-
1
-
-
75149166672
-
Metabolic effects of fructose and the worldwide increase in obesity
-
Tappy L, Le KA. Metabolic effects of fructose and the worldwide increase in obesity. Physiol Rev. 2010;90:23-46.
-
(2010)
Physiol Rev
, vol.90
, pp. 23-46
-
-
Tappy, L.1
Le, K.A.2
-
2
-
-
34547226533
-
Ability of the normal human small intestine to absorb fructose: Evaluation by breath testing
-
Rao SS, Attaluri A, Anderson L, Stumbo P. Ability of the normal human small intestine to absorb fructose: evaluation by breath testing. Clin Gastroenterol Hepatol. 2007;5:959-63.
-
(2007)
Clin Gastroenterol Hepatol
, vol.5
, pp. 959-963
-
-
Rao, S.S.1
Attaluri, A.2
Anderson, L.3
Stumbo, P.4
-
3
-
-
60549110854
-
Hypothesis: Could excessive fructose intake and uric acid cause type 2 diabetes?
-
Johnson RJ, Perez-Pozo SE, Sautin YY, Manitius J, Sanchez-Lozada LG, Feig DI, et al. Hypothesis: could excessive fructose intake and uric acid cause type 2 diabetes? Endocr Rev. 2009;30:96-116.
-
(2009)
Endocr Rev
, vol.30
, pp. 96-116
-
-
Johnson, R.J.1
Perez-Pozo, S.E.2
Sautin, Y.Y.3
Manitius, J.4
Sanchez-Lozada, L.G.5
Feig, D.I.6
-
4
-
-
7044272753
-
Dietary fructose and gastrointestinal symptoms: A review
-
Skoog SM, Bharucha AE. Dietary fructose and gastrointestinal symptoms: a review. Am J Gastroenterol. 2004;99:2046-50.
-
(2004)
Am J Gastroenterol
, vol.99
, pp. 2046-2050
-
-
Skoog, S.M.1
Bharucha, A.E.2
-
5
-
-
0034532207
-
Peripheral glucose appearance rate following fructose ingestion in normal subjects
-
Nuttall FQ, Khan MA, Gannon MC. Peripheral glucose appearance rate following fructose ingestion in normal subjects. Metabolism. 2000;49:1565-71.
-
(2000)
Metabolism
, vol.49
, pp. 1565-1571
-
-
Nuttall, F.Q.1
Khan, M.A.2
Gannon, M.C.3
-
6
-
-
0035232487
-
Cooperation of liver cells in health and disease
-
III-XIII
-
Kmiec Z. Cooperation of liver cells in health and disease. Adv Anat Embryol Cell Biol. 2001;161:III-XIII, 1-151.
-
(2001)
Adv Anat Embryol Cell Biol
, vol.161
, pp. 1-151
-
-
Kmiec, Z.1
-
8
-
-
0018988343
-
Mechanisms of acute hyperinsulinemia after Kupffer cell phagocytosis
-
Cornell RP. Mechanisms of acute hyperinsulinemia after Kupffer cell phagocytosis. Am J Physiol. 1980;238:E276-83.
-
(1980)
Am J Physiol
, vol.238
-
-
Cornell, R.P.1
-
9
-
-
73349127065
-
Loss of Kupffer cells in diet-induced obesity is associated with increased hepatic steatosis, STAT3 signaling, and further decreases in insulin signaling
-
Clementi AH, Gaudy AM, van Rooijen N, Pierce RH, Mooney RA. Loss of Kupffer cells in diet-induced obesity is associated with increased hepatic steatosis, STAT3 signaling, and further decreases in insulin signaling. Biochim Biophys Acta. 2009;1792:1062-72.
-
(2009)
Biochim Biophys Acta
, vol.1792
, pp. 1062-1072
-
-
Clementi, A.H.1
Gaudy, A.M.2
Rooijen, N.V.3
Pierce, R.H.4
Mooney, R.A.5
-
10
-
-
67349130130
-
Critical role of Kupffer cells in the management of diet-induced diabetes and obesity
-
Neyrinck AM, Cani PD, Dewulf EM, De Backer F, Bindels LB, Delzenne NM. Critical role of Kupffer cells in the management of diet-induced diabetes and obesity. Biochem Biophys Res Commun. 2009;385:351-6.
-
(2009)
Biochem Biophys Res Commun
, vol.385
, pp. 351-356
-
-
Neyrinck, A.M.1
Cani, P.D.2
Dewulf, E.M.3
Backer, F.D.4
Bindels, L.B.5
Delzenne, N.M.6
-
11
-
-
77449117735
-
Depletion of liver Kupffer cells prevents the development of diet-induced hepatic steatosis and insulin resistance
-
Huang W, Metlakunta A, Dedousis N, Zhang P, Sipula I, Dube JJ, et al. Depletion of liver Kupffer cells prevents the development of diet-induced hepatic steatosis and insulin resistance. Diabetes. 2010;59:347-57.
-
(2010)
Diabetes
, vol.59
, pp. 347-357
-
-
Huang, W.1
Metlakunta, A.2
Dedousis, N.3
Zhang, P.4
Sipula, I.5
Dube, J.J.6
-
12
-
-
66149120712
-
Endocrine and metabolic effects of consuming fructose-and glucose-sweetened beverages with meals in obese men and women: Infuence of insulin resistance on plasma triglyceride responses
-
Teff KL, Grudziak J, Townsend RR, Dunn TN, Grant RW, Adams SH, et al. Endocrine and metabolic effects of consuming fructose-and glucose-sweetened beverages with meals in obese men and women: infuence of insulin resistance on plasma triglyceride responses. J Clin Endocrinol Metab. 2009;94:1562-9.
-
(2009)
J Clin Endocrinol Metab
, vol.94
, pp. 1562-1569
-
-
Teff, K.L.1
Grudziak, J.2
Townsend, R.R.3
Dunn, T.N.4
Grant, R.W.5
Adams, S.H.6
-
13
-
-
55849086887
-
Fructose consumption and consequences for glycation, plasma triacylglycerol, and body weight: Meta-analyses and meta-regression models of intervention studies
-
Livesey G, Taylor R. Fructose consumption and consequences for glycation, plasma triacylglycerol, and body weight: meta-analyses and meta-regression models of intervention studies. Am J Clin Nutr. 2008;88:1419-37.
