Kinetic properties of the α2 homo-oligomeric glycine receptor impairs a proper synaptic functioning

Journal of Physiology

Volumn 553, Issue 2, 2003, Pages 369-386

  Mangin, J M ^b   Baloul, M ^b   Prado de Carvalho, L ^b   Rogister, B ^a   Rigo, J M ^a   Legendre, P ^b  

^a Faculte de Medecine de Liege   (Belgium)

^b CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCINE; GLYCINE RECEPTOR; IONOTROPIC RECEPTOR; LIGAND; NEUROTRANSMITTER; RECEPTOR SUBUNIT; ALPHA 2 HOMO OLIGOMERIC GLYCINE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL MATURATION; CENTRAL NERVOUS SYSTEM; CHANNEL GATING; CHO CELL; CONTROLLED STUDY; GENETIC TRANSFECTION; KINETICS; LATENT PERIOD; NERVE CELL; NEUROTRANSMITTER RELEASE; NONHUMAN; PARACRINE SIGNALING; PATCH CLAMP; PRIORITY JOURNAL; PROBABILITY; PROTEIN EXPRESSION; PROTEIN SECRETION; RAT; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; SPINAL CORD NERVE CELL; SYNAPTIC TRANSMISSION; TIME; CHO CELL LINE; CONCENTRATION (PARAMETERS); EVOKED RESPONSE; FLOW RATE; PATCH CLAMP TECHNIQUE; PROTEIN SUBUNIT; PROTEIN TRANSPORT; SYNAPTIC POTENTIAL; ALGORITHM; ANIMAL; BIOLOGICAL MODEL; CELL MEMBRANE POTENTIAL; CHEMISTRY; COMPUTER SIMULATION; CRICETULUS; DIMERIZATION; DOSE RESPONSE; DRUG EFFECT; GENETICS; HAMSTER; INFORMATION PROCESSING; PHYSIOLOGY; SYNAPSE;

ALGORITHMS; ANIMALS; AUTOMATIC DATA PROCESSING; CHO CELLS; COMPUTER SIMULATION; CRICETINAE; CRICETULUS; DIMERIZATION; DOSE-RESPONSE RELATIONSHIP, DRUG; GLYCINE; KINETICS; MEMBRANE POTENTIALS; MODELS, BIOLOGICAL; PARACRINE COMMUNICATION; PATCH-CLAMP TECHNIQUES; RECEPTORS, GLYCINE; SYNAPSES; SYNAPTIC TRANSMISSION; TRANSFECTION;

EID: 0347503524     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1113/jphysiol.2003.052142     Document Type: Article

References (49)

