The enigma of tripeptidyl-peptidase II: Dual roles in housekeeping and stress

Journal of Oncology

Volumn , Issue , 2010, Pages

  Glas, Rickard ^a   Preta, Giulio ^a   De Klark, Rainier ^a   Gavioli, Riccardo ^b  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b UNIVERSITY OF FERRARA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PEPTIDASE; REACTIVE OXYGEN METABOLITE; TRIPEPTIDYL PEPTIDASE II; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; APOPTOSIS; CELL FUNCTION; CELL NUCLEUS; CELL STRESS; CYTOLOGY; CYTOSOL; DNA DAMAGE; GENE TRANSLOCATION; GENETIC STABILITY; NONHUMAN; PROTEIN METABOLISM; REVIEW;

EID: 77956859744     PISSN: 16878450     EISSN: 16878469     Source Type: Journal    
DOI: 10.1155/2010/128478     Document Type: Review

References (73)

1. Blw R. M., Ragnarsson U., Zetterqvist O., Tripeptidyl aminopeptidase in the extralysosomal fraction of rat liver The Journal of Biological Chemistry 1983 258 19 11622 11628
2. Rose C., Vargas F., Facchinetti P., Bourgeat P., Bambal R. B., Bishop P. B., Chan S. M. T., Moore A. N. J., Ganellin C. R., Schwartz J.-C., Characterization and inhibition of a cholecystokinin-inactivating serine peptidase Nature 1996 380 6573 403 409 (Pubitemid 26102716)
3. Tomkinson B., Linds A.-C., Tripeptidyl-peptidase II: a multi-purpose peptidase International Journal of Biochemistry and Cell Biology 2005 37 10 1933 1937
4. Eriksson S., Guitrrez O. A., Bjerling P., Tomkinson B., Development, evaluation and application of tripeptidyl-peptidase II sequence signatures Archives of Biochemistry and Biophysics 2009 484 1 39 45
5. Renn S. C. P., Tomkinson B., Taghert P. H., Characterization and cloning of tripeptidyl peptidase II from the fruit fly, Drosophila melanogaster The Journal of Biological Chemistry 1998 273 30 19173 19182
6. Rockel B., Peters J., Khlmorgen B., Glaeser R. M., Baumeister W., A giant protease with a twist: the TPP II complex from Drosophila studied by electron microscopy EMBO Journal 2002 21 22 5979 5984
7. Hilbi H., Jozsa E., Tomkinson B., Identification of the catalytic triad in tripeptidyl-peptidase II through site-directed mutagenesis Biochimica et Biophysica Acta 2002 1601 2 149 154
8. Macpherson E., Tomkinson B., Balow R.-M., Hoglund S., Zetterqvist O., Supramolecular structure of tripeptidyl peptidase II from human erythrocytes as studied by electron microscopy, and its correlation to enzyme activity Biochemical Journal 1987 248 1 259 263
9. Seyit G., Rockel B., Baumeister W., Peters J., Size matters for the tripeptidylpeptidase II complex from drosophila: the 6-MDa spindle form stabilizes the activated state The Journal of Biological Chemistry 2006 281 35 25723 25733
10. Rockel B., Peters J., Mller S. A., Seyit G., Ringler P., Hegerl R., Glaeser R. M., Baumeister W., Molecular architecture and assembly mechanism of Drosophila tripeptidyl peptidase II Proceedings of the National Academy of Sciences of the United States of America 2005 102 29 10135 10140
11. Glas R., Bogyo M., McMaster J. S., Gaczynska M., Ploegh H. L., A proteolytic system that compensates for loss of proteasome function Nature 1998 392 6676 618 622
12. Geier E., Pfeifer G., Wilm M., Lucchiari-Hartz M., Baumeister W., Eichmann K., Niedermann G., A giant protease with potential to substitute for some functions of the proteasome Science 1999 283 5404 978 981
