Interaction of kendomycin and semi-synthetic analogues with the anti-apoptotic protein Bcl-xl

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 21, 2008, Pages 5771-5773

  Janssen, Christian O ^a   Lim, Stephanie ^a   Lo, Ee Peng ^a   Wan, Kah Fei ^b   Yu, Victor C ^c   Lee, May Ann ^b   Ng, Siew Bee ^a   Everett, Martin J ^a   Buss, Antony D ^a   Lane, David P ^b   Boyce, Rustum S ^a  

^a MerLion Pharmaceuticals Pte Ltd   (Singapore)

^b Agency for Science   (Singapore)

^c INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

Author keywords

Apoptotic; Bcl 2, Bcl xl; High throughput screening; Kendomycin; Ketal; Semi synthetic

Indexed keywords

KENDOMYCIN; MACROLIDE; PROTEIN BAK; PROTEIN BCL XL; UNCLASSIFIED DRUG;

ARTICLE; CYTOTOXICITY; DRUG STABILITY; DRUG SYNTHESIS; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; HYDROLYSIS; PROTEIN PROTEIN INTERACTION;

APOPTOSIS; BCL-X PROTEIN; CELL LINE, TUMOR; HUMANS; RIFABUTIN;

EID: 54149095207     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.09.071     Document Type: Article

References (19)

1. Kroemer G. Nat. Med. 3 (1997) 614
2. Adams J.M., and Cory S. Science 281 (1998) 1322
3. Amundson S.A., et al. Cancer Res. 60 (2000) 6101
4. O'Neill J., et al. Biochim. Biophys. Acta 1705 (2004) 43
5. Kline M.P., et al. Leukemia 21 (2007) 1549
6. Oltersdorf T., et al. Nature 435 (2005) 677
7. Sturla J.S., et al. Cancer Res. 67 (2007) 6539
8. Feher M., and Schmidt J.M. J. Chem. Inf. Comput. Sci. 43 (2002) 218
9. Butler M.S. Nat. Prod. Rep. 22 (2005) 162
10. Chan S.-L., et al. J. Biol. Chem. 23 (2003) 20453
11. Funahashi, Y. et al. Japanese Patent 08,231,551, 1996; Chem. Abstr. 1997, 126, 6553.
12. Funahashi, Y et al. Japanese Patent 08,231,552, 1996; Chem. Abstr. 1996, 125, 326518.
13. Su, M. H. et al. U.S. Patent, 5,728,727, 1998; Chem. Abstr., 1998, 128, 239489.
14. Bode H.B., and Zeeck A. J. Chem. Soc., Perkin Trans. 1 (2000) 323
15. Elnakady Y.A., et al. ChemBioChem 8 (2007) 2161
16. +: found m/z 583.3620, calcd m/z 583.3629.
17. -1]).
18. Wilson-Annan J., et al. J. Cell Biol. 162 (2003) 877
19. Meng Y., et al. Mol. Cancer Ther. 7 (2008) 2192