Magnesium in acute and chronic brain injury: An update

Magnesium Research

Volumn 22, Issue 3, 2009, Pages 158-162

  Vink, Robert ^a   Cook, Naomi L ^a   van den Heuvel, Corinna ^a  

^a UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

Hypoxia; Ischemia; Magnesium; Neurodegeneration; Neurotrauma; Parkinson's disease

Indexed keywords

MAGNESIUM; NEUROPROTECTIVE AGENT;

ANIMAL; ARTICLE; BRAIN INJURY; DEGENERATIVE DISEASE; HUMAN; META ANALYSIS; PATHOLOGY; STROKE;

ANIMALS; BRAIN INJURIES; BRAIN INJURY, CHRONIC; HUMANS; MAGNESIUM; META-ANALYSIS AS TOPIC; NEURODEGENERATIVE DISEASES; NEUROPROTECTIVE AGENTS; STROKE;

ANIMALIA; MUS;

EID: 70349524697     PISSN: 09531424     EISSN: 19524021     Source Type: Journal    
DOI: 10.1684/mrh.2009.0175     Document Type: Article

References (43)

1. Vink R, McIntosh TK, Demediuk P, Weiner MW, Faden AI. Decline in intracellular free magnesium concentration is associated with irreversible tissue injury following brain trauma. J Biol Chem 1988; 263: 757-61.
2. Ramadan NM, Halvorson H, Vande-Linde A, Levine SR, Helpern JA, Welch KMA. Low brain magnesium in migraine. Headache 1989; 29: 416-9.
3. 31P NMR of the brain. Biochim Biophys Acta 1992; 1111: 271-4.
4. Altura BM. Ethanol promotes rapid depletion of intracellular free Mg in cerebral vascular smooth muscle cells - possible relation to alcohol induced behavioural and stroke like effects. Alcohol 1993; 10: 563-6.
5. Mullins PGM, Vink R. Chronic alcohol exposure decreases brain intracellular free magnesium concentration in rats. Neuroreport 1995; 6: 1633-6.
6. Lin MC, Huang YL, Liu HW, Yang DY, Lee CP, Yang LL, etal. On-line microdialysis-graphite furnace atomic absorption spectrometry in the determination of brain magnesium levels in gerbils subjected to cerebral ischemia/reperfusion. J Am Coll Nutr 2004; 23: 561S-565S.
7. 31P magnetic resonance spectroscopy to study the effect of cortical magnesium and energy metabolism after subarachnoid hemorrhage. Cerebrovasc Dis 2008; 26: 223-30.
8. Andrasi E, Igaz S, Molnar Z, Mako S. Disturbances of magnesium concentrations in various brain areas in Alzheimer's disease. Magnes Res 2000; 13: 189-96.
9. Nechifor M. Interactions between magnesium and psychotropic drugs. Magnes Res 2008; 21: 97-100.
10. Jacka FN, Overland S, Stewart R, Tell G S, Bjelland I, Mykletun A. Association between magnesium intake and depression and anxiety in community-dwelling adults: the Hordaland Health Study. Aust N Z J Psychiatry 2009; 43: 45-52.
11. Starling AJ, Andre VM, Cepeda C, de Lima M, Chandler SH, Levine MS. Alterations in N-methyl-D-aspartate receptor sensitivity and magnesium blockade occur early in development in the R6/2 mouse model of Huntington's disease. J Neurosci Res 2005; 82: 377-86.
12. Vink R, Cernak I. Regulation of brain intracellular free magnesium following traumatic injury to the central nervous system. Front Biosci 2000; 5: 656-65.
13. Ozgurtas T, Kahraman S. State of the art of new data on the role of magnesium in brain injury: clinical interest of measurements of total and ionized magnesium. Magnes Res 2004; 17: 327-34.
14. Romani AM. Magnesium homeostasis and alcohol consumption. Magnes Res 2008; 21: 197-204.
15. Temkin NR, Anderson GD, Winn HR, etal. Magnesium sulfate for neuroprotection after traumatic brain injury: a randomised controlled trial. Lancet Neurol 2007; 6: 29-38.
16. Heath DL, Vink R. Optimization of magnesium therapy following severe diffuse axonal brain injury in rats. J Pharmacol Exp Ther 1999; 288: 1311-6.
17. McKee JA, Brewer RP, Macy GE, Phillips-Bute B, Campbell KA, Borel CO, etal. Analysis of the brain bioavailability of peripherally administered magnesium sulfate: Astudy in humans with acute brain injury undergoing prolonged induced hypermagnesemia. Crit Care Med 2005; 33: 661-6.
18. HabgoodMD, ByeN, DziegielewskaKM, EkCJ, LaneMA, PotterA, etal. Changes in blood-brain barrier permeability to large and small molecules following traumatic brain injury in mice. Eur J Neurosci 2007; 25: 231-8.
19. Heath DL, Vink R. Delayed therapy with magnesium up to 24h following traumatic brain injury improves motor outcome. J Neurosurg 1999; 90: 504-9.
20. Miller JW, D'Ambrosio R. When basic research doesn't translate to the bedside-lessons from the Magnesium Brain Trauma study. Epilepsy Curr 2007; 7: 133-5.