13. Wang E. W., Kessler B. M., Borodovsky A., Cravatt B. F., Bogyo M., Ploegh H. L., Glas R., Integration of the ubiquitin-proteasome pathway with a cytosolic oligopeptidase activity Proceedings of the National Academy of Sciences of the United States of America 2000 97 18 9990 9995
14. Gavioli R., Frisan T., Vertuani S., Bornkamm G. W., Masucci M. G., C-myc overexpression activates alternative pathways for intracellular proteolysis in lymphoma cells Nature Cell Biology 2001 3 3 283 288
15. Reits E., Neijssen J., Herberts C., Benckhuijsen W., Janssen L., Drijfhout J. W., Neefjes J., A major role for TPPII in trimming proteasomal degradation products for MHC class I antigen presentation Immunity 2004 20 4 495 506
16. Seifert U., Maran C., Shmueli A., Desoutter J.-F., Wesoloski L., Janek K., Henklein P., Diescher S., Andrieu M., de la Salle H., Weinschenk T., Schild H., Laderach D., Galy A., Haas G., Kloetzel P.-M., Reiss Y., Hosmalin A., An essential role for tripeptidyl peptidase in the generation of an MHC class I epitope Nature Immunology 2003 4 4 375 379
17. Stoltze L., Schirle M., Schwarz G., Schrter C., Thompson M. W., Hersh L. B., Kalbacher H., Stevanovic S., Rammensee H.-G., Schild H., Two new proteases in the MHC class I processing pathway Nature Immunology 2000 1 5 413 418
18. Firat E., Huai J., Saveanu L., Gaedicke S., Aichele P., Eichmann K., Van Endert P., Niedermann G., Analysis of direct and cross-presentation of antigens in TPPII knockout mice Journal of Immunology 2007 179 12 8137 8145
19. Diekmann J., Adamopoulou E., Beck O., Rauser G., Lurati S., Tenzer S., Einsele H., Rammensee H. G., Schild H., Topp M. S., Processing of two latent membrane protein 1 MHC class I epitopes requires tripeptidyl peptidase II involvement Journal of Immunology 2009 183 3 1587 1597
20. Guil S., Rodrguez-Castro M., Aguilar F., Villasevil E. M., Antn L. C., Del Val M., Need for tripeptidyl-peptidase II in major histocompatibility complex class I viral antigen processing when proteasomes are detrimental The Journal of Biological Chemistry 2006 281 52 39925 39934
21. Grauling-Halama S., Bahr U., Schenk S., Geginat G., Role of tripeptidyl peptidase II in the processing of Listeria monocytogenes-derived MHC class I-presented antigenic peptides Microbes and Infection 2009 11 8-9 795 802
22. Shrimpton C. N., Smith A. I., Lew R. A., Soluble metalloendopeptidases and neuroendocrine signaling Endocrine Reviews 2002 23 5 647 664
23. Lovshin J. A., Drucker D. J., Incretin-based therapies for type 2 diabetes mellitus Nature Reviews Endocrinology 2009 5 5 262 269
24. Radu D., Tomkinson B., Zachrisson O., Weber G., de Belleroche J., Hirsch S., Lindefors N., Overlapping regional distribution of CCK and TPPII mRNAs in Cynomolgus monkey brain and correlated levels in human cerebral cortex (BA 10) Brain Research 2006 1104 1 175 182
25. Hong X., Lei L., Glas R., Tumors acquire inhibitor of apoptosis protein (IAP)-mediated apoptosis resistance through altered specificity of cytosolic proteolysis Journal of Experimental Medicine 2003 197 12 1731 1743
26. Basler M., Groettrup M., No essential role for tripeptidyl peptidase II for the processing of LCMV-derived T cell epitopes European Journal of Immunology 2007 37 4 896 904
27. Kawahara M., York I. A., Hearn A., Farfan D., Rock K. L., Analysis of the role of tripeptidyl peptidase II in MHC class I antigen presentation in vivo Journal of Immunology 2009 183 10 6069 6077
28. Preta G., Marescotti D., Fortini C., Carcoforo P., Castelli C., Masucci M., Gavioli R., Inhibition of serine-peptidase activity enhances the generation of a survivin-derived HLA-A2-presented CTL epitope in colon-carcinoma cells Scandinavian Journal of Immunology 2008 68 6 579 588