-
(2008)
Am J Clin Nutr
, vol.88
, pp. 1419-1437
-
-
Livesey, G.1
Taylor, R.2
-
14
-
-
4644231257
-
Sugar-added beverages and adolescent weight change
-
Berkey CS, Rockett HR, Field AE, Gillman MW, Colditz GA. Sugar-added beverages and adolescent weight change. Obes Res. 2004;12:778-88.
-
(2004)
Obes Res
, vol.12
, pp. 778-788
-
-
Berkey, C.S.1
Rockett, H.R.2
Field, A.E.3
Gillman, M.W.4
Colditz, G.A.5
-
15
-
-
34347234818
-
Substitution of drinking water by fructose solution induces hyperinsulinemia and hyperglycemia in hamsters
-
Barros CM, Lessa RQ, Grechi MP, Mouco TL, Souza MG, Wiernsperger N, et al. Substitution of drinking water by fructose solution induces hyperinsulinemia and hyperglycemia in hamsters. Clinics. 2007;62:327-34.
-
(2007)
Clinics
, vol.62
, pp. 327-334
-
-
Barros, C.M.1
Lessa, R.Q.2
Grechi, M.P.3
Mouco, T.L.4
Souza, M.G.5
Wiernsperger, N.6
-
16
-
-
29744433021
-
Consuming fructose-sweetened beverages increases body adiposity in mice
-
Jurgens H, Haass W, Castaneda TR, Schurmann A, Koebnick C, Dombrowski F, et al. Consuming fructose-sweetened beverages increases body adiposity in mice. Obes Res. 2005;13:1146-56.
-
(2005)
Obes Res
, vol.13
, pp. 1146-1156
-
-
Jurgens, H.1
Haass, W.2
Castaneda, T.R.3
Schurmann, A.4
Koebnick, C.5
Dombrowski, F.6
-
17
-
-
66749103785
-
Fructose ingestion: Dose-dependent responses in health research
-
Livesey G. Fructose ingestion: dose-dependent responses in health research. J Nutr. 2009;139:1246S-52S.
-
(2009)
J Nutr
, vol.139
-
-
Livesey, G.1
-
18
-
-
53649104150
-
Consumption of fructose-sweetened beverages for 10 weeks increases postprandial triacylglycerol and apolipoprotein-B concentrations in overweight and obese women
-
Swarbrick MM, Stanhope KL, Elliott SS, Graham JL, Krauss RM, Christiansen MP, et al. Consumption of fructose-sweetened beverages for 10 weeks increases postprandial triacylglycerol and apolipoprotein-B concentrations in overweight and obese women. Br J Nutr. 2008;100:947-52.
-
(2008)
Br J Nutr
, vol.100
, pp. 947-952
-
-
Swarbrick, M.M.1
Stanhope, K.L.2
Elliott, S.S.3
Graham, J.L.4
Krauss, R.M.5
Christiansen, M.P.6
-
19
-
-
33845482041
-
A 4-wk high-fructose diet alters lipid metabolism without affecting insulin sensitivity or ectopic lipids in healthy humans
-
Le KA, Faeh D, Stettler R, Ith M, Kreis R, Vermathen P, et al. A 4-wk high-fructose diet alters lipid metabolism without affecting insulin sensitivity or ectopic lipids in healthy humans. Am J Clin Nutr. 2006;84:1374-9.
-
(2006)
Am J Clin Nutr
, vol.84
, pp. 1374-1379
-
-
Le, K.A.1
Faeh, D.2
Stettler, R.3
Ith, M.4
Kreis, R.5
Vermathen, P.6
-
20
-
-
66849124938
-
Fructose overconsumption causes dyslipidemia and ectopic lipid deposition in healthy subjects with and without a family history of type 2 diabetes
-
Le KA, Ith M, Kreis R, Faeh D, Bortolotti M, Tran C, et al. Fructose overconsumption causes dyslipidemia and ectopic lipid deposition in healthy subjects with and without a family history of type 2 diabetes. Am J Clin Nutr. 2009;89:1760-5.
-
(2009)
Am J Clin Nutr
, vol.89
, pp. 1760-1765
-
-
Le, K.A.1
Ith, M.2
Kreis, R.3
Faeh, D.4
Bortolotti, M.5
Tran, C.6
-
21
-
-
70350570495
-
Diabetes of the liver: The link between nonalcoholic fatty liver disease and HFCS-55
-
Collison KS, Saleh SM, Bakheet RH, Al-Rabiah RK, Inglis AL, Makhoul NJ, et al. Diabetes of the liver: the link between nonalcoholic fatty liver disease and HFCS-55. Obesity (Silver Spring). 2009;17:2003-13.
-
(2009)
Obesity (Silver Spring)
, vol.17
, pp. 2003-2013
-
-
Collison, K.S.1
Saleh, S.M.2
Bakheet, R.H.3
Al-Rabiah, R.K.4
Inglis, A.L.5
Makhoul, N.J.6
-
22
-
-
67649429383
-
Metabolic syndrome signs in Wistar rats submitted to different high-fructose ingestion protocols
-
de Moura RF, Ribeiro C, de Oliveira JA, Stevanato E, de Mello MA. Metabolic syndrome signs in Wistar rats submitted to different high-fructose ingestion protocols. Br J Nutr. 2009;101:1178-84.
-
(2009)
Br J Nutr
, vol.101
, pp. 1178-1184
-
-
Moura, R.F.D.1
Ribeiro, C.2
Oliveira, J.A.D.3
Stevanato, E.4
Mello, M.A.D.5
-
23
-
-
0019494049
-
Long-term effects of moderate fructose feeding on glucose tolerance parameters in rats
-
Blakely SR, Hallfrisch J, Reiser S, Prather ES. Long-term effects of moderate fructose feeding on glucose tolerance parameters in rats. J Nutr. 1981;111:307-14.
-
(1981)
J Nutr
, vol.111
, pp. 307-314
-
-
Blakely, S.R.1
Hallfrisch, J.2
Reiser, S.3
Prather, E.S.4
-
24
-
-
70350317887
-
Rats fed fructose-enriched diets have characteristics of nonalcoholic hepatic steatosis
-
Kawasaki T, Igarashi K, Koeda T, Sugimoto K, Nakagawa K, Hayashi S, et al. Rats fed fructose-enriched diets have characteristics of nonalcoholic hepatic steatosis. J Nutr. 2009;139:2067-71.
