Synthesis and biological activities of new di-and trimeric quinoline derivatives

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 19, 2010, Pages 7132-7143

  Broch, Sidonie ^a,b,f   Héènon, Hélne ^a,b   Debaud, Anne Laure ^c,d,e   Fogeron, Marie Laure ^c,d,e   Bonnefoy Bérard, Nathalie ^c,d,e   Anizon, Fabrice ^a,b   Moreau, Pascale ^a,b  

^a UNIVERSITÉ CLERMONT AUVERGNE   (France)

^b CNRS   (France)

^c UNIVERSITÉ DE LYON   (France)

^d INSERM   (France)

^e UNIVERSITÉ LYON 1   (France)

^f UNIVERSITY OF PATRAS   (Greece)

Author keywords

Apoptosis; Bcl 2 protein; Helix mimetic; Quinoline

Indexed keywords

1 (7 BROMO 2 METHOXYQUINOLIN 5 YL)ETHAN 1 ONE; 2 CHLORO 5 (PROPEN 2 YL)QUINOLINE; 2 ETHOXY 5' ISOPROPYL2' METHOXY 3,7' BIQUINOLINE; 2 METHOXY 5 (PROPEN 2 YL)QUINOLINE; 2,2' DIMETHOXY 5' ISOBUTYL 5 ISOPROPYL 3,7' BIQUINOLINE; 5 (2 HYDROXYPROPAN 2 YL)QUINOLIN 2(1H)ONE; 5 (PROPEN 2 YL)QUINOLIN 2(1H)ONE; 5 ISOPROPYL 2 METHOXYQUINOLINE; 5' ISOBUTYL 5 ISOPROPYL 3,7' BIQUINOLINE 2,2'(1H,1'H)DIONE; 5'' (BUTAN 2 YL) 5' ISOBUTYL 5 ISOPROPYL 2,2',2'' TRIMETHOXY 3,7':3,7'' TERQUINOLINE; 5'' (BUTAN 2 YL) 5' ISOBUTYL 5 ISOPROPYL 3,7':3,7'' TERQUINOLINE 2,2',2''(1H,10H,1''H)TRIONE; 7 BROMO 2 CHLORO 5 (PROPEN 2 YL)QUINOLINE; 7 BROMO 2 METHOXY 5 (2 METHYLPROPEN 1 YL)QUINOLINE; 7 BROMO 2 METHOXY 5 (PROPEN 2 YL)QUINOLINE; 7 BROMO 2 METHOXYQUINOLIN 5 YLMETHANOL; 7 BROMO 2 METHOXYQUINOLINE 5 CARBALDEHYDE; 7 BROMO 5 (2 HYDROXYPROPAN 2 YL)QUINOLIN 2(1H)ONE; 7 BROMO 5 (BUT 2 EN 2 YL) 2 METHOXYQUINOLINE; 7 BROMO 5 (PROPEN 2 YL)QUINOLIN 2(1H)ONE; 7 BROMO 5 ISOPROPYL 2 METHOXYQUINOLINE; BROMO N,2 DIMETHOXY N METHYLQUINOLINE 5 CARBOXAMIDE; METHYL 2 OXO 1,2 DIHYDROQUINOLINE 5 CARBOXYLATE; METHYL 7 BROMO 2 CHLOROQUINOLINE 5 CARBOXYLATE; METHYL 7 BROMO 2 METHOXYQUINOLINE 5 CARBOXYLATE; METHYL 7 BROMO 2 OXO 1,2 DIHYDROQUINOLINE 5 CARBOXYLATE; PROTEIN BAK; PROTEIN BCL 2; PROTEIN BCL XL; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

APOPTOSIS; ARTICLE; BIOLOGICAL ACTIVITY; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; PROTEIN PROTEIN INTERACTION; PROTON NUCLEAR MAGNETIC RESONANCE;

APOPTOSIS; BCL-X PROTEIN; BINDING SITES; DIMERIZATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTO-ONCOGENE PROTEINS C-BCL-2; QUINOLINES; RECOMBINANT PROTEINS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77956650502     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.07.029     Document Type: Article

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