Increased anxiety and impaired pain response in puromycin-sensitive aminopeptidase gene-deficient mice obtained by a mouse gene-trap method

Journal of Neuroscience

Volumn 19, Issue 14, 1999, Pages 6068-6078

  Osada, Tomoharu ^a,b   Ikegami, Shiro ^a   Takiguchi Hayashi, Keiko ^a   Yamazaki, Yukiko ^a,c   Katoh Fukui, Yuko ^a   Higashinakagawa, Toru ^a,d   Sakaki, Yoshiyuki ^b   Takeuchi, Takashi ^a  

^a MITSUBISHI KASEI INST OF LIFE SCI   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c NATIONAL INSTITUTE FOR PHYSIOLOGICAL SCIENCES   (Japan)

^d WASEDA UNIVERSITY   (Japan)

Author keywords

Analgesia; Anxiety; Dwarfism; Enkephalins; Gene trap; Puromycin sensitive aminopeptidase

Indexed keywords

AMINOPEPTIDASE; PUROMYCIN; PUROMYCIN SENSITIVE AMINOPEPTIDASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANXIETY; ARTICLE; BODY GROWTH; CLINICAL FEATURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORPUS STRIATUM; ENZYME ACTIVITY; ENZYME LOCALIZATION; GENETIC ENGINEERING; HIPPOCAMPUS; HYPOALGESIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSCRIPTION REGULATION;

EID: 0033565386     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.19-14-06068.1999     Document Type: Article

References (32)

1. Chapman CR, Casey KL, Dubner R, Foley KM, Gracely RH, Reading AE (1985) Pain measurement: overview. Pain 22:1-31.
2. Constam DB, Tobler AR, Rensing-Ehl A, Kemler I, Hersh LB, Fontana A (1995) Puromycin-sensitive aminopeptidase. Sequence, analysis, expression, and functional characterization. J Biol Chem 270:26931-26939.
3. Dyer SH, Slaughter CA, Orth K, Moomaw CR, Hersh LB (1990) Comparison of the soluble and membrane-bound forms of the puromycin-sensitive enkephalin-degrading aminopeptidases from rat. J Neurochem 54:547-554.
4. Eddy NB, Touchberry CF, Lieberman JE (1950) Synthetic analgesics. I. Methadone isomer and derivatives. J Pharmacol Exp Ther 98:121-137.
5. Eicher EM, Beamer WG (1976) Inherited ateliotic dwarfism in mice. J Hered 67:87-91.
6. Eicher EM, Beamer WD (1980) New mouse dw allele: genetic location and effects of lifespan and growth hormone levels. J Hered 71:187-190.
7. Gerlai R (1996) Gene-targeting studies of mammalian behavior: is it the mutation or the background genotype? Trends Neurosci 19:177-181.
8. Gossler A, Joyner AL, Rossant J, Skarnes WC (1989) Mouse embryonic stem cells and reporter constructs to detect developmentally regulated genes. Science 244:463-465.
9. Heimer L, Zahm DS, Alheid F (1995) Basal ganglia. In: The rat nervous system, Ed 2 (Paxinos G, ed), pp 579-628. San Diego: Academic.
10. Hersh LB (1985) Characterization of membrane-bound aminopeptidases from rat brain: identification of the enkephalin-degrading aminopeptidase. J Neurochem 44:1427-1435.
11. Hersh LB, McKelvy JF (1981) An aminopeptidase from bovine brain which catalyzes the hydrolysis of enkephalin. J Neurochem 36:171-178.
12. Hui KS, Saito M, Hui M (1998) A novel neuron-specific aminopeptidase in rat brain synaptosomes. Its identification, purification, and characterization. J Biol Chem 273:31053-31060.
13. Hui M, Budai ED, Lajtha A, Palkovits M, Hui K-S (1995) Changes in puromycin-sensitive aminopeptidases in postmortem schizophrenic brain regions. Neurochem Int 4/5:433-441.
14. Ikegami S (1994) Behavioral impairment in radial-arm maze learning and acetylcholine content of the hippocampus and cerebral cortex in aged mice. Behav Brain Res 65:103-111.
15. Kendall SK, Saumuelson LC, Saunders TL, Wood RI, Camper SA (1995) Targeted disruption of the pituitary glycoprotein hormone α-subunit produces hypogonadal and hypothyroid mice. Genes Dev 9:2007-2019.
16. Kitajima K, Takeuchi T (1999) Mouse gene trap approach: identification of novel genes and characterization of their biological functions. Biochem Cell Biol, in press.
17. Köning M, Zimmer AM, Steiner H, Holmes PV, Crawley JN, Brownstein MJ, Zimmer A (1996) Pain, anxiety and aggression in mice deficient in pre-proenkephalin. Nature 383:535-538.
18. Lister RG (1987) The use of a plus-maze to measure anxiety in the mouse. Psychopharmacology 92:180-185.
19. Maniatis T, Fritsch EF, Sambrook J (1989) Molecular cloning: a laboratory manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory.
20. McLellan S, Dyer SH, Rodriguez G, Hersh LB (1988) Studies on the tissue distribution of the puromycin-sensitive enkephalin-degrading aminopeptidase. J Neurochem 51:1552-1559.
21. Motoyama J, Kitajima K, Kojima M, Kondo S, Takeuchi T (1997) Organogenesis of the liver, thymus, spleen is affected in jumonji mutant mice. Mech Dev 66:27-37.
22. Nelson RJ, Young KA (1998) Behavior in mice with targeted disruption of single genes. Neurosci Biobehav Rev 22:453-462.
23. Olson GA, Olson RD, Kastin AJ (1996) Endogenous opiates: 1995. Peptides 17:1421-1466.
24. Pellow S, File SE (1986) Anxiolytic and anxiogenic drug effects on exploratory activity in an elevated plus-maze: a novel test of anxiety in the rat. Pharmacol Biochem Behav 11:99-106.
25. Raff MC (1996) Size control: the regulation of cell numbers in animal development. Cell 86:173-175.
26. Sicinski P, Donaher JL, Parker SB, Li T, Fazeli A, Gardner H, Haslam SZ, Bronson RT, Elledge SJ, Weinberg, RA (1995) Cyclin D1 provides a link between development and oncogenesis in the retina and breast. Cell 82:621-630.
27. Takeuchi T, Yamazaki Y, Katoh-Fukui Y, Tsuchiya R, Kondo S, Motoyama J, Higashinakagawa T (1995) Gene trap capture of a novel mouse gene, jumonji, required for neural tube formation. Genes Dev 9:1211-1222.
28. Takiguchi-Hayashi K, Sato M, Sugo N, Ishida M, Sato K, Uratani Y, Arimatsu Y (1998) Latexin expression in smaller diameter primary sensory neurons in the rat. Brain Res 801:9-20.
29. Tobler AR, Constam DB, Schmitt-Graff A, Malipiero U, Schlapbach R, Fontana A (1997) Cloning of the human puromycin-sensitive aminopeptidase and evidence for expression in neurons. J Neurochem 68:889-897.
30. Treit D, Fundytus M (1989) Thigmotaxis as a test for anxiolytic activity in rats. Pharmacol Biochem Behav 31:959-962.
31. Woolf CJ, Mannion RJ, Neumann S (1998) Null mutations lacking substance: elucidating pain mechanisms by genetic pharmacology. Neuron 20:1063-1066.
32. Woolfe G, Macdonald AD (1943) The evaluation of the analgesic action of pethidine hydrochloride (Demerol). J Pharmacol Exp Ther 80:300-307.