Synthesis and characterization of a cyclobutane duocarmycin derivative incorporating the 1,2,10,11-tetrahydro-9 H-cyclobuta[ c ]benzo[ e ]indol-4-one (CbBI) alkylation subunit

Journal of the American Chemical Society

Volumn 132, Issue 39, 2010, Pages 13936-13940

  Lajiness, James P ^a   Boger, Dale L ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYL HALIDES; CYCLOBUTANES; ENTHALPY OF ACTIVATION; ENTROPY OF ACTIVATION; GEOMETRIC ALIGNMENT; NATURAL PRODUCTS; RATE OF REACTION; SINGLE CRYSTAL X-RAY STRUCTURES; SPIROCYCLIZATION; STRUCTURAL CHARACTERIZATION; STRUCTURAL MODIFICATIONS; STRUCTURAL ORIGIN; SYNTHESIS AND CHARACTERIZATIONS;

ALIGNMENT; ALKYLATION; AMIDES; ARGON; CHEMICAL ACTIVATION; CHEMICAL MODIFICATION; CRYSTAL STRUCTURE; CYCLOHEXANE; PHENOLS; PROPANE; REGIOSELECTIVITY; SYNTHESIS (CHEMICAL);

BUTANE;

1,2,10,11 TETRAHYDRO 9H CYCLOBUTA[C]BENZO[E]INDOL 4 ONE; ANTINEOPLASTIC AGENT; CYCLOBUTANE DERIVATIVE; CYCLOPROPANE; DUOCARMYCIN SA; NATURAL PRODUCT; RACHELMYCIN; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; CHEMICAL MODIFICATION; CHEMICAL REACTION; CHEMICAL STRUCTURE; CRYSTAL STRUCTURE; CYCLIZATION; SYNTHESIS; ULTRAVIOLET SPECTROPHOTOMETRY; X RAY CRYSTALLOGRAPHY;

ALKYLATION; CRYSTALLOGRAPHY, X-RAY; CYCLIZATION; CYCLOBUTANES; ENTROPY; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; INDOLES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PYRROLES; STEREOISOMERISM;

EID: 77957298667     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja106986f     Document Type: Article

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