α1b-Adrenergic Receptors Control Locomotor and Rewarding Effects of Psychostimulants and Opiates

Journal of Neuroscience

Volumn 22, Issue 7, 2002, Pages 2873-2884

  Drouin, Candice ^a   Darracq, Laurent ^a   Trovero, Fabrice ^b   Blanc, Gérard ^a   Glowinski, Jacques ^a   Cotecchia, Susanna ^c   Tassin, Jean Pol ^a  

^a l'alimentation et l'Environnement   (France)

^b SA Centre d'Innovation   (France)

^c University of Lausanne Departement de Pharmacologie et de Toxicologie   (Switzerland)

Author keywords

Behavioral sensitization; Cocaine; CPP; D amphetamine; Knock out mice; Locomotor activity; Morphine; Oral test; 1b adrenergic receptors

Indexed keywords

ADRENERGIC RECEPTOR; ALPHA 1B ADRENERGIC RECEPTOR; CATECHOLAMINE; COCAINE; DEXAMPHETAMINE; DOPAMINE 1 RECEPTOR; DOPAMINE 2 RECEPTOR; MORPHINE; MUSCARINIC RECEPTOR BLOCKING AGENT; OPIATE AGONIST; PSYCHOSTIMULANT AGENT; SCOPOLAMINE; SODIUM CHLORIDE; 3,4 DIHYDROXYPHENYLACETIC ACID; ADRENERGIC RECEPTOR ALPHA(1B); ALPHA 1 ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; CENTRAL STIMULANT AGENT; DOPAMINE; DOPAMINE RECEPTOR STIMULATING AGENT; NARCOTIC AGENT; NORADRENALIN; PRAZOSIN;

ADDICTION; ADRENERGIC TRANSMISSION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; CONDITIONING; CONTROLLED STUDY; DOPAMINERGIC TRANSMISSION; HYPERACTIVITY; KNOCKOUT MOUSE; LOCOMOTION; MALE; MOUSE; NEUROLOGIC DISEASE; NONHUMAN; PLACE PREFERENCE; PRIORITY JOURNAL; REWARD; WILD TYPE; ANIMAL; BRAIN; CROSS BREEDING; DECISION MAKING; DRUG EFFECT; DRUG POTENTIATION; GENETICS; METABOLISM; MOTOR ACTIVITY; MOUSE MUTANT; MOUSE STRAIN; PHYSIOLOGY; SYNAPTIC TRANSMISSION;

3,4-DIHYDROXYPHENYLACETIC ACID; ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; BRAIN; CENTRAL NERVOUS SYSTEM STIMULANTS; CHOICE BEHAVIOR; COCAINE; CROSSES, GENETIC; DEXTROAMPHETAMINE; DOPAMINE; DOPAMINE AGONISTS; MALE; MICE; MICE, INBRED STRAINS; MICE, KNOCKOUT; MORPHINE; MOTOR ACTIVITY; MUSCARINIC ANTAGONISTS; NARCOTICS; NOREPINEPHRINE; PRAZOSIN; RECEPTORS, ADRENERGIC, ALPHA-1; RECEPTORS, DOPAMINE D1; RECEPTORS, DOPAMINE D2; REWARD; SUBSTANCE-RELATED DISORDERS; SYNAPTIC TRANSMISSION;

EID: 0036550282     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.22-07-02873.2002     Document Type: Article

References (90)

