Major SNP (Q141K) variant of human ABC transporter ABCG2 undergoes lysosomal and proteasomal degradations

Pharmaceutical Research

Volumn 26, Issue 2, 2009, Pages 469-479

  Furukawa, Tomoka ^a   Wakabayashi, Kanako ^a,b   Tamura, Ai ^a,b   Nakagawa, Hiroshi ^a   Morishima, Yoshihiro ^c   Osawa, Yoichi ^c   Ishikawa, Toshihisa ^a  

^a TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

^b JAPAN SOCIETY FOR THE PROMOTION OF SCIENCE   (Japan)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

ABCG2; Endoplasmic reticulum associated degradation (ERAD); Proteasome; SNP; Ubiquitin

Indexed keywords

7 ETHYL 10 HYDROXYCAMPTOTHECIN; ABC TRANSPORTER; BAFILOMYCIN A1; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; BREAST CANCER RESISTANCE PROTEIN; PROTEASOME; RECOMBINASE; UBIQUITIN;

ANIMAL CELL; ARTICLE; CELL VIABILITY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DRUG RESISTANCE; ENDOPLASMIC RETICULUM; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; IMMUNOFLUORESCENCE MICROSCOPY; LYSOSOME; NONHUMAN; PHARMACOGENOMICS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN STRUCTURE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SINGLE NUCLEOTIDE POLYMORPHISM; WILD TYPE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; ATP-BINDING CASSETTE TRANSPORTERS; CAMPTOTHECIN; CELL LINE; CELL SURVIVAL; CYSTEINE PROTEINASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, NEOPLASM; HUMANS; IMMUNOBLOTTING; LEUPEPTINS; LYSOSOMES; MACROLIDES; MICROSCOPY, FLUORESCENCE; NEOPLASM PROTEINS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN STABILITY; RNA, MESSENGER; TIME FACTORS; UBIQUITIN;

EID: 58549097067     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-008-9752-7     Document Type: Article

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