-
(2009)
J Nutr
, vol.139
, pp. 2067-2071
-
-
Kawasaki, T.1
Igarashi, K.2
Koeda, T.3
Sugimoto, K.4
Nakagawa, K.5
Hayashi, S.6
-
25
-
-
60349083114
-
Dietary fructose, fruits, fruit juices and glucose tolerance status in Japanese-Brazilians
-
Sartorelli DS, Franco LJ, Gimeno SG, Ferreira SR, Cardoso MA. Dietary fructose, fruits, fruit juices and glucose tolerance status in Japanese-Brazilians. Nutr Metab Cardiovasc Dis. 2009;19:77-83.
-
(2009)
Nutr Metab Cardiovasc Dis
, vol.19
, pp. 77-83
-
-
Sartorelli, D.S.1
Franco, L.J.2
Gimeno, S.G.3
Ferreira, S.R.4
Cardoso, M.A.5
-
26
-
-
19544387005
-
Dietary carbohydrates and glycaemic load and the incidence of symptomatic gall stone disease in men
-
Tsai CJ, Leitzmann MF, Willett WC, Giovannucci EL. Dietary carbohydrates and glycaemic load and the incidence of symptomatic gall stone disease in men. Gut. 2005;54:823-8.
-
(2005)
Gut
, vol.54
, pp. 823-828
-
-
Tsai, C.J.1
Leitzmann, M.F.2
Willett, W.C.3
Giovannucci, E.L.4
-
29
-
-
0037983622
-
Experimental studies on the role of fructose in the development of diabetic complications
-
Sakai M, Oimomi M, Kasuga M. Experimental studies on the role of fructose in the development of diabetic complications. Kobe J Med Sci. 2002;48:125-36.
-
(2002)
Kobe J Med Sci
, vol.48
, pp. 125-136
-
-
Sakai, M.1
Oimomi, M.2
Kasuga, M.3
-
30
-
-
77649094326
-
Soft drink consumption and obesity: It is all about fructose
-
Bray GA. Soft drink consumption and obesity: it is all about fructose. Curr Opin Lipidol. 2010;21:51-7.
-
(2010)
Curr Opin Lipidol
, vol.21
, pp. 51-57
-
-
Bray, G.A.1
-
31
-
-
0027445113
-
Protein fructosylation: Fructose and the Maillard reaction
-
SUPPL
-
Dills WL, Jr. Protein fructosylation: fructose and the Maillard reaction. Am J Clin Nutr. 1993;58(5 Suppl):779S-87S.
-
(1993)
Am J Clin Nutr
, vol.58
, Issue.5
-
-
Dills, W.L.1
-
32
-
-
33745061876
-
Site specifcity of glycation and carboxymethylation of bovine serum albumin by fructose
-
Hinton DJ, Ames JM. Site specifcity of glycation and carboxymethylation of bovine serum albumin by fructose. Amino Acids. 2006;30:425-34.
-
(2006)
Amino Acids
, vol.30
, pp. 425-434
-
-
Hinton, D.J.1
Ames, J.M.2
-
33
-
-
67349083565
-
Role of fructose concentration on cataractogenesis in senile diabetic and non-diabetic patients
-
Gul A, Rahman MA, Hasnain SN. Role of fructose concentration on cataractogenesis in senile diabetic and non-diabetic patients. Graefes Arch Clin Exp Ophthalmol. 2009;247:809-14.
-
(2009)
Graefes Arch Clin Exp Ophthalmol
, vol.247
, pp. 809-814
-
-
Gul, A.1
Rahman, M.A.2
Hasnain, S.N.3
-
34
-
-
0032533545
-
Immunological detection of fructated proteins in vitro and in vivo
-
Miyazawa N, Kawasaki Y, Fujii J, Theingi M, Hoshi A, Hamaoka R, et al. Immunological detection of fructated proteins in vitro and in vivo. Biochem J. 1998;336:101-7.
-
(1998)
Biochem J
, vol.336
, pp. 101-107
-
-
Miyazawa, N.1
Kawasaki, Y.2
Fujii, J.3
Theingi, M.4
Hoshi, A.5
Hamaoka, R.6
-
35
-
-
29844439896
-
Fructose ingestion enhances atherosclerosis and deposition of advanced glycated end-products in cholesterol-fed rabbits
-
Tokita Y, Hirayama Y, Sekikawa A, Kotake H, Toyota T, Miyazawa T, et al. Fructose ingestion enhances atherosclerosis and deposition of advanced glycated end-products in cholesterol-fed rabbits. J Atheroscler Thromb. 2005;12:260-7.
-
(2005)
J Atheroscler Thromb
, vol.12
, pp. 260-267
-
-
Tokita, Y.1
Hirayama, Y.2
Sekikawa, A.3
Kotake, H.4
Toyota, T.5
Miyazawa, T.6
-
37
-
-
40449113838
-
Attenuation of hypertension development by scavenging methylglyoxal in fructose-treated rats
-
Wang X, Jia X, Chang T, Desai K, Wu L. Attenuation of hypertension development by scavenging methylglyoxal in fructose-treated rats. J Hypertens. 2008;26:765-72.
-
(2008)
J Hypertens
, vol.26
, pp. 765-772
-
-
Wang, X.1
Jia, X.2
Chang, T.3
Desai, K.4
Wu, L.5
-
38
-
-
20244365646
-
Hyperuricemia induces endothelial dysfunction
-
Khosla UM, Zharikov S, Finch JL, Nakagawa T, Roncal C, Mu W, et al. Hyperuricemia induces endothelial dysfunction. Kidney Int. 2005;67:1739-42.
-
(2005)
Kidney Int
, vol.67
, pp. 1739-1742
-
-
Khosla, U.M.1
Zharikov, S.2
Finch, J.L.3
Nakagawa, T.4
Roncal, C.5
Mu, W.6
-
40
-
-
33645560926
-
A causal role for uric acid in fructose-induced metabolic syndrome
-
Nakagawa T, Hu H, Zharikov S, Tuttle KR, Short RA, Glushakova O, et al. A causal role for uric acid in fructose-induced metabolic syndrome. Am J Physiol Renal Physiol. 2006;290:F625-31.
