Mutation of the ATP cassette binding transporter A1 (ABCA1) C-terminus disrupts HIV-1 Nef binding but does not block the Nef enhancement of ABCA1 protein degradation

Biochemistry

Volumn 49, Issue 38, 2010, Pages 8338-8349

  Mujawar, Zahedi ^a   Tamehiro, Norimasa ^a   Grant, Angela ^b   Sviridov, Dmitri ^c   Bukrinsky, Michael ^b   Fitzgerald, Michael L ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

^c BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; DISEASE CONTROL; ORGANIC ACIDS;

ANTIRETROVIRALS; C-TERMINUS; CALPAINS; CARDIO-VASCULAR DISEASE; CHOLESTEROL EFFLUX; DIRECT INTERACTIONS; DOWN-REGULATION; DYSLIPIDEMIAS; ENDOPLASMIC RETICULUM; HEK293 CELLS; HIGH-DENSITY LIPOPROTEINS; HIV-1 INFECTIONS; HIV-1 NEF; LOW LEVEL; PROTEIN DEGRADATION; PROTEIN LEVEL; PROTEIN-PROTEIN INTERACTIONS; TRANS-MEMBRANE PROTEINS; UNFOLDED PROTEIN RESPONSE;

DEGRADATION;

ABC TRANSPORTER A1; CALPAIN; NEF PROTEIN; ABC TRANSPORTER; ABCA1 PROTEIN, HUMAN; CARRIER PROTEIN; HIGH DENSITY LIPOPROTEIN; NEF PROTEIN, HUMAN IMMUNODEFICIENCY VIRUS 1;

AMINO ACID SEQUENCE; ARTICLE; CELL STRAIN HEK293; DOWN REGULATION; ENDOPLASMIC RETICULUM; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNOBLOTTING; IMMUNOPRECIPITATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; VIRUS INHIBITION; ANIMAL; CELL LINE; GENETICS; MACROPHAGE; METABOLISM; MOUSE; MUTATION; TRANSPORT AT THE CELLULAR LEVEL; UNFOLDED PROTEIN RESPONSE;

HUMAN IMMUNODEFICIENCY VIRUS 1;

ANIMALS; ATP BINDING CASSETTE TRANSPORTER 1; ATP-BINDING CASSETTE TRANSPORTERS; BIOLOGICAL TRANSPORT; CELL LINE; DOWN-REGULATION; LIPOPROTEINS, HDL; MACROPHAGES; MEMBRANE TRANSPORT PROTEINS; MICE; MUTATION; NEF GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; UNFOLDED PROTEIN RESPONSE;

EID: 77957080013     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi100466q     Document Type: Article

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