1. Akagi H & Miledi R (1988). Heterogeneity of glycine receptors and their messenger RNAs in rat brain and spinal cord. Science 242, 270-273.
2. Aldrich RW, Corey DP & Stevens CF (1983). A reinterpretation of mammalian sodium channel gating based on single channel recording. Nature 306, 436-441.
3. Beato M, Groot-Kormelink PJ, Colquhoun D & Sivilotti LG (2002). Openings of the rat recombinant alpha 1 homomeric glycine receptor as a function of the number of agonist molecules bound. J Gen Physiol 119, 443-466.
4. Belachew S, Rogister B, Rigo JM, Malgrange B, Mazy-Servais C, Xhauflaire G, Coucke P & Moonen G (1998). Cultured oligodendrocyte progenitors derived from cerebral cortex express a glycine receptor which is pharmacologically distinct from the neuronal isoform. Eur J Neurosci 10, 3556-3564.
5. Ben-Ari Y (2001). Developing networks play a similar melody. Trends Neurosci 24, 353-360.
6. Bormann J, Rundstrom N, Betz H & Langosch D (1993). Residues within transmembrane segment M2 determine chloride conductance of glycine receptor homo- and hetero-oligomers. EMBO J 12, 3729-3737.
7. Breitinger HG & Becker CM (2002). The inhibitory glycine receptor-simple views of a complicated channel. Chembiochem 3, 1042-1052.
8. Burkat PM, Yang J & Gingrich KJ (2001). Dominant gating governing transient GABA(A) receptor activity: a first latency and Po/o analysis. J Neurosci 21, 7026-7036.
9. Clements JD (1996). Transmitter timecourse in the synaptic cleft: its role in central synaptic function. Trends Neurosci 19, 163-171.
10. Clements JD & Westbrook GL (1991). Activation kinetics reveal the number of glutamate and glycine binding sites on the N-methyl-D-aspartate receptor. Neuron 7, 605-613.
11. Colquhoun D (1998). Binding, gating, affinity and efficacy: the interpretation of structure-activity relationships for agonists and of the effects of mutating receptors. Br J Pharmacol 125, 924-947.
12. Colquhoun D & Hawkes AG (1995). Desensitization of N-methyl-D-aspartate receptors: a problem of interpretation. Proc Natl Acad Sci U S A 92, 10327-10329.
13. 2 homomeric glycine receptors by taurine and GABA. J Physiol 535, 741-755.
14. 2+- and SNARE-independent release of GABA and glutamate prior to synapse formation. Neuron 36, 1051-1061.
15. Flint AC, Liu X & Kriegstein AR (1998). Nonsynaptic glycine receptor activation during early neocortical development. Neuron 20, 43-53.
16. Franke C, Hatt H & Dudel J (1987). Liquid filament switch for ultra-fast exchanges of solutions at excised patches of synaptic membrane of crayfish muscle. Neurosci Lett 77, 199-204.
17. Fucile S, De Saint Jan D, Prado De Carvalho L & Bregestovski P (2000). Fast potentiation of glycine receptor channels of intracellular calcium in neurons and transfected cells. Neuron 28, 571-583.
18. Furuya, S, Tabata T, Mitoma J, Yamada K, Yamasaki M, Makino A, Yamamoto T, Watanabe M, Kano M & Hirabayashi Y. (2000). L-serine and glycine serve as major astroglia-derived trophic factors for cerebellar Purkinje neurons. Proc Natl Acad Sci U S A 97, 11528-11533.
19. Gentet LJ & Clements JD (2002). Binding site stoichiometry and the effects of phosphorylation on human alpha 1 homomeric glycine receptors. J Physiol 544, 97-106.
20. Hamill OP, Marty A, Neher E, Sakmann B & Sigworth FJ (1981). Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch 391, 85-100.
21. Harty TP & Manis PB (1998). Kinetic analysis of glycine receptor currents in ventral cochlear nucleus. J Neurophysiol 79, 1891-1901.
22. Horn R (1991). Estimating the number of channels in patch recordings. Biophys J 60, 433-439.
23. Kirsch J, Kuhse J & Betz H (1995). Targeting of glycine receptor subunits to gephyrin-rich domains in transfected human embryonic kidney cells. Mol Cell Neurosci 6, 450-461.
24. Kneussel M & Betz H (2000). Clustering of inhibitory neurotransmitter receptors at developing postsynaptic sites: the membrane activation model. Trends Neurosci 23, 429-435.
25. Legendre P (1998). A reluctant gating mode of glycine receptor channels determines the time course of inhibitory miniature synaptic events in zebrafish hindbrain neurons. J Neurosci 18, 2856-2870.
26. Legendre P (2001). The glycinergic inhibitory synapse. Cell Mol Life Sci 58, 760-793.
27. Lewis TM, Schofield PR & McClellan AM (2003). Kinetic determinants of agonist action at the recombinant human glycine receptor. J Physiol 549, 361-374.