29. Chand A., Wyke S. M., Tisdale M. J., Effect of cancer cachexia on the activity of tripeptidyl-peptidase II in skeletal muscle Cancer Letters 2005 218 2 215 222
30. Wray C. J., Tomkinson B., Robb B. W., Hasselgren P.-O., Tripeptidyl-peptidase II expression and activity are increased in skeletal muscle during sepsis Biochemical and Biophysical Research Communications 2002 296 1 41 47
31. Rckrich T., Kraus M., Gogel J., Beck A., Ovaa H., Verdoes M., Overkleeft H. S., Kalbacher H., Driessen C., Characterization of the ubiquitin-proteasome system in bortezomib-adapted cells Leukemia 2009 23 6 1098 1105
32. Hong X., Lei L., Knert B., Naredla R., Applequist S. E., Grandien A., Glas R., Tripeptidyl-peptidase II controls DNA damage responses and in vivo -irradiation resistance of tumors Cancer Research 2007 67 15 7165 7174
33. Preta G., de Klark R., Glas R., A role for nuclear translocation of tripeptidyl-peptidase II in reactive oxygen species-dependent DNA damage responses Biochemical and Biophysical Research Communications 2009 389 4 575 579
34. Stavropoulou V., Vasquez V., Cereser B., Freda E., Masucci M. G., TPPII promotes genetic instability by allowing the escape from apoptosis of cells with activated mitotic checkpoints Biochemical and Biophysical Research Communications 2006 346 2 415 425
35. Stavropoulou V., Xie J., Henriksson M., Tomkinson B., Imreh S., Masucci M. G., Mitotic infidelity and centrosome duplication errors in cells overexpressing tripeptidyl-peptidase II Cancer Research 2005 65 4 1361 1368
36. McKay R. M., McKay J. P., Suh J. M., Avery L., Graff J. M., Tripeptidyl peptidase II promotes fat formation in a conserved fashion EMBO Reports 2007 8 12 1183 1189
37. Huai J., Firat E., Nil A., Million D., Gaedicke S., Kanzler B., Freudenberg M., Van Endert P., Kohler G., Pahl H. L., Aichele P., Eichmann K., Niedermann G., Activation of cellular death programs associated with immunosenescence-like phenotype in TPPII knockout mice Proceedings of the National Academy of Sciences of the United States of America 2008 105 13 5177 5182
38. Koike H., Seki H., Kouchi Z., Ito M., Kinouchi T., Tomioka S., Sorimachi H., Saido T. C., Maruyama K., Suzuki K., Ishiura S., Thimet oligopeptidase cleaves the full-length Alzheimer amyloid precursor protein at a -secretase cleavage site in COS cells Journal of Biochemistry 1999 126 1 235 242
39. York I. A., Mo A. X. Y., Lemerise K., Zeng W., Shen Y., Abraham C. R., Saric T., Goldberg A. L., Rock K. L., The cytosolic endopeptidase, thimet oligopeptidase, destroys antigenic peptides and limits the extent of MHC class I antigen presentation Immunity 2003 18 3 429 440
40. Lefterov I. M., Koldamova R. P., Lefterova M. I., Schwartz D. R., Lazo J. S., Cysteine 73 in bleomycin hydrolase is critical for amyloid precursor protein processing Biochemical and Biophysical Research Communications 2001 283 4 994 999
41. Towne C. F., York I. A., Watkin L. B., Lazo J. S., Rock K. L., Analysis of the role of bleomycin hydrolase in antigen presentation and the generation of CD8 T cell responses Journal of Immunology 2007 178 11 6923 6930
42. Schwartz D. R., Homanics G. E., Hoyt D. G., Klein E., Abernethy J., Lazo J. S., The neutral cysteine protease bleomycin hydrolase is essential for epidermal integrity and bleomycin resistance Proceedings of the National Academy of Sciences of the United States of America 1999 96 8 4680 4685