1. Antelman SM, Caggiula AR (1977) Norepinephrine-dopamine interactions and behavior. Science 195:646-653.
2. Aston-Jones G, Bloom FE (1981) Nonrepinephrine-containing locus coeruleus neurons in behaving rats exhibit pronounced responses to non-noxious environmental stimuli. J Neurosci 1:887-900.
3. Berthold CW 3rd:Gonzales RA, Moerschbaecher JM (1992) Prazosin attenuates the effects of cocaine on motor activity but not on schedule-controlled behavior in the rat. Pharmacol Biochem Behav 43:111-115.
4. Blanc G, Trovero F, Vezina P, Herve D, Godeheu AM, Glowinski J, Tassin JP (1994) Blockade of prefronto-cortical alpha 1-adrenergic receptors prevents locomotor hyperactivity induced by subcortical D-amphetamine injection. Eur J Neurosci 6:293-298.
5. Borg PJ, Taylor DA (1994) Voluntary oral morphine self-administration in rats: effect of haloperidol or ondansetron. Pharmacol Biochem Behav 47:633-646.
6. Carboni E, Spielewoy C, Vacca C, Nosten-Bertrand M, Giros B, Di Chiara G (2001) Cocaine and amphetamine increase extracellular dopamine in the nucleus accumbens of mice lacking the dopamine transporter gene. J Neurosci 21:RC141:1-5.
7. Carr DB, Sesack SR (2000) Projections from the rat prefrontal cortex to the ventral tegmental area: target specificity in the synaptic associations with mesoaccumbens and mesocortical neurons. J Neurosci 20:3864-3873.
8. Castellano C, Filibeck L, Oliverio A (1976) Effects of heroin, alone or in combination with other drugs, on the locomotor activity in two inbred strains of mice. Psychopharmacology (Berl) 49:29-31.
9. Cavalli A, Lattion AL, Hummler E, Nenniger M, Pedrazzini T, Aubert JF, Michel MC, Yang M, Lembo G, Vecchione C, Mostardini M, Schmidt A, Beermann F, Cotecchia S (1997) Decreased blood pressure response in mice deficient of the alpha1b-adrenergic receptor. Proc Natl Acad Sci USA 94:11589-11594.
10. Chergui K, Charlety PJ, Akaoka H, Saunier CF, Brunet JL, Buda M, Svensson TH, Chouvet G (1993) Tonic activation of NMDA receptors causes spontaneous burst discharge of rat midbrain dopamine neurons in vivo. Eur J Neurosci 5:137-144.
11. Darracq L, Blanc G, Glowinski J, Tassin JP (1998) Importance of the noradrenaline-dopamine coupling in the locomotor activating effects of D-amphetamine. J Neurosci 18:2729-2739.
12. Darracq L, Drouin C, Blanc G, Glowinski J, Tassin JP (2001) Stimulation of metabotropic but not ionotropic glutamatergic receptors in the nucleus accumbens is required for the D-amphetamine-induced release of functional dopamine. Neuroscience 103:395-403.
13. Davis M, Kehne JH, Commissaris RL (1985) Antagonism of apomorphine-enhanced startle by alpha 1-adrenergic antagonists. Eur J Pharmacol 108:233-241.
14. Day HE, Campeau S, Watson Jr SJ, Akil H (1997) Distribution of alpha 1a-, alpha 1b- and alpha 1d-adrenergic receptor mRNA in the rat brain and spinal cord. J Chem Neuroanat 13:115-139.
15. Delfs JM, Schreiber L, Kelley AE (1990) Microinjection of cocaine into the nucleus accumbens elicits locomotor activation in the rat. J Neurosci 10:303-310.
16. Delfs JM, Zhu Y, Druhan JP, Aston-Jones G (2000) Noradrenaline in the ventral forebrain is critical for opiate withdrawal-induced aversion. Nature 403:430-434.
17. Di Chiara G, Imperato A (1988) Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. Proc Natl Acad Sci USA 85:5274-5278.
18. Dickinson SL, Gadie B, Tulloch IF (1988) Alpha 1- and alpha 2-adrenoreceptor antagonists differentially influence locomotor and stereotyped behaviour induced by d-amphetamine and apomorphine in the rat. Psychopharmacology (Berl) 96:521-527.