-
(2006)
Am J Physiol Renal Physiol
, vol.290
-
-
Nakagawa, T.1
Hu, H.2
Zharikov, S.3
Tuttle, K.R.4
Short, R.A.5
Glushakova, O.6
-
42
-
-
65549154830
-
Fructose-rich diet-induced abdominal adipose tissue endocrine dysfunction in normal male rats
-
Alzamendi A, Giovambattista A, Raschia A, Madrid V, Gaillard RC, Rebolledo O, et al. Fructose-rich diet-induced abdominal adipose tissue endocrine dysfunction in normal male rats. Endocrine. 2009;35:227-32.
-
(2009)
Endocrine
, vol.35
, pp. 227-232
-
-
Alzamendi, A.1
Giovambattista, A.2
Raschia, A.3
Madrid, V.4
Gaillard, R.C.5
Rebolledo, O.6
-
43
-
-
0029051888
-
Plasma plasminogen activator inhibitor activity in rats with nutritionally induced insulin resistance
-
Scelles V, Alessi MC, Raccah D, Juhan-Vague I, Vague P. Plasma plasminogen activator inhibitor activity in rats with nutritionally induced insulin resistance. Thromb Haemost. 1995;74:806-7.
-
(1995)
Thromb Haemost
, vol.74
, pp. 806-807
-
-
Scelles, V.1
Alessi, M.C.2
Raccah, D.3
Juhan-Vague, I.4
Vague, P.5
-
44
-
-
77649151750
-
Transition of pathophysiological signifcance of plasminogen activator inhibitor-From a chief player in antiinfammation, antifbrinolysis to that in the development of insulin resistance
-
Kosugi T, Nakamura M, Sunagawa M. Transition of pathophysiological signifcance of plasminogen activator inhibitor-From a chief player in antiinfammation, antifbrinolysis to that in the development of insulin resistance. Pathophysiology.;17:109-18.
-
Pathophysiology
, vol.17
, pp. 109-118
-
-
Kosugi, T.1
Nakamura, M.2
Sunagawa, M.3
-
45
-
-
15744394674
-
Fructose, insulin resistance, and metabolic dyslipidemia
-
Basciano H, Federico L, Adeli K. Fructose, insulin resistance, and metabolic dyslipidemia. Nutr Metab (Lond). 2005;2:5.
-
(2005)
Nutr Metab (Lond)
, vol.2
, pp. 5
-
-
Basciano, H.1
Federico, L.2
Adeli, K.3
-
46
-
-
50449097852
-
Postprandial dyslipidemia in insulin resistance: Mechanisms and role of intestinal insulin sensitivity
-
Hsieh J, Hayashi AA, Webb J, Adeli K. Postprandial dyslipidemia in insulin resistance: mechanisms and role of intestinal insulin sensitivity. Atheroscler Suppl. 2008;9:7-13.
-
(2008)
Atheroscler Suppl
, vol.9
, pp. 7-13
-
-
Hsieh, J.1
Hayashi, A.A.2
Webb, J.3
Adeli, K.4
-
47
-
-
34250000890
-
Mechanisms for the acute effect of fructose on postprandial lipemia
-
Chong MF, Fielding BA, Frayn KN. Mechanisms for the acute effect of fructose on postprandial lipemia. Am J Clin Nutr. 2007;85:1511-20.
-
(2007)
Am J Clin Nutr
, vol.85
, pp. 1511-1520
-
-
Chong, M.F.1
Fielding, B.A.2
Frayn, K.N.3
-
48
-
-
0027364672
-
Intermediary metabolism of fructose
-
SUPPL
-
Mayes PA. Intermediary metabolism of fructose. Am J Clin Nutr. 1993;58(5 Suppl):754S-65S.
-
(1993)
Am J Clin Nutr
, vol.58
, Issue.5
-
-
Mayes, P.A.1
-
49
-
-
0015250464
-
The immediate effects of insulin and fructose on the metabolism of the perfused liver. Changes in lipoprotein secretion, fatty acid oxidation and esterifcation, lipogenesis and carbohydrate metabolism
-
Topping DL, Mayes PA. The immediate effects of insulin and fructose on the metabolism of the perfused liver. Changes in lipoprotein secretion, fatty acid oxidation and esterifcation, lipogenesis and carbohydrate metabolism. Biochem J. 1972;126:295-311.
-
(1972)
Biochem J
, vol.126
, pp. 295-311
-
-
Topping, D.L.1
Mayes, P.A.2
-
50
-
-
42749092583
-
Dietary fructose induces a wide range of genes with distinct shift in carbohydrate and lipid metabolism in fed and fasted rat liver
-
Koo HY, Wallig MA, Chung BH, Nara TY, Cho BH, Nakamura MT. Dietary fructose induces a wide range of genes with distinct shift in carbohydrate and lipid metabolism in fed and fasted rat liver. Biochim Biophys Acta. 2008;1782:341-8.
-
(2008)
Biochim Biophys Acta
, vol.1782
, pp. 341-348
-
-
Koo, H.Y.1
Wallig, M.A.2
Chung, B.H.3
Nara, T.Y.4
Cho, B.H.5
Nakamura, M.T.6
-
51
-
-
43049170503
-
Fructose consumption as a risk factor for non-alcoholic fatty liver disease
-
Ouyang X, Cirillo P, Sautin Y, McCall S, Bruchette JL, Diehl AM, et al. Fructose consumption as a risk factor for non-alcoholic fatty liver disease. J Hepatol. 2008;48:993-9.
-
(2008)
J Hepatol
, vol.48
, pp. 993-999
-
-
Ouyang, X.1
Cirillo, P.2
Sautin, Y.3
McCall, S.4
Bruchette, J.L.5
Diehl, A.M.6
-
53
-
-
70349738087
-
Soft drink consumption is associated with fatty liver disease independent of metabolic syndrome
-
Abid A, Taha O, Nseir W, Farah R, Grosovski M, Assy N. Soft drink consumption is associated with fatty liver disease independent of metabolic syndrome. J Hepatol. 2009;51:918-24.
-
(2009)
J Hepatol
, vol.51
, pp. 918-924
-
-
Abid, A.1
Taha, O.2
Nseir, W.3
Farah, R.4
Grosovski, M.5
Assy, N.6
-
54
-
-
71849088380
-
Effect of moderate intake of sweeteners on metabolic health in the rat
-
Figlewicz DP, Ioannou G, Bennett Jay J, Kittleson S, Savard C, Roth CL. Effect of moderate intake of sweeteners on metabolic health in the rat. Physiol Behav. 2009;98:618-24.