28. Loturco JJ, Blanton MG & Kriegstein AR (1991). Initial expression and endogenous activation of NMDA channels in early neocortical development. J Neurosci 11, 792-799.
29. Malosio ML, Marqueze-Pouey B, Kuhse J & Betz H (1991). Widespread expression of glycine receptor subunit mRNAs in the adult and developing rat brain. EMBO J 10, 2401-2409.
30. Mangin JM, Guyon A, Eugene D, Paupardin-tritsch D & Legendre P (2002). Functional glycine receptor maturation in the absence of glycinergic input in dopaminergic neurones of the rat substantia nigra. J Physiol 542, 685-697.
31. Meyer G, Kirsch J, Betz H & Langosch D (1995). Identification of a gephyrin binding motif on the glycine receptor beta subunit. Neuron 15, 563-572.
32. Mozrzymas JW, Barberis A, Mercik K & Zarnowska ED (2003). Binding sites, singly bound states, and conformation coupling shape GABA-evoked currents. J Neurophysiol 89, 871-883.
33. Nguyen L, Rigo JM, Rocher V, Belachew S, Malgrange B, Rogister B, Leprince P & Moonen G (2001). Neurotransmitters as early signals for central nervous system development. Cell Tissue Res 305, 187-202.
34. Nguyen, L, Malgrange B, Belachew S, Rogister B, Rocher V, Moonen G & Rigo JM. (2002). Functional glycine receptors are expressed by postnatal nestin-positive neural stem/progenitor cells. Eur J Neurosci 15, 1299-1305.
35. Nguyen, L, Malgrange B, Breuskin I, Bettendorff L, Moonen G, Belachew S & Rigo JM. (2003b). Autocrine/paracrine activation of the GABA(A) receptor inhibits the proliferation of neurogenic: polysialylated neural cell adhesion molecule-positive (PSA-NCAM+) precursor cells from postnatal striatum. J Neurosci 23, 3278-3294.
36. Nguyen L, Malgrange B, Breuskin I, Lallemend F, Hans G, Moonen G, Belachew S & Rigo JM (2003a). Striatal PSA-NCAM+ precusor cells from the newborn rat express functional glycine receptors. Neuroreport (in the press).
37. Pastor A, Chvatal A, Sykova E & Kettenmann H (1995). Glycine- and GABA-activated currents in identified glial cells of the developing rat spinal cord slice. Eur J Neurosci 7, 1188-1198.
38. Reichling DB, Kyrozis A, Wang J & MacDermott AB (1994). Mechanisms of GABA and glycine depolarization-induced calcium transients in rat dorsal horn neurons. J Physiol 476, 411-421.
39. Sanes, DH & Hafidi A. (1996). Glycinergic transmission regulates dendrite size in organotypic culture. J Neurobiol 31, 503-511.
40. Sigworth FJ (1980). The variance of sodium current fluctuations at the node of Ranvier. J Physiol 307, 97-129.
41. Sigworth FJ & Sine SM (1987). Data transformations for improved display and fitting of single-channel dwell time histograms. Biophys J 52, 1047-1054.
42. Singer JH & Berger AJ (1999). Contribution of single-channel properties to the time course and amplitude variance of quantal glycine currents recorded in rat motoneurons. J Neurophysiol 81, 1608-1616.
43. Singer JH, Talley EM, Bayliss DA & Berger AJ (1998). Development of glycinergic synaptic transmission to rat brain stem motoneurons. J Neurophysiol 80, 2608-2620.
44. Suwa H, Saint-Amant L, Triller A, Drapeau P & Legendre P (2001). High-affinity zinc potentiation of inhibitory postsynaptic glycinergic currents in the zebrafish hindbrain. J Neurophysiol 85, 912-925.
45. Takahashi T, Momiyama A, Hirai K, Hishinuma F & Akagi H (1992). Functional correlation of fetal and adult forms of glycine receptors with developmental changes in inhibitory synaptic receptor channels. Neuron 9, 1155-1161.
46. Tapia, JC, Mentis GZ, Navarrete R, Nualart F, Figueroa E, Sanchez A & Aguayo LG (2001). Early expression of glycine and GABA(A) receptors in developing spinal cord neurons. Effects on neurite outgrowth. Neuroscience 108, 493-506.
47. Twyman RE & Macdonald RL (1991). Kinetic properties of the glycine receptor main- and sub-conductance states of mouse spinal cord neurones in culture. J Physiol 435, 303-331.
48. Van Zundert B, Alvarez FJ, Yevenes GE, Carcamo JG, Vera JC, Aguayo LG (2002). Glycine receptors involved in synaptic transmission are selectively regulated by the cytoskeleton in mouse spinal neurons. J Neurophysiol 87, 640-644.
49. Virginio C & Cherubini E (1997). Glycine-activated whole cell and single channel currents in rat cerebellar granule cells in culture. Brain Res Dev Brain Res 98, 30-40.