19. Dilts RP, Kalivas PW (1989) Autoradiographic localization of muopioid and neurotensin receptors within the mesolimbic dopamine system. Brain Res 488:311-327.
20. Drouin C, Blanc G, Trovero F, Glowinski J, Tassin JP (2001) Cortical α1-adrenergic regulation of acute and sensitized morphine locomotor effects. NeuroReport 12:3483-3486.
21. Drouin C, Blanc G, Villegier A-S, Glowinski J, Tassin JP (2002) Critical role of alpha1-adrenergic receptors in acute and sensitized locomotor effects of D-amphetamine, cocaine and GBR 12783: Influence of preexposure conditions and pharmacological characteristics. Synapse 43:51-61.
22. Ferraro TN, Golden GT, Berrettini WH, Gottheil E, Yang CH, Cuppels GR, Vogel WH (2000) Cocaine intake by rats correlates with cocaine-induced dopamine changes in the nucleus accumbens shell. Pharmacol Biochem Behav 66:397-401.
23. Florin SM, Kuczenski R, Segal DS (1994) Regional extracellular norepinephrine responses to amphetamine and cocaine and effects of clonidine pretreatment. Brain Res 654:53-62.
24. Gariano RF, Groves PM (1988) Burst firing induced in midbrain dopamine neurons by stimulation of the medial prefrontal and anterior cingulate cortices. Brain Res 462:194-198.
25. Gioanni Y, Thierry AM, Glowinski J, Tassin JP (1998) Alpha1-adrenergic, D1, and D2 receptors interactions in the prefrontal cortex: implications for the modality of action of different types of neuroleptics. Synapse 30:362-370.
26. Giros B, Jaber M, Jones SR, Wightman RM, Caron MG (1996) Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter. Nature 379:606-612.
27. Grenhoff J, Svensson TH (1993) Prazosin modulates the firing pattern of dopamine neurons in rat ventral tegmental area. Eur J Pharmacol 233:79-84.
28. Hess HJ (1975) Prazosin: biochemistry and structure-activity studies. Postgrad Med Spec: 9-17.
29. Hooks MS, Jones GH, Smith AD, Neill DB, Justice Jr JB (1991) Individual differences in locomotor activity and sensitization. Pharmacol Biochem Behav 38:467-470.
30. Howell LL, Byrd LD (1991) Characterization of the effects of cocaine and GBR 12909, a dopamine uptake inhibitor, on behavior in the squirrel monkey. J Pharmacol Exp Ther 258:178-185.
31. Johnson SW, North RA (1992) Opioids excite dopamine neurons by hyperpolarization of local interneurons. J Neurosci 12:483-488.
32. Joyce EM, Koob GF (1981) Amphetamine-, scopolamine- and caffeine-induced locomotor activity following 6-hydroxydopamine lesions of the mesolimbic dopamine system. Psychopharmacology (Berl) 73:311-313.
33. Kalivas PW, Duffy P (1987) Sensitization to repeated morphine injection in the rat: possible involvement of A10 dopamine neurons. J Pharmacol Exp Ther 241:204-212.
34. Kalivas PW, Widerlov E, Stanley D, Breese G, Prange Jr AJ (1983) Enkephalin action on the mesolimbic system: a dopamine-dependent and a dopamine-independent increase in locomotor activity. J Pharmacol Exp Ther 227:229-237.
35. Kleven MS, Koek W (1998) Discriminative stimulus properties of cocaine: enhancement by monoamine reuptake blockers. J Pharmacol Exp Ther 284:1015-1025.
36. Kleven MS, Kamenka JM, Vignon J, Koek W (1999) Pharmacological characterization of the discriminative stimulus properties of the phencyclidine analog, N-[1-(2-benzo(b)thiophenyl)-cyclohexyl]piperidine. Psychopharmacology (Berl) 145:370-377.
