz, C. Blockade of bradykinin receptor B1 but not bradykinin receptor B2 provides protection from cerebral infarction and brain edema. Stroke 2009, 40, 285-293.
    • (2009) Stroke , vol.40 , pp. 285-293
    • Austinat, M.1    Braeuninger, S.2    Pesquero, J.B.3    Brede, M.4    Bader, M.5    Stoll, G.6    Renne, T.7    Kleinschnitz, C.8
  • 99
    • 69249212164 scopus 로고    scopus 로고
    • Blockade of bradykinin B2 receptor more effectively reduces postischemic blood-brain barrier disruption and cytokines release than B1 receptor inhibition
    • Su, J.; Cui, M.; Tang, Y.; Zhou, H.; Liu, L.; Dong, Q. Blockade of bradykinin B2 receptor more effectively reduces postischemic blood-brain barrier disruption and cytokines release than B1 receptor inhibition. Biochem. Biophys. Res. Commun. 2009, 388, 205-211.
    • (2009) Biochem. Biophys. Res. Commun. , vol.388 , pp. 205-211
    • Su, J.1    Cui, M.2    Tang, Y.3    Zhou, H.4    Liu, L.5    Dong, Q.6
  • 100
    • 0030878204 scopus 로고    scopus 로고
    • CP-0597, a selective bradykinin B2 receptor antagonist, inhibits brain injury in a rat model of reversible middle cerebral artery occlusion
    • Relton, J. K.; Beckey, V. E.; Hanson, W. L.; Whalley, E. T. CP-0597, a selective bradykinin B2 receptor antagonist, inhibits brain injury in a rat model of reversible middle cerebral artery occlusion. Stroke 1997, 28, 1430-1436.
    • (1997) Stroke , vol.28 , pp. 1430-1436
    • Relton, J.K.1    Beckey, V.E.2    Hanson, W.L.3    Whalley, E.T.4
  • 101
    • 65549106019 scopus 로고    scopus 로고
    • Ischemic postconditioning as a novel avenue to protect against brain injury after stroke
    • Zhao, H. Ischemic postconditioning as a novel avenue to protect against brain injury after stroke. J. Cerebr. Blood Flow Metabol. 2009, 29, 873-885.
    • (2009) J. Cerebr. Blood Flow Metabol. , vol.29 , pp. 873-885
    • Zhao, H.1
  • 103
    • 28944442996 scopus 로고    scopus 로고
    • Evidence for a role of second pathophysiological stress in prevention of delayed neuronal death in the hippocampal CA1 region
    • Burda, J.; Matiasova, M.; Gottlieb, M.; Danielisova, V.; Nemethova, M.; Garcia, L.; Salinas, M.; Burda, R. Evidence for a role of second pathophysiological stress in prevention of delayed neuronal death in the hippocampal CA1 region. Neurochem. Res. 2005, 30, 1397-1405.
    • (2005) Neurochem. Res. , vol.30 , pp. 1397-1405
    • Burda, J.1    Matiasova, M.2    Gottlieb, M.3    Danielisova, V.4    Nemethova, M.5    Garcia, L.6    Salinas, M.7    Burda, R.8
  • 104
    • 0842332614 scopus 로고    scopus 로고
    • Kallikrein gene transfer protects against ischemic stroke by promoting glial cell migration and inhibiting apoptosis
    • Xia, C. F.; Yin, H.; Borlongan, C. V.; Chao, L.; Chao, J. Kallikrein gene transfer protects against ischemic stroke by promoting glial cell migration and inhibiting apoptosis. Hypertension 2004, 43, 452-459.
    • (2004) Hypertension , vol.43 , pp. 452-459
    • Xia, C.F.1    Yin, H.2    Borlongan, C.V.3    Chao, L.4    Chao, J.5
  • 105
    • 32944463282 scopus 로고    scopus 로고
    • Kallikrein protects against ischemic stroke by inhibiting apoptosis and inflammation and promoting angiogenesis and neurogenesis
    • DOI 10.1089/hum.2006.17.206
    • Xia, C. F.; Yin, H.; Yao, Y. Y.; Borlongan, C. V.; Chao, L.; Chao, J. Kallikrein protects against ischemic stroke by inhibiting apoptosis and inflammation and promoting angiogenesis and neurogenesis. Hum. Gene Ther. 2006, 17, 206-219. (Pubitemid 43262036)
    • (2006) Human Gene Therapy , vol.17 , Issue.2 , pp. 206-219
    • Xia, C.-F.1    Yin, H.2    Yao, Y.-Y.3    Borlongan, C.V.4    Chao, L.5    Chao, J.6
  • 106
    • 77049085479 scopus 로고    scopus 로고
    • Differential regulation of inducible and endothelial nitric oxide synthase by kinin B1 and B2 receptors
    • Kuhr, F.; Lowry, J.; Zhang, Y.; Brovkovych, V.; Skidgel, R. A. Differential regulation of inducible and endothelial nitric oxide synthase by kinin B1 and B2 receptors. Neuropeptides 2010, 44, 145-154.
