(Phenylpiperidinyl)cyclohexylsulfonamides: Development of α1a/1d-selective adrenergic receptor antagonists for the treatment of benign prostatic hyperplasia/lower urinary tract symptoms (BPH/LUTS)

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 14, 2007, Pages 3930-3934

  Chiu, George ^a   Li, Shengjian ^a   Connolly, Peter J ^a   Pulito, Virginia ^a   Liu, Jingchun ^a   Middleton, Steven A ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

1 Blockers; 1a 1d Adrenergic receptor; 1a 1d Adrenoceptor selective antagonists; (Phenylpiperidinyl)cyclohexylsulfonamides; BPH LUTS

Indexed keywords

(PHENYLPIPERIDINYL)CYCLOHEXYLSULFONAMIDE DERIVATIVE; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA 1A ADRENERGIC RECEPTOR; ALPHA 1D ADRENERGIC RECEPTOR; DOPAMINE 2 RECEPTOR; DUTASTERIDE; FINASTERIDE; FLUORINE; PIPERIDINE DERIVATIVE; RECEPTOR SUBTYPE; SULFONAMIDE; TAMSULOSIN; TERAZOSIN; UNCLASSIFIED DRUG;

ARTICLE; CARDIOVASCULAR DISEASE; DRUG DESIGN; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; LOWER URINARY TRACT SYMPTOM; ORTHOSTATIC HYPOTENSION; PROSTATE HYPERTROPHY; RECEPTOR AFFINITY;

ADRENERGIC ALPHA-ANTAGONISTS; HUMANS; MALE; PROSTATIC HYPERPLASIA; RECEPTORS, ADRENERGIC, ALPHA-1; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 34250352238     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.04.098     Document Type: Article

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25. Unpublished results.
26. f values are the trans isomers. The assignment is based on the NMR pattern of similar (piperazinyl)cyclohexylsulfonamide compound with known cis or trans configuration.
27. 3) 1.26 (m, 4H), 1.35 (d, J = 6.1 Hz, 6H), 1.64 (m, 2H), 1.8-2.0 (m, 6H), 2.32 (m, 3H), 2.90 (m, 3H), 3.04 (m, 1H), 3.94 (s, 3H), 3.98 (s, 3H), 4.52 (m, 1H), 4.70 (d, J = 7.8 Hz, NH, 1H), 6.7-7.6 (m, 6H) MS: 535 (M+1).