37. Kokkinidis L, Anisman H (1978) Involvement of norepinephrine in startle arousal after acute and chronic D-amphetamine administration. Psychopharmacology (Berl) 59:285-292.
38. Kokkinidis L, Anisman H (1979) Circling behavior following systemic D-amphetamine administration: potential noradrenergic and dopaminergic involvement. Psychopharmacology (Berl) 64:45-54.
39. Koob GF, Sanna PP, Bloom FE (1998) Neuroscience of addiction. Neuron 21:467-476.
40. Korf J, Bunney BS, Aghajanian GK (1974) Noradrenergic neurons: morphine inhibition of spontaneous activity. Eur J Pharmacol 25:165-169.
41. Lategan AJ, Marien MR, Colpaert FC (1990) Effects of locus coeruleus lesions on the release of endogenous dopamine in the rat nucleus accumbens and caudate nucleus as determined by intracerebral microdialysis. Brain Res 523:134-138.
42. Li Y, Hu XT, Berney TG, Vartanian AJ, Stine CD, Wolf ME, White FJ (1999) Both glutamate receptor antagonists and prefrontal cortex lesions prevent induction of cocaine sensitization and associated neuroadaptations. Synapse 34:169-180.
43. Linner L, Endersz H, Ohman D, Bengtsson F, Schalling M, Svensson TH (2001) Reboxetine modulates the firing pattern of dopamine cells in the ventral tegmental area and selectively increases dopamine availability in the prefrontal cortex. J Pharmacol Exp Ther 297:540-546.
44. Lu XY, Churchill L, Kalivas PW (1997) Expression of D1 receptor mRNA in projections from the forebrain to the ventral tegmental area. Synapse 25:205-214.
45. Marinelli M, Aouizerate B, Barrot M, Le Moal M, Piazza PV (1998) Dopamine-dependent responses to morphine depend on glucocorticoid receptors. Proc Natl Acad Sci USA 95:7742-7747.
46. Miner LA, Liprando LA, Blakely RD, Sesack SR (2001) Ultrastructural interactions between terminals expressing the norepinephrine transporter and dopamine neurons in the rat ventral tegmental area. Soc Neurosci Abstr 27;373.2.
47. Mohammed AK, Danysz W, Ogren SO, Archer T (1986) Central noradrenaline depletion attenuates amphetamine-induced locomotor behavior. Neurosci Lett 64:139-144.
48. O'Brien C, Ehrman R, Terns J (1986) Classical conditionning in human. In: Behavioral analysis of drug dependence (Goldberg S, Stlerman I, eds), pp 329-338. London: Academic.
49. Ogren SO, Archer T, Johansson C (1983) Evidence for a selective brain noradrenergic involvement in the locomotor stimulant effects of amphetamine in the rat. Neurosci Lett 43:327-331.
50. Page ME, Abercrombie ED (1999) Discrete local application of corticotropin-releasing factor increases locus coeruleus discharge and extracellular norepinephrine in rat hippocampus. Synapse 33:304-313.
51. Paladini CA, Firillo CD, Morikawa H, Williams JT (2001) Amphetamine selecticvely blocks inhibitory glutamate transmission in dopamine neurons. Nat Neurosci 4:275-281.
52. Pavcovich LA, Valentino RJ (1997) Regulation of a putative neurotransmitter effect of corticotropin-releasing factor: effects of adrenalectomy. J Neurosci 17:401-408.
53. Pert A, Sivit C (1977) Neuroanatomical focus for morphine and enkephalin-induced hypermotility. Nature 265:645-647.
54. Piazza PV, Deminiere JM, Le Moal M, Simon H (1989) Factors that predict individual vulnerability to amphetamine self-administration. Science 245:1511-1513.
55. Piazza PV, Marinelli M, Rouge-Pont F, Deroche V, Maccari S, Simon H, Le Moal M (1996) Stress, glucocorticoids, and mesencephalic dopaminergic neurons: a pathophysiological chain determining vulnerability to psychostimulant abuse. NIDA Res Monogr 163:277-299.