    • (2010) Neuropeptides , vol.44 , pp. 145-154
    • Kuhr, F.1    Lowry, J.2    Zhang, Y.3    Brovkovych, V.4    Skidgel, R.A.5
  • 107
    • 42149133588 scopus 로고    scopus 로고
    • Effects of bradykinin postconditioning on endogenous antioxidant enzyme activity after transient forebrain ischemia in rat
    • Danielisova, V.; Gottlieb, M.; Nemethova, M.; Burda, J. Effects of bradykinin postconditioning on endogenous antioxidant enzyme activity after transient forebrain ischemia in rat. Neurochem. Res. 2008, 33, 1057-1064.
    • (2008) Neurochem. Res. , vol.33 , pp. 1057-1064
    • Danielisova, V.1    Gottlieb, M.2    Nemethova, M.3    Burda, J.4
  • 109
    • 42349095662 scopus 로고    scopus 로고
    • Deficiency of bradykinin receptor B2 is not detrimental in experimental stroke
    • Kleinschnitz, C.; Austinat, M.; Bader, M.; Renne, T.; Stoll, G. Deficiency of bradykinin receptor B2 is not detrimental in experimental stroke. Hypertension 2008, 51, e41.
    • (2008) Hypertension , vol.51
    • Kleinschnitz, C.1    Austinat, M.2    Bader, M.3    Renne, T.4    Stoll, G.5
  • 110
    • 33744967754 scopus 로고    scopus 로고
    • Increased substance P immunoreactivity and edema formation following reversible ischemic stroke
    • Turner, R. J.; Blumbergs, P. C.; Sims, N. R.; Helps, S. C.; Rodgers, K. M.; Vink, R. Increased substance P immunoreactivity and edema formation following reversible ischemic stroke. Acta Neurochir. Suppl. 2006, 96, 263-266.
    • (2006) Acta Neurochir. Suppl. , vol.96 , pp. 263-266
    • Turner, R.J.1    Blumbergs, P.C.2    Sims, N.R.3    Helps, S.C.4    Rodgers, K.M.5    Vink, R.6
  • 112
    • 0035936931 scopus 로고    scopus 로고
    • Release of substance P by low oxygen in the rabbit carotid body: Evidence for the involvement of calcium channels
    • Kim, D. K.; Oh, E. K.; Summers, B. A.; Prabhakar, N. R.; Kumar, G. K. Release of substance P by low oxygen in the rabbit carotid body: evidence for the involvement of calcium channels. Brain Res. 2001, 892, 359-369.
    • (2001) Brain Res. , vol.892 , pp. 359-369
    • Kim, D.K.1    Oh, E.K.2    Summers, B.A.3    Prabhakar, N.R.4    Kumar, G.K.5
  • 113
    • 0030790069 scopus 로고    scopus 로고
    • Neurokinin-1 receptor antagonist SR140333: A novel type of drug to treat cerebral ischemia
    • Yu, Z.; Cheng, G.; Huang, X.; Li, K.; Cao, X. Neurokinin-1 receptor antagonist SR140333: a novel type of drug to treat cerebral ischemia. Neuroreport 1997, 8, 2117-2119.
    • (1997) Neuroreport , vol.8 , pp. 2117-2119
    • Yu, Z.1    Cheng, G.2    Huang, X.3    Li, K.4    Cao, X.5
  • 114
    • 34547793705 scopus 로고    scopus 로고
    • Inhibition of neurogenic inflammation as a novel treatment for ischemic stroke
    • Turner, R.; Vink, R. Inhibition of neurogenic inflammation as a novel treatment for ischemic stroke. Drug News Perspect. 2007, 20, 221-226.
    • (2007) Drug News Perspect. , vol.20 , pp. 221-226
    • Turner, R.1    Vink, R.2
  • 115
    • 0030971879 scopus 로고    scopus 로고
    • Magnesium-deficiency-enhanced post-ischemic myocardial injury is reduced by substance P receptor blockade
    • Kramer, J. H.; Phillips, T. M.; Weglicki, W. B. Magnesium-deficiency- enhanced post-ischemic myocardial injury is reduced by substance P receptor blockade. J. Mol. Cell. Cardiol. 1997, 29, 97-110.
    • (1997) J. Mol. Cell. Cardiol. , vol.29 , pp. 97-110
    • Kramer, J.H.1    Phillips, T.M.2    Weglicki, W.B.3


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