Tripeptidyl peptidase II promotes fat formation in a conserved fashion

EMBO Reports

Volumn 8, Issue 12, 2007, Pages 1183-1189

  McKay, Renée M ^a   McKay, James P ^a   Suh, Jae Myoung ^a   Avery, Leon ^a   Graff, Jonathan M ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEINASE; TRIPEPTIDYL PEPTIDASE II; UNCLASSIFIED DRUG;

ADIPOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ANALYSIS; FOOD INTAKE; GENE INSERTION; GENE LOCUS; HETEROZYGOSITY; HOMEOSTASIS; HOMOZYGOSITY; LIPID METABOLISM; LIPID STORAGE; MAMMAL CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; RNA INTERFERENCE; WILD TYPE;

3T3-L1 CELLS; ADIPOGENESIS; ADIPOSE TISSUE; ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CHOLECYSTOKININ; HETEROZYGOTE; LIPID METABOLISM; MICE; MUTATION; PEPTIDE FRAGMENTS; RECEPTORS, CHOLECYSTOKININ; RNA INTERFERENCE; SERINE ENDOPEPTIDASES;

CAENORHABDITIS ELEGANS; MAMMALIA; MUS;

EID: 36749070379     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.1038/sj.embor.7401086     Document Type: Article

References (28)

1. Ashrafi K, Chang F, Watts J, Fraser A, Kamath R, Ahringer J, Ruvkun G (2003) Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes. Nature 421: 268-272
2. Balow R, Tomkinson B, Ragnarsson U, Zetterqvist O (1986) Purification, substrate specificity, and classification of tripeptidyl peptidase II. J Biol Chem 261: 2409-2417
3. Campbell P, Dhand R (2000) Obesity. Nature 404: 631-671
4. Clerc P et al 2006 Involvement of cholecystokinin 2 receptor in food intake regulation: Hyperphagia and increased fat deposition in cholecystokinin 2 receptor-deficient mice. Endocrinology 148 1039-1049
5. Cornelius P, MacDougald OA, Lane MD (1994) Regulation of adipocyte development. Annu Rev Nutr 14: 99-129
6. Drucker D (2006) Incretin-based therapies: A clinical need filled by unique metabolic effects. Diabetes Educ 32: 65S-71S
7. Dufresne M, Seva C, Fourmy D (2006) Cholecystokinin and gastrin receptors. Physiol Rev 86: 805-847
8. Facchinetti P, Rose C, Rostaing P, Triller A, Schwartz J-C (1998) Immunolocalization of tripeptidyl peptidase II, a cholecystokinin-inactivating enzyme, in rat brain. Neuroscience 88: 1225-1240
9. Geier E, Pfeifer G, Wilm M, Lucchiari-Hartz M, Baumeister W, Eichmann K, Niedermann G (1999) A giant protease with potential to substitute for some functions of the proteasome. Science 283: 978-981
10. Green H, Kehinde O (1975) An established preadipose cell line and its differentiation in culture. II. Factors affecting the adipose conversion. Cell 5: 19-27
11. Hilbi H, Puro R, Zychlinsky A (2000) Tripeptidyl peptidase II promotes maturation of caspase-1 in Shigella flexneri-induced macrophage apoptosis. Infect Immun 68: 5502-5508
12. Hilbi H, Jozsa E, Tomkinson B (2002) Identification of the catalytic triad in tripeptidyl-peptidase II through site-directed mutagenesis. Biochim Biophys Acta 1601: 149-154
13. Kahn B, Flier J (2000) Obesity and insulin resistance. J Clin Invest 106: 473-481
14. Kimura K, Tissenbaum H, Liu Y, Ruvkun G (1997) daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science 277: 942-946
15. Li C (2005) The ever-expanding neuropeptide gene families in the nematode Caenorhabditis elegans. Parasitology 131: S109-S127
16. Loster K, Zeilinger K, Schuppan D, Reutter W (1995) The cysteine-rich region of dipeptidyl peptidase IV (CD 26) is the collagen-binding site. Biochem Biophys Res Commun 217: 341-348
17. Mak H, Nelson L, Basson M, Johnson C, Ruvkun G (2006) Polygenic control of Caenorhabditis elegans fat storage. Nat Genet 38: 363-368
18. McKay RM, McKay JP, Avery L, Graff JM (2003) C. elegans: A model for exploring the genetics of fat storage. Dev Cell 4: 131-142
19. Mukhopadhyay A, Deplancke B, Walhout A, Tissenbaum H (2005) C. elegans tubby regulates life span and fat storage by two independent mechanisms. Cell Metab 2: 35-42
20. Piazza G, Callanan H, Mowery J, Hixson D (1989) Evidence for a role of dipeptidyl peptidase IV in fibronectin-mediated interactions of hepatocytes with extracellular matrix. Biochem J 262: 327-334
21. Pierce S et al (2001) Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family. Genes Dev 15: 672-686
22. Rose C, Vargas F, Facchinetti P, Bourgeat P, Bambal R, Bishop P, Chan S, Moore A, Ganellin C, Schwartz J-C (1996) Characterization and inhibition of a cholecystokinin-inactivating serine peptidase. Nature 380 403-409
23. Seifert U, Maranon C, Shmueli A, Desoutter J, Wesoloski L, Janek K, Henklin P, Diescher S, Andrieu M (2003) An essential role for tripeptidyl peptidase in the generation of an MHC class I epitope. Nat Immunol 4: 375-379
24. Simmer F, Tijsterman M, Parrish S, Koushika S, Nonet M, Fire A, Ahringer J, Plasterk R (2002) Loss of putative RNA-directed RNA polymerase RRF-3 makes C. elegans hypersensitive to RNAi. Curr Biol 12: 1317-1319
25. Spiegelman BM, Flier JS (2001) Obesity and the regulation of energy balance. Cell 104: 531-543
26. Sze J, Victor M, Loer C, Shi Y, Ruvkun G (2000) Food and metabolic signalling defects in a Caenorhabditis elegans serotonin-synthesis mutant. Nature 403: 560-564
27. Tomkinson B (1994) Characterization of cDNA for murine tripeptidyl-peptidase II reveals alternative splicing. Biochem J 304: 517-523
28. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman J (1994) Positional cloning of the mouse obese gene and its human homologue. Nature 372: 425-432