56. Pieribone VA, Nicholas AP, Dagerlind A, Hökfelt T (1994) Distribution of alpha 1 adrenoreceptors in rat brain revealed by in situ hybridization experiments utilizing subtype-specific probes. J Neurosci 14:4252-4268.
57. Poncelet M, Chermat R, Soubrie P, Simon P (1983) The progressive ratio schedule as a model for studying the psychomotor stimulant activity of drugs in the rat. Psychopharmacology 80:184-189.
58. Pontieri FE, Tanda G, Di Chiara G (1995) Intravenous cocaine, morphine, and amphetamine preferentially increase extracellular dopamine in the "shell" as compared with the "core" of the rat nucleus accumbens. Proc Natl Acad Sci USA 92:12304-12308.
59. Robbins TW, Everitt BJ (1999) Drug addiction: bad habits add up. Nature 398:567-570.
60. Robinson TE, Berridge KC (2001) Incentive-sensitization and addiction. Addiction 96:103-114.
61. Rocha BA, Fumagalli F, Gainetdinov RR, Jones SR, Ator R, Giros B, Miller GW, Caron MG (1998) Cocaine self-administration in dopamine-transporter knockout mice. Nat Neurosci [Erratum (1998) 1:330] 1:132-137.
62. Ruffolo Jr RR, Goldberg MR, Morgan EL (1984) Interactions of epinephrine, noradrenaline, dopamine and their corresponding alpha-methyl-substituted derivatives with alpha and beta adrenoceptors in the pithed rat. J Pharmacol Exp Ther 230:595-600.
63. Salomon Y, Londos C, Rodbell M (1974) A highly sensitive adenylate cyclase assay. Anal Biochem 58:541-548.
64. Sasaki JE, Tatham TA, Barrett JE (1995) The discriminativ(1974) e stimulus effects of methamphetamine in pigeons. Psychopharmacology (Berl) 120:303-310.
65. Sesack SR, Pickel VM (1992) Prefrontal cortical efferents in the rat synapse on unlabeled neuronal targets of catecholamine terminals in the nucleus accumbens septi and on dopamine neurons in the ventral tegmental area. J Comp Neurol 320:145-160.
66. Shi WX, Pun CL, Zhang XX, Jones MD, Bunney BS (2000) Dual effects of D-amphetamine on dopamine neurons mediated by dopamine and nondopamine receptors. J Neurosci 20:3504-3511.
67. Shiffman S (1991) Refining models of dependence: variations across persons and situations. Br J Addict 86:611-615.
68. Sillaber I, Montkowski A, Landgraf R, Barden N, Holsboer F, Spanagel R (1998) Enhanced morphine-induced behavioural effects and dopamine release in the nucleus accumbens in a transgenic mouse model of impaired glucocorticoid (type II) receptor function: influence of long-term treatment with the antidepressant moclobemide. Neuroscience 85:415-425.
69. Smith P, Krohn R, Hermanson G, Mallia A, Gartner F, Provenzano M, Fujimoto E, Goeke N, Olson B, Klenk D (1985) Measurement of protein using bicinchoninic acid. Anal Biochem: 15076-15085.
70. Snoddy AM, Tessel RE (1985) Prazosin: effect on psychomotor-stimulant cues and locomotor activity in mice. Eur J Pharmacol 116:221-228.
71. Spealman RD (1995) Noradrenergic involvement in the discriminative stimulus effects of cocaine in squirrel monkeys. J Pharmacol Exp Ther 275:53-62.
72. Stone EA, Rosengarten H, Lin Y, Quartermain D (2001) Pharmacological blockade of brain alpha (1)-adrenoceptors as measured by ex vivo. Eur J Pharmacol 420:97-102.
73. Taghzouti K, Simon H, Herve D, Blanc G, Studler JM, Glowinski J, LeMoal M, Tassin JP (1988) Behavioural deficits induced by an electrolytic lesion of the rat ventral mesencephalic tegmentum are corrected by a superimposed lesion of the dorsal noradrenergic system. Brain Res 440:172-176.
