Deciphering the antitumoral activity of quinacrine: Binding to and inhibition of Bcl-xL

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 6, 2009, Pages 1592-1595

  Orzáez, Mar ^a   Mondragón, Laura ^a   García Jareño, Alicia ^a   Mosulén, Silvia ^a   Pineda Lucena, Antonio ^a   Pérez Payá, Enrique ^a,b  

^a CENTRO DE INVESTIGACIÓN PRÍNCIPE FELIPE   (Spain)

^b INSTITUTO DE BIOMEDICINA DE VALENCIA   (Spain)

Author keywords

Acridine; Anticancer; Apoptosis; bcl 2; bcl xL; Fluorescence polarization spectroscopy; Quinacrine

Indexed keywords

BH3 PROTEIN; MEPACRINE; PROTEIN BCL XL;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG BINDING; DRUG INHIBITION; DRUG SCREENING; DRUG STRUCTURE; HUMAN; HUMAN CELL; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION;

ACRIDINES; ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BCL-X PROTEIN; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INHIBITORY CONCENTRATION 50; JURKAT CELLS; MOLECULAR STRUCTURE; PROTEIN BINDING; QUINACRINE; SPECTROMETRY, FLUORESCENCE;

EID: 61349176648     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.02.020     Document Type: Article

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