Structure-activity relationships in 1,4-benzodioxan-related compounds. 9. 1 From 1,4-benzodioxane to 1,4-dioxane ring as a promising template of novel α1D-adrenoreceptor antagonists, 5-HT1A full agonists, and cytotoxic agents

Journal of Medicinal Chemistry

Volumn 51, Issue 20, 2008, Pages 6359-6370

  Quaglia, Wilma ^a   Piergentili, Alessandro ^a   Del Bello, Fabio ^a   Farande, Yogita ^a   Giannella, Mario ^a   Pigini, Maria ^a   Rafaiani, Giovanni ^a   Carrieri, Antonio ^b   Amantini, Consuelo ^a   Lucciarini, Roberta ^a   Santoni, Giorgio ^a   Poggesi, Elena ^c   Leonardi, Amedeo ^c  

^a UNIVERSITY OF CAMERINO   (Italy)

^b UNIVERSITY OF BARI   (Italy)

^c Recordati SpA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 BENZODIOXAN DERIVATIVE; 2 [[2 (2,6 DIMETHOXYPHENOXY)ETHYL]AMINOMETHYL] 1,4 BENZODIOXAN; 2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 5 CARBAMOYLTRYPTAMINE; 8 [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] 8 AZASPIRO[4.5]DECANE 7,9 DIONE; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA 1D ADRENERGIC RECEPTOR; CYTOTOXIC AGENT; MOLECULAR SCAFFOLD; SEROTONIN; SEROTONIN 1A AGONIST; SEROTONIN 1A RECEPTOR;

ANIMAL CELL; ANIMAL TISSUE; AORTA; ARTICLE; CANCER CELL CULTURE; CHO CELL; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; HELA CELL; HUMAN; HUMAN CELL; NONHUMAN; RAT; SPLEEN; STRUCTURE ACTIVITY RELATION; VAS DEFERENS;

BENZENE; CELL LINE, TUMOR; CELL SURVIVAL; DIOXANES; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; RECEPTOR, SEROTONIN, 5-HT1A; RECEPTORS, ADRENERGIC, ALPHA-1; SEROTONIN AGONISTS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 54549110214     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm800461k     Document Type: Article

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