Associations between serum uric acid and adipokines, markers of inflammation, and endothelial dysfunction

Journal of Endocrinological Investigation

Volumn 31, Issue 6, 2008, Pages 499-504

  Bo, S ^a   Gambino, R ^a   Durazzo, M ^a   Ghione, F ^a   Musso, G ^a   Gentile, L ^b   Cassader, M ^a   Cavallo Perin, P ^a   Pagano, G ^a  

^a UNIVERSITY OF TURIN   (Italy)

^b Hospital of Asti   (Italy)

Author keywords

Adipokines; Endothelial dysfunction; Inflammation; Oxidative stress; Uric acid

Indexed keywords

3 NITROTYROSINE; ADIPOCYTOKINE; ADIPONECTIN; BIOLOGICAL MARKER; C REACTIVE PROTEIN; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; LEPTIN; RESISTIN; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; URIC ACID; VASCULAR CELL ADHESION MOLECULE 1;

ADULT; ARTICLE; BODY HEIGHT; BODY MASS; BODY WEIGHT; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; DIASTOLIC BLOOD PRESSURE; DISEASE MARKER; ENDOTHELIAL DYSFUNCTION; GLUCOSE BLOOD LEVEL; HOMEOSTASIS MODEL ASSESSMENT INSULIN RESISTANCE; HUMAN; INFLAMMATION; MAJOR CLINICAL STUDY; MALE; METABOLIC DISORDER; OXIDATIVE STRESS; PREVALENCE; RATING SCALE; SYSTOLIC BLOOD PRESSURE; TRIACYLGLYCEROL BLOOD LEVEL; URIC ACID BLOOD LEVEL; WAIST CIRCUMFERENCE;

EID: 48449097307     PISSN: 03914097     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03346397     Document Type: Article

References (43)