74. Tassin JP, Simon H, Hervé D, Blanc G, Le Moal M, Glowinski J, Bockaërt J (1982) Non-dopaminergic fibres may regulate dopamine-sensitive adenylate cyclase in the prefrontal cortex and nucleus accumbens. Nature 295:696-698.
75. Tassin JP, Studler JM, Herve D, Blanc G, Glowinski J (1986) Contribution of noradrenergic neurons to the regulation of dopaminergic (D1) receptor denervation supersensitivity in rat prefrontal cortex. J Neurochem 46:243-248.
76. Tempel A, Zukin RS (1987) Neuroanatomical patterns of the mu, delta, and kappa opioid receptors of rat brain as determined by quantitative in vitro autoradiography. Proc Natl Acad Sci USA 84:4308-4312.
77. Tessel RE, Barrett JE (1986) Antagonism of the behavioral effects of cocaine and D-amphetamine by prazosin. Psychopharmacology 90:436-440.
78. Trovero F, Herve D, Blanc G, Glowinski J, Tassin JP (1992a) In vivo partial inactivation of dopamine D1 receptors induces hypersensitivity of cortical dopamine-sensitive adenylate cyclase: permissive role of alpha 1-adrenergic receptors. J Neurochem 59:331-337.
79. Trovero F, Blanc G, Herve D, Vezina P, Glowinski J, Tassin JP (1992b) Contribution of an alpha 1-adrenergic receptor subtype to the expression of the "ventral tegmental area syndrome." Neuroscience 47:69-76.
80. Trovero F, Marin P, Tassin JP, Premont J, Glowinski J (1994) Accelerated resensitization of the D1 dopamine receptor-mediated response in cultured cortical and striatal neurons from the rat: respective role of alpha 1-adrenergic and N-methyl-D-aspartate receptors. J Neurosci 14:6280-6288.
81. U'Prichard DC, Snyder SH (1977) Binding of 3H-catecholamines to alpha-noradrenergic receptor sites in calf brain. J Biol Chem 252:6450-6463.
82. Valentino RJ, Foote SL, Page ME (1993) The locus coeruleus as a site for integrating corticotropin-releasing factor and noradrenergic mediation of stress responses. Ann NY Acad Sci 697:173-188.
83. Valverde O, Fournie-Zaluski MC, Roques BP, Maldonado R (1996) The CCKB antagonist PD-134,308 facilitates rewarding effects of endogenous enkephalins but does not induce place preference in rats. Psychopharmacology (Berl) 123:119-126.
84. van Haaren F (1992) Effects of cocaine alone and in combination with prazosin or ondansetron on multiple fixed-interval fixed-ratio performance in pigeons. Pharmacol Biochem Behav 42:849-853.
85. Vezina P (1993) Amphetamine injected into the ventral tegmental area sensitizes the nucleus accumbens dopaminergic response to systemic amphetamine: an in vivo microdialysis study in the rat. Brain Res 605:332-337.
86. Vezina P, Blanc G, Glowinski J, Tassin J (1991) Opposed behavioral outputs of increased dopamine transmission in prefrontocortical and subcortical areas: a role for the cortical D-1 dopamine receptor. Eur J Neurosci 3:1001-1007.
87. Vezina P, Blanc G, Glowinski J, Tassin JP (1992) Nicotine and morphine differentially activate brain dopamine in prefrontocortical and subcortical terminal fields: effects of acute and repeated injections. J Pharmacol Exp Ther 261:484-490.
88. Wise RA, Rompre PP (1989) Brain dopamine and reward. Annu Rev Psychol 40:191-225.
89. Woolverton WL (1987) Evaluation of the role of norepinephrine in the reinforcing effects of psychomotor stimulants in rhesus monkeys. Pharmacol Biochem Behav 26:835-839.
90. Xu F, Gainetdinov RR, Wetsel WC, Jones SR, Bohn LM, Miller GW, Wang YM, Caron MG (2000) Mice lacking the norepinephrine transporter are supersensitive to psychostimulants. Nat Neurosci 3:465-471.