Activation of cellular death programs associated with immunosenescence-like phenotype in TPPII knockout mice

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 13, 2008, Pages 5177-5182

  Huai, Jisen ^a   Firat, Elke ^a   Nil, Ahmed ^a   Million, Daniele ^b   Gaedicke, Simone ^a   Kanzler, Benoit ^b   Freudenberg, Marina ^b   Van Endert, Peter ^c   Kohler, Gabriele ^d   Pahl, Heike L ^a   Aichele, Peter ^e   Eichmann, Klaus ^b   Niedermann, Gabriele ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b MAX PLANCK INSTITUTE OF IMMUNOBIOLOGY AND EPIGENETICS   (Germany)

^c INSERM   (France)

^d UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^e UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Apoptosis; Senescence; T lymphocytes; Tripeptidyl peptidase II

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN P53; PROTEINASE; TRIPEPTIDYL PEPTIDASE II; SERINE PROTEINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER CELL; CD8+ T LYMPHOCYTE; CELL DEATH; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVITY; EXTRAMEDULLARY HEMATOPOIESIS; FIBROBLAST; GRANULOPOIESIS; INFLAMMATION; KNOCKOUT MOUSE; LIFESPAN; LYMPHOCYTE PROLIFERATION; LYMPHOCYTOPENIA; LYMPHOMA CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SENESCENCE; T LYMPHOCYTE SUBPOPULATION; AGING; ANIMAL; CELL CULTURE; CELL DIFFERENTIATION; CYTOLOGY; ENZYMOLOGY; GENE DELETION; GENETICS; IMMUNOLOGY; METABOLISM; MOUSE MUTANT; PATHOLOGY; PHENOTYPE; T LYMPHOCYTE; THYMUS;

MUS;

AGING; ANIMALS; APOPTOSIS; CELL DIFFERENTIATION; CELLS, CULTURED; FIBROBLASTS; GENE DELETION; LYMPHOPENIA; MICE; MICE, KNOCKOUT; NF-KAPPA B; PHENOTYPE; SERINE ENDOPEPTIDASES; T-LYMPHOCYTES; THYMUS GLAND; TUMOR SUPPRESSOR PROTEIN P53;

EID: 42449115238     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0801413105     Document Type: Article

References (39)