1. Baker JF, Krishnan E, Chen L, Schumacher HR. Serum uric acid and cardiovascular disease: recent developments, and where do they leave us? Am J Med 2005, 118: 816-26.
2. Dawson J, Walters M. Uric acid and xanthine oxidase: future therapeutic targets in the prevention of cardiovascular disease? Br J Clin Pharmacol 2006, 62: 633-44.
3. Wheeler JG, Juzwishin KD, Eiriksdottir G, Gudnason V, Danesh J. Serum uric acid and coronary heart disease in 9,458 incident cases and 155,084 controls: prospective study and meta-analysis. PLoS Med 2005, 2: e76.
4. Ishizaka N, Ishizaka Y, Toda E, Nagai R, Yamakado M. Association between serum uric acid, metabolic syndrome, and carotid atherosclerosis in Japanese individuals. Arterioscler Thromb Vasc Biol 2005, 25: 1038-44.
5. Short RA. Reviewer's perspective of the role of uric acid. Am J Hypertens 2006, 19: 1063.
6. Tsouli SG, Liberopoulos EN, Mikhailidis DP, Athyros VG, Elisaf MS. Elevated serum uric acid levels in metabolic syndrome: an active component or an innocent bystander? Metabolism 2006, 55: 1293-301.
7. Onat A, Uyarel H, Hergenç G, et al. Serum uric acid is a determinant of metabolic syndrome in a population-based study. Am J Hypertens 2006, 19: 1055-62.
8. Leyva F, Anker SD, Godsland IF, et al. Uric acid in chronic heart failure: a marker of chronic inflammation. Eur Heart J 1998, 19: 1814-22.
9. Ruggiero C, Cherubini A, Ble A, et al. Uric acid and inflammatory markers. Eur Heart J 2006, 27: 1174-81.
10. Mercuro G, Vitale C, Cerquetani E, et al. Effects of hyperuricemia upon endothelial function in patients at increased cardiovascular risk. Am J Cardiol 2004, 94: 932-5.
11. Kanellis J, Kang DH. Uric acid as a mediator of endothelial dysfunction, inflammation, and vascular disease. Semin Nephrol 2005, 25: 39-42.
12. Rao GN, Corson MA, Berk BC. Uric acid stimulates vascular smooth muscle cell proliferation by increasing platelet-derived growth factor A-chain expression. J Biol Chem 1991, 266: 8604-8.
13. Pischon T, Girman CJ, Hotamisligil GS, Rifai N, Hu FB, Rimm EB. Plasma adiponectin levels and risk of myocardial infarction in men. JAMA 2004, 291: 1730-7.
14. Wallace AM, McMahon AD, Packard CJ, et al. Plasma leptin and the risk of cardiovascular disease in the West of Scotland Coronary Prevention Study (WOSCOPS). Circulation 2001, 104: 3052-6.
15. Reilly MP, Lehrke M, Wolfe ML, Rohatgi A, Lazar MA, Rader DJ. Resistin is an inflammatory marker of atherosclerosis in humans. Circulation 2005, 111: 932-9.
16. Ridker PM, Hennekens CH, Buring JE, Rifai N. C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. New Engl J Med 2000, 342: 836-43.
17. Cesari M, Penninx BW, Newman AB, et al. Inflammatory markers and onset of cardiovascular events: results from the Health ABC study. Circulation 2003, 108: 2317-22.
18. Shishehbor MH, Aviles RJ, Brennan ML, et al. Association of nitrotyrosine levels with cardiovascular disease and modulation by statin therapy. JAMA 2003, 289: 1675-80.
19. Hwang SJ, Ballantyne CM, Sharrett AR, et al. Circulating adhesion molecules VCAM-1, ICAM-1, and E-selectin in carotid atherosclerosis, and incident coronary heart disease cases: the Atherosclerosis Risk In Communities (ARIC) study. Circulation 1997, 96: 4219-25.
20. Fruehwald-Schultes B, Peters A, Kern W, Beyer J, Pfützner A. Serum leptin is associated with serum uric acid concentrations in humans. Metabolism 1999, 48: 677-80.
21. Matsubara M, Chiba H, Maruoka S, Katayose S. Elevated serum leptin concentrations in women with hyperuricemia. J Atheroscler Thromb 2002, 9: 28-34.
22. Bedir A, Topbas M, Tanyeri F, Alvur M, Arik N. Leptin might be a regulator of serum uric acid concentrations in humans. Jpn Heart J 2003, 44: 527-36.
23. Bo S, Gentile L, Ciccone G, et al. The metabolic syndrome and high C-reactive protein: prevalence and difference by sex in a southern-European population-based cohort. Diabetes Metab Res Rev 2005, 21: 515-24.
24. Bo S, Gambino R, Uberti B, et al. Does C-reactive protein identify a subclinical metabolic disease in healthy subjects? Eur J Clin Invest 2005, 35: 265-70.
25. Saltin B, Grimby G. Physiological analysis of middle-aged and old former athletes. Comparison with still active athletes of the same ages. Circulation 1968, 38: 1104-15.
26. Bo S, Durazzo M, Guidi S, et al. Dietary magnesium and fiber intakes and inflammatory and metabolic indicators in middle-aged subjects from a population-based cohort. Am J Clin Nutr 2006, 84: 1062-9.
27. Kroke A, Klipstein-Grobusch K, Voss S, et al. Validation of a self-administered food-frequency questionnaire administered in the European Prospective Investigation into Cancer and Nutrition (EPIC) study: comparison of energy, protein, and macronutrient intakes estimated with the doubly labeled water, urinary nitrogen, and repeated 24-h dietary recall methods. Am J Clin Nutr 1999, 70: 439-47.
28. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985, 28: 412-9.
29. Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron 1976, 16: 31-41.
30. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive summary of the third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 2001, 285: 2486-97.
31. Quiñones Galvan A, Natali A, Baldi S, et al. Effect of insulin on uric acid excretion in humans. Am J Physiol 1995, 268: E1-5.
32. Ter Maaten JC, Voorburg A, Heine RJ, Ter Wee PM, Donker AJ, Gans RO. Renal handling of urate and sodium during acute physiological hyperinsulinaemia inn healthy subjects. Clin Sci (Lond) 1997, 92: 51-8.
33. Hayden MR, Tyagi SC. Uric acid: a new look at an old risk marker for cardiovascular disease, metabolic syndrome, and type 2 diabetes mellitus: The urate redox shuttle. Nutr Metab (Lond) 2004, 1: 10.
34. Waring WS, Convery A, Mishra V, Shenkin A, Webb DJ, Maxwell SRJ. Uric acid reduces exercise-induced oxidative stress in healthy adults. Clin Sci (Lond) 2003, 105: 425-30.
35. Patterson RA, Horsley ET, Leake DS. Prooxidant and antioxidant properties of human serum ultrafiltrates toward LDL: important role of uric acid. J Lipid Res 2003, 44: 512-21.
36. Santos CXC, Anjos EI, Augusto O. Uric acid oxidation by peroxynitrite: multiple reactions, free radical formation, and amplification of lipid oxidation. Arch Biochem Bioph 1999, 372: 285-94.
37. Kang DH, Park SK, Lee IK, Johnson RJ. Uric acid-induced C-reactive protein expression: implication on cell proliferation and nitric oxide production of human vascular cells. J Am Soc Nephrol 2005, 16: 3553-62.
38. Johnson RJ, Rodriguez-Iturbe B, Kang DH, Feig DI, Herrera-Acosta J. A unifying pathway for essential hypertension. Am J Hypertens 2005, 18: 431-40.
39. Waring WS, Adwani SH, Breukels O, Webb DJ, Maxwell SR. Hyperuricemia does not impair cardiovascular function in healthy adults. Heart 2004, 90: 155-9.
40. Chen NG, Holmes M, Reaven GM. Relationships between insulin resistance, soluble adhesion molecules, and mononuclear cell binding in healthy volunteers. J Clin Endocrinol Metab 1999, 84: 3485-9.
41. Chandran M, Phillips SA, Ciaraldi T, Henry RR. Adiponectin: more than just another fat cell hormone? Diabetes Care 2003, 26: 2442-50.
42. Ouchi N, Kihara S, Anita Y, et al. Novel modulator for endothelial adhesion molecules. Adipocyte-derived plasma protein adiponectin. Circulation 1999, 100: 2473-6.
43. Suliman ME, Johnson RJ, García-López E, et al. J-shaped mortality relationship for uric acid in CKD. Am J Kidney Dis 2006, 48: 761-7.