Uric acid is positively associated with metabolic syndrome but negatively associated with diabetes in Japanese men

Internal Medicine

Volumn 48, Issue 20, 2009, Pages 1785-1791

  Oda, Eiji ^a   Kawai, Ryu ^a   Sukumaran, Vijayakumar ^b   Watanabe, Kenichi ^b  

^a Tachikawa Medical Center   (Japan)

^b NIIGATA UNIVERSITY OF PHARMACY AND APPLIED LIFE SCIENCES   (Japan)

Author keywords

Diabetes; Gender difference; Metabolic syndrome; Uric acid

Indexed keywords

ALANINE AMINOTRANSFERASE; C REACTIVE PROTEIN; GAMMA GLUTAMYLTRANSFERASE; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; URIC ACID;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; BODY MASS; CHOLESTEROL BLOOD LEVEL; DIABETES MELLITUS; DIASTOLIC BLOOD PRESSURE; ETHNICITY; FEMALE; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; GLOMERULUS FILTRATION RATE; GLUCOSE BLOOD LEVEL; HEMOGLOBIN BLOOD LEVEL; HUMAN; JAPANESE; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; PREVALENCE; PROTEIN BLOOD LEVEL; RISK FACTOR; SEX DIFFERENCE; SYSTOLIC BLOOD PRESSURE; TRIACYLGLYCEROL BLOOD LEVEL; URIC ACID BLOOD LEVEL; WAIST CIRCUMFERENCE;

ADULT; BIOLOGICAL MARKERS; CROSS-SECTIONAL STUDIES; DIABETES MELLITUS; FEMALE; HUMANS; MALE; METABOLIC SYNDROME X; MIDDLE AGED; URIC ACID;

EID: 71049191062     PISSN: 09182918     EISSN: 13497235     Source Type: Journal    
DOI: 10.2169/internalmedicine.48.2426     Document Type: Article

References (30)

