Peptide ligands selected with CD4-induced epitopes on native dualtropic HIV-1 envelope proteins mimic extracellular coreceptor domains and bind to HIV-1 gp120 independently of coreceptor usage

Journal of Virology

Volumn 84, Issue 19, 2010, Pages 10131-10138

  Dervillez, Xavier ^a,e   Klaukien, Volker ^b   Dürr, Ralf ^a   Koch, Joachim ^a   Kreutz, Alexandra ^a   Haarmann, Thomas ^a,f   Stoll, Michaela ^a   Lee, Donghan ^b   Carlomagno, Teresa ^b,g   Schnierle, Barbara ^c   Möbius, Kalle ^d   Königs, Christoph ^a,h   Griesinger, Christian ^b   Dietrich, Ursula ^a  

^a INSTITUTE FOR TUMOR BIOLOGY AND EXPERIMENTAL THERAPY   (Germany)

^b MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

^c PAUL EHRLICH INSTITUT   (Germany)

^d UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^e INSERM   (France)

^f AB Enzymes GmbH   (Germany)

^g EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^h GOETHE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTIC ACID; CD4 ANTIGEN; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR4; GLYCOPROTEIN GP 120; HISTIDYLLYSYLGLUTAMINYLPROLYLTRYPTOPHYLPHENYLALANYLASPARTYLPHENYLALANYLTRYPTOPHYLLEUCYLLEUCYLARGININE; HISTIDYLLYSYLGLUTAMINYLPROLYLTRYPTOPHYLTYROSYLASPARTYLTYROSYLTRYPTOPHYLLEUCYLLEUCYLARGININE; HISTIDYLLYSYLTYROSYLGLUTAMINYLPROLYLTRYPTOPHYLASPARTYLTRYPTOPHYLLEUCYLTYROSYLLEUCYLARGININE; HUMAN IMMUNODEFICIENCY VIRUS FUSION INHIBITOR; LEUCYLARGINYLTRYPTOPHYLPROLYLLEUCYLTYROSYLLYSYLTYROSYLHISTIDYLASPARTYLTRYPTOPHYLGLUTAMINE; LEUCYLARGINYLTYROSYLTRYPTOPHYLPROLYLLEUCYLLYSYLHISTIDYLASPARTYLTYROSYLTRYPTOPHYLGLUTAMINE; MONOCLONAL ANTIBODY; TYROSINE; TYROSYLHISTIDYLLYSYLGLUTAMINYLPROLYLTRYPTOPHYLASPARTYLTYROSYLTRYPTOPHYLLEUCYLLEUCYLARGININE; TYROSYLHISTIDYLLYSYLGLUTAMINYLPROLYLTYROSYLTRYPTOPHYLASPARTYLTRYPTOPHYLLEUCYLLEUCYLARGININE; UNCLASSIFIED DRUG; VIRUS ENVELOPE PROTEIN; CXCR4 PROTEIN, HUMAN; GP120 PROTEIN, HUMAN IMMUNODEFICIENCY VIRUS 1; LIGAND; PEPTIDE; PEPTIDE LIBRARY; PRIMER DNA; VIRUS DNA;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; DRUG PROTEIN BINDING; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN IMMUNODEFICIENCY VIRUS 1; PHAGE DISPLAY; PRIORITY JOURNAL; RETROVIRUS; VIRUS ENTRY; VIRUS PARTICLE; ANIMAL; CELL LINE; CHEMISTRY; CHO CELL LINE; CRICETULUS; ENVELOPE GENE; GENETIC TRANSDUCTION; GENETICS; HAMSTER; IMMUNOLOGY; IN VITRO STUDY; METABOLISM; MOLECULAR GENETICS; MOLECULAR MIMICRY; NUCLEOTIDE SEQUENCE; PEPTIDE LIBRARY; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE;

HUMAN IMMUNODEFICIENCY VIRUS 1;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, CD4; BASE SEQUENCE; CELL LINE; CHO CELLS; CRICETINAE; CRICETULUS; DNA PRIMERS; DNA, VIRAL; GENES, ENV; HIV ENVELOPE PROTEIN GP120; HIV-1; HUMANS; IN VITRO TECHNIQUES; LIGANDS; MOLECULAR MIMICRY; MOLECULAR SEQUENCE DATA; PEPTIDE LIBRARY; PEPTIDES; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, CCR5; RECEPTORS, CXCR4; TRANSDUCTION, GENETIC; VIRUS INTERNALIZATION;

EID: 77956853388     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.00165-10     Document Type: Article

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