43. Montoya S. E., Thiels E., Card J. P., Lazo J. S., Astrogliosis and behavioral changes in mice lacking the neutral cysteine protease bleomycin hydrolase Neuroscience 2007 146 3 890 900
44. Joza N., Pospisilik J. A., Hangen E., Hanada T., Modjtahedi N., Penninger J. M., Kroemer G., AIF: not just an apoptosis-inducing factor Annals of the New York Academy of Sciences 2009 1171 2 11
45. Towne C. F., York I. A., Neijssen J., Karow M. L., Murphy A. J., Valenzuela D. M., Yancopoulos G. D., Neefjes J. J., Rock K. L., Puromycin-sensitive aminopeptidase limits MHC class I presentation in dendritic cells but does not affect CD8 T cell responses during viral infections Journal of Immunology 2008 180 3 1704 1712
46. Ferro E. S., Hyslop S., Camargo A. C. M., Intracellullar peptides as putative natural regulators of protein interactions Journal of Neurochemistry 2004 91 4 769 777
47. Osada T., Ikegami S., Takiguchi-Hayashi K., Yamazaki Y., Katoh-Fukui Y., Higashinakagawa T., Sakaki Y., Takeuchi T., Increased anxiety and impaired pain response in puromycin-sensitive aminopeptidase gene-deficient mice obtained by a mouse gene-trap method Journal of Neuroscience 1999 19 14 6068 6078
48. Reinhold D., Biton A., Goihl A., Pieper S., Lendeckel U., Faust J., Neubert K., Bank U., Tger M., Ansorge S., Brocke S., Dual inhibition of dipeptidyl peptidase IV and aminopeptidase N suppresses inflammatory immune responses Annals of the New York Academy of Sciences 2007 1110 402 409
49. Wherry E. J., Golovina T. N., Morrison S. E., Sinnathamby G., McElhaugh M. J., Shockey D. C., Eisenlohr L. C., Re-evaluating the generation of a proteasome-independent MHC class I-restricted CD8 T cell epitope Journal of Immunology 2006 176 4 2249 2261
50. Lvy F., Burri L., Morel S., Peitrequin A.-L., Lvy N., Bachi A., Hellman U., Van den Eynde B. J., Servis C., The final N-terminal trimming of a subaminoterminal proline-containing HLA class I-restricted antigenic peptide in the cytosol is mediated by two peptidases Journal of Immunology 2002 169 8 4161 4171
51. York I. A., Bhutani N., Zendzian S., Goldberg A. L., Rock K. L., Tripeptidyl peptidase II is the major peptidase needed to trim long antigenic precursors, but is not required for most MHC class I antigen presentation Journal of Immunology 2006 177 3 1434 1443
52. Benham A. M., Gromm M., Neefjes J., Allelic differences in the relationship between proteasome activity and MHC class I peptide loading Journal of Immunology 1998 161 1 83 89
53. Marcilla M., Villasevil E. M., Lpez de Castro J. A., Tripeptidyl peptidase II is dispensable for the generation of both proteasome-dependent and proteasome-independent ligands of HLA-B27 and other class I molecules European Journal of Immunology 2008 38 3 631 639
54. van Endert P., Role of tripeptidyl peptidase II in MHC class I antigen processingthe end of controversies? European Journal of Immunology 2008 38 3 609 613
55. York I. A., Chang S.-C., Saric T., Keys J. A., Favreau J. M., Goldberg A. L., Rock K. L., The Er aminopeptidase ERAP I enhances or limits antigen presentation by trimming epitopes to 8-9 residues Nature Immunology 2002 3 12 1177 1184
56. Serwold T., Gonzalez F., Kim J., Jacob R., Shastri N., ERAAP customizes peptides for MHC class I molecules in the endoplasmic reticulum Nature 2002 419 6906 480 483
