Requirement of multiple phage displayed peptide libraries for optimal mapping of a conformational antibody epitope on CCR5

Journal of Immunological Methods

Volumn 299, Issue 1-2, 2005, Pages 21-35

  O'Connor, Karen H ^a   Königs, Christoph ^b,c   Rowley, Merrill J ^a   Irving, James A ^a   Wijeyewickrema, Lakshmi C ^a   Pustowka, Anette ^b   Dietrich, Ursula ^b   Mackay, Ian R ^a  

^a MONASH UNIVERSITY   (Australia)

^b INSTITUTE FOR TUMOR BIOLOGY AND EXPERIMENTAL THERAPY   (Germany)

^c UNIVERSITY HOSPITAL FRANKFURT   (Germany)

Author keywords

CCR5; Chemokine receptor; Epitope; HIV infectivity; Phage library; Type II collagen

Indexed keywords

ALANINE; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CCR5 ANTIBODY; COAT PROTEIN; COLLAGEN ANTIBODY; COLLAGEN TYPE 2 ANTIBODY; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 3A9; PEPTIDE LIBRARY; RECEPTOR ANTIBODY; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANTIBODY SPECIFICITY; ARTICLE; CLONE; EMBRYO; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITOPE MAPPING; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; MOLECULAR MODEL; MUTAGENESIS; PHAGE DISPLAY; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN MOTIF; SEQUENCE HOMOLOGY;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; EPITOPE MAPPING; HUMANS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PEPTIDE LIBRARY; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, CCR5;

EID: 19444372844     PISSN: 00221759     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jim.2004.11.025     Document Type: Article

References (34)