1. Tomkinson B (1999) Tripeptidyl peptidases: Enzymes that count. Trends Biochem Sci 24:355-359.
2. Rockel B, Peters J, Kuhlmorgen B, Glaeser RM, Baumeister W (2002) A giant protease with a twist: The TPP II complex from Drosophila studied by electron microscopy. EMBO J 21:5979-5984.
3. Geier E, et al. (1999) A giant protease with potential to substitute for some functions of the proteasome. Science 283:978-981.
4. Reits E, et al. (2004) A major role for TPPII in trimming proteasomal degradation products for MHC class I antigen presentation. Immunity 20:495-506.
5. Glas R, Bogyo M, McMaster JS, Gaczynska M, Ploegh HL (1998)Aproteolytic system that compensates for loss of proteasome function. Nature 392:618-622.
6. Wang EW, et al. (2000) Integration of the ubiquitin-proteasome pathway with a cytosolic oligopeptidase activity. Proc Natl Acad Sci USA 97:9990-9995.
7. Gavioli R, Frisan T, Vertuani S, Bornkamm GW, Masucci MG (2001) c-myc overexpression activates alternative pathways for intracellular proteolysis in lymphoma cells. Nat Cell Biol 3:283-288.
8. Hong X, Lei L, Glas R (2003) Tumors acquire inhibitor of apoptosis protein (IAP)-mediated apoptosis resistance through altered specificity of cytosolic proteolysis. J Exp Med 197:1731-1743.
9. Stavropoulou V, et al. (2005) Mitotic infidelity and centrosome duplication errors in cells overexpressing tripeptidyl-peptidase II. Cancer Res 65:1361-1368.
10. Stavropoulou V, Vasquez V, Cereser B, Freda E, Masucci MG (2006) TPPII promotes genetic instability by allowing the escape from apoptosis of cells with activated mitotic checkpoints. Biochem Biophys Res Commun 346:415-425.
11. Hilbi H, Puro RJ, Zychlinsky A (2000) Tripeptidyl peptidase II promotes maturation of caspase-1 in Shigella flexneri-induced macrophage apoptosis. Infect Immun 68:5502-5508.
12. Firat E, et al. (2007) Analysis of direct and cross-presentation of antigens in TPPII knockout mice. J Immunol 179:8137-8145.
13. Hilbi H, Jozsa E, Tomkinson B (2002) Identification of the catalytic triad in tripeptidyl-peptidase II through site-directed mutagenesis. Biochim Biophys Acta 1601:149-154.
14. Germain RN (2002) T-cell development and the CD4-CD8 lineage decision. Nat Rev Immunol 2:309-322.
15. Su DM, Manley NR (2002) Stage-specific changes in fetal thymocyte proliferation during the CD4-8- to CD4+8+ transition in wild type, Rag1-/-, and Hoxa3, Pax1 mutant mice. BMC Immunol 3:12.
16. Andrew D, Aspinall R (2001) Il-7 and not stem cell factor reverses both the increase in apoptosis and the decline in thymopoiesis seen in aged mice. J Immunol 166:1524-1530.
17. Min H, Montecino-Rodriguez E, Dorshkind K (2004) Reduction in the developmental potential of intrathymic T cell progenitors with age. J Immunol 173:245-250.
18. Wang X, et al. (2006) Phenotype of genetically regulated thymic involution in young BXD RI strains of mice. Scand J Immunol 64:287-294.
19. Morrison SJ, Wandycz AM, Akashi K, Globerson A, Weissman IL (1996) The aging of hematopoietic stem cells. Nat Med 2:1011-1016.
20. Sudo K, Ema H, Morita Y, Nakauchi H (2000) Age-associated characteristics of murine hematopoietic stem cells. J Exp Med 192:1273-1280.
21. Janzen V, et al. (2006) Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a. Nature 443:421-426.
22. Haines DC, Chattopadhyay S, Ward JM (2001) Pathology of aging B6;129 mice. Toxicol Pathol 29:653-661.
23. Gupta S, Agrawal A, Agrawal S, Su H, Gollapudi S (2006) A paradox of immunodeficiency and inflammation in human aging: Lessons learned from apoptosis. Immun Ageing 3:5.
24. Assounga AG, Warner CM (2004) Transcription of major histocompatibility complex class I (Kb) and transporter associated with antigen processing 1 and 2 genes is up-regulated with age. Immunology 113:378-383.
25. Siebenlist U, Brown K, Claudio E (2005) Control of lymphocyte development by nuclear factor-kappaB. Nat Rev Immunol 5:435-445.
26. Campisi J (2005) Senescent cells, tumor suppression, and organismal aging: Good citizens, bad neighbors. Cell 120:513-522.
27. Lowe SW, Cepero E, Evan G (2004) Intrinsic tumour suppression. Nature 432:307-315.
28. Campisi J (2001) Cellular senescence as a tumor-suppressor mechanism. Trends Cell Biol 11:S27-S31.
29. Mason DX, Jackson TJ, Lin AW (2004) Molecular signature of oncogenic ras-induced senescen. Oncogene 23:9238-9246.
30. Eom YW, et al. (2005) Two distinct modes of cell death induced by doxorubicin: Apoptosis and cell death through mitotic catastrophe accompanied by senescence-like phenotype. Oncogene 24:4765-4777.
31. Karin M, Lin A (2002) NF-kappaB at the crossroads of life and death. Nat Immunol 3:221-227.
32. Helenius M, Hanninen M, Lehtinen SK, Salminen A (1996) Changes associated with aging and replicative senescence in the regulation of transcription factor nuclear factor-kappa B. Biochem J 318:603-608.
33. Ly DH, Lockhart DJ, Lerner RA, Schultz PG (2000) Mitotic misregulation and human aging. Science 287:2486-2492.
34. Wada T, et al. (2004) MKK7 couples stress signalling to G2/M cell-cycle progression and cellular senescence. Nat Cell Biol 6:215-226.
35. Castedo M (2004) Cell death by mitotic catastrophe: A molecular definition. Oncogene 23:2825-2837.
36. Haks MC, Krimpenfort P, van den Brakel JH, Kruisbeek AM (1999) Pre-TCR signaling and inactivation of p53 induces crucial cell survival pathways in pre-T cells. Immunity 11:91-101.
37. Tyner SD (2002) p53 mutant mice that display early ageing-associated phenotypes. Nature 415:45-53.
38. Fagnoni FF, et al. (2000) Shortage of circulating naive CD8(+) T cells provides new insights on immunodeficiency in aging. Blood 95:2860-2868.
39. Gupta S, Su H, Bi R, Agrawal S, Gollapudi S (2005) Life and death of lymphocytes: A role in immunesenescence. Immun Ageing 2:12.