57. Saric T., Chang S.-C., Hattori A., York I. A., Markant S., Rock K. L., Tsujimoto M., Goldberg A. L., An IFN- -induced aminopeptidase in the ER, ERAP I, trims precursors to MHC class I-presented peptides Nature Immunology 2002 3 12 1169 1176
58. Yewdell J. W., Not such a dismal science: the economics of protein synthesis, folding, degradation and antigen processing Trends in Cell Biology 2001 11 7 294 297
59. Princiotta M. F., Schubert U., Chen W., Bennink J. R., Myung J., Crews C. M., Yewdell J. W., Cells adapted to the proteasome inhibitor 4-hydroxy-5-iodo-3-nitrophenylacetyl-Leu-Leu-leucinal-vinyl sulfone require enzymatically active proteasomes for continued survival Proceedings of the National Academy of Sciences of the United States of America 2001 98 2 513 518
60. Kheifets V., Bright R., Inagaki K., Schechtman D., Mochly-Rosen D., Protein kinase C ( PKC)-annexin V interaction: a required step in PKC translocation and function The Journal of Biological Chemistry 2006 281 32 23218 23226
61. Yang Y., Fang S., Jensen J. P., Weissman A. M., Ashwell J. D., Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli Science 2000 288 5467 874 877
62. Samuel T., Okada K., Hyer M., Welsh K., Zapata J. M., Reed J. C., cIAP1 localizes to the nuclear compartment and modulates the cell cycle Cancer Research 2005 65 1 210 218
63. Karl M., Stefan D., Methods of use for tripeptidyl-peptidase II inhibitors as anticancer agents. International/Publication number, vol. WO 03/105835 no. A1, 2003
64. Constam D. B., Tobler A. R., Rensing-Ehl A., Kemler I., Hersh L. B., Fontana A., Puromycin-sensitive aminopeptidase. Sequence analysis, expression, and functional characterization The Journal of Biological Chemistry 1995 270 45 26931 26939
65. Firat E., Tsurumi C., Gaedicke S., Huai J., Niedermann G., Tripeptidyl peptidase II plays a role in the radiation response of selected primary cell types but not based on nuclear translocation and p53 stabilization Cancer Research 2009 69 8 3325 3331
66. Raha S., Robinson B. H., Mitochondria, oxygen free radicals, and apoptosis American Journal of Medical Genetics 2001 106 1 62 70
67. Karawajew L., Rhein P., Czerwony G., Ludwig W.-D., Stress-induced activation of the p53 tumor suppressor in leukemia cells and normal lymphocytes requires mitochondrial activity and reactive oxygen species Blood 2005 105 12 4767 4775
68. Liu B., Chen Y., St. Clair D. K., ROS and p53: a versatile partnership Free Radical Biology and Medicine 2008 44 8 1529 1535
69. Tsurumi C., Firat E., Gaedicke S., Huai J., Mandal P. K., Niedermann G., Viability and DNA damage responses of TPPII-deficient Myc- and Ras-transformed fibroblasts Biochemical and Biophysical Research Communications 2009 386 4 563 568
70. Konishi A., Shimizu S., Hirota J., Takao T., Fan Y., Matsuoka Y., Zhang L., Yoneda Y., Fujii Y., Skoultchi A. I., Tsujimoto Y., Involvement of histone H1.2 in apoptosis induced by DNA double-strand breaks Cell 2003 114 6 673 688
71. Book A. J., Yang P., Scalf M., Smith L. M., Vierstra R. D., Tripeptidyl peptidase II. An oligomeric protease complex from Arabidopsis Plant Physiology 2005 138 2 1046 1057
72. Di Micco R., Fumagalli M., Cicalese A., Piccinin S., Gasparini P., Luise C., Schurra C., Garr M., Giovanni Nuciforo P., Bensimon A., Maestro R., Giuseppe Pelicci P., D'Adda Di Fagagna F., Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication Nature 2006 444 7119 638 642
73. Csiszar A., Wang M., Lakatta E. G., Ungvari Z., Inflammation and endothelial dysfunction during aging: role of NF- B Journal of Applied Physiology 2008 105 4 1333 1341