-
(2009)
Physiol Behav
, vol.98
, pp. 618-624
-
-
Figlewicz, D.P.1
Ioannou, G.2
Bennett, J.J.3
Kittleson, S.4
Savard, C.5
Roth, C.L.6
-
56
-
-
70350075402
-
Toll-like receptor 4 is involved in the development of fructose-induced hepatic steatosis in mice
-
Spruss A, Kanuri G, Wagnerberger S, Haub S, Bischoff SC, Bergheim I. Toll-like receptor 4 is involved in the development of fructose-induced hepatic steatosis in mice. Hepatology. 2009;50:1094-104.
-
(2009)
Hepatology
, vol.50
, pp. 1094-1104
-
-
Spruss, A.1
Kanuri, G.2
Wagnerberger, S.3
Haub, S.4
Bischoff, S.C.5
Bergheim, I.6
-
57
-
-
42249083760
-
Comparison of breath testing with fructose and high fructose corn syrups in health and IBS
-
Skoog SM, Bharucha AE, Zinsmeister AR. Comparison of breath testing with fructose and high fructose corn syrups in health and IBS. Neurogastroenterol Motil. 2008;20:505-11.
-
(2008)
Neurogastroenterol Motil
, vol.20
, pp. 505-511
-
-
Skoog, S.M.1
Bharucha, A.E.2
Zinsmeister, A.R.3
-
58
-
-
70349802137
-
Clinical impact of identifying lactose maldigestion or fructose malabsorption in irritable bowel syndrome or other conditions
-
Corlew-Roath M, Di Palma JA. Clinical impact of identifying lactose maldigestion or fructose malabsorption in irritable bowel syndrome or other conditions. South Med J. 2009;102:1010-2.
-
(2009)
South Med J
, vol.102
, pp. 1010-1012
-
-
Corlew-Roath, M.1
Palma, J.A.D.2
-
59
-
-
39749192582
-
Fructose intolerance in IBS and utility of fructose-restricted diet
-
Choi YK, Kraft N, Zimmerman B, Jackson M, Rao SS. Fructose intolerance in IBS and utility of fructose-restricted diet. J Clin Gastroenterol. 2008;42:233-8.
-
(2008)
J Clin Gastroenterol
, vol.42
, pp. 233-238
-
-
Choi, Y.K.1
Kraft, N.2
Zimmerman, B.3
Jackson, M.4
Rao, S.S.5
-
60
-
-
25844453563
-
Fructose intake at current levels in the United States may cause gastrointestinal distress in normal adults
-
Beyer PL, Caviar EM, McCallum RW. Fructose intake at current levels in the United States may cause gastrointestinal distress in normal adults. J Am Diet Assoc. 2005;105:1559-66.
-
(2005)
J Am Diet Assoc
, vol.105
, pp. 1559-1566
-
-
Beyer, P.L.1
Caviar, E.M.2
McCallum, R.W.3
-
61
-
-
33846581917
-
Review article: Fructose malabsorption and the bigger picture
-
Gibson PR, Newnham E, Barrett JS, Shepherd SJ, Muir JG. Review article: fructose malabsorption and the bigger picture. Aliment Pharmacol Ther. 2007 15;25:349-63.
-
(2007)
Aliment Pharmacol Ther
, vol.15
, Issue.25
, pp. 349-363
-
-
Gibson, P.R.1
Newnham, E.2
Barrett, J.S.3
Shepherd, S.J.4
Muir, J.G.5
-
63
-
-
0034043549
-
Liquid versus solid carbohydrate: Effects on food intake and body weight
-
DiMeglio DP, Mattes RD. Liquid versus solid carbohydrate: effects on food intake and body weight. Int J Obes Relat Metab Disord. 2000;24:794-800.
-
(2000)
Int J Obes Relat Metab Disord
, vol.24
, pp. 794-800
-
-
Dimeglio, D.P.1
Mattes, R.D.2
-
64
-
-
0742289628
-
Infuence of repeated consumption of beverages containing sucrose or intense sweeteners on food intake
-
Van Wymelbeke V, Beridot-Therond ME, de La Gueronniere V, Fantino M. Infuence of repeated consumption of beverages containing sucrose or intense sweeteners on food intake. Eur J Clin Nutr. 2004;58:154-61.
-
(2004)
Eur J Clin Nutr
, vol.58
, pp. 154-161
-
-
Wymelbeke, V.V.1
Beridot-Therond, M.E.2
Gueronniere, V.D.L.3
Fantino, M.4
-
65
-
-
16244382888
-
Does the consumption of caloric and non-caloric beverages with a meal affect energy intake?
-
DellaValle DM, Roe LS, Rolls BJ. Does the consumption of caloric and non-caloric beverages with a meal affect energy intake? Appetite. 2005;44:187-93.
-
(2005)
Appetite
, vol.44
, pp. 187-193
-
-
Dellavalle, D.M.1
Roe, L.S.2
Rolls, B.J.3
-
66
-
-
66749156511
-
Dietary fructose and metabolic syndrome and diabetes
-
Bantle JP. Dietary fructose and metabolic syndrome and diabetes. J Nutr. 2009;139:1263S-8S.
-
(2009)
J Nutr
, vol.139
-
-
Bantle, J.P.1
-
67
-
-
0346025354
-
Oxidative stress: The special case of diabetes
-
Wiernsperger NF. Oxidative stress: the special case of diabetes. Biofactors. 2003;19:11-8.
-
(2003)
Biofactors
, vol.19
, pp. 11-18
-
-
Wiernsperger, N.F.1
-
68
-
-
74149083433
-
Comparison of free fructose and glucose to sucrose in the ability to cause fatty liver
-
Sanchez-Lozada LG, Mu W, Roncal C, Sautin YY, Abdelmalek M, Reungjui S, et al. Comparison of free fructose and glucose to sucrose in the ability to cause fatty liver. Eur J Nutr. 2010;49:1-9.
-
(2010)
Eur J Nutr
, vol.49
, pp. 1-9
-
-
Sanchez-Lozada, L.G.1
Mu, W.2
Roncal, C.3
Sautin, Y.Y.4
Abdelmalek, M.5
Reungjui, S.6
-
69
-
-
70350575347
-
Acute, food-induced moderate elevation of plasma uric acid protects against hyperoxia-induced oxidative stress and increase in arterial stiffness in healthy humans
-
Vukovic J, Modun D, Budimir D, Sutlovic D, Salamunic I, Zaja I, et al. Acute, food-induced moderate elevation of plasma uric acid protects against hyperoxia-induced oxidative stress and increase in arterial stiffness in healthy humans. Atherosclerosis. 2009;207:255-60.
