Structure-activity relationships in 1,4-benzodioxan-related compounds. 10. Novel α1-adrenoreceptor antagonists related to openphendioxan: Synthesis, biological evaluation, and α1d computational study

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 19, 2010, Pages 7065-7077

  Carrieri, Antonio ^a   Piergentili, Alessandro ^b   Bello, Fabio Del ^b   Giannella, Mario ^b   Pigini, Maria ^b   Leonardi, Amedeo ^c   Fanelli, Francesca ^d   Quaglia, Wilma ^b  

^a UNIVERSITY OF BARI   (Italy)

^b UNIVERSITY OF CAMERINO   (Italy)

^c Recordati SpA   (Italy)

^d UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

1 Adrenoreceptor antagonists; Comparative modeling; Docking; GPCRs; Openphendioxan analogues; QSAR

Indexed keywords

1,4 BENZODIOXAN DERIVATIVE; 2 (2 (BENZYLOXY)PHENOXY) N (2 (2 CHLORO 6 METHOXY PHENOXY)ETHYL)ACETAMIDE; 2 (2 (BENZYLOXY)PHENOXY) N (2 (2 CHLORO 6 METHOXY PHENOXY)ETHYL)ETHANAMINE; 2 (2 (BENZYLOXY)PHENOXY) N (2 (2 ETHOXYPHENOXY)ETHYL)ACETAMIDE; 2 (2 (BENZYLOXY)PHENOXY) N (2 (2 ETHOXYPHENOXY)ETHYL)ETHANAMINE; 2 (2 (BENZYLOXY)PHENOXY) N (2 (2 METHOXY 6 METHYL PHENOXY)ETHYL)ETHANAMINE; 2 (2 (BENZYLOXY)PHENOXY) N (2 (2 METHOXY 6 NITROPHENOXY)ETHYL)ETHANAMINE; 2 (2 (BENZYLOXY)PHENOXY) N (2 (2 METHOXYPHENOXY)ETHYL)ACETAMIDE; 2 (2 (BENZYLOXY)PHENOXY) N (2 (2 METHOXYPHENOXY)ETHYL)ETHANAMINE; 2 (2 (BENZYLOXY)PHENOXY) N (2 (2,6 DICHLOROPHENOXY)ETHYL)ACETAMIDE; 2 (2 (BENZYLOXY)PHENOXY) N (2 (2,6 DIETHOXYPHENOXY)ETHYL)ACETAMIDE; 2 (2 (BENZYLOXY)PHENOXY) N (2 (2,6 DIETHOXYPHENOXY)ETHYL)ETHANAMINE; 2 (2 (BENZYLOXY)PHENOXY) N (2 (2,6 DIMETHOXYPHENYL SULFINYL)ETHYL)ETHANAMINE; 2 (2 (BENZYLOXY)PHENOXY) N (2 (2,6 DIMETHOXYPHENYLTHIO)ETHYL)ACETAMIDE; 2 (2 (BENZYLOXY)PHENOXY) N (2 (2,6 DIMETHOXYPHENYLTHIO)ETHYL)ETHANAMINE; 2 (2 (BENZYLOXY)PHENOXY) N (2 (2,6 DIMETHYLPHENOXY)ETHYL)ACETAMIDE; 2 (2 (BENZYLOXY)PHENOXY) N (2 PHENOXYETHYL)ACETAMIDE)ACETAMIDE; 2 (2 (BENZYLOXY)PHENOXY)ACETAMIDE; 2 (2 (BENZYLOXY)PHENOXY)ETHANAMINE; 2 (2,6 DIETHOXYPHENOXY)ACETAMIDE; 2 (2,6 DIETHOXYPHENOXY)ETHANAMINE; 2 (2,6 DIMETHOXYPHENYLTHIO)ACETAMIDE; 2 (2,6 DIMETHOXYPHENYLTHIO)ETHANAMINE; 2 [[2 (2,6 DIMETHOXYPHENOXY)ETHYL]AMINOMETHYL] 1,4 BENZODIOXAN; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; N (2 (2 (BENZYLOXY)PHENOXY)ETHYL) 2 (2 METHOXY 6 METHYLPHENOXY)ACETAMIDE; N (2 (2 (BENZYLOXY)PHENOXY)ETHYL) 2 (2 METHOXY 6 NITROPHENOXY)ACETAMIDE; N (2 (2 (BENZYLOXY)PHENOXY)ETHYL) 2 (2,6 BIS(METHOXY METHOXY)PHENOXY)ACETAMIDE; N (2 (2 (BENZYLOXY)PHENOXY)ETHYL) 3 (2,6 DIMETHOXY PHENYL)PROPAN 1 AMINE; N (2 (2 (BENZYLOXY)PHENOXY)ETHYL) 3 (2,6 DIMETHOXY PHENYL)PROPANAMIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DIFFUSION; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROPHOBICITY; MOLECULAR DOCKING; MULTIPLE REGRESSION; NONHUMAN; PHARMACOPHORE; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RAT; STRUCTURE ACTIVITY RELATION;

ADRENERGIC ALPHA-1 RECEPTOR ANTAGONISTS; ANIMALS; BINDING SITES; COMPUTATIONAL BIOLOGY; COMPUTER SIMULATION; DIOXANES; LIGANDS; MALE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; RATS; RATS, WISTAR; RECEPTORS, ADRENERGIC, ALPHA-1; REGRESSION ANALYSIS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77956650794     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.08.002     Document Type: Article

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