1. G. Alkhatib, S.S. Ahuja, D. Light, S. Mummidi, E.A. Berger, and S.K. Ahuja CC chemokine receptor 5-mediated signaling and HIV-1 Co-receptor activity share common structural determinants. Critical residues in the third extracellular loop support HIV-1 fusion J. Biol. Chem. 272 1997 19771
2. S.F. Altschul, T.L. Madden, A.A. Schaffer, J. Zhang, Z. Zhang, W. Miller, and D.J. Lipman Gapped BLAST and PSI-BLAST: a new generation of protein database search programs Nucleic Acids Res. 25 1997 3389
3. D.C. Benjamin, J.A. Berzofsky, I.J. East, F.R. Gurd, C. Hannum, S.J. Leach, E. Margoliash, J.G. Michael, A. Miller, and E.M. Prager The antigenic structure of proteins: a reappraisal Annu. Rev. Immunol. 2 1984 67
4. L.L. Bonnycastle, J.S. Mehroke, M. Rashed, X. Gong, and J.K. Scott Probing the basis of antibody reactivity with a panel of constrained peptide libraries displayed by filamentous phage J. Mol. Biol. 258 1996 747
5. B.C. Braden, and R.J. Poljak Structural features of the reactions between antibodies and protein antigens FASEB J. 9 1995 9
6. R. Chenna, H. Sugawara, T. Koike, R. Lopez, T.J. Gibson, D.G. Higgins, and J.D. Thompson Multiple sequence alignment with the Clustal series of programs Nucleic Acids Res. 31 2003 3497
7. A.D. Cook, J.M. Davies, M.A. Myers, I.R. Mackay, and M.J. Rowley Mimotopes identified by phage display for the monoclonal antibody CII-C1 to type II collagen J. Autoimmun. 11 1998 205
8. J.M. Davies, M.J. Rowley, and I.R. Mackay Phagotopes derived by antibody screening of phage-displayed random peptide libraries vary in immunoreactivity: studies using an exemplary monoclonal antibody, CII-C1, to type II collagen Immunol. Cell Biol. 77 1999 483
9. P.A. De Ciechi, C.S. Devine, S.C. Lee, S.C. Howard, P.O. Olins, and M.H. Caparon Utilization of multiple phage display libraries for the identification of dissimilar peptide motifs that bind to a B7-1 monoclonal antibody Mol. Divers. 1 1996 79
10. F. Felici, L. Castagnoli, A. Musacchio, R. Jappelli, and G. Cesareni Selection of antibody ligands from a large library of oligopeptides expressed on a multivalent exposition vector J. Mol. Biol. 222 1991 301
11. H.M. Geysen, S.J. Rodda, and T.J. Mason A priori delineation of a peptide which mimics a discontinuous antigenic determinant Mol. Immunol. 23 1986 709
12. N. Ikuno, M. Scealy, J.M. Davies, S.F. Whittingham, K. Omagari, I.R. Mackay, and M.J. Rowley A comparative study of antibody expressions in primary biliary cirrhosis and autoimmune cholangitis using phage display Hepatology 34 2001 478
13. L. Jin, B.M. Fendly, and J.A. Wells High resolution functional analysis of antibody-antigen interactions J. Mol. Biol. 226 1992 851
14. C. Königs, M.J. Rowley, P. Thompson, M.A. Myers, M. Scealy, J.M. Davies, L. Wu, U. Dietrich, C.R. Mackay, and I.R. Mackay Monoclonal antibody screening of a phage-displayed random peptide library reveals mimotopes of chemokine receptor CCR5: implications for the tertiary structure of the receptor and for an N-terminal binding site for HIV-1 gp120 Eur. J. Immunol. 30 2000 1162
15. P.J. Kraulis MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures J. Appl. Crystallogr. 24 1991 946
16. R.A. Laskowski, D.S. Moss, and J.M. Thornton Main-chain bond lengths and bond angles in protein structures J. Mol. Biol. 231 1993 1049
17. W.G. Laver, G.M. Air, R.G. Webster, and S.J. Smith-Gill Epitopes on protein antigens: misconceptions and realities Cell 61 1990 553
18. B. Lee, M. Sharron, C. Blanpain, B.J. Doranz, J. Vakili, P. Setoh, E. Berg, G. Liu, H.R. Guy, S.R. Durell, M. Parmentier, C.N. Chang, K. Price, M. Tsang, and R.W. Doms Epitope mapping of CCR5 reveals multiple conformational states and distinct but overlapping structures involved in chemokine and coreceptor function J. Biol. Chem. 274 1999 9617
19. C. Notredame, D.G. Higgins, and J. Heringa T-Coffee: a novel method for fast and accurate multiple sequence alignment J. Mol. Biol. 302 2000 205
20. J. Novotny, R.E. Bruccoleri, and F.A. Saul On the attribution of binding energy in antigen-antibody complexes McPC 603, D1.3, and HyHEL-5 Biochemistry 28 1989 4735
21. T. Okada, I. Le Trong, B.A. Fox, C.A. Behnke, R.E. Stenkamp, and K. Palczewski X-ray diffraction analysis of three-dimensional crystals of bovine rhodopsin obtained from mixed micelles J. Struct. Biol. 130 2000 73
22. W.C. Olson, G.E. Rabut, K.A. Nagashima, D.N. Tran, D.J. Anselma, S.P. Monard, J.P. Segal, D.A. Thompson, F. Kajumo, Y. Guo, J.P. Moore, P.J. Maddon, and T. Dragic Differential inhibition of human immunodeficiency virus type 1 fusion, gp120 binding, and CC-chemokine activity by monoclonal antibodies to CCR5 J. Virol. 73 1999 4145
23. M.G. Paterlini Structure modeling of the chemokine receptor CCR5: implications for ligand binding and selectivity Biophys. J. 83 2002 3012
24. M.J. Rowley, K. O'Connor, and L. Wijeyewickrema Phage display for epitope determination: a paradigm for identifying receptor-ligand interactions Biotechnol. Annu. Rev. 10 2004 151
25. A. Sali, and T.L. Blundell Comparative protein modelling by satisfaction of spatial restraints J. Mol. Biol. 234 1993 779
26. J. Sambrook, E.F. Fritsch, and T. Maniatis Molecular cloning: a laboratory manual 1989 Cold Spring Harbor New York
27. M. Samson, O. Labbe, C. Mollereau, G. Vassart, and M. Parmentier Molecular cloning and functional expression of a new human CC-chemokine receptor gene Biochemistry 35 1996 3362
28. S. Schulte, C. Unger, J.A. Mo, O. Wendler, E. Bauer, S. Frischholz, K. von der Mark, J.R. Kalden, R. Holmdahl, and H. Burkhardt Arthritis-related B cell epitopes in collagen II are conformation-dependent and sterically privileged in accessible sites of cartilage collagen fibrils J. Biol. Chem. 273 1998 1551
29. S.J. Smith-Gill, A.C. Wilson, M. Potter, E.M. Prager, R.J. Feldmann, and C.R. Mainhart Mapping the antigenic epitope for a monoclonal antibody against lysozyme J. Immunol. 128 1982 314
30. C.D. Surh, R. Coppel, and M.E. Gershwin Structural requirement for autoreactivity on human pyruvate dehydrogenase-E2, the major autoantigen of primary biliary cirrhosis. Implication for a conformational autoepitope J. Immunol. 144 1990 3367
31. G. Tribbick Multipin peptide libraries for antibody and receptor epitope screening and characterization J. Immunol. Methods 267 2002 27
32. L. Wu, G. LaRosa, N. Kassam, C.J. Gordon, H. Heath, N. Ruffing, H. Chen, J. Humblias, M. Samson, M. Parmentier, J.P. Moore, and C.R. Mackay Interaction of chemokine receptor CCR5 with its ligands: multiple domains for HIV-1 gp120 binding and a single domain for chemokine binding J. Exp. Med. 186 1997 1373
33. Y. Xu, P.A. Ramsland, J.M. Davies, M. Scealy, K.S. Nandakumar, R. Holmdahl, and M.J. Rowley Two monoclonal antibodies to precisely the same epitope of type II collagen select non-crossreactive phage clones by phage display: implications for autoimmunity and molecular mimicry Mol. Immunol. 41 2004 411
34. N. Zhou, Z. Luo, J.W. Hall, J. Luo, X. Han, and Z. Huang Molecular modeling and site-directed mutagenesis of CCR5 reveal residues critical for chemokine binding and signal transduction Eur. J. Immunol. 30 2000 164