-
(2009)
Atherosclerosis
, vol.207
, pp. 255-260
-
-
Vukovic, J.1
Modun, D.2
Budimir, D.3
Sutlovic, D.4
Salamunic, I.5
Zaja, I.6
-
70
-
-
48449097307
-
Associations between serum uric acid and adipokines, markers of infammation, and endothelial dysfunction
-
Bo S, Gambino R, Durazzo M, Ghione F, Musso G, Gentile L, et al. Associations between serum uric acid and adipokines, markers of infammation, and endothelial dysfunction. J Endocrinol Invest. 2008;31:499-504.
-
(2008)
J Endocrinol Invest
, vol.31
, pp. 499-504
-
-
Bo, S.1
Gambino, R.2
Durazzo, M.3
Ghione, F.4
Musso, G.5
Gentile, L.6
-
71
-
-
0033990966
-
Uric acid and serum antioxidant capacity: A reaction to atherosclerosis?
-
Nieto FJ, Iribarren C, Gross MD, Comstock GW, Cutler RG. Uric acid and serum antioxidant capacity: a reaction to atherosclerosis? Atherosclerosis. 2000;148:131-9.
-
(2000)
Atherosclerosis
, vol.148
, pp. 131-139
-
-
Nieto, F.J.1
Iribarren, C.2
Gross, M.D.3
Comstock, G.W.4
Cutler, R.G.5
-
72
-
-
34547733397
-
Adverse effects of the classic antioxidant uric acid in adipocytes: NADPH oxidase-mediated oxidative/nitrosative stress
-
Sautin YY, Nakagawa T, Zharikov S, Johnson RJ. Adverse effects of the classic antioxidant uric acid in adipocytes: NADPH oxidase-mediated oxidative/nitrosative stress. Am J Physiol Cell Physiol. 2007;293:C584-96.
-
(2007)
Am J Physiol Cell Physiol
, vol.293
-
-
Sautin, Y.Y.1
Nakagawa, T.2
Zharikov, S.3
Johnson, R.J.4
-
73
-
-
79954433663
-
Prevalence of insulin resistance and metabolic syndrome in patients with gouty arthritis
-
Yoo HG, Lee SI, Chae HJ, Park SJ, Lee YC, Yoo WH. Prevalence of insulin resistance and metabolic syndrome in patients with gouty arthritis. Rheumatol Int. 2009; 20.
-
(2009)
Rheumatol Int
, vol.20
-
-
Yoo, H.G.1
Lee, S.I.2
Chae, H.J.3
Park, S.J.4
Lee, Y.C.5
Yoo, W.H.6
-
74
-
-
77949471032
-
Carotid intima-media thickness, dietary intake, and cardiovascular phenotypes in adolescents: Relation to metabolic syndrome
-
Croymans DM, Sanchez A, Barth JD, Roberts CK. Carotid intima-media thickness, dietary intake, and cardiovascular phenotypes in adolescents: relation to metabolic syndrome. Metabolism. 2010;59:533-9.
-
(2010)
Metabolism
, vol.59
, pp. 533-539
-
-
Croymans, D.M.1
Sanchez, A.2
Barth, J.D.3
Roberts, C.K.4
-
75
-
-
70349678815
-
Serum uric acid levels improve prediction of incident type 2 diabetes in individuals with impaired fasting glucose: The Rancho Bernardo Study
-
Kramer CK, von Muhlen D, Jassal SK, Barrett-Connor E. Serum uric acid levels improve prediction of incident type 2 diabetes in individuals with impaired fasting glucose: the Rancho Bernardo Study. Diabetes Care. 2009;32:1272-3.
-
(2009)
Diabetes Care
, vol.32
, pp. 1272-1273
-
-
Kramer, C.K.1
von Muhlen, D.2
Jassal, S.K.3
Barrett-Connor, E.4
-
76
-
-
39549085729
-
Soft drinks, fructose consumption, and the risk of gout in men: Prospective cohort study
-
Choi HK, Curhan G. Soft drinks, fructose consumption, and the risk of gout in men: prospective cohort study. Bmj. 2008;336:309-12.
-
(2008)
Bmj
, vol.336
, pp. 309-312
-
-
Choi, H.K.1
Curhan, G.2
-
77
-
-
71349083886
-
Relationship between uric acid and hepatic steatosis among Koreans
-
Lee K. Relationship between uric acid and hepatic steatosis among Koreans. Diabetes Metab. 2009;35:447-51.
-
(2009)
Diabetes Metab
, vol.35
, pp. 447-451
-
-
Lee, K.1
-
78
-
-
77449090055
-
The relationship between serum uric acid concentration and metabolic syndrome in university freshmen
-
Lin KP. The relationship between serum uric acid concentration and metabolic syndrome in university freshmen. J Nurs Res. 2009;17:286-92.
-
(2009)
J Nurs Res
, vol.17
, pp. 286-292
-
-
Lin, K.P.1
-
79
-
-
33646338312
-
Hypothesis: Fructose-induced hyperuricemia as a causal mechanism for the epidemic of the metabolic syndrome
-
Nakagawa T, Tuttle KR, Short RA, Johnson RJ. Hypothesis: fructose-induced hyperuricemia as a causal mechanism for the epidemic of the metabolic syndrome. Nat Clin Pract Nephrol. 2005;1:80-6.
-
(2005)
Nat Clin Pract Nephrol
, vol.1
, pp. 80-86
-
-
Nakagawa, T.1
Tuttle, K.R.2
Short, R.A.3
Johnson, R.J.4
-
80
-
-
72149100521
-
Relationship between hyperuricemia (HUC) and metabolic syndrome (MS) in institutionalized elderly men
-
Chang CH, Chen YM, Chuang YW, Liao SC, Lin CS, Tang YJ, et al. Relationship between hyperuricemia (HUC) and metabolic syndrome (MS) in institutionalized elderly men. Arch Gerontol Geriatr. 2009;49 Suppl 2:S46-9.
-
(2009)
Arch Gerontol Geriatr
, vol.49
, Issue.SUPPL. 2
-
-
Chang, C.H.1
Chen, Y.M.2
Chuang, Y.W.3
Liao, S.C.4
Lin, C.S.5
Tang, Y.J.6
-
82
-
-
58949099524
-
Uric acid and insulin sensitivity and risk of incident hypertension
-
Forman JP, Choi H, Curhan GC. Uric acid and insulin sensitivity and risk of incident hypertension. Arch Intern Med. 2009 26;169:155-62.