21. Muir KW, Lees KR, Ford I, Davis S. Magnesium for acute stroke (Intravenous Magnesium Efficacy in Stroke trial): randomised controlled trial. Lancet 2004; 363: 439-45.
22. Aslanyan S, Weir CJ, Muir KW, Lees KR. Magnesium for treatment of acute lacunar stroke syndromes: further analysis of the IMAGES trial. Stroke 2007; 38: 1269-73.
23. Lecrux C, McCabe C, Weir CJ, Gallagher L, Mullin J, Touzani O, etal. Effects of magnesium treatment in a model of internal capsule lesion in spontaneously hypertensive rats. Stroke 2008; 39: 448-54.
24. Mittendorf R, Dammann O, Lee KS. Brain lesions in newborns exposed to high-dose magnesium sulfate during preterm labor. J Perinatol 2006; 26: 57-63.
25. Doyle LW, Crowther CA, Middleton P, Marret S, Rouse D. Magnesium sulphate for women at risk of preterm birth for neuroprotection of the fetus. Cochrane Database Syst Rev 2009: CD004661.
26. Dribben WH, Creeley CE, Wang HH, Smith DJ, Farber NB, Olney JW. High dose magnesium sulfate exposure induces apoptotic cell death in the developing neonatal mouse brain. Neonatology 2009; 96: 23-32.
27. Bhat MA, Charoo BA, Bhat JI, Ahmad SM, Ali SW, Mufti MU. Magnesium sulfate in severe perinatal asphyxia: a randomized, placebo-controlled trial. Pediatrics 2009; 123: e764-e769.
28. Ichiba H, Yokoi T, Tamai H, Ueda T, Kim TJ, Yamano T. Neurodevelopmental outcome of infants with birth asphyxia treated with magnesium sulfate. Pediatr Int 2006; 48: 70-5.
29. 4 administration after cerebral hypoxia-ischemia in newborn rats is related to the severity of brain damage. Reprod Sci 2007; 14: 667-77.
30. Vink R, Nimmo AJ. Multifunctional drugs for head injury. Neurotherapeutics 2009; 6: 28-42.
31. Imer M, Omay B, Uzunkol A, Erdem T, Sabanci P, Karasu A, etal. Effect of magnesium, MK-801 and combination of magnesium and MK-801 on blood-brain barrier permeability and brain edema after experimental traumatic diffuse brain injury. Neurol Res 2009; 11: 11.
32. Guluma KZ, Saatman KE, Brown A, Raghupathi R, McIntosh TK. Sequential pharmacotherapy with magnesium chloride and basic fibroblast growth factor after fluid percussion brain injury results in less neuromotor efficacy than that achieved with magnesium alone. J Neurotrauma 1999; 16: 311-2.
33. Barbre AB, Hoane MR. Magnesium and riboflavin combination therapy following cortical contusion injury in the rat. Brain Res Bull 2006; 69: 639-46.
34. Scholler K, Zausinger S, Baethmann A, Schmid-Elsaesser R. Neuroprotection in ischemic stroke--combination drug therapy and mild hypothermia in a rat model of permanent focal cerebral ischemia. Brain Res 2004; 1023: 272-8.
35. Kwon BK, Roy J, Lee JH, Okon EB, Zhang H, Marx JC, etal. Magnesium chloride in a polyethylene glycol formulation as a neuroprotective therapy for acute spinal cord injury: preclinical refinement and optimization. J Neurotrauma 2009; 24: 24.
36. Chung SY, Lin J Y, Lin MC, Liu HM, Wang MF, Cheng FC. Synergistic efficacy of magnesium sulfate and FK506 on cerebral ischemia-induced infarct volume in gerbil. Med Sci Monit 2004; 10: BR105-BR108.
37. Meloni BP, Campbell K, Zhu H, Knuckey NW. In search of clinical neuroprotection after brain ischemia: the case for mild hypothermia (35°C) and magnesium. Stroke 2009; 40: 2236-40.
38. 31P-MRS. Magnes Res 2008; 21: 157-62.
39. Muroyama A, Inaka M, Matsushima H, Sugino H, Marunaka Y, Mitsumoto Y. Enhanced susceptibility to MPTP neurotoxicity in magnesium-deficient C57BL/6N mice. Neurosci Res 2009; 63: 72-5.
40. Hashimoto T, Nishi K, Nagasao J, Tsuji S, Oyanagi K. Magnesium exerts both preventive and ameliorating effects in an in vitro rat Parkinson disease model involving 1-methyl-4-phenylpyridinium (MPP+) toxicity in dopaminergic neurons. Brain Res 2008; 1197: 143-51.
41. Oyanagi K, Kawakami E, Kikuchi-Horie K, etal. Magnesium deficiency over generations in rats with special references to the pathogenesis of the Parkinsonism-dementia complex and amyotrophic lateral sclerosis of Guam. Neuropathology 2006; 26: 115-28.
42. Hermosura MC, Garruto RM. TRPM7 and TRPM2-Candidate susceptibility genes for Western Pacific ALS and PD? Biochim Biophys Acta 2007; 1772: 822-35.
43. Chassain C, Eschalier A, Durif F. Antidyskinetic effect of magnesium sulfate in MPTP-lesioned monkeys. Exp Neurol 2003; 182: 490-6.