Blocking of HIV-1 infection by targeting CD4 to nonraft membrane domains

Journal of Experimental Medicine

Volumn 196, Issue 3, 2002, Pages 293-301

  Del Real, Gustavo ^a   Jiménez Baranda, Sonia ^a   Lacalle, Rosa Ana ^a   Mira, Emilia ^a   Lucas, Pilar ^a   Gómez Moutón, Concepción ^a   Carrera, Ana C ^a   Martínez A, Carlos ^a   Mañes, Santos ^a  

^a CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

Author keywords

CD4; HIV 1; Infection inhibition; Lck; Lipid rafts

Indexed keywords

CD4 ANTIGEN; CELL RECEPTOR; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR4; CHOLESTEROL; GLYCOPROTEIN GP 120; MEMBRANE PROTEIN; MUTANT PROTEIN;

ARTICLE; CONTROLLED STUDY; CYTOPLASM; HOST CELL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFECTION PREVENTION; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN DOMAIN; VIRUS ENVELOPE;

ACQUIRED IMMUNODEFICIENCY SYNDROME; AMINO ACID SEQUENCE; ANTIGENS, CD4; CELL LINE; ENZYME ACTIVATION; HIV ENVELOPE PROTEIN GP120; HIV-1; HUMANS; LIPOPROTEINS, LDL; LYMPHOCYTE SPECIFIC PROTEIN TYROSINE KINASE P56(LCK); MEMBRANE MICRODOMAINS; MOLECULAR SEQUENCE DATA; RECEPTORS, CXCR4;

EID: 0037025989     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20020308     Document Type: Article

References (42)

1. Lipid rafts and signal transduction
2. Functions of lipid rafts in biological membranes
3. Lipid domain structure of the plasma membrane revealed by patching of membrane components
4. Exclusion of CD45 inhibits activity of p56lck associated with glycolipid-enriched membrane domains
5. Segregation of leading-edge and uropod components into specific lipid rafts during T cell polarization
6. Raft membrane domains: From a liquid-ordered membrane phase to a site of pathogen attack
7. The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain
8. Membrane compartimentalization is required for efficient T cell activation
9. Co-receptors for HIV-1 entry
10. A new classification for HIV-1
11. Chemokine receptors: Keys to AIDS pathogenesis?
12. Chemokine signaling and functional responses: The role of receptor dimerization and TK pathway activation
13. Membrane raft microdomains in chemokine receptor function
14. Membrane raft microdomains mediate lateral assemblies required for HIV-1 infection
15. Lipid rafts and HIV pathogenesis: Host membrane cholesterol is required for infection by HIV type 1
16. Vaginal transmission of cell-associated HIV-1 in the mouse is blocked by a topical, membrane-modifying agent
17. Human erythrocyte glycosphingolipids as alternative cofactors for human immunodeficiency virus type 1 (HIV-1) entry: Evidence for CD4-induced interactions between HIV-1 gp120 and reconstituted membrane microdomains of glycosphingolipids (Gb3 and GM3)
18. Glycosphingolipids promote entry of a broad range of human immunodeficiency virus type 1 isolates into cell lines expressing CD4, CXCR4, and/or CCR5
19. Constitutive cell surface association between CD4 and CCR5
20. Cooperation of multiple CCR5 coreceptors is required for infections by human immunodeficiency virus type 1
21. Membrane raft microdomains mediate front-rear polarity in migrating cells
22. Evidence for cell surface association between CXCR4 and ganglioside GM3 after gp120 binding in SupT1 lymphoblastoid cells
23. CXCR4 function requires membrane cholesterol: Implications for HIV infection
24. Segregation of CD4 and CXCR4 into distinct lipid microdomains in T lymphocytes suggests a mechanism for membrane destabilization by human immunodeficiency virus
25. Sphingolipid-cholesterol rafts diffuse as small entities in the plasma membrane of mammalian cells
26. Cell-surface expression of CD4 reduces HIV-1 infectivity by blocking Env incorporation in a Nef- and Vpu-inhibitable manner
27. Involvement of the CD4 molecule in a post-activation event on T cell proliferation
28. Lck unique domain influences Lck specificity and biological function
29. Human cytotoxic T cell structures associated with expression of cytolysis. I. Analysis at the clonal cell level of the cytolysis-inhibiting effect of 7 monoclonal antibodies
30. A role for chemokine receptor transactivation in growth factor signaling
31. Interaction of influenza virus haemagglutinin with sphingolipid-cholesterol membrane domains via its transmembrane domain
32. Role of lipid modifications in targeting proteins to detergent-resistant membrane rafts. Many raft proteins are acylated, while few are prenylated
33. Identification of palmitoylation sites on CD4, the human immunodeficiency virus receptor
34. Requirement for kinase activity of CD4-associated p56lck in antibody-triggered T cell signal transduction
35. The level of CD4 expression limits infection of primary rhesus monkey macrophages by a T-tropic simian immunodeficiency virus and macrophagetropic human immunodeficiency viruses
36. Chemokine/CD4 receptor density ratios correlate with HIV replication in lymph node and peripheral blood of HIV-infected individuals
37. Sensitivity of human immunodeficiency virus type 1 to fusion inhibitors targeted to the gp41 first heptad repeat involves distinct regions of gp41 and is consistently modulated by gp120 interactions with the coreceptor
38. Internalization of the human immunodeficiency virus does not require the cytoplasmic domain of CD4
39. Human immunodeficiency virus infection is efficiently mediated by a glycolipid-anchored form of CD4
40. The neutral glycophingolipid globotriaosylceramide promotes fusion mediated by a CD4-dependent CXCR4-utilizing HIV type 1 envelope glycoprotein
41. Nef increases infectivity of HIV via lipid rafts
42. Plasma membrane rafts play a critical role in HIV-1 assembly and release