-
(2009)
Arch Intern Med
, vol.26
, Issue.169
, pp. 155-162
-
-
Forman, J.P.1
Choi, H.2
Curhan, G.C.3
-
83
-
-
12344252176
-
Uric acid as a mediator of endothelial dysfunction, infammation, and vascular disease
-
Kanellis J, Kang DH. Uric acid as a mediator of endothelial dysfunction, infammation, and vascular disease. Semin Nephrol. 2005;25:39-42.
-
(2005)
Semin Nephrol
, vol.25
, pp. 39-42
-
-
Kanellis, J.1
Kang, D.H.2
-
84
-
-
11244264034
-
Relations of serum uric acid to longitudinal blood pressure tracking and hypertension incidence
-
Sundstrom J, Sullivan L, D'Agostino RB, Levy D, Kannel WB, Vasan RS. Relations of serum uric acid to longitudinal blood pressure tracking and hypertension incidence. Hypertension. 2005;45:28-33.
-
(2005)
Hypertension
, vol.45
, pp. 28-33
-
-
Sundstrom, J.1
Sullivan, L.2
D'agostino, R.B.3
Levy, D.4
Kannel, W.B.5
Vasan, R.S.6
-
85
-
-
0017660720
-
Effect of increased serum urate levels on virgin rats with no arteriosclerosis versus breeder rats with preexistent arteriosclerosis
-
Wexler BC, Greenberg BP. Effect of increased serum urate levels on virgin rats with no arteriosclerosis versus breeder rats with preexistent arteriosclerosis. Metabolism. 1977;26:1309-20.
-
(1977)
Metabolism
, vol.26
, pp. 1309-1320
-
-
Wexler, B.C.1
Greenberg, B.P.2
-
86
-
-
34447514239
-
Uric acid and oxidative stress: Relative impact on cardiovascular risk?
-
Strazzullo P, Puig JG. Uric acid and oxidative stress: relative impact on cardiovascular risk? Nutr Metab Cardiovasc Dis. 2007;17:409-14.
-
(2007)
Nutr Metab Cardiovasc Dis
, vol.17
, pp. 409-414
-
-
Strazzullo, P.1
Puig, J.G.2
-
87
-
-
33645461474
-
Uric acid-induced C-reactive protein expression: Implication on cell proliferation and nitric oxide production of human vascular cells
-
Kang DH, Park SK, Lee IK, Johnson RJ. Uric acid-induced C-reactive protein expression: implication on cell proliferation and nitric oxide production of human vascular cells. J Am Soc Nephrol. 2005;16:3553-62.
-
(2005)
J Am Soc Nephrol
, vol.16
, pp. 3553-3562
-
-
Kang, D.H.1
Park, S.K.2
Lee, I.K.3
Johnson, R.J.4
-
88
-
-
66749153184
-
The effect of high-fructose corn syrup consumption on triglycerides and uric acid
-
Angelopoulos TJ, Lowndes J, Zukley L, Melanson KJ, Nguyen V, Huffman A, et al. The effect of high-fructose corn syrup consumption on triglycerides and uric acid. J Nutr. 2009;139:1242S-5S.
-
(2009)
J Nutr
, vol.139
-
-
Angelopoulos, T.J.1
Lowndes, J.2
Zukley, L.3
Melanson, K.J.4
Nguyen, V.5
Huffman, A.6
-
89
-
-
38649087348
-
Sugar-sweetened soft drinks, diet soft drinks, and serum uric acid level: The Third National Health and Nutrition Examination Survey
-
Choi JW, Ford ES, Gao X, Choi HK. Sugar-sweetened soft drinks, diet soft drinks, and serum uric acid level: the Third National Health and Nutrition Examination Survey. Arthritis Rheum. 2008;59:109-16.
-
(2008)
Arthritis Rheum
, vol.59
, pp. 109-116
-
-
Choi, J.W.1
Ford, E.S.2
Gao, X.3
Choi, H.K.4
-
90
-
-
77949661516
-
Lack of association between dietary fructose and hyperuricemia risk in adults. Nutr Metab
-
Sun SZ, Flickinger BD, Williamson-Hughes PS, Empie MW. Lack of association between dietary fructose and hyperuricemia risk in adults. Nutr Metab. (Lond). 2010;7:16.
-
(2010)
Lond
, vol.7
, pp. 16
-
-
Sun, S.Z.1
Flickinger, B.D.2
Williamson-Hughes, P.S.3
Empie, M.W.4
-
91
-
-
33846243394
-
Effects of high-fructose corn syrup and sucrose consumption on circulating glucose, insulin, leptin, and ghrelin and on appetite in normal-weight women
-
Melanson KJ, Zukley L, Lowndes J, Nguyen V, Angelopoulos TJ, Rippe JM. Effects of high-fructose corn syrup and sucrose consumption on circulating glucose, insulin, leptin, and ghrelin and on appetite in normal-weight women. Nutrition. 2007;23:103-12.
-
(2007)
Nutrition
, vol.23
, pp. 103-112
-
-
Melanson, K.J.1
Zukley, L.2
Lowndes, J.3
Nguyen, V.4
Angelopoulos, T.J.5
Rippe, J.M.6
-
92
-
-
66749086870
-
The state of the science on dietary sweeteners containing fructose: Summary and issues to be resolved
-
Murphy SP. The state of the science on dietary sweeteners containing fructose: summary and issues to be resolved. J Nutr. 2009;139:1269S-70S.
-
(2009)
J Nutr
, vol.139
-
-
Murphy, S.P.1
-
93
-
-
66749154237
-
Dietary fructose and glucose differentially affect lipid and glucose homeostasis
-
Schaefer EJ, Gleason JA, Dansinger ML. Dietary fructose and glucose differentially affect lipid and glucose homeostasis. J Nutr. 2009;139:1257S-62S.
-
(2009)
J Nutr
, vol.139
-
-
Schaefer, E.J.1
Gleason, J.A.2
Dansinger, M.L.3
-
94
-
-
0033680479
-
Comparison of the effects of sucrose and fructose on insulin action and glucose tolerance
-
Thresher JS, Podolin DA, Wei Y, Mazzeo RS, Pagliassotti MJ. Comparison of the effects of sucrose and fructose on insulin action and glucose tolerance. Am J Physiol Regul Integr Comp Physiol. 2000;279:R1334-40.