1. Facchini F, Chen YD, Hollenbeck CB, Reaven GM. Relationship between resistance to insulin-mediated glucose uptake, urinary uric acid clearance, and plasma uric acid concentration. JAMA 266: 3008-3011, 1991.
2. Reaven GM. Role of insulin resistance in human disease. Diabetes 37: 1595-1607, 1988.
3. Alverti KGMM, Zimmet P, Shaw J. Metabolic syndrome - a new world-wide definition. A consensus statement from the International Diabetes Federation. Diabet Med 23: 469-480, 2006.
4. Grundy SM, Cleeman JI, Daniels SR, et al. Diagnosis and management of the metabolic syndrome: a statement for health care professionals: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation 112: 2735-2752, 2005.
5. Kahn R, Buse J, Ferrannini E, Stern M. The metabolic syndrome: time for a critical appraisal: joint statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care 28: 2289-2304, 2005. (Pubitemid 41242486)
6. Koenig W, Meisinger C. Uric acid, type 2 diabetes, and cardiovascular diseases: Fueling the common soil hypothesis? Clin Chem 54: 231-233, 2008.
7. Patterson RA, Horsley ETM, Leake DS. Prooxidant and antioxidant properties of human serum ultrafiltrates toward LDL: important role of uric acid. J Lipid Res 44: 512-521, 2003.
8. Fang J, Alderman MH. Serum uric acid and cardiovascular mortality: The NHANES I epidemiologic follow-up study, 1971-1992. JAMA 283: 2404-2410, 2000.
9. Bos MJ, Koudstaal PJ, Hofman A, Witteman JCM, Breteler MMB. Uric acid is a risk factor for myocardial infarction and stroke. The Rotterdam Study. Stroke 37: 1503-1507, 2006.
10. Strasak A, Ruttmann E, Brant L, et al. Serum uric acid and risk of cardiovascular mortality: a prospective long-term study of 83,683 Austrian men. Clin Chem 54: 273-284, 2008. (Pubitemid 351302628)
11. Taniguchi Y, Hayashi T, Tsumura K, Endo G, Fujii S, Okada K. Serum uric acid and the risk for hypertension and type 2 diabetes in Japanese men: Osaka Health Survey. J Hypertens 19: 1209-1215, 2001. (Pubitemid 32595276)
12. Nakanishi N, Okamoto M, Yoshida H, Matsuo Y, Suzuki K, Tatara K. Serum uric acid and risk for development of hypertension and impaired fasting glucose or type 2 diabetes in Japanese male office workers. Eur J Epidemiol 18: 523-530, 2003. (Pubitemid 36899556)
13. Chien K-L, Chen H-C, Chang W-T, Su T-C, Lee Y-T, Hu HB. Plasma uric acid and the risk of type 2 diabetes in a Chinese community. Clin Chem 54: 310-316, 2008. (Pubitemid 351302633)
14. Chou P, Lin KC, Lin HY, Tsai ST. Gender differences in the relationships of serum uric acid with fasting serum insulin and plasma glucose in patients without diabetes. J Rheumatol 28: 571-576, 2001. (Pubitemid 32202662)
15. The Examination Committee for Criteria of Metabolic Syndrome. Definition and criteria of metabolic syndrome. J Jpn Soc Intern Med 94: 794-809, 2005 (in Japanese).
16. Kadota A, Hozawa A, Okamura T, et al. Relationship between metabolic risk factor clustering and cardiovascular mortality stratified by high blood glucose and obesity: NIPPON DATA90, 1990-2000. Diabetes Care 30: 1533-1538, 2007.
17. Saito I, Iso H, Kokubo Y, Inoue M, Tsugane S. Metabolic syndrome and all-cause and cardiovascular disease mortality: Japan Public Health Center-based Prospective (JPHC) Study. Circ J 73: 878-884, 2009.
18. Kokubo Y, Okamura T, Yoshimasa Y, et al. Impact of metabolic syndrome components on the incidence of cardiovascular disease in a general urban Japanese population: the Suita study. Hypertens Res 31: 2027-2035, 2008.
19. Noda H, Iso H, Saito I, Konishi M, Inoue M, Tsugane S. The impact of the metabolic syndrome and its components on the incidence of ischemic heart disease and stroke: Japan Public Health Center-based Study. Hypertens Res 32: 289-298, 2009.
20. Grundy SM. Does the metabolic syndrome exist? Diabetes Care 29: 1689-1692, 2006.
21. Kahn R. The metabolic syndrome (emperor) wears no clothes. Diabetes Care 29: 1693-1696, 2006. (Pubitemid 44127606)
22. Reaven GM. The metabolic syndrome: is this diagnosis necessary? Am J Clin Nutr 83: 1237-1247, 2006.
23. Sattar N. Why metabolic syndrome criteria have not made prime time: a view from the clinic. Int J Obes 32 (S2): S30-S34, 2008. (Pubitemid 351671300)
24. Ruderman NB, Schneider SH, Berchtold P. The "metabolically-obese, " normal-weight individual. Am J Clin Nutr 34: 1617-1621, 1981.
25. Matsuzawa YM. Pathophysiology and molecular mechanism of visceral fat syndrome: the Japanese experience. Diabetes Metab Rev 13: 3-13, 1997.
26. Fox CS, Massaro JM, Hoffmann U, et al. Abdominal visceral and subcutaneous adipose tissue compartments. Association with metabolic risk factors in the Framingham Heart Study. Circulation 116: 39-48, 2007.
27. Pou KM, Massaro JM, Hoffmann U, et al. Visceral and subcutaneous adipose tissue volumes are cross-sectionally related to markers of inflammation and oxidative stress. The Framingham Heart Study. Circulation 116: 1234-1241, 2007. (Pubitemid 47517534)
28. Oda E. The metabolic syndrome as a concept of adipose tissue disease. Hypertens Res 31: 1285-1293, 2008.
29. Erdberg A, Boner G, van Dyk DJ, Carel R. Urine uric acid excretion in patients with insulin-dependent diabetes mellitus. Nephron 60: 134-137, 1992.
30. Bo S, Cavallo-Perin P, Gentile L, Repetti E, Pagano G. Hypouricemia and hyperuricemia in type 2 diabetes: two different phenotypes. Eur Clin Invest 31: 318-321, 2001.