-
(2000)
Am J Physiol Regul Integr Comp Physiol
, vol.279
-
-
Thresher, J.S.1
Podolin, D.A.2
Wei, Y.3
Mazzeo, R.S.4
Pagliassotti, M.J.5
-
95
-
-
36849080743
-
No differences in satiety or energy intake after high-fructose corn syrup, sucrose, or milk preloads
-
Soenen S, Westerterp-Plantenga MS. No differences in satiety or energy intake after high-fructose corn syrup, sucrose, or milk preloads. Am J Clin Nutr. 2007;86:1586-94.
-
(2007)
Am J Clin Nutr
, vol.86
, pp. 1586-1594
-
-
Soenen, S.1
Westerterp-Plantenga, M.S.2
-
96
-
-
43549110957
-
Twenty-four-hour endocrine and metabolic profiles following consumption of high-fructose corn syrup-, sucrose-, fructose-, and glucose-sweetened beverages with meals
-
Stanhope KL, Griffen SC, Bair BR, Swarbrick MM, Keim NL, Havel PJ. Twenty-four-hour endocrine and metabolic profiles following consumption of high-fructose corn syrup-, sucrose-, fructose-, and glucose-sweetened beverages with meals. Am J Clin Nutr. 2008;87:1194-203.
-
(2008)
Am J Clin Nutr
, vol.87
, pp. 1194-1203
-
-
Stanhope, K.L.1
Griffen, S.C.2
Bair, B.R.3
Swarbrick, M.M.4
Keim, N.L.5
Havel, P.J.6
-
97
-
-
77956743188
-
Effects of a short-term overfeeding with fructose or glucose in healthy young males
-
Ngo Sock ET, Le KA, Ith M, Kreis R, Boesch C, Tappy L. Effects of a short-term overfeeding with fructose or glucose in healthy young males. Br J Nutr. 2009 24:1-5.
-
(2009)
Br J Nutr
, vol.24
, pp. 1-5
-
-
Sock, E.T.N.1
Le, K.A.2
Ith, M.3
Kreis, R.4
Boesch, C.5
Tappy, L.6
-
98
-
-
66749181719
-
Fructose consumption: Considerations for future research on its effects on adipose distribution, lipid metabolism, and insulin sensitivity in humans
-
Stanhope KL, Havel PJ. Fructose consumption: considerations for future research on its effects on adipose distribution, lipid metabolism, and insulin sensitivity in humans. J Nutr. 2009;139:1236S-41S.
-
(2009)
J Nutr
, vol.139
-
-
Stanhope, K.L.1
Havel, P.J.2
-
99
-
-
0036204977
-
Metformin improves lipid metabolism and attenuates lipid peroxidation in high fructose-fed rats
-
Anurag P, Anuradha C V. Metformin improves lipid metabolism and attenuates lipid peroxidation in high fructose-fed rats. Diabetes Obes Metab. 2002;4:36-42.
-
(2002)
Diabetes Obes Metab
, vol.4
, pp. 36-42
-
-
Anurag, P.1
Anuradha, C.V.2
-
100
-
-
0036710674
-
Increased intraabdominal adipose tissue mass in fructose fed rats: Correction by metformin
-
Baret G, Peyronnet J, Grassi-Kassisse D, Dalmaz Y, Wiernsperger N, Geloen A. Increased intraabdominal adipose tissue mass in fructose fed rats: correction by metformin. Exp Clin Endocrinol Diabetes. 2002;110:298-303.
-
(2002)
Exp Clin Endocrinol Diabetes
, vol.110
, pp. 298-303
-
-
Baret, G.1
Peyronnet, J.2
Grassi-Kassisse, D.3
Dalmaz, Y.4
Wiernsperger, N.5
Geloen, A.6
-
101
-
-
0033008628
-
An insulin sensitizer improves the free radical defense system potential and insulin sensitivity in high fructose-fed rats
-
Faure P, Rossini E, Wiernsperger N, Richard MJ, Favier A, Halimi S. An insulin sensitizer improves the free radical defense system potential and insulin sensitivity in high fructose-fed rats. Diabetes. 1999;48:353-7.
-
(1999)
Diabetes
, vol.48
, pp. 353-357
-
-
Faure, P.1
Rossini, E.2
Wiernsperger, N.3
Richard, M.J.4
Favier, A.5
Halimi, S.6
-
102
-
-
0036458758
-
Metformin improves liver antioxidant potential in rats fed a high-fructose diet
-
Srividhya S, Anuradha CV. Metformin improves liver antioxidant potential in rats fed a high-fructose diet. Asia Pac J Clin Nutr. 2002;1:319-22.
-
(2002)
Asia Pac J Clin Nutr
, vol.1
, pp. 319-322
-
-
Srividhya, S.1
Anuradha, C.V.2
-
103
-
-
70450252198
-
The fructose-fed rat: A review on the mechanisms of fructose-induced insulin resistance and hypertension
-
Tran LT, Yuen VG, McNeill JH. The fructose-fed rat: a review on the mechanisms of fructose-induced insulin resistance and hypertension. Mol Cell Biochem. 2009;332:145-59.
-
(2009)
Mol Cell Biochem
, vol.332
, pp. 145-159
-
-
Tran, L.T.1
Yuen, V.G.2
McNeill, J.H.3
-
104
-
-
71049191062
-
Uric acid is positively associated with metabolic syndrome but negatively associated with diabetes in Japanese men
-
Oda E, Kawai R, Sukumaran V, Watanabe K. Uric acid is positively associated with metabolic syndrome but negatively associated with diabetes in Japanese men. Intern Med. 2009;48:1785-91.
-
(2009)
Intern Med
, vol.48
, pp. 1785-1791
-
-
Oda, E.1
Kawai, R.2
Sukumaran, V.3
Watanabe, K.4
-
105
-
-
77951023327
-
Sugar-sweetened beverages and risk of obesity and type 2 diabetes: Epidemiologic evidence
-
Hu FB, Malik VS. Sugar-sweetened beverages and risk of obesity and type 2 diabetes: Epidemiologic evidence. Physiol Behav. 2010;100:47-54.
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(2010)
Physiol Behav
, vol.100
, pp. 47-54
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Hu, F.B.1